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TETRALOGY OF FALLOT: REPORT OF TWO CASES IN
TETRALOGY OF FALLOT: REPORT OF TWO CASES IN

... We presented two children of similar age with TOF ― one girl (from the second pregnancy) and one boy (from twin pregnancy). Both children were without hereditary load. However, the boy, according to the literature, had the risk of ―twin process‖ [19]. The literature describes cases of twin pregnanci ...
A Comparison of Regional Blood Flow and Oxygen
A Comparison of Regional Blood Flow and Oxygen

... the heart failure patient which might serve to maintain an adequate systemic blood pressure in the face of a limited cardiac output response to dynamic exercise. Although this abnormality might be partially advantageous, it is not known whether any adverse metabolic consequences result from this red ...
Cardiac electrophysiology
Cardiac electrophysiology

... The resting membrane potential is caused by the difference in ionic concentrations and conductances across the membrane of the cell during phase 4 of the action potential. The normal resting membrane potential in the ventricular myocardium is about -85 to -95 mV. This potential is determined by the ...
A contemporary European experience with surgical septal
A contemporary European experience with surgical septal

... of myectomy programmes in several European countries. Therefore, many HCM candidates for myectomy in Europe cannot be offered the option of this procedure. The purpose of our study is to report the difficulties and results in developing a myectomy programme for HCM in a centre without previous exper ...
Cardiac Computed Tomographic Angiography
Cardiac Computed Tomographic Angiography

... sample sizes conclude that the presence of myocardial hypoenhancement on cardiac CTA in acute chest pain patients has a high positive predictive value and specificity but only moderate sensitivity for presence of acute or healed MI. Additional studies conclude that the presence and size of early per ...
transcatheter closure of patent ductus arteriosus using the amplatzer
transcatheter closure of patent ductus arteriosus using the amplatzer

... smaller catheters, and its high closure rate approaching 98%-100%.(5,16,18) The coil has disadvantages, the most important one is the lack of a controlled-release mechanism, that once they are released they cannot be retrieved back. Recently, controlled-release coils have been developed(19) and are ...
Intensive Insulin Therapy in Critically Ill Patients
Intensive Insulin Therapy in Critically Ill Patients

frequency and clinical outcome in conduction defects in acute
frequency and clinical outcome in conduction defects in acute

... Background: Conduction defects complicating acute myocardial infarction (MI) are frequent and associated with increased mortality and complications. Common conduction defects after acute MI are atrioventricular nodal blocks (1 st, 2nd and 3 rd degree) and intraventricular conduction defects (right o ...
Coronary Revascularization in Patients with Stable
Coronary Revascularization in Patients with Stable

... All patients with coronary artery disease should have optimal medical management, regardless of whether or not they are revascularized. Medical management is aimed at ways to limit progression of disease while prolonging quantity and improving quality of life. The mainstays of optimal medical manage ...
to the Session 1 notes
to the Session 1 notes

... cables to the patient, these include; metal crocodile clips (filed down, flattened or bent to reduce the animal’s discomfort (Tilley 1992)), plastic crocodile clips, electrode pads or metal plates which are attached to the leg / foot. The cables are then connected to these. One study showed that the ...
Document
Document

... Ischemic cardiomyopathy is a weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease being the most common cause. Anemia and sleep apnea are relatively common conditions that can contribute to ischemic myocardium and hyperthyroidism can ca ...
CARDIAC MURMUR What does it mean?
CARDIAC MURMUR What does it mean?

... n  Humans: sarcomeric gene mutation n  Progressive disease n  Apparent at 2 years of age in males; females affected at 3 years n  Often do not see clinical signs until 6 to 7 years of age n  ...
Why is Regression of Left Ventricular Hypertrophy Convenient? QCVC Committees
Why is Regression of Left Ventricular Hypertrophy Convenient? QCVC Committees

... In some studies carried out by our group, we have been able to identify, in an objective way a linear, positive, continuous and statistically significant correlation between the left ventricular mass index corrected by body surface or by height to the 2.7 power and the maximum corrected QT so that t ...
Should rhythm control be preferred in younger atrial fibrillation
Should rhythm control be preferred in younger atrial fibrillation

