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Cardiovascular autonomic nervous system
Cardiovascular autonomic nervous system

... Cardiovascular ANS assessment in RA has been studied by several investigators, and there have been conflicting results because of the way in which controls were selected and the criteria used to determine ANS dysfunction. Tests measuring heart rate variation have been most commonly employed, and the ...
Congestive Heart Failure
Congestive Heart Failure

... • An implantable cardioverter defibrillator (ICD). Some people with heart failure have very rapid, irregular heartbeats. Without treatment, the problem can cause sudden cardiac arrest. Doctors implant ICDs to solve this problem. ICDs are similar to pacemakers. The device checks your heart rate and c ...
QRS Complexes (Fast and Easy ECGs, Shade / Wesley)
QRS Complexes (Fast and Easy ECGs, Shade / Wesley)

1 - LSU School of Medicine
1 - LSU School of Medicine

... Singh, A., et al, Ann Emerg MED 50(5):552, November 2007 BACKGROUND: Alpha-antagonists and calcium channel blockers (CCBs) have been reported to inhibit the contraction of ureteral muscle and to facilitate passage of distal ureteral stones. METHODS: The authors, from Alameda County Medical Center in ...
Atrial fibrillation in the acute, hypercapnic exacerbations of COPD
Atrial fibrillation in the acute, hypercapnic exacerbations of COPD

... The number of patients with AF is likely to increase 2.5-fold during the next 50 years, reflecting the growing proportion of individuals with advanced age, many of whom have ridden out cardiovascular events that would have been fatal in a recent past. Incidence of AF in men is reported to be increas ...
Anatomy Lab Heart Dissection Name: 1 LEARNING OBJECTIVES
Anatomy Lab Heart Dissection Name: 1 LEARNING OBJECTIVES

... 9. Notice that the heart is made up of three histological layers: the epicardium (which is the same as the visceral pericardium), the myocardium (literally "heart muscle"), and the endocardium ("inside the heart"). Locate the side with the thickest myocardial wall. This will orient you to the left s ...
skeletal muscle apoptosis in experimental heart failure
skeletal muscle apoptosis in experimental heart failure

... Is Myosin Ubiquitinisation a mechanism of skeletal muscle atrophy in heart failure? patients with moderate to advanced heart failure. The portfolio of cytokines that will constitute the focus of inflammation in Heart Failure (CHF) is given by TNF and the interleukin (IL)-1 family (including the rec ...
Bottle feeding
Bottle feeding

... The location and radiation of the murmur, as well as the timing during cardiac cycle, is another way to determine the underlying cause. This can be accomplished by conducting a variety of tests, including chest X-rays, Doppler studies, and echocardiography. A complete blood count, meanwhile, is one ...
Neoplasms involving the heart, their simulators
Neoplasms involving the heart, their simulators

... Cardiac neoplasms may involve only the endocardium, only the myocardium, only the epicardium, or any combination of these (Figure 1). By far the most common location of metastatic cardiac neoplasm is the epicardium. Neoplasms limited to parietal pericardium without extension into the epicardium are ...
left atrium volume as a surrogate marker of left ventricular diastolic
left atrium volume as a surrogate marker of left ventricular diastolic

... Thus LAV increase reflects, the chronic exposure of the left atrium to high LV filling pressures and DD severity6,11. Left atrium (LA) is a reservoir for the LV during systole, a conduit [for blood to flow from pulmonary veins (PVs) to the LV] during early diastole and an active contractile chamber i ...
Gene expression profiling reveals potential prognostic biomarkers
Gene expression profiling reveals potential prognostic biomarkers

... prognostic value in patients with acute coronary syndromes in terms of the development of heart failure [11,12]. Their diagnostic/prognostic usefulness is enhanced by other biomarkers such as troponin I and C-reactive protein (CRP) [13]. However, these biomarkers exhibit elevated levels also in pati ...
Prolonged P wave dispersion in pre−diabetic patients
Prolonged P wave dispersion in pre−diabetic patients

... with an increased risk of ischaemic stroke, heart failure, and overall mortality [1–4]. Thus, identifying risk factors is important for the development of therapeutic approaches to AF. Diabetes has been reported to be one of the independent risk factors in AF development [11–14]. However, previous s ...
Left Venticular Diastolic Dysfunction in Essential Hypertension
Left Venticular Diastolic Dysfunction in Essential Hypertension

