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... The study population included 111 patients from three tertiary-care centers in Switzerland with a definite (n = 80), borderline (n = 19), and possible (n = 12, all first degree family members of patients with confirmed ARVC/D) diagnosis of ARVC/D according to the 2010 TFC, who had an ECG recorded be ...
Use of Injectable Potassium Chloride for
Use of Injectable Potassium Chloride for

... and esthetically acceptable for personnel carrying out the procedure. It is also stated that a euthanasia method should “…produce rapid unconsciousness and thus assurance of insensitivity to pain; this must be followed by cardiac and respiratory arrest.” Death can be due to either direct or indirect ...
Data from a study of 54 healthy subjects administered a... dasatinib 30 minutes following consumption of a high-fat meal indicated...
Data from a study of 54 healthy subjects administered a... dasatinib 30 minutes following consumption of a high-fat meal indicated...

... primary efficacy endpoint in these trials was major cytogenetic response (MCyR). An open-label, randomised, comparative multicentre study was conducted in patients who failed initial treatment with 400 or 600 mg imatinib. They were randomised (2:1) to either dasatinib (70 mg twice daily) or imatinib ...
Epidemiology of Stroke and Death in Atrial Fibrillation
Epidemiology of Stroke and Death in Atrial Fibrillation

... quality of data retrieval; however, in other settings, it may be necessary to validate data entries against medical records6. In this present study, data in the used registers were very reliable which a previous study has concluded after validating these data12,13. However, often investigators do no ...
Poster Arrhythmia Recognition Part 1
Poster Arrhythmia Recognition Part 1

... Arrhythmia Recognition (poster 1 of 2) This is part one of two posters to assist healthcare professionals in recognizing basic arrhythmias. According to the Practice Standards for Electrocardiographic Monitoring in Hospital Settings (Circulation. 2004;110:2721-2746) in general, the mechanisms of arr ...
PDF
PDF

... been invoked as the cause of sudden death. Only 2 cases have been diagnosed premortem, both at operative surgery (Edlund and Holmdahl, 0 1957; Svejda and Tomasek,25 1960). Only 1 case in the childhood group was an incidental finding (Auriol and colleagues,1 1958). Most intramural fibromas are locate ...
OSOP – Cardiology - Oxford Society of Paediatrics
OSOP – Cardiology - Oxford Society of Paediatrics

... • Q3) On a routine baby check, you notice that a 48 hour old baby has absent femoral pulses. Which three of these is correct? – A) There is a loud, late systolic murmur at the upper left sternal edge – B) Blood pressure may be higher in the right arm than the right leg – C) Closure of the patent duc ...
p227.pdf
p227.pdf

... by CT made mutual information fail, being incapable of properly assessing the agreement between both poses when limited to the cardiac region only. The emission-driven method had results equivalent to those obtained by manual registration. The correlation between the variation of measured uptake pro ...
Doping and effects of anabolic androgenic steroids on the heart: histological,
Doping and effects of anabolic androgenic steroids on the heart: histological,

... and the function of cardiac tissue. These properties may now be measured using either Doppler or twodimensional ultrasound techniques. Echocardiographic strain rate imaging (SRI) has been applied for the assessment of resting ventricular function, the assessment of myocardial viability using lowdose ...
Inhaled Beta-2 adrenergic receptor agonists and
Inhaled Beta-2 adrenergic receptor agonists and

... 1.3; 95% CI: 0.6 to 2.7), after adjustment for risk factors. This association was observed only with use of two or more canisters of metered-dose, inhaled ␤-agonists for 3 months, and when inhaled steroids were not used. CONCLUSION: These results support current guidelines recommending inhaled stero ...
Provisional PDF - BioMed Central
Provisional PDF - BioMed Central

... A follow-up ECG was available in 77 patients. In the remaining 34 patients, a follow-up ECG was not obtained due to short follow-up periods (n = 14) or loss of follow-up/heart transplantation/death (n = 20). The median time between baseline and follow-up ECG was 4 years (IQR 1.9-9.2 , range 0.3–21.8 ...
Respiration and Circulation in Patients with Portal Cirrhosis
Respiration and Circulation in Patients with Portal Cirrhosis

... conceivably initiate a cycle of events that ultimately leads to an increased plasma volume. 45' 46 From the foregoing review, one can conclude that cirrhosis of the liver may be accompanied by marked changes in the respiratory pattern, pulmonary vasculature, and systemic circulation. Information abo ...
PERICARDIAL EFFUSION IN CANINE PATIENTS
PERICARDIAL EFFUSION IN CANINE PATIENTS

