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Valtensin Tablets Valsartan - Actavis HK Pharmaceuticals
Valtensin Tablets Valsartan - Actavis HK Pharmaceuticals

... Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Whilst there is no controlled epidemiological data on the risk with Angiotensin II ...
Evaluation of right and left ventricular function
Evaluation of right and left ventricular function

... longitudinal strain based on speckle tracking can detect subtle right (RV) or left ventricular (LV) dysfunction as an early sign of ARVC. Methods and results: Seventeen male patients, fulfilling Task force criteria for ARVC, 49 (32–70) years old, nineteen male first degree relatives 29 (19–73) y.o. ...
Editorial Commentary
Editorial Commentary

... during wakefulness?” The first randomized trial of CPAP in OSA with sympathetic vasoconstrictor nerve traffic as its primary end point demonstrated a significant reduction during wakefulness in all of the treated subjects and a parallel decrease in concurrently measured systolic BP.7 Thus, an import ...
as a PDF
as a PDF

... during wakefulness?” The first randomized trial of CPAP in OSA with sympathetic vasoconstrictor nerve traffic as its primary end point demonstrated a significant reduction during wakefulness in all of the treated subjects and a parallel decrease in concurrently measured systolic BP.7 Thus, an import ...
Fine-tuning ECG Parameters Technique for Precise Abnormalities Detection
Fine-tuning ECG Parameters Technique for Precise Abnormalities Detection

... accurately detect and classify ECG signals very fast, to provide a useful means for tracing the heart health in the right time. The effectiveness of such systems is affected by several factors, including the ECG signals, the estimated ECG’s features and descriptors, the dataset used for learning pur ...
Clinical outcome of transcatheter closure of patent ductus arteriosus
Clinical outcome of transcatheter closure of patent ductus arteriosus

... was successfully deployed in this patient and was observed in the intensive care unit. However, position of device was unstable on follow-up echocardiography after one day. As a result, the patient was then referred for surgery. ...


... Epidemiological evidence regarding the risk of teratogenicity following exposure to ACE inhibitors during the first trimester of pregnancy has not been conclusive; however a small increase in risk cannot be excluded. Whilst there is no controlled epidemiological data on the risk with Angiotensin II ...
Diastolic Dysfunction Cardiovascular Aging and the
Diastolic Dysfunction Cardiovascular Aging and the

... results in left atrial enlargement due to pressure and volume overload. It has been suggested that left atrial enlargement is associated with age (32,33); however, there is evidence that increased left atrial size is not a normal result of aging (34,35) and is more likely a compensatory response to ...
Cardiovascular Emergencies: Pericardial Effusion and Cardiac
Cardiovascular Emergencies: Pericardial Effusion and Cardiac

... activation of the renin-angiotensin-aldosterone system as the body attempts to increase blood volume and improve stoke volume (Bullock). As a result, workload on the failing heart is greatly increased. As these compensatory mechanisms are exhausted, a cycle of increased fluid, with decreased cardiac ...
1443 Final Protocol - Medical Services Advisory Committee
1443 Final Protocol - Medical Services Advisory Committee

... Define the proposed patient population that would benefit from the use of this service. This could include issues such as patient characteristics and /or specific circumstances that patients would have to satisfy in order to access the service. The proposed patient population that would benefit fro ...
Full-Text PDF
Full-Text PDF

... significant proepicardial contribution to the cardiac endothelium [19,23,24,26]. The PEO was thought to be a genetically homogeneous tissue. However, recent studies in both chick and mouse suggest that the PEO is a highly heterogeneous collection of genetically distinct sub-populations of cells with ...
Imaging focal and interstitial fibrosis with cardiovascular magnetic
Imaging focal and interstitial fibrosis with cardiovascular magnetic

... and there is increasing interest in the detection of early markers of an abnormal myocardial process, to which newer CMR techniques may have a role. ...
Clinical recommendations of cardiac magnetic resonance, Part II
Clinical recommendations of cardiac magnetic resonance, Part II

