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... to further study echocardiographic markers of right ventricular contractile reserve in search of a noninvasive correlative parameter to the haemodynamic markers of contractile reserve and RV-PA coupling. The study by SHARMA et al. [12] may help answer this final question. The authors compared right ...
Polymorphous Ventricular Tachycardia
Polymorphous Ventricular Tachycardia

... class Ia drugs at the onset of PVT and those with primary or secondary ventricular fibrillation were not included in the study. However, one patient (3) was included who had initially received three doses of quinidine but continued having recurrent episodes of PVT more than 72 hours after the quinid ...
Acute Dyspnea in the Office - American Academy of Family Physicians
Acute Dyspnea in the Office - American Academy of Family Physicians

... plays a role in the early management of dyspnea. Once the patient is in the office, the initial goal of assessment is to determine the severity of the dyspnea with respect to the need for oxygenation and intubation. Unstable patients typically present with abnormal vital signs, altered mental status ...
Pericardial effusion after open heart surgery for - Heart
Pericardial effusion after open heart surgery for - Heart

... surgical and anaesthetic techniques, myocardial protection, and improved postoperative haemodynamics.7 Additionally, our study describes the evolution of the development of pericardial effusion. While pericardial effusion can be detected within the first two weeks of surgery in the majority (79%) of ...
Asymptomatic Patient Screening
Asymptomatic Patient Screening

... Magnetocardiography for Heart Wellness Screening A screening test must be accurate, reproducible, and provide information that can lead to a recommended course of action, suggest therapy or provide a prognosis. Non-invasive tests like echocardiography and the 12-lead ECG lack sufficient sensitivity ...
State of the Art in Forensic Investigation of Sudden Cardiac Death
State of the Art in Forensic Investigation of Sudden Cardiac Death

... the onset of symptoms in an apparently healthy subject or whose disease was not so severe as to predict an abrupt outcome.[7 This well describes many witnessed deaths in the community or in emergency departments. It is less satisfactory in forensic practice where autopsies may be requested on patien ...
Chronic Ischemic Heart Disease
Chronic Ischemic Heart Disease

... myocardial ischemia is induced, resulting in lower diagnostic yields. On the other hand, bicycle exercise can be performed in the supine position, which facilitates some myocardial ischemia detection methods such as echocardiography. In patients with peripheral vascular disease or lower limb amputa ...
PDF - Medical Express
PDF - Medical Express

... of weight) for at least 10 minutes and, in simultaneity, anastomosis of lateral posterior wall was started. The primary objective was the occurrence of postoperative complication. Mean arterial pressure and central venous pressure were collected at time-points T1, T5 and T10 (at 1, 5 and 10 minutes) ...
The P Wave: Indicator of Atrial Enlargement - e
The P Wave: Indicator of Atrial Enlargement - e

... Atrial chamber enlargement can occur in the presence of either increased resistance to blood flow (pressure overload or systolic overload) or increased quantity of blood within the chamber (volume overload or diastolic overload). Increased resistance to blood flow results in hypertrophy of the myoca ...
prevalence of asymptomatic left ventricular diastolic dysfunction in
prevalence of asymptomatic left ventricular diastolic dysfunction in

... have normal diastolic function. Majority of patients having age ≥ 55 years had develop Left ventricular diastolic dysfunction. The presence of left ventricular diastolic dysfunction in a significant proportion of our patients—especially after eliminating patients with other co-morbid illnesses and c ...
Computed tomographic versus
Computed tomographic versus

... the scanning time, leading to more respiratory artefacts; the high heart rate in infants makes it difficult to obtain adequate high-resolution images; and most of the extracardiac anatomy can be adequately depicted without ECG gating. Even though the distal coronary arteries cannot be visualized witho ...
08 General principles of skeletal, cardiac, and smooth muscles II
08 General principles of skeletal, cardiac, and smooth muscles II

...  skeletal is under voluntary (somatic) control, cardiac is under involuntary (autonomic) control o First, the heart has autorhythmicity (beat on its own) due to intrinsic cardiac conduction system o Second, the cardiac conduction system is subject to control by the autonomic nervous system  In ske ...
Interpreting AV (Heart) Blocks: Breaking Down the Mystery 2 Contact Hours
Interpreting AV (Heart) Blocks: Breaking Down the Mystery 2 Contact Hours

