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Percutaneous Coronary Angioplasty Compared With
Percutaneous Coronary Angioplasty Compared With

... stenoses was observed in the majority of patients, improved endothelium-dependent vasodilation may represent the most important mechanism to explain the marked reduction of myocardial ischemia.8,9 Single-center randomized clinical studies confirmed the effect of exercise training on clinical symptom ...
Conduction disturbances after surgical
Conduction disturbances after surgical

... and 2 children were excluded because of left axis deviation on the preoperative electrocardiogram. In both groups, the majority of ventricular septal defects were of the membraneous variety, 85 per cent in group 1; 89-5 per cent in group 2. All the ventricular septal defects were closed with a patch ...
Austin Wong Cardiac Imaging
Austin Wong Cardiac Imaging

... KG Friedman & ME Alexander, “Chest Pain and Syncope in Children: A Practical Approach to the Diagnosis of Cardiac Disease”, Journal of Pediatrics, 163(3):896-901; Sept 2013 DA Kane et al, “Needles in the Hay: Chest Pain as the Presenting Symptom in Children with Serious Underlying Cardiac Pathology” ...
valve replacement for acute left heart endocarditis
valve replacement for acute left heart endocarditis

... cardiac lesions. Since the introduction of antibiotherapy and the ageing of our european population, incidence of rheumatic heart disease and congenital cardiac disease have markedly decreased (22). Sclerosis and degenerative lesions [39%, n=12] are yet the most frequent underlying valvular diseases ...
Growth-Differentiation Factor-15 for Risk Stratification in Patients
Growth-Differentiation Factor-15 for Risk Stratification in Patients

... Methods and Results—The circulating levels of GDF-15 were measured by immunoradiometric assay in patients with stable angina pectoris (n⫽1352) or acute coronary syndrome (n⫽877) who were followed up for a median of 3.6 years. Stable angina pectoris patients presenting with normal (⬍1200 ng/L), moder ...
Pathological Q waves as an indicator of prior myocardial infarction in
Pathological Q waves as an indicator of prior myocardial infarction in

... Inclusion criteria were: —— previous angiographically proven clinical diagnosis of CAD; —— previous diagnosis of type 2 diabetes mellitus according to the American Diabetes Association criteria, and —— provision of informed consent for the study participation. Exclusion criteria consisted of: —— pre ...
Modeling Pathologies of Diastolic and Systolic Heart Failure
Modeling Pathologies of Diastolic and Systolic Heart Failure

... University, Stanford, USA. Electronic mail: [email protected] ...
12 Lead EKG and Acute Myocardial Infarction:
12 Lead EKG and Acute Myocardial Infarction:

... An EKG complex is a recording of the cardiac cycle of the heart— heart—it is depicted by waveforms (deflections) labeled with alphabetical letters ...
The circulatory system
The circulatory system

... Some arrhythmias are serious. One example is ventricular ­fibrillation, which causes a severely abnormal heart rhythm that leads to death unless treated right away with an electrical shock to the heart (called defibrillation). Other arrhythmias are less severe but can ­develop ­into more serious con ...
Aldosterone Receptor Antagonist and Heart Failure Following Acute
Aldosterone Receptor Antagonist and Heart Failure Following Acute

... chronic heart failure patients, the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) demonstrated that the selective aldosterone blocker eplerenone offered a significant survival benefit, attenuated the progression of heart failure, and prevented sudden ...
Strategic Programming of Detection and Therapy Parameters in
Strategic Programming of Detection and Therapy Parameters in

... from the previously conducted MIRACLE ICD (Multicenter InSync Implantable Cardioversion Defibrillation Randomized Clinical Evaluation) and EMPIRIC trials who met the primary prevention definition and had VT/VF detection and therapy parameters programmed at the discretion of the physician. The MIRACL ...
Noncontact mapping using the Endocardial Solutions
Noncontact mapping using the Endocardial Solutions

... at any filtering frequency, filter settings between 30 to 40 and 500 Hz are best suited for sharp intracardiac signals such as those from the His bundle and accessorypathways . Undesirable lowfrequency signals can be reduced by a high-pass filter setting of more than 50 to 100 Hz. On the other hand, ...
Frog Heart Physiology
Frog Heart Physiology

