
Mechanism of Aortic Valve Opening: Beyond the Pressure Gradient
... ratio, a CAC score >0 to 10 AU was associated with a 2.5-fold increase in odds for progression (odds ratio: 2.5 [95% confidence interval: 1.6 to 3.9]). A mild CAC score (>10 to 100 AU) was associated with a 12-fold increase in odds for progression (odds ratio: 12.0 [95% confidence interval: 6.2 to 23. ...
... ratio, a CAC score >0 to 10 AU was associated with a 2.5-fold increase in odds for progression (odds ratio: 2.5 [95% confidence interval: 1.6 to 3.9]). A mild CAC score (>10 to 100 AU) was associated with a 12-fold increase in odds for progression (odds ratio: 12.0 [95% confidence interval: 6.2 to 23. ...
Curriculum Vitae - Amazon Web Services
... investigate mechanisms of ventricular tachycardia and heterogeneities in conduction in left bundle branch block. Non-contact mapping records global activation from an entire cardiac chamber on a beat-by-beat basis thereby enabling insights previously only possible using animal models. In addition to ...
... investigate mechanisms of ventricular tachycardia and heterogeneities in conduction in left bundle branch block. Non-contact mapping records global activation from an entire cardiac chamber on a beat-by-beat basis thereby enabling insights previously only possible using animal models. In addition to ...
Vasodilator therapy for acute myocardial infarction and
... retention with consequent deterioration in heart failure. In some patients with severe heart failure, angiotensin II contributes significantly to elevating systemic vascular resistance. When these patients are treated with angiotensinconverting enzyme inhibitors, systemic vascular resistance decreas ...
... retention with consequent deterioration in heart failure. In some patients with severe heart failure, angiotensin II contributes significantly to elevating systemic vascular resistance. When these patients are treated with angiotensinconverting enzyme inhibitors, systemic vascular resistance decreas ...
Risk of Heart Failure With Preserved Ejection Fraction in Older
... symptoms, signs, and chest radiograph or echocardiographic evidence of HF (Table III in the online-only Data Supplement). Patients with other explanations (ie, lung metastasis) for HF symptoms were excluded. The medical records of potential controls were also reviewed with the use of free text data ...
... symptoms, signs, and chest radiograph or echocardiographic evidence of HF (Table III in the online-only Data Supplement). Patients with other explanations (ie, lung metastasis) for HF symptoms were excluded. The medical records of potential controls were also reviewed with the use of free text data ...
Ventricular Arterial Stiffening
... from the same set of PV loops shown in Figure 1B. Decreasing preload results in only a modest decline in systolic blood pressure in the younger individual but a much greater change in the older subject. As previously reported,5 the slope of such relations is determined by both arterial and ventricul ...
... from the same set of PV loops shown in Figure 1B. Decreasing preload results in only a modest decline in systolic blood pressure in the younger individual but a much greater change in the older subject. As previously reported,5 the slope of such relations is determined by both arterial and ventricul ...
Subdivisions of mediastinum
... rings surrouding the four orifices of heart • Epicardium 心外膜- serous membrane (visceral pericardium) ...
... rings surrouding the four orifices of heart • Epicardium 心外膜- serous membrane (visceral pericardium) ...
- Wiley Online Library
... effects by preventing cardiac fibrosis and hypertrophy.3 However, the potential cardiovascular beneficial effects of PPARg agonism have recently been questioned based on the evidence that rosiglitazone treatment to diabetic individuals may cause an increase in cardiovascular mortality of an unclear ...
... effects by preventing cardiac fibrosis and hypertrophy.3 However, the potential cardiovascular beneficial effects of PPARg agonism have recently been questioned based on the evidence that rosiglitazone treatment to diabetic individuals may cause an increase in cardiovascular mortality of an unclear ...
Ventricular Structure and Function
... necessity of a surgical intervention in severe aortic13–20 or mitral21–26 regurgitation. These cutoff values have entered the current guidelines27,28 for the management of valvular heart disease. It was consistently shown that besides symptomatic status and ventricular systolic function, LV dimensio ...
... necessity of a surgical intervention in severe aortic13–20 or mitral21–26 regurgitation. These cutoff values have entered the current guidelines27,28 for the management of valvular heart disease. It was consistently shown that besides symptomatic status and ventricular systolic function, LV dimensio ...
