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ASD Patient Brochure
ASD Patient Brochure

... Once inside the heart, the ePTFE material-covered wire frame of the GORE® Septal Occluder is deployed to form the device on either side of the defect between the left and right atria. Your physician will choose a GORE® Septal Occluder size larger than the defect in order to cover the hole. The ePTFE ...
Heart sounds Lecture (2012).
Heart sounds Lecture (2012).

...  2nd component occurs due to the closure of the A-V valves  3rd component is produced when semi-lunar valves open  4th component produced due to turbulent blood flow into large arteries  The mitral component heard at the apex beat area [left 5th intercostal ...
Quantification of the Contribution of Cardiac and Arterial - VU-dare
Quantification of the Contribution of Cardiac and Arterial - VU-dare

... parameters in the control group (Emin). There was a good agreement (Figure 2) between measured and predicted arterial pressure and flow, which supports that the model parameter values we used are correct. The only arbitrary parameter we entered was venous filling pressure in the control group. As LV ...
chapt19_student - Human Anatomy and Physiology
chapt19_student - Human Anatomy and Physiology

... • spontaneous firing from some part of heart not the SA node – ectopic foci - region of spontaneous firing • nodal rhythm – if SA node is damaged, heart rate is set by AV node, 40 to 50 bpm • intrinsic ventricular rhythm – if both SA and AV nodes are not functioning, rate set at 20 to 40 bpm – this ...
High-Intensity Interval Exercise in Chronic Heart Failure: Protocol
High-Intensity Interval Exercise in Chronic Heart Failure: Protocol

... and transplantation outpatient clinics of the Montreal Heart Institute. Inclusion criteria were: age $18 years, left ventricular ejection fraction (LVEF) !40% (measured within 6 months of enrollment by echocardiography, radionuclide ventriculography or cardiac magnetic resonance), stage C CHF as def ...
Acute Myocardial Infarction, Ischemic, Inflammation
Acute Myocardial Infarction, Ischemic, Inflammation

... We find further support in the fact that higher heart rate, presumably a surrogate marker for sympathetic activity, is an independent predictor of ischemic stroke in patients with AMI.5 van de Graff et al reported that there was no difference in the use of β-blocking medications among the various gr ...
Cardiorespiratory Function of Pediatric Heart Transplant Recipients
Cardiorespiratory Function of Pediatric Heart Transplant Recipients

... The reference range of V̇E varies and increases with age increment in children and adolescents.15 The V̇E/V̇O2 reflects the ventilatory requirement for any oxygen uptake, and it is an index of ventilatory efficiency. The V̇E/V̇CO2 represents the ventilatory requirement to eliminate a given amount of ...
Cardiovascular_math
Cardiovascular_math

Thoracic cage, mediastinum
Thoracic cage, mediastinum

... arteriole level. Mostly pericardial vessels are involved. • Anastomoses in the interventricular septum and within the posterior wall of the left ventricle are more important than the surface anastomoses ...
The Electrical System of the Heart
The Electrical System of the Heart

... Defects in the intrinsic conduction system may result in 1. Arrhythmias: irregular heart rhythms 2. Uncoordinated atrial and ventricular contractions 3. Fibrillation: rapid, irregular contractions; useless for pumping blood ...
The Physiological and Evolutionary Significance of
The Physiological and Evolutionary Significance of

... Regulation of pulmonary and systemic vascular resistances results from changes in autonomic tone and the release of neurohumoral factors. In addition, these combined factors also influence heart rate, ventricular contractility, and ventricular blood volumes, which together can contribute to the size ...
Chronic Mitral Regurgitation
Chronic Mitral Regurgitation

... Management Principles • Severe MS - is usually symptomatic - Percutaneous mitral commissurotomy (PMC) is the treatment modality of choice in the vast majority - PMC in optimal anatomy has acturial survival rate of 95% after 7 years - PMC in skilled centers has a mortality of < 1% ...
cardiovascular system
cardiovascular system

... diaphragm. But in lawer animal it is separated from diaphragm. 3: Anteriorly it is connected to the upper and lower ends of body of sternum by weak ...
Cardiac Metastasis from Ascending Colon Cancer - J
Cardiac Metastasis from Ascending Colon Cancer - J

