Full PDF - IOSR Journal of Pharmacy
... The results on cardiotonic activity of paraoxon induced and normal parotoid gland secretions (without induction) are presented in Tables 1&2, Fig 1&2 and Graphs.1&2. The results indicated that the parotoid exudates on isolated perfused frog hearts elicited dose dependent effect. There was an increas ...
... The results on cardiotonic activity of paraoxon induced and normal parotoid gland secretions (without induction) are presented in Tables 1&2, Fig 1&2 and Graphs.1&2. The results indicated that the parotoid exudates on isolated perfused frog hearts elicited dose dependent effect. There was an increas ...
Atrioventricular Conduction in Atrial Fibrillation: Pathophysiology
... making up the conduction system. The ion channel expression in the AV node is specialized, similar to the sinoatrial node. There is very little expression of Kir2 channels, responsible for the IK,1 K+ current, the main current to keep working cardiomyocytes at a negative resting potential. Other Kir ...
... making up the conduction system. The ion channel expression in the AV node is specialized, similar to the sinoatrial node. There is very little expression of Kir2 channels, responsible for the IK,1 K+ current, the main current to keep working cardiomyocytes at a negative resting potential. Other Kir ...
Heart failure ontology - Zemris
... domain, as well as for unambiguous communication between professionals. In the process of developing the HF ontology there have been significant technical and medical dilemmas. The current result should not be treated as the ultimate solution but as a starting point that will stimulate further resea ...
... domain, as well as for unambiguous communication between professionals. In the process of developing the HF ontology there have been significant technical and medical dilemmas. The current result should not be treated as the ultimate solution but as a starting point that will stimulate further resea ...
Detection of scarred and viable myocardium using a new magnetic
... there is persistently impaired left ventricular contraction at rest which can be restored partially or completely to normal after revascularisation.1 2 Hibernation is a state of adaptation of the myocardium that acts as endogenous protection against ischaemia, preserving the structural integrity of ...
... there is persistently impaired left ventricular contraction at rest which can be restored partially or completely to normal after revascularisation.1 2 Hibernation is a state of adaptation of the myocardium that acts as endogenous protection against ischaemia, preserving the structural integrity of ...
Acute mitral regurgitation in pregnancy due to ruptured chordae
... mg b.d. and frusemide, and was delivered by forceps of a normal male child on 3 May I968. After this she continued to be breathless on exertion and easily fatigued. Cardiac catheterization was repeated in October I968, at which time a left ventricular angiogram was obtained. The pressure recordings ...
... mg b.d. and frusemide, and was delivered by forceps of a normal male child on 3 May I968. After this she continued to be breathless on exertion and easily fatigued. Cardiac catheterization was repeated in October I968, at which time a left ventricular angiogram was obtained. The pressure recordings ...
The Mural Left Anterior Descending Coronary Artery,
... ischemic ECG changes and abnormal lactate production or extraction with tachycardia (atrial pacing at 150 beats/min). Two of the remaining six patients who had 50-75% systolic compression developed ischemic ECG changes with tachycardia. In this paper, we report sudden death with strenuous exercise i ...
... ischemic ECG changes and abnormal lactate production or extraction with tachycardia (atrial pacing at 150 beats/min). Two of the remaining six patients who had 50-75% systolic compression developed ischemic ECG changes with tachycardia. In this paper, we report sudden death with strenuous exercise i ...
Week 5 – Electrocardiography and Blood pressure Objectives
... increases blood pressure to a maximum, which is the systolic pressure. In this lab activity you will record the ECG and heart sounds from a subject and, with the aid of a stethoscope, hear those characteristic sounds of the heartbeat, typically described as a "lub-dub." These sounds are produced by ...
... increases blood pressure to a maximum, which is the systolic pressure. In this lab activity you will record the ECG and heart sounds from a subject and, with the aid of a stethoscope, hear those characteristic sounds of the heartbeat, typically described as a "lub-dub." These sounds are produced by ...
evaluation of a patient with suspected pulmonary hypertension.
... patients was 43.47±17.44 years. 21.8% patients were in NYHA class II, 45.9% were in NYHA class III and 32.3% were in NYHA class IV. Mean ages of patients in NYHA class II, III and IV were 42.14±18.49, 45.39±16.55 and 41.63±18.09 years respectively, with a p value of <0.001. The mean PASP in NYHA cla ...
... patients was 43.47±17.44 years. 21.8% patients were in NYHA class II, 45.9% were in NYHA class III and 32.3% were in NYHA class IV. Mean ages of patients in NYHA class II, III and IV were 42.14±18.49, 45.39±16.55 and 41.63±18.09 years respectively, with a p value of <0.001. The mean PASP in NYHA cla ...
