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Permanent cardiac pacemaker: an emergency perspective
Permanent cardiac pacemaker: an emergency perspective

... There is no contraindication to perform cardiopulmonary resuscitation and institute advanced cardiac life support for pacemaker patients in cardiac arrest. However, the new semi-automatic defibrillation used by paramedics may fail to discharge in the presence of ventricular fibrillation as it overse ...
Electromechanical wavebreak in a model of the human left ventricle
Electromechanical wavebreak in a model of the human left ventricle

... Refs. 34, 37, 38) and may have both proarrhythmic and antiarrhythmic consequences. However, the mechanisms underlying these phenomena are not well understood. One of the problems in experimental studies of mechanoelectrical feedback is that it is difficult to control and record both the electrical a ...
Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary
Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary

... along with neurohormonal factors such as endothelin, catecholamines and tumour necrosis factor. Over the past several years, NT-proBNP has been studied in various populations of patients with PAH and found to be useful in diagnosing PAH in patients with scleroderma and predicting survival in both PA ...
Print EKG Factors that affect the Heart Lab
Print EKG Factors that affect the Heart Lab

... line is called the isoelectric line. Deviation from this line indicates electrical activity of the heart muscles. ...
Predictors of adverse neurological outcome following cardiac surgery
Predictors of adverse neurological outcome following cardiac surgery

... will be useful in selecting patients for pre- or intraoperative ...
doc - Computer Science
doc - Computer Science

... meanders with a characteristic pattern that depends on local electrophysiology. In heterogenous media meander is accompanied by drift. If the core of the re-entrant wave moves beyond the inexcitable boundary of the medium then re-entry ceases, and this has been proposed as a mechanism for self termi ...
Left Ventricular Assist Devices for Destination Therapy: An Evidence
Left Ventricular Assist Devices for Destination Therapy: An Evidence

... We reviewed the medical and economic literature to find out whether continuous-flow left ventricular assist devices improve patient outcomes (for example, increase survival, improve quality of life, reduce adverse events) and offers value for money over optimal medical (drug) therapy. One study comp ...
REGULATION OF BLOOD CIRCULATION
REGULATION OF BLOOD CIRCULATION

... mesoderm thus forming many blood vessels and a network of blood vessels. These blood vessels are filled with body fluid i.e. blood and thus a closed type of circulatory system is formed. In open type of circulatory system the body fluid freely flows in the cavity however to facilitate proper circul ...
Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing
Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing

... 1.5 times the upper limit of normal, or a level of function would have allowed for additional interim troponin T greater than 2 ng per milliliter); or diag- analyses, if necessary. For the study to have this level nostic changes on the electrocardiogram. A resting of power, at least 424 primary end ...
Dangers of Statin Drugs: What You Haven`t Been Told About
Dangers of Statin Drugs: What You Haven`t Been Told About

... and pain in the hands and feet as well as difficulty walking. Researchers who studied 500,000 residents of Denmark, about 9 percent of that country’s population, found that people who took statins were more likely to develop polyneuropathy.10 Taking statins for one year raised the risk of nerve dama ...
Role of the Echocardiography Laboratory in Diagnosis and
Role of the Echocardiography Laboratory in Diagnosis and

... Most often arising from the electrode, vegetations may additionally arise from the tricuspid valve leaflet. Vegetations may be found attached to the electrode within the right atrium or right ventricle, at the level of the atrioventricular plane, or even at the ostium of the coronary sinus.26 More o ...
Oxygen Cost of Electrical Activation of the Heart
Oxygen Cost of Electrical Activation of the Heart

... the accompanying carrier preamplifier and recording system were similar to those used with the Walton-Brodie strain gauge arch and permitted detecting changes of tension in the right ventricular segment of less than 0.5 g. The choice of the right ventricle for the more sensitive strain gauge arch wa ...
Prognostic Significance of Right Bundle Branch Block in Patients
Prognostic Significance of Right Bundle Branch Block in Patients

... acute anterior myocardial infarction (MI). Considering the anatomy and vascular supply of the conduction system, RBBB is usually the manifestation of large anterior MI that are often accompanied by heart failure and atrioventricular (AV) conduction block [1, 2], but the mechanism by which it represe ...
Cardiac Output
Cardiac Output

