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ICD in LV Dysfunction
ICD in LV Dysfunction

... risk for sudden cardiac death (1). Implantable cardioverter defibrillators (ICDs) can potentially mitigate this risk by delivering rapid life-saving therapy and have been substantially refined since their initial development in the late 1970s (2). Randomized, controlled trials (RCTs) have tested the ...
Jemds.com
Jemds.com

... the platelet activation, but they are of limited use due to complex pre-analytical factors, reduced specificity and poor reproducibility. MPV is a simpler marker that does not require advanced or expensive technology. MPV may reflect platelet production and stimulation; therefore, elevated MPV value ...
Since the function of the heart is that of a pump it is of interest both to
Since the function of the heart is that of a pump it is of interest both to

Print - Circulation Research
Print - Circulation Research

... enzyme studies were the same as those in animals studied histologically, and in all cases included cardiac hypertrophy, hydrothorax, and hepatomegaly. Preparation of Tissue Fractions.—All preparative procedures were performed at 0 to 4°C. Seven to ten days postoperatively control and experimental an ...
Gene expression profiling reveals potential prognostic biomarkers
Gene expression profiling reveals potential prognostic biomarkers

... prognostic value in patients with acute coronary syndromes in terms of the development of heart failure [11,12]. Their diagnostic/prognostic usefulness is enhanced by other biomarkers such as troponin I and C-reactive protein (CRP) [13]. However, these biomarkers exhibit elevated levels also in pati ...
Cardiac arrhythmias
Cardiac arrhythmias

... The prognosis is worse for patients with established coronary heart disease and ventricular premature beats than for those without the arrhythmia. When ventricular premature beats are present and ventricular function is diminished, survival is reduced further. Ventricular premature beats also increa ...
THE ROLE OF MAGNESIUM IN CARDIAC ARRHYTHMIAS
THE ROLE OF MAGNESIUM IN CARDIAC ARRHYTHMIAS

... longs the RR interval, slows down the atrioventricular (AV) conduction and restores the sinus rhythm (WESLEY et al. 1981, STILES et al. 2007, SAGER et al. 1990, VISKEN et al. 1992). Invasive electrophysiological studies carried out on patients with paroxysmal supraventricular tachycardia indicate th ...
Antiplatelet therapy and Coronary Interventions
Antiplatelet therapy and Coronary Interventions

... died from cardiac death, one (<1%) patient had periprocedural myocardial infarction, and two (2%) patients needed clinically driven target lesion revascularisation. No definite or probable scaffold thrombosis was observed. ΕΚΕ 2015 ...
determination of cardiac output in medical students by pulse
determination of cardiac output in medical students by pulse

... output (COP) is expressed as product of stroke volume and heart rate. Pulse pressure is determined approximately by the ratio of stroke volume output to the compliance of arterial tree. We hypothesized that by simply determining pulse pressure COP can be measured and these observations were made bef ...
Mitral Valve Repair in Patients With Low Left Ventricular
Mitral Valve Repair in Patients With Low Left Ventricular

... 1983 and 2001, we compared the course of 302 patients with preoperative LVEF of > 35% (group I) to that of 36 patients with LVEF of < 35% (group II). Results: Preoperatively, group II patients were more likely to be associated with ischemic heart disease (IHD) [p < 0.0002], and to have undergone eme ...
Pattern and severity of left ventricular diastolic dysfunction in early
Pattern and severity of left ventricular diastolic dysfunction in early

... function in subjects with preserved systolic function is not well defined. Objective: Our aim was to investigate whether renal insufficiency (RI) is associated with DD among patients with left ventricular ejection fraction (LVEF) > 50%, and to investigate whether there is a correlation between CKD a ...
Accelerated idioventricular rhythm observed under total intravenous
Accelerated idioventricular rhythm observed under total intravenous

... severe when their doses were decreased (+1), because the surgery 1 year prior had no episode of an AIVR with balanced anesthesia using sevoflurane, remifentanil, and propofol, the doses of which were lower than those at this time. The arrhythmias were objectively recorded on an ECG trace (+1). Most ...
Excess mortality and morbidity associated with right bundle branch
Excess mortality and morbidity associated with right bundle branch

