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Copyright Information of the Article Published Online TITLE
Copyright Information of the Article Published Online TITLE

... have an embolic mechanism and a significant proportion are likely to be related to undiagnosed AF. Ziegler et al[13] analysed data from patients at risk of thromboembolism (stroke/TIA) who had implantable cardiac devices capable of recording atrial arrhythmias. They identified newly detected episode ...
Right ventricular failure in patients with the HeartMate
Right ventricular failure in patients with the HeartMate

... insufficient.1 Although cardiac transplantation remains an attractive therapeutic option for select patients, only 2000 heart transplantations are performed each year in the United States, largely as a result of donor shortages.2 This continued limitation underscores the need for alternative avenues ...
Case Report Hemolysis and Pulmonary Insufficiency
Case Report Hemolysis and Pulmonary Insufficiency

... had an uncomplicated recovery and was discharged home on the tenth postoperative day. ...
the PDF - Heart Rhythm Society
the PDF - Heart Rhythm Society

... ECG conferences. Additional experience in heart rhythm disorders and clinical correlations can be obtained from didactic sessions and conferences; however, they must be supplemented by rotation on an arrhythmia consultation service, during which time the trainee should gain first-hand experience as ...
Dose-Response Relationships and Plasma Concentrations of
Dose-Response Relationships and Plasma Concentrations of

... of this method appears well established [17]. However, there are few data about the relationship between therapeutic plasma levels of digitalis and glycoside effects. The first attempts to correlate glycoside concentration and therapeutic effect were made from the reduction in heart rate during atri ...
Indications and Evaluation for ASD Closure
Indications and Evaluation for ASD Closure

... criteria are met, then the defect can be closed in the same setting. In general, ASD closure is recommended in all symptomatic and asymptomatic patients with PVR < 10 Woods units. However, it is absolutely contraindicated in patients with PVR of 15 Woods unit or more. Patients with PVR between 10 an ...
Chapter 14 Review - greene
Chapter 14 Review - greene

Cardiac output and peripheral resistance during larval development
Cardiac output and peripheral resistance during larval development

... few studies have focused on the chick embryo, with data available on cardiac output, central blood pressures, and peripheral resistance (1, 7-12, 14, 18). Heart rate in the chick embryo is variously reported to increase progressively, peak midway, or remain constant through incubation (9, 16, 18, 31 ...
CARDIOMYOPATHY SUPPORT GROUP IRELAND
CARDIOMYOPATHY SUPPORT GROUP IRELAND

... Assessment generally involves a review of your family’s medical history, a physical examination and tests including an electrocardiogram (ECG), an echocardiogram (Echo) and exercise stress tests. These tests look at the electrical activity and structure of the heart at rest and during exercise, and ...
Mitral Valve Disease
Mitral Valve Disease

... stretches in response to the backup of blood, the electrical pathways that keep the heart rhythm stable can become disturbed, and a rapid irregular heartbeat may result, causing palpitations. Other symptoms may include fatigue, chest pain, dizziness, and occasionally coughing up blood. The only effe ...
A study of inflammatory markers and their
A study of inflammatory markers and their

... Chronic heart failure (CHF) is a complex syndrome, which is characterized by shortness of breath, fatigue, congestion, and cachexia, and symptoms related to inadequate tissue perfusion, fluid retention, and neurohormonal activation. Despite significant improvement in medical therapy of cardiovascula ...
Acoustic Cardiography-Archived Policy
Acoustic Cardiography-Archived Policy

... necessarily mean the diagnosis of heart failure is uncertain when all clinical information is considered; therefore, this type of evidence is not sufficient to conclude that acoustic cardiography improves the diagnosis of heart failure. In patients treated with a CRT device, does optimization of hem ...
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... Dublin 2, Ireland ...
Electrical alternansin cardiac tamponade
Electrical alternansin cardiac tamponade