... Purpose Rate- and rhythm control are two fundamental strategies to treat atrial fibrillation (AF). However, there are inconsistent results between clinical trials about which treatment should be preferred. The aims of this study were to systematically summarize the clinical trials and compare rate- ...
Diesel Exhaust Inhalation Increases Cardiac
Diesel Exhaust Inhalation Increases Cardiac

... adjacent RR intervals (RMSSD), triangular index, and percent of adjacent normal RR intervals differing by ≥ 15 ms (pNN15). pNN15 is a measure of parasympathetic tone. SDNN and triangular index represent overall HRV, whereas RMSSD represents parasympathetic influence over HR (Rowan et al., 2007). HRV ...
Estrogen Receptor Я Protects the Murine Heart Against Left
Estrogen Receptor Я Protects the Murine Heart Against Left

... in E2-treated versus ⬍5 pg/mL in placebo-treated). Uterus weight (UW) was measured to demonstrate the effectiveness of ovariectomy and E2 substitution in all animals. In all groups (8 conditions with TAC or sham and placebo or E2 treatment for ER␣⫺/⫺ as well as ER␤⫺/⫺), the UW/BW and UW/tibia length ...
ventricular hypertrophy
ventricular hypertrophy

... negative complex preceded by a small r wave is found.* The transition point between the qR (or rR) and the rS patterns lies usually in the sternal region anteriorly (Fig. 4), but may frequently be somewhat to the right of the sternum in position V3R (Fig. 7). In some cases in which R-S waves of equa ...
Rheumatic Fever and Heart Disease
Rheumatic Fever and Heart Disease

... A. Acute rheumatic mitral valvulitis superimposed on chronic rheumatic heart disease. Small vegetations (verrucae) are visible along the line of closure of the mitral valve leaflet (arrowheads). Previous episodes of rheumatic valvulitis have caused fibrous thickening and fusion of the tendinous cor ...
Decreased polycystin 2 expression alters β-adrenergic calcium-contraction coupling and changes signaling pathways
Decreased polycystin 2 expression alters β-adrenergic calcium-contraction coupling and changes signaling pathways

... (Pkd2+/−) undergo cardiac remodeling as a result of changes in calcium handling, separate from renal complications. We found that Pkd2+/− cardiomyocytes have altered calcium handling, independent of desensitized calcium-contraction coupling. Paradoxically, in Pkd2+/− mice, protein kinase A (PKA) pho ...
Management of Fetal Arrhythmias
Management of Fetal Arrhythmias

... decided to proceed with attempted conversion of SVT using digoxin. Baseline EKG was performed and was within normal limits. The patient was then loaded with 0.5 mg IV digoxin and then started on oral digoxin 0.25 mg three times a day with a plan to check digoxin level in 24 hours. The patient ...
The Influence of Acute Kidney Injury on Acute Cardiovascular Disease
The Influence of Acute Kidney Injury on Acute Cardiovascular Disease

... overall mortality rate was 57.8%, and the AKIN0-hour, AKIN24-hour, and AKIN48-hour scoring systems exhibited excellent discrimination power according to areas under the receiver operating characteristic curve (AUROC) analysis. Furthermore, multiple logistic regression analysis indicated that AKIN48- ...
2016 Canadian Cardiovascular Congress
2016 Canadian Cardiovascular Congress

Baroreflex sensitivity changes with calcium antagonist
Baroreflex sensitivity changes with calcium antagonist

... elderly subjects, predominantly with either angiotensin-converting enzyme inhibitors9–12 or with calcium channel blocking drugs.12–17 The basis for the observed increases in BRS with treatment, although not seen in every study,17 is thought to be an increase in large artery compliance permitting res ...
21 January 2015
21 January 2015

... per minute. These are most commonly narrow complex supraventricular tachycardia but also ventricular tachycardia, long QT syndrome, ventricular fibrillation and sinoatrial node dysfunction (4).  Bradyarrhythmias - where heart rate is usually less than 100 beats per minute and include congenital hea ...
WPW and Preexcitation Syndromes
WPW and Preexcitation Syndromes

... cardiologists’ attention not only because of its clinical importance but also because of the opportunity it provides to learn about electrical conduction in the heart.1 The diagnosis of WPW syndrome is reserved for patients who have both pre-excitation and tachyarrhythmias. Historically, the possibi ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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