Cardiac Pacemaker - Hospital Chronicles
... between If and pacemaker activity, it is to be expected that If inhibition, such as the one that can be achieved by f-channel block, can lead to slowing of cardiac rate. Several recently developed drugs able to specifically slow heart rate without substantial side-effects (the “heart rate-inhibiting ...
... between If and pacemaker activity, it is to be expected that If inhibition, such as the one that can be achieved by f-channel block, can lead to slowing of cardiac rate. Several recently developed drugs able to specifically slow heart rate without substantial side-effects (the “heart rate-inhibiting ...
Cardiac Electrophysiology Basics
... controls all AV conduction system components. Pacing catheter is localized posterior of tricuspid valve. His electrogram (Fig. 3) contains deflection (A) i.e. depolarization of low RA, and then impulse enters the His and AV node and slows down due to lack of rapid sodium channels. No high frequency ...
... controls all AV conduction system components. Pacing catheter is localized posterior of tricuspid valve. His electrogram (Fig. 3) contains deflection (A) i.e. depolarization of low RA, and then impulse enters the His and AV node and slows down due to lack of rapid sodium channels. No high frequency ...
Print - Circulation
... concept that extrasystole-induced short-to-long cycle length changes may promote such dispersion,77'78 as manifest in electrocardiographic recordings that reveal the onset of sustained VT following a postextrasystolic sinus beat.19'40 This phenomenon could facilitate occurrence of sustained VT regar ...
... concept that extrasystole-induced short-to-long cycle length changes may promote such dispersion,77'78 as manifest in electrocardiographic recordings that reveal the onset of sustained VT following a postextrasystolic sinus beat.19'40 This phenomenon could facilitate occurrence of sustained VT regar ...
Giant Molecule Titin and Myocardial Stiffness
... hearts was the result of a “coordinated change in both collagen and titin, with titin dominating at short to intermediate sarcomere lengths and collagen at long sarcomere lengths.” Because end-diastolic sarcomere lengths in failing hearts are likely to be intermediate to long, LV size and geometry m ...
... hearts was the result of a “coordinated change in both collagen and titin, with titin dominating at short to intermediate sarcomere lengths and collagen at long sarcomere lengths.” Because end-diastolic sarcomere lengths in failing hearts are likely to be intermediate to long, LV size and geometry m ...
Basic ECG Interpretation
... To get the most out of the Basic ECG Interpretation Study Day please read this Package prior to attendance. At the study day, you will be required to undertake a pre test so it is important the information has been read properly. If you are not confident in your ECG knowledge and / or it has been a ...
... To get the most out of the Basic ECG Interpretation Study Day please read this Package prior to attendance. At the study day, you will be required to undertake a pre test so it is important the information has been read properly. If you are not confident in your ECG knowledge and / or it has been a ...
SA Node: impulse
... simply because it generates impulses slightly faster than the other areas with pacemaker potential. Because cardiac myocytes, like all nerve cells, have refractory ...
... simply because it generates impulses slightly faster than the other areas with pacemaker potential. Because cardiac myocytes, like all nerve cells, have refractory ...
Contemporary management of acute right ventricular failure: a
... return into the pulmonary circulation for gas exchange. Right ventricular function integrates preload, afterload, contractility, pericardial constraint, interaction with the left ventricle, and cardiac rhythm.12 – 14 Venous return depends on the pressure gradient between the peripheral vasculature w ...
... return into the pulmonary circulation for gas exchange. Right ventricular function integrates preload, afterload, contractility, pericardial constraint, interaction with the left ventricle, and cardiac rhythm.12 – 14 Venous return depends on the pressure gradient between the peripheral vasculature w ...
Contemporary management of acute right ventricular failure: a
... return into the pulmonary circulation for gas exchange. Right ventricular function integrates preload, afterload, contractility, pericardial constraint, interaction with the left ventricle, and cardiac rhythm.12 – 14 Venous return depends on the pressure gradient between the peripheral vasculature w ...
... return into the pulmonary circulation for gas exchange. Right ventricular function integrates preload, afterload, contractility, pericardial constraint, interaction with the left ventricle, and cardiac rhythm.12 – 14 Venous return depends on the pressure gradient between the peripheral vasculature w ...