... myocarditis, can lead to false negative results for myocardial edema.6 Hyperemia identification, as proposed by Lake Louise criteria, is very challenging and poorly used in the clinical setting. Recently, postcontrast cine steadystate free precession (SSFP) sequences were proposed as a new method fo ...
Echotech Reporting Guidelines
Echotech Reporting Guidelines

... • If E:Ea ratio <8, the patient will have normal diastolic function • If the E:Ea ratio 8-15 and LA size is normal then there is no significant diastolic dysfunction • If E:Ea ratio 8-15 and LA size is increased (>4.00cm), significant LV diastolic dysfunction can not be excluded • When Diastology as ...
Increased Soluble ST2 Predicts Long-term Mortality in Patients with
Increased Soluble ST2 Predicts Long-term Mortality in Patients with

... hospital-based cohort of white individuals referred to coronary angiography and to evaluate the predictive value of potential markers on long-term outcome. LURIC study objectives, recruitment procedures, and characteristics have been described in detail previously (21 ). In brief, 3316 patients, who ...
Takotsubo Cardiomyopathy
Takotsubo Cardiomyopathy

Ventilatory control in patients with sleep apnoea and left ventricular
Ventilatory control in patients with sleep apnoea and left ventricular

... patients included in this study presented with a clinical sleep disorder; those with OSA confirmed by overnight polysomnography were younger, more obese, had better resting left ventricular function and appeared to show a trend towards dilated cardiomyopathy as the underlying cause of their heart fa ...
Circulation Research AUGUST
Circulation Research AUGUST

... It has also been appreciated that the increase in MVoo associated with muscular exercise or administration of catecholamines is often disproportionate to the changes in myocardial wall tension or heart rate which may occur, and that other factors must affect the MVo2 (10, 11). Recent studies have es ...
Accelerated idioventricular rhythm associated
Accelerated idioventricular rhythm associated

... arrhythmia resolved spontaneously. To the best of our knowledge, this is the first case report of AIVR associated with propranolol treatment. Accelerated idioventricular rhythm is characterized by an ectopic ventricular rhythm with three or more consecutive ventricular premature beats at a rate fast ...
Ventricular Electrical Heterogeneity in Experimental Diabetes
Ventricular Electrical Heterogeneity in Experimental Diabetes

... interindividual variations in the ischemia-induced ARI response were observed. It is noteworthy that several control animals demonstrated the prolongation of ARIs. Verkerk et al. (1996) showed that more than a half of rabbit cardiomyocytes demonstrated phasic prolongation of action potential duratio ...
Feasibility of Peripheral Venous Access for Temporary Right
Feasibility of Peripheral Venous Access for Temporary Right

... through the basilic vein to the axillary vein and further into the subclavian, from where it can follow the usual route of insertion after catheterization of the subclavian vein, without the use of fluoroscopy) ...
Percutaneous interventions in CHD [1]Shunt lesions
Percutaneous interventions in CHD [1]Shunt lesions

... Several studies have shown outcomes from transcatheter device closure of secundum ASD to be comparable to surgical outcome in carefully selected adult and pediatric patients. ...
Atrial Septal Defect
Atrial Septal Defect

... Ostium secundum atrial septal defects are by far the most common and are occasionally familial. There is a higher incidence in females, and about 20 percent of patients have associated mitral valve prolapse. Anomalous return of a right upper lobe pulmonary vein to the superior vena cava occurs in mo ...
ROLE OF ANAHATA CHAKRA AND CARDIAC PLEXUS IN
ROLE OF ANAHATA CHAKRA AND CARDIAC PLEXUS IN

Arrhythmias
Arrhythmias

... • The rhythm is irregular and rapid (approx. 140 – 150 beats per minute) • Q is usually d by 10% to 20% (no atrial “kick” to ventricular filling) • May be seen in CAD (especially following surgery), mitral valve stenosis, LV hypertrophy, CHF • Treatment: DC cardioversion & O2 if patient is unstable ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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