... Increased Parasympathetic Stimulation - Parasympathetic activity increases after a crisis has passed. This reduces heart rate and stroke volume from their high levels, bringing cardiac output back to normal. Increased Venous Return - Cardiac muscle fibers are stretched by increased blood volume retu ...
Exploration of the Cause of the Low Intensity Aortic Component of
Exploration of the Cause of the Low Intensity Aortic Component of

... vibrate analogously to a vibrating membrane, then the driving force productive of valvular vibration is the diastolic pressure gradient.13 Acoustical theory indicates the amplitude of sound generated by a vibrating source in the form of a piston relates directly to the velocity of the vibrating sour ...
G-Protein Beta-3 Subunit Genotype Predicts Enhanced Benefit of
G-Protein Beta-3 Subunit Genotype Predicts Enhanced Benefit of

... incorporated death, hospital stay for heart failure, and change in quality of life (QoL) and on event-free survival were assessed in GNB3 genotype subsets. RESULTS The GRAHF cohort was 60% male, 25% ischemic, 97% New York Heart Association functional class III, age 57  13 years, with a mean qualify ...
Cardiac Output
Cardiac Output

... • Increased Parasympathetic Stimulation - Parasympathetic activity increases after a crisis has passed. This reduces heart rate and stroke volume from their high levels, bringing cardiac output back to normal. • Increased Venous Return - Cardiac muscle fibers are stretched by increased blood volume ...
management and follow up of prosthetic heart valves - Heart
management and follow up of prosthetic heart valves - Heart

... valves, Starr Edwards valves, mechanical prostheses in mitral position, the presence of risk factors for thrombosis (see below), or the first three postoperative months following bioprosthetic valve replacement.5 Patients with a biological valve and risk factors for thrombosis, such as atrial fibril ...
Advances in Genetics - Circulation: Cardiovascular Genetics
Advances in Genetics - Circulation: Cardiovascular Genetics

... United States identified a total of 1866 athletes over a period of 27 years who died suddenly (or were resuscitated) during exercise, equating to an incidence of <100 per year.10 In contrast to the Italian study, HCM was the most common cause of death accounting for approximately one third of all de ...
Cardiovascular abnormalities accompanying acute spinal cord
Cardiovascular abnormalities accompanying acute spinal cord

... two groups). These five individuals ranged in age from 20 to 85 years. All five had complete loss of neurologic function below the level of their cervical cord lesion (that is, all were in category cervical A). Although the exact arrhythmia triggering the arrest could not be determined in most insta ...
Heart Rate Recovery Immediately After Treadmill
Heart Rate Recovery Immediately After Treadmill

... Background—An attenuated heart rate recovery after exercise has been shown to be predictive of mortality. In prior studies, recovery heart rates were measured while patients were exercising lightly, that is, during a cool-down period. It is not known whether heart rate recovery predicts mortality wh ...
Favorable Survival after Aortic Valve Replacement Compared to the
Favorable Survival after Aortic Valve Replacement Compared to the

... Survival was estimated using the Kaplan-Meier method, and expected survival was estimated using the Ederer II method, using the ‘survexp’ function within the R statistical program. Expected survival is the survival in a reference population which is similar to the study cohort of patients at the sta ...
valve replacement for acute left heart endocarditis
valve replacement for acute left heart endocarditis

... cardiac lesions. Since the introduction of antibiotherapy and the ageing of our european population, incidence of rheumatic heart disease and congenital cardiac disease have markedly decreased (22). Sclerosis and degenerative lesions [39%, n=12] are yet the most frequent underlying valvular diseases ...
Conduction disturbances after surgical
Conduction disturbances after surgical

... and 2 children were excluded because of left axis deviation on the preoperative electrocardiogram. In both groups, the majority of ventricular septal defects were of the membraneous variety, 85 per cent in group 1; 89-5 per cent in group 2. All the ventricular septal defects were closed with a patch ...
Percutaneous Coronary Angioplasty Compared With
Percutaneous Coronary Angioplasty Compared With

... stenoses was observed in the majority of patients, improved endothelium-dependent vasodilation may represent the most important mechanism to explain the marked reduction of myocardial ischemia.8,9 Single-center randomized clinical studies confirmed the effect of exercise training on clinical symptom ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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