... stasis from colorectal cancer11,13,16,17). Koizumi et al16) reported that although surgery is rarely recommended for treating metastatic cardiac tumors, surgical treat‐ ment could be especially effective in occurrences of obstructive and solitary lesions to ensure relief from symptoms and to prolong ...
Manuscript - Journal of Cardiothoracic Surgery
Manuscript - Journal of Cardiothoracic Surgery

... stop flow in the shunt. An aortotomy was performed to close the aneurysms and repair the aortic valve, as is performed in arrested hearts. After the intracardiac procedures were completed, standard de-airing maneuvers were emplyed. Transesophageal echocardiography(TEE) evaluated the condition of the ...
Control of ventricular excitability by neurons of the dorsal motor
Control of ventricular excitability by neurons of the dorsal motor

... as well as DVMN dysfunction, which results in a host of autonomic abnormalities.18,20 Aggregation of α-synuclein is a major molecular event in the development of the disease because of the toxicity of certain intermediate products of this process. Age-dependent decline of substantia nigra pars compa ...
Atrial Fibrillation: Management Strategies
Atrial Fibrillation: Management Strategies

... (UF EP Fellowship Support) ...
Heart disease and depression: Don`t ignore the relationship
Heart disease and depression: Don`t ignore the relationship

... • In the past month, have you felt “down,” depressed, or hopeless? • In the past month, have you had little pleasure or interest in doing things? The test is 96% sensitive: almost all who are depressed answer yes to both questions. ...
Anesthetic Management of an Atrial Septal Defect in Adult
Anesthetic Management of an Atrial Septal Defect in Adult

... accounts for 70%). Typically, the fossa ovalis is involved in the mid septallocation in most cases of ASD [5]. Some unusual presentations have been described [13]. Significant or complex ASD is often associated with other anatomical anomalies such as Eisenmenger or Lutembacher syndromes [14,15]. Pat ...
Physiologic signals - O6U E
Physiologic signals - O6U E

... The AV node slows impulse conduction, which allows time for the atria to contract and for blood to be pumped from the atria to the ventricles prior to ventricular contraction. Conduction time through the AV node accounts for most of the duration of the PR interval. ...
Regional patterns of cardiac sympathetic denervation in patients
Regional patterns of cardiac sympathetic denervation in patients

... 20% to 40% of diabetics also have abnormal autonomic function on clinical testing, even when DM is first diagnosed [1-3]. Cardiac autonomic neuropathy is associated with increased morbidity and mortality and has been linked to the occurrence of sudden death. Diabetic patients with autonomic dysfunct ...
1 A Stepwise Approach to the Management of Post
1 A Stepwise Approach to the Management of Post

... (MI) is associated with poorer prognosis. In such patients, implantable cardioverter-defibrillators (ICD) are recommended. Catheter ablation of VT is currently recommended only as an adjunctive therapy. Whether a successful VT ablation alone might be a viable strategy in some of these patients, howe ...
Prognostic Utility of Dobutamine Stress Echocardiography in the
Prognostic Utility of Dobutamine Stress Echocardiography in the

... standard indications such as severe chest pain, >2 mm ST depression, marked hypertensive response of >210 mm hg systolic blood pressure, development of new regional wall motion abnormalities or if requested by patient. Images were digitized and displayed in 4 quadrant views for side by side comparis ...
Telemedicine for Post-Myocardial Infarction Patients - Tel
Telemedicine for Post-Myocardial Infarction Patients - Tel

... year or had died within 1 year. Of the 3,950 patients with confirmed MI who were discharged alive from hospital in the ACSIS group, 51 were lost to follow-up and were excluded from final analysis, leaving a total of 3,899 patients who had completed a follow-up of 1 year or had died within 1 year. Se ...
The effect of aerobic continuous training and detraining on left
The effect of aerobic continuous training and detraining on left

... at rest to up to 40 l/min during maximal exercise. Besides an increase in cardiac output, the blood pressure increases as well, although not to the same extent as during strength training [13]. Lack of change in heart rate, systolic and diastolic blood pressure variables in this study may be due to ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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