Depression and heart disease: What do we know, and where are we
... for many years after the initial medical diagnosis is made.41 Katon et al42 reviewed 31 studies involving 16,922 patients, that assessed the impact of depression and anxiety in chronic medical illnesses such as heart disease, diabetes, pulmonary disease, and arthritis. After the severity of the me ...
... for many years after the initial medical diagnosis is made.41 Katon et al42 reviewed 31 studies involving 16,922 patients, that assessed the impact of depression and anxiety in chronic medical illnesses such as heart disease, diabetes, pulmonary disease, and arthritis. After the severity of the me ...
15-Lead ECG
... of left circumflex artery occlusion improved by twofold with the posterior leads. Additionally, 11% of patients with ST elevation in the posterior lead had no elevation or depression in any other lead. ...
... of left circumflex artery occlusion improved by twofold with the posterior leads. Additionally, 11% of patients with ST elevation in the posterior lead had no elevation or depression in any other lead. ...
Giant Molecule Titin and Myocardial Stiffness
... The study by Neagoe et al,2 though carried out in human hearts, is hampered by the fact that patients with CAD represent an extremely variable cohort. The fact that hemodynamic data were available from only 2 CAD patients makes it difficult to draw definitive conclusions as to changes of chamber sti ...
... The study by Neagoe et al,2 though carried out in human hearts, is hampered by the fact that patients with CAD represent an extremely variable cohort. The fact that hemodynamic data were available from only 2 CAD patients makes it difficult to draw definitive conclusions as to changes of chamber sti ...
Role of PET/ CT for the Identification of Cardiac Sarcoid Disease
... dle-aged adults(11,12) . Such middle-aged patients ...
... dle-aged adults(11,12) . Such middle-aged patients ...
Magnetic Resonance and Computed Tomography Imaging of
... disarray, and RVOT enlargement. Functional abnormalities include regional contraction abnormalities, aneurysms, RV global dilation/dysfunction, and RV diastolic dysfunction. The sites of involvement of these abnormalities are observed in the “triangle of dysplasia,” which is constituted by the infer ...
... disarray, and RVOT enlargement. Functional abnormalities include regional contraction abnormalities, aneurysms, RV global dilation/dysfunction, and RV diastolic dysfunction. The sites of involvement of these abnormalities are observed in the “triangle of dysplasia,” which is constituted by the infer ...
Chapter 19 Lecture Outline
... obstruction of coronary circulation – Atheroma (blood clot or fatty deposit) often obstructs coronary arteries – Cardiac muscle downstream of the blockage dies – Heavy pressure or squeezing pain radiating into the left arm – Some painless heart attacks may disrupt electrical conduction pathways, lea ...
... obstruction of coronary circulation – Atheroma (blood clot or fatty deposit) often obstructs coronary arteries – Cardiac muscle downstream of the blockage dies – Heavy pressure or squeezing pain radiating into the left arm – Some painless heart attacks may disrupt electrical conduction pathways, lea ...
Creatine kinase-MB fraction and cardiac troponin T to
... tory arrest. To assess whether the patient had a prior history of MI, the patient (if he or she had recovered) and/or the patient's relatives, as well as the physician, were interviewed. Prior MI was presumed if the patient had a history of chest pain and documented unequivocal changes on the ECG or ...
... tory arrest. To assess whether the patient had a prior history of MI, the patient (if he or she had recovered) and/or the patient's relatives, as well as the physician, were interviewed. Prior MI was presumed if the patient had a history of chest pain and documented unequivocal changes on the ECG or ...
Development of the Heart
... distributing blood through the vessels and the vital exchange of nutrients, oxygen, and wastes both to and from the developing baby. The critical early development of the heart is reected by the prominent heart bulge that appears on the anterior surface of the embryo. The heart forms from an embryo ...
... distributing blood through the vessels and the vital exchange of nutrients, oxygen, and wastes both to and from the developing baby. The critical early development of the heart is reected by the prominent heart bulge that appears on the anterior surface of the embryo. The heart forms from an embryo ...
Cardiac contractility modulation
.jpg?width=300)
Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.