... polarized at rest). When depolarized, the interior cell becomes positively charged and the cardiac cell will contract. Since the polarized or resting cell has the negative charge on the inside at rest, depolarization occurs when potassium and sodium move across the cell membrane and the inside of th ...
Donor heart preservation and perfusion
Donor heart preservation and perfusion

... method allowed save extension of ischemic time of beyond 6 hours in a large animal model. In our own institution at the University Heart Center Hamburg such method was introduced clinically 2006 and applied in a total cohort of 114 orthotopic heart transplantations. Primary preservation was based on ...
The pathophysiology of acute heart failure—Is it
The pathophysiology of acute heart failure—Is it

... chronic ischemic heart disease, and ischemia is often invoked as an important trigger for AHF. Surprisingly, however, little data exist on the incidence of acute ischemia during an AHF event. However, in the large European registry, 4 only 32% of patients admitted with AHF had chest pain at admissio ...
J Am Coll Cardiol - ABcomm, Inc. Home
J Am Coll Cardiol - ABcomm, Inc. Home

... – Most patients see three or more physicians over a threeyear period before an accurate diagnosis is made ...
viding diagnostic insights into the pathophysiologic mechanisms under
viding diagnostic insights into the pathophysiologic mechanisms under

... with inspiration. Isometric hand-grip exercise (or transient arterial occlusion of both arms with 2 blood pressure cuffs) increases the murmurs of MR, VSD, and AR and can also be of value. Alterations in cycle length as in atrial fibrillation or the long pause following a premature ventricular contr ...
Recognizing and Managing Asymptomatic Left Ventricular Dysfunction: After Myocardial Infarction
Recognizing and Managing Asymptomatic Left Ventricular Dysfunction: After Myocardial Infarction

... models that have been successful in patients with chronic heart failure, nurse clinicians should ensure that patients who have had a myocardial infarction receive the right medications, comprehensive self-care education to decrease the risk for new cardiac events, and an appointment for follow-up af ...
Arrhythmia? Does This Patient With Palpitations Have a Cardiac
Arrhythmia? Does This Patient With Palpitations Have a Cardiac

... Context Many patients have palpitations and seek advice from general practitioners. Differentiating benign causes from those resulting from clinically significant cardiac arrhythmia can be challenging and the clinical examination may aid in this process. Objective To systematically review the accura ...
cardiac masses - NT Cardiovascular Center
cardiac masses - NT Cardiovascular Center

... Successful Rx with Chemo and XRT followed by transplant reported ...
Print this article - Publicatii USAMV Cluj
Print this article - Publicatii USAMV Cluj

... The purpose of this study is to emphasize the clinical signs, diagnosis of the cervical heart ectopia and to establish the possible genetic prevention methods of this disorder. The study was carried out on a two days old calf, which presented the clinical signs of heart ectopia. At palpation, the cl ...
Electrocardiography
Electrocardiography

... • The fastest functioning pacemaker in the heart takes over, by default • The closer to the AV node, the more the escape beat will resemble normal QRS • The closer to the ventricle, the more wide and bizarre the QRS will appear • Escape rhythm – pacemaker other than SA node takes over, because SA no ...
Association of Left Ventricular Dilation at Listing for Heart Transplant
Association of Left Ventricular Dilation at Listing for Heart Transplant

... or dilated cardiomyopathy (DCM), the subsequent myocardial changes at the genomic, molecular, cellular, and interstitial levels are referred to as cardiac remodeling.1–5 In DCM, remodeling manifests as progressive dilation of the left ventricle (LV) that becomes more spherical and hypertrophied with ...
Cardiac risk assessment before the use of stimulant medications in
Cardiac risk assessment before the use of stimulant medications in

... Health Canada) identified 25 sudden deaths in individuals prescribed ADHD medications from Adverse Event Reporting System data, resulting in the current concern over a possible association (6,31,32). However, when the number of patient-years of prescribed medication is incorporated into the evaluati ...
Diagnosis and Management of Chronic Heart Failure Quick
Diagnosis and Management of Chronic Heart Failure Quick

... mild (NYHA Class II) symptoms, despite receiving standard therapies with ACEIs and beta-blockers. Use diuretics, digoxin and nitrates to manage symptoms as indicated in people already receiving ACEIs and beta-blockers. Fish oils should be considered as a second-line treatment for people with CHF who ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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