... previous profile or whenever a significant change in status occurred . A complete profile was also prepared for the last available follow-up. Patients with electrocardiograms that revealed complete atrioventricular (A V) dissociation with a ventricular rate of less than 60 beat s/min were considered ...
Left Atrial Remodeling and Response to Valsartan in the Prevention
Left Atrial Remodeling and Response to Valsartan in the Prevention

... 54.4% of patients had AFr. LAVmax was unchanged by rhythm, time or randomized treatment. Higher baseline LAVmax and lower LA emptying fraction (LAEF) were linearly related to increasing AFr duration during follow-up. ConclusionsʊGISSI-AF patients in sinus rhythm and history of AF showed severely inc ...
cardiomyopathy - UMF IASI 2015
cardiomyopathy - UMF IASI 2015

... Epsilon waves or localized prolongation Late potentials on signal averaged ECG. (>110 ms) of.the QRS complex in right precordial leads (V1–V3). LBBB type ventricular tachycardia (sustained and non-sustained). Frequent ventricular extrasystoles (more than 1000/24h). Familial disease confirmed at auto ...
The Heart and Its Electrical System
The Heart and Its Electrical System

... occur when holes in the heart are closed or when artificial valves are placed. It can also be damaged during surgery to correct narrowing under the aortic valve. ...
Management of Acute Coronary Syndromes
Management of Acute Coronary Syndromes

... American Heart Association. Cardiac procedures and surgeries. http://www.heart.org/HEARTORG/Conditions/HeartAttack/PreventionTreatmentofHeartAttack/CardiacProcedures-and-Surgeries_UCM_303939_Article.jsp. Updated May 2, 2011. Accessed May 5, 2011. Popma JU. Coronary arteriography. In: Bonow RO, Mann ...
Diastolic LV function and HFNEF
Diastolic LV function and HFNEF

... • E/E ’ ratio >15 - ∆ of ↑ LV filling pressure and thus HFNEF • An E/E ’ ratio 8 – 15- asso with very wide range of mean LV diastolic pressures, thus, ...
1 A case report on Ebstein anomaly
1 A case report on Ebstein anomaly

... the anterior leaflet. Treatment of Ebstein anomaly is complex and dictated mainly by the severity of the disease itself and the effect of accompanying congenital structural and electrical abnormalities. Treatment options include medical therapy, radiofrequency ablation, and surgical therapy. The cas ...
Is Mitral Valve Prolapse Due to Cardiac
Is Mitral Valve Prolapse Due to Cardiac

... years). EBCT alone was also performed on 200 patients who had reported atypical chest discomfort and palpitations to their physicians (group C) and on 200 asymptomatic patients (group D). The EBCT measurements included the following: anteroposterior chest diameter (APD); the angle formed by the conf ...
To the Heart of the Matter - examining the conceptual context of the
To the Heart of the Matter - examining the conceptual context of the

... The Human Context of Disease Throughout history, mankind has been continually striving to develop and refine an understanding of the mechanisms of the life processes ultimately defined by disease and death. ...
pdf
pdf

... increased without an underlying structural abnormality. It has been associated with maternal diabetes and often regresses during the first 6 months of life. Ventricular hypertrophy can also be seen because of increased afterload. Decreased LV compliance results in cardiac and respiratory distress. R ...
Quiz 12
Quiz 12

... D. Widespread malignancy In patients with widespread malignancy or any illness that precludes meaningful recovery or preclusion to ICU admission, therapeutic hypothermia is contraindicated ...
as a PDF
as a PDF

... simulating a single beat on a model of the human heart at “cellular” spatial resolution [5]. The volume of heart muscle is roughly 225 cm3 . To simulate the flow of current, we must first subdivide this volume into a computational grid of roughly similar sized elements. For box elements of volume (0 ...
Symptoms, Adverse Effects, and Complications
Symptoms, Adverse Effects, and Complications

... Hospital, #5420, 926 West Michigan St, Indianapolis, IN ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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