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Impaired left ventricular relaxation in hypertrophic
Impaired left ventricular relaxation in hypertrophic

... dependent, although if deactivation is grossly depressed, relaxation may become load independent (3,4) . Thus, in the absence of mitral stenosis, the major determinant of peak early mitral inflow velocity is the left atrial-left ventricular pressure difference in early diastole (8) . In addition to ...
PDF file
PDF file

... 2 – where the heart-beat signals of the studied individuals are displayed (20 seconds recordings obtained along 7 days of measurements). The signal intensity (as recorded by an oscillograph) could reach 3 V. The HR in the oysters did not varied significantly, as values ranged between 30.2 and 33.5 b ...
Echocardiography of Congenital Heart Disease
Echocardiography of Congenital Heart Disease

... •Two large papillary muscles •Empties into left ventricle ...
chapter 22 cardiopulmonary and right-left heart interactions
chapter 22 cardiopulmonary and right-left heart interactions

... output were related to intrathoracic pressure. Positive-pressure ventilation via a mask in conscious volunteers led to a fall in cardiac output of approximately 10% to 15%. This was initially thought to be entirely due to changes in systemic venous return (and reduced ventricular preload) imposed by ...
Uremic autonomic neuropathy studied by spectral analysis of heart
Uremic autonomic neuropathy studied by spectral analysis of heart

... month to 22 years. None of them had heart failure, severe hypertension, ischemic heart disease, diabetes mellitus, bronchopneumopathy, or amyloidosis, nor were they taking medications known to affect the autonomic nervous system. Thirteen patients had mild-to-moderate hypertension and were on therap ...
Q and A-ASD_V3.indd - Adult Congenital Heart Association
Q and A-ASD_V3.indd - Adult Congenital Heart Association

... left and right atria. If there is a hole in the atrial septum, it is called an atrial septal defect (ASD). Some of the blood that should flow into the left ventricle (or lower pumping chamber) from the left atrium now flows into the right atrium through the ASD. In turn, more blood goes to the right ...
Ventricular Conduction Disturbances: Bundle Branch Blocks and
Ventricular Conduction Disturbances: Bundle Branch Blocks and

... shunting of blood, chronic pulmonary disease with pulmonary artery hypertension, and valvular lesions such as pulmonary stenosis, as well as cardiomyopathies and coronary disease. In some people (particularly older individuals), RBBB is related to chronic degenerative changes in the conduction syste ...
Structural heart disease interventions: rapid
Structural heart disease interventions: rapid

... regurgitation have already shown preliminary results that will likely lead to the treatment of patients who had previously been ineligible for traditional surgical valve repair or replacement. In addition, many patients will potentially be switched from open surgical to catheter-based treatments if ...
Distribution of Heart Potentials on the Thoracic Surface of Normal
Distribution of Heart Potentials on the Thoracic Surface of Normal

... the single equivalent dipole.3 During larger portions of the ventricular depolarization time, however, several simultaneous maxima and minima can be observed. Such a complex distribution of surface potentials cannot be reconciled with the above-mentioned theory. A multipolar equivalent generator sho ...
cardiology
cardiology

...  ISCHEMIA CRITERIA—1 mm horizontal or downsloping ST # over multiple leads, or ST " ! myocardial ischemia (sens 68%, spc 77%) ! proceed to angiogram  INCONCLUSIVE—premature termination due to chest pain/poor exercise tolerance ! proceed to pharmacological stress test  DUKE TREADMILL SCORE—(exerc ...
Two preventive multivessel stenting strategy with zotarolimus eluting
Two preventive multivessel stenting strategy with zotarolimus eluting

... revascularization during the second intervention. Earlier results of trials comparing MPS and CO approaches were controversial [12-19], probably due to the heterogeneity of patient samples, variable endpoints, distinct inclusion criteria and different study protocols. European and American Cardiolog ...
Beyond arterial remodelling: pulmonary venous and
Beyond arterial remodelling: pulmonary venous and