... by pneumothorax, emphysema, and infiltrative myocardial disease.5 • Electrical alternans occurs when the size or configuration of the QRS complex, and occasionally the T wave, changes beat-to-beat. This ECG finding may suggest a large volume of pericardial effusion, and results from the heart moving ...
Reversible cardiac fibrosis and heart failure induced - HAL
Reversible cardiac fibrosis and heart failure induced - HAL

... myocardial heterogeneity, increasing diastolic stiffness, systolic dysfunction, and the propensity for reentry arrhythmias (1). Animal models are necessary to investigate the mechanisms of appearance and regression of cardiac remodeling and to improve therapeutic strategies. In this paper, we report ...
Persistent ductus arteriosus
Persistent ductus arteriosus

... A coarctation of the aorta is a narrowing of the aorta at or just distal to the insertion of the ductus arteriosus (distal to the origin of the left subclavian artery. Rarely it can occur proximal to the left subclavian. It occurs twice as commonly in men as in women. It is also associated with Tur ...
Transcatheter therapies for mitral regurgitation CLINICAL GUIDELINES
Transcatheter therapies for mitral regurgitation CLINICAL GUIDELINES

... using several imaging capabilities is essential before the procedure and at follow-up. Additional insights are to be gained through coronary angiography (either invasive or noninvasive) and delineation of the anatomic relationship between the coronary sinus and the mitral annulus. Standardized datas ...
Survival After Rate-Responsive Programming in Patients With
Survival After Rate-Responsive Programming in Patients With

... patients undergoing cardiac resynchronization therapy defibrillator (CRT-D) implants. The heart rate score (HRSc), an indicator of heart rate variation, may predict survival. We hypothesized that high-risk HRSc CRT-D patients will have improved survival with DDDR versus DDD alone. Methods and Result ...
Template for BMJ Cases - ELSO 2016
Template for BMJ Cases - ELSO 2016

... positioned into the left ventricle in curve "U" and was returned to left atrium, this procedure was performed bedside at the PICU without complications. Target organ damage recovery was achieved between the third and fifth day of ECMO support. After approximately 84 hours of ECMO support, we tested ...
Reduced Inhospital Mortality in Patients with Acute Myocardial
Reduced Inhospital Mortality in Patients with Acute Myocardial

... those with a baseline blood pressure of ³ 140/90 mmHg were considered to have hypertension (HTN). Diabetes mellitus (DM) was defined by a fasting blood glucose level > 140 mg/dL, a random blood glucose level > 200 mg/dL, or the use of oral hypoglycemic agents or insulin. Hyperlipidemia was defined b ...
Acute left Ventricular Failure in Adults JCG0001 v2
Acute left Ventricular Failure in Adults JCG0001 v2

... 3) If very breathless or hypoxic consider giving CPAP with a PEEP of 510mmHg. Caution should be exercised in those with type 2 respiratory failure Regular blood gas monitoring and senior advice is mandatory. CPAP remains the treatment of choice in type 2 respiratory failure caused by LVF. If hyperca ...
chap 18b - Dr. Jerry Cronin
chap 18b - Dr. Jerry Cronin

... • Three differences from skeletal muscle: – ~1% of cells have automaticity ...
Increasing plasma potassium with amiloride shortens the QT interval
Increasing plasma potassium with amiloride shortens the QT interval

... the added effect of blocking aldosterone. In both of the above papers,6 7 the authors did not differentiate between potassium sparing agents; therefore it is difficult to know whether this beneficial effect was indeed caused by increasing potassium per se or whether aldosterone blockade contributed. ...
Detecting B-Type Natriuretic Peptide to Better Diagnose Congestive
Detecting B-Type Natriuretic Peptide to Better Diagnose Congestive

... When BNP binds to NPR-C, BNP is removed from the bloodstream and broken down, and swelling in that area reduces. Since CHF patients have a large amount of BNP, the receptors are unable to break down all of it and the swelling remains. Continual stress and swelling can be fatal. A way to measure the ...
Crayfish Heart
Crayfish Heart

... in the absence of any neural input. The cells throughout the heart beat in a coordinated fashion because they are electrically coupled and beat at the same rate as the pacemaker cells in the sino-atrial and atrial-ventricular nodes. In most vertebrates, the blood is pumped into a closed circulatory ...
New-born Babies with Abnormal Heart Rhythm CA6034 v1.1
New-born Babies with Abnormal Heart Rhythm CA6034 v1.1

... These audits will be presented at Departmental Clinical Governance Meetings Summary of development and consultation process undertaken before registration and dissemination The authors on behalf of the Neonatal Department, which has agreed the final content, drafted the guideline. It has been discus ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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