... TDiastolic dysfunction is very frequent and is actually sign of manifest heart weakness. Over  of patients with heart weakness have isolated left ventricular diastolic dysfunction (LVDD) . New diagnostics methods as Doppler Echocardiography with close monitoring enables precise and early LVDD dia ...
Jemds.com
Jemds.com

... the platelet activation, but they are of limited use due to complex pre-analytical factors, reduced specificity and poor reproducibility. MPV is a simpler marker that does not require advanced or expensive technology. MPV may reflect platelet production and stimulation; therefore, elevated MPV value ...
Electrocardiography in horses – part 2
Electrocardiography in horses – part 2

... (Hilwig, 1977; Fregin, 1992). It can occur in resting horses but appears much more frequently during the recovery period following exercise. Usually, the rhythm becomes regular again when the heart rate slows down to resting level. The condition is considered physiological but should disappear with ...
ICD in LV Dysfunction
ICD in LV Dysfunction

... risk for sudden cardiac death (1). Implantable cardioverter defibrillators (ICDs) can potentially mitigate this risk by delivering rapid life-saving therapy and have been substantially refined since their initial development in the late 1970s (2). Randomized, controlled trials (RCTs) have tested the ...
The diagnostic and prognostic value of right ventricular myocardial
The diagnostic and prognostic value of right ventricular myocardial

... of the onset of symptoms. Follow up including in-hospital events was performed. Results: Out of 101 patients (58 males, mean age 63.7 ± 11.1 years), RVMI was found in 37 (37%). In multivariate analysis, peak systolic RV velocity (SmRV) (OR 5.12), peak early diastolic RV velocity (EmRV) (OR 5.03) and ...
EXTERNAL PACEMAKER By Pat Hock, RN
EXTERNAL PACEMAKER By Pat Hock, RN

... battery, low output setting, or an increase in the pacing threshold because of edema or scarring. Failure to sense occurs when the pacemaker fails to detect native rhythm. Nursing assessment of a pacemaker should include that pacer settings are reflective of current orders. The pacemaker needs to be ...
Print - Circulation Research
Print - Circulation Research

... enzyme studies were the same as those in animals studied histologically, and in all cases included cardiac hypertrophy, hydrothorax, and hepatomegaly. Preparation of Tissue Fractions.—All preparative procedures were performed at 0 to 4°C. Seven to ten days postoperatively control and experimental an ...
Gene expression profiling reveals potential prognostic biomarkers
Gene expression profiling reveals potential prognostic biomarkers

... prognostic value in patients with acute coronary syndromes in terms of the development of heart failure [11,12]. Their diagnostic/prognostic usefulness is enhanced by other biomarkers such as troponin I and C-reactive protein (CRP) [13]. However, these biomarkers exhibit elevated levels also in pati ...
Repair of Prosthetic Mitral Valve Paravalvular Leak Using an Off
Repair of Prosthetic Mitral Valve Paravalvular Leak Using an Off

... valve) approach, or both, may be used. This technique avoids a thoracotomy and has been performed with technical success rates of 60% to 90% in selected patients [1]. It is of note that a retrograde approach is precluded in patients who have received a previous mechanical aortic valve. Limited data ...
What does an indeterminate troponin really mean?
What does an indeterminate troponin really mean?

... providing marker of increased mortality • Does not rule out concurrent CAD but clinical suspicion and risk factors are very important in guiding initial management • Cause should be indentified and treatment based on treating underlying pathology ...
Since the function of the heart is that of a pump it is of interest both to
Since the function of the heart is that of a pump it is of interest both to

- Austin Publishing Group
- Austin Publishing Group

... evaluated through echocardiography and magnetic resonance), as well as histopathological (if endomyorcardial biopsy is chosen), electrical (by electrocardiography, exercise testing and Holter monitor) and genetic/familial [1]. Frequently, the risk of sudden cardiac death is evaluated by electrophysi ...
Effects of n–3 fatty acids from fish on premature ventricular 1–3
Effects of n–3 fatty acids from fish on premature ventricular 1–3

... experiencing frequent PVCs. In a clinical setting, an individual positive response to treatment can be defined as a reduction by 쏜70% in the number of PVCs in a particular patient. In the current study, only 3 patients in the fish-oil group and 7 patients in the placebo group showed such a reduction ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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