... the latter parameter predicts survival. WILLIAMS et al. [19] have previously shown that increased NT-proBNP serum levels in connective tissue disease-associated PAH patients closely correlated with altered haemodynamics and reliably predicted survival. In considering the main findings of these studi ...
successful rescue of sustained ventricular tachycardia/ventricular
successful rescue of sustained ventricular tachycardia/ventricular

... Vf) after coronary artery bypass grafting (CABG) who was successfully resuscitated using ECMO. The sustained VT/Vf might have been secondary to myocardial stunning, ischemia, infarction, or reperfusion. There were 40 cardioversions within the first 5 postoperative days. The patient improved after 8 ...
1, 6 % Study  design  and  rationale
1, 6 % Study design and rationale

... The PAD Trial is a prospective, multicenter, randomized clinical study testing whether volunteer, non-medical responders can improve survival from out-of-hospital cardiac arrest (OOH-CA) by using automated external defibrillators (AEDs). These lay volunteers, who have no traditional responsibility t ...
Midregional Pro–Atrial Natriuretic Peptide for
Midregional Pro–Atrial Natriuretic Peptide for

... thus remains a daily challenge for emergency physicians (1 ). Congestive heart failure (CHF) is the most frequent etiology for dyspnea and is more likely to affect elderly patients (2, 3 ). High concentrations of related morbidity and mortality will fall if an early and accurate diagnosis can be mad ...
Tachyarrhythmias
Tachyarrhythmias

... creating physiologic “interference” and block. Under the right conditions, some anterograde impulses may slip through. This phenomenon is not equivalent to third degree AV block ...
WIDE QRS TACHYCARDIA DR ANKUR
WIDE QRS TACHYCARDIA DR ANKUR

... recovered and conducted normally. • While AF, marked sinus arrhythmia, blocked atrial extrasystole there is sudden prolongation of ensuing RP. This may result in delay or block in conduction. ...
Early Regional Myocardial Dysfunction in Young
Early Regional Myocardial Dysfunction in Young

... Methods: Thirty-two patients with DMD (mean age, 7.9 years; range, 3-12 years) and 29 age-matched normal controls were studied with echocardiography. Standard echocardiographic measurements of left ventricular (LV) systolic and diastolic function were performed. Myocardial velocity and deformation d ...
Packer -PARADIGM - Clinical Trial Results
Packer -PARADIGM - Clinical Trial Results

... neprilysin ...
BE III PG 1-5
BE III PG 1-5

... questions: Are the P waves occurring at regular intervals? Do the P waves all have the same appearance on the ECG? Are the P waves visible at all? Normal sinus rhythm and respiratory sinus arrhythmia are two normal rhythms that apply to the first two questions; rhythms that do not have recognizable ...
Diapositivas-Estudio-PARADIGM-HF-Trial-ppt-pptx
Diapositivas-Estudio-PARADIGM-HF-Trial-ppt-pptx

... neprilysin ...
Netherlands Heart Journal Supplements Abstracts of the Scientifi c Spring
Netherlands Heart Journal Supplements Abstracts of the Scientifi c Spring

... We observed 213 pregnancies in 203 women with CHD; 12 women were again pregnant < 6 months after delivery, 18 women were lost to follow up, rendering 183 pregnancies in 173 women available for follow up. Late CVC were observed after 12 pregnancies (6.6%). Women with CVC during pregnancy were at risk ...
Slide 1
Slide 1

... • Known prior coronary stenosis of >50% • ST segment deviation on presenting ECG • At least 2 anginal events in prior 24 hours • Use of aspirin in prior 7 days ...
Is Computed Tomography Coronary Angiography the Most Accurate
Is Computed Tomography Coronary Angiography the Most Accurate

... Single-photon emission computed tomography (SPECT), the most commonly performed diagnostic test, is complex, costly, and time-consuming (ie, ⬇150 minutes for stress SPECT). In addition, this test is generally not available 24/7 due to the need to have a specifically trained personnel on-site.48 A nu ...
99311 Brugada/JB3
99311 Brugada/JB3

... Abstract: We describe a 45-year-old Taiwanese man with specific features of Brugada syndrome but no clinical features of structural heart disease. He was successfully treated with an implantable cardioverter-defibrillator. His electrocardiogram (ECG) patterns changed intermittently. Alpha-adrenocept ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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