... With the last method both oscillatory and twisting cardiac motions with varying frequency, plane, and amplitude were observed. The variation in size of the alternating QRS complexes as seen in the present cases can be explained by accepting the view that the heart is oscillating within the distended ...
Pediatric Cardiology and Cardiovascular Surgery
Pediatric Cardiology and Cardiovascular Surgery

... alphabet nomenclature. These 2 schools of cardiac nomenclature were initially quite polarized, and although they share many similarities, their differences have not been completely resolved. Thus, these 2 schools of cardiac nomenclature are now widely used by the loyal disciples of each. As yet, the ...
Min-dose双源CT技术与三维超声心动图在主动脉瓣狭窄中的对比研究
Min-dose双源CT技术与三维超声心动图在主动脉瓣狭窄中的对比研究

... Data correlation analysis between MinDose-DSCT and TTE Results are shown in Fig. 4. In the experimental group, there was a strong correlation between LVEF measured by MinDose-DSCT and 2D-TTE (r=0.87, P<0.01), much stronger correlation between MinDose-DSCT and 4D-TTE (r=0.90, P<0.01) was regarded to ...
Basic science behind the cardiovascular benefits of exercise
Basic science behind the cardiovascular benefits of exercise

... Cardiorespiratory fitness is a strong predictor of cardiovascular (CV) disease and all-cause mortality, with increases in cardiorespiratory fitness associated with corresponding decreases in CV disease risk. The effects of exercise upon the myocardium and vascular system are dependent upon the frequen ...
High prevalence of occult left heart disease in scleroderma-pulmonary hypertension
High prevalence of occult left heart disease in scleroderma-pulmonary hypertension

... atrial pressure in diastole, except in patients with mitral valve disease or pulmonary veno-occlusive disease. It has been previously reported that in patients with PH, the PAWP and LVEDP are frequently discordant [4]. In that series, 37% of patients with suspected PAH based on the standard PAWP-bas ...
Wound model of myocardial infarction - AJP
Wound model of myocardial infarction - AJP

... preventing hypertrophy and fibrosis in residual surviving myocardium with the use of angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor antagonists. Thus clinical research has focused on strategies for an optimal reperfusion therapy during the first hours of developing myocar ...
Longitudinally and circumferentially directed movements of the left
Longitudinally and circumferentially directed movements of the left

... anterior heart surface, they are likely to determine the dominant direction of initial LV rotation, causing the entire ventricle to rotate in a counter-clockwise direction, as viewed from the apex. We believe this explains the initial counter-clockwise movement of the left ventricle at the beginning ...
Congenital Heart Disease from the Block
Congenital Heart Disease from the Block

... for her colleagues on the differential diagnosis of stroke in pediatrics. You point out that certain patients who have cardiovascular pathology may be at increased risk for cerebrovascular accident. Which of the following cardiac conditions is MOST likely to be associated with a cerebrovascular acci ...
Left ventricular filling in hypertrophic cardiomyopathy - Heart
Left ventricular filling in hypertrophic cardiomyopathy - Heart

... rather than mechanical obstruction to inflow. A significant component of the overall impairment of cardiac function in hypertrophic cardiomyopathy appears to be the abnormal diastolic function of the left ventricle (Hansen et al., 1962; Goodwin, 1974). It has been suggested that increased elastic st ...
Valtensin Tablets Valsartan - Actavis HK Pharmaceuticals
Valtensin Tablets Valsartan - Actavis HK Pharmaceuticals

... Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Whilst there is no controlled epidemiological data on the risk with Angiotensin II ...
Clinical outcome of transcatheter closure of patent ductus arteriosus
Clinical outcome of transcatheter closure of patent ductus arteriosus

... was successfully deployed in this patient and was observed in the intensive care unit. However, position of device was unstable on follow-up echocardiography after one day. As a result, the patient was then referred for surgery. ...
Editorial Commentary
Editorial Commentary

... during wakefulness?” The first randomized trial of CPAP in OSA with sympathetic vasoconstrictor nerve traffic as its primary end point demonstrated a significant reduction during wakefulness in all of the treated subjects and a parallel decrease in concurrently measured systolic BP.7 Thus, an import ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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