... terminals. This neurotransmitter binds with muscarinic receptors and initiates many effects, including a cascade that increases the number of K+ channels in the open position; thus keeping the membrane near the equilibrium potential for K+ and making depolarization more difficult. The sympathetic ca ...
Potential role of vitamin D deficiency on Fabry cardiomyopathy
Potential role of vitamin D deficiency on Fabry cardiomyopathy

... vitamin D binding protein in the urine, are mainly responsible for the high prevalence of depressed 25(OH)D levels (Jacob et al 1984; Wolf et al 2007; Wang et al 2008; Mehrotra et al 2009). Fabry patients typically suffer from so-called Fabry crises due to heat intolerance, especially during the sum ...
Arrhythmogenic Right Ventricular Dysplasia
Arrhythmogenic Right Ventricular Dysplasia

... The conventional criteria that can be displayed with CMR as major criteria are: the high signal intensity on T1-weighted images of the fatty infiltration of the RV myocardium; regional wall motion abnormalities (akinesis or dyskinesis or dyssynchronous RV contraction); bulges of the RV and RVOT; dil ...
Conocimiento de la Fibrilación auricular/ Aleteo auricular
Conocimiento de la Fibrilación auricular/ Aleteo auricular

... In hemodynamic studies, TIKOSYN had no effect on cardiac output, cardiac index, stroke volume index, or systemic vascular resistance in patients with ventricular tachycardia, mild to moderate congestive heart failure or angina, and either normal or low left ventricular ejection fraction. There was n ...
Long-Term Outcome of Alcohol Septal Ablation in Patients With
Long-Term Outcome of Alcohol Septal Ablation in Patients With

... wire into the target perforator artery and inflated. ASA was performed with the assistance of myocardial contrast (1 mL SonoVue, Bracco, Geneva, Switzerland) echocardiography to identify the septal region by the selected septal branch. If no contrast was seen outside the thickened basal septum, 0.5 ...
Thermal Therapy Improves Left Ventricular Diastolic Function in
Thermal Therapy Improves Left Ventricular Diastolic Function in

... These findings suggest that mitral flow velocity pattern changed from an abnormal relaxation pattern toward a more normal relaxation pattern, because tissue Doppler data showed that LV diastolic function was improved by sauna.8) Systolic indices such as percentage fractional shortening, stroke volum ...
Prognostication of long-term outcomes for patients with ischemic
Prognostication of long-term outcomes for patients with ischemic

... coronary syndromes, reduced EF (<40%) and increased heart rate (>70 beats per minute) were the strongest independent predictors of one-year mortality. Conclusion. A scoring system for the assessment of mortality risk within one year for patients with acute and chronic coronary syndromes was construc ...
Supraventricular tachycardia
Supraventricular tachycardia

... be put onto your child’s arms, legs and chest. These are connected to an ECG recording machine which picks up the electrical signals that make their heart beat. The test will only take a few minutes and won’t hurt your child at all. ...
Cardiac Examination
Cardiac Examination

...  Precordial bulge suggests cardiac enlargement which may be :  Acute: due to pericardial effusion.  Chronic: due to heart disease dating since early childhood (either congenital or acquired) . ...
Heart Restarts Teachers` notes - School
Heart Restarts Teachers` notes - School

... Finally the class could vote on whether they would like to carry donor cards or not. ...
Infórmese más acerca de TIKOSYN® (dofetilide)
Infórmese más acerca de TIKOSYN® (dofetilide)

... In hemodynamic studies, TIKOSYN had no effect on cardiac output, cardiac index, stroke volume index, or systemic vascular resistance in patients with ventricular tachycardia, mild to moderate congestive heart failure or angina, and either normal or low left ventricular ejection fraction. There was n ...
Video-assisted bilateral pulmonary vein isolation and left atrial
Video-assisted bilateral pulmonary vein isolation and left atrial

... enter the oblique sinus behind the heart. An articulated lighted dissector (AtriCure, Inc, Cincinnati, Ohio; Figure 2) is then introduced into the chest through a port and passed into the oblique sinus beneath the right inferior pulmonary veins. While the superior vena cava is distracted medially, d ...
Rate Versus Rhythm Control Pharmacotherapy For Atrial Fibrillation
Rate Versus Rhythm Control Pharmacotherapy For Atrial Fibrillation

... produce worsened sinus node function inpatients with the brady-tachy syndrome, and hence, is the preferred agent inthis condition where its use may avoid the necessity of inserting a pacemakerto support the use of an alternative AV nodal blocking agent; 3) ablation of ordrug suppression of an antegr ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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