Week 5 – Electrocardiography and Blood pressure Objectives
... increases blood pressure to a maximum, which is the systolic pressure. In this lab activity you will record the ECG and heart sounds from a subject and, with the aid of a stethoscope, hear those characteristic sounds of the heartbeat, typically described as a "lub-dub." These sounds are produced by ...
... increases blood pressure to a maximum, which is the systolic pressure. In this lab activity you will record the ECG and heart sounds from a subject and, with the aid of a stethoscope, hear those characteristic sounds of the heartbeat, typically described as a "lub-dub." These sounds are produced by ...
Diagnostic Approach to Palpitations
... arrhythmias or anxiety. Most patients with arrhythmias do not complain of palpitations. However, any arrhythmia, including sinus tachycardia, atrial fibrillation, premature ventricular contractions, or ventricular tachycardia, can cause palpitations. Palpitations should be considered as potentially ...
... arrhythmias or anxiety. Most patients with arrhythmias do not complain of palpitations. However, any arrhythmia, including sinus tachycardia, atrial fibrillation, premature ventricular contractions, or ventricular tachycardia, can cause palpitations. Palpitations should be considered as potentially ...
Sudden Cardiac Sudden Cardiac Death
... Figure 1. Echocardiograms in parasternal long-axis view from an elite athlete (Olympic rower) (left) and a young asymptomatic patient with hypertrophic cardiomyopathy (HCM) (right). Magnitude of anterior ventricular septal (VS) hypertrophy is similar in each, demonstrating the morphological gray zon ...
... Figure 1. Echocardiograms in parasternal long-axis view from an elite athlete (Olympic rower) (left) and a young asymptomatic patient with hypertrophic cardiomyopathy (HCM) (right). Magnitude of anterior ventricular septal (VS) hypertrophy is similar in each, demonstrating the morphological gray zon ...
TRANSCATHETER AORTIC VALVE REPLACEMENT: REVIEw AND
... average of 5% for moderate or greater aortic insufficiency.21 Two-thirds of patients undergoing TAVR at LGH are discharged directly to home and more than 70% report a large improvement in quality of life. In addition, TAVR outcomes at LGH including mortality rate, stroke, atrial fibrillation, and re ...
... average of 5% for moderate or greater aortic insufficiency.21 Two-thirds of patients undergoing TAVR at LGH are discharged directly to home and more than 70% report a large improvement in quality of life. In addition, TAVR outcomes at LGH including mortality rate, stroke, atrial fibrillation, and re ...
Delayed-enhancement cardiac MRI in the evaluation of
... Cardiac MRI has a spectrum of tools available for the assessment of hypertrophic cardio myopathy (HCM), including the pattern and magnitude of myocardial hypertrophy, which may be particularly valuable in regions that are difficult to visualize by transthoracic echocardiography (e.g., the apex and ...
... Cardiac MRI has a spectrum of tools available for the assessment of hypertrophic cardio myopathy (HCM), including the pattern and magnitude of myocardial hypertrophy, which may be particularly valuable in regions that are difficult to visualize by transthoracic echocardiography (e.g., the apex and ...
Percutaneous Mitral Valve Intervention and modelling with multi
... respectively. Death rates were similar (17.4 vs. 17.8%, p=0.91) as was the incidence of MR grade 3 / 4 + (21.7 vs. 24.7%, p= 0.745), respectively. Surgery for mitral valve dysfunction occurred in 24 vs. 5.5 %, respectively, (p<0.001) at four years. The EVEREST II trial confirmed that following Mitra ...
... respectively. Death rates were similar (17.4 vs. 17.8%, p=0.91) as was the incidence of MR grade 3 / 4 + (21.7 vs. 24.7%, p= 0.745), respectively. Surgery for mitral valve dysfunction occurred in 24 vs. 5.5 %, respectively, (p<0.001) at four years. The EVEREST II trial confirmed that following Mitra ...
Cardiac output in two different types of exercise testing
... show whether the differences in CO and SV between rowing and cycling are caused more by increased contractility or by decreased peripheral vascular resistance. CO at rest and during submaximal exercise has been evaluated with acceptable reliability using a series of invasive and noninvasive techniqu ...
... show whether the differences in CO and SV between rowing and cycling are caused more by increased contractility or by decreased peripheral vascular resistance. CO at rest and during submaximal exercise has been evaluated with acceptable reliability using a series of invasive and noninvasive techniqu ...
Inappropriate ICD Shocks_Incidence, Predictors and
... starting with a shock not delivered for VT or VF and ending if sinus rhythm was redetected by the ICD. Consequently, it was possible that multiple inappropriate shocks occur within 1 episode. If a subsequent episode started within 5 min after the previous episode ended, it was not considered as a ne ...
... starting with a shock not delivered for VT or VF and ending if sinus rhythm was redetected by the ICD. Consequently, it was possible that multiple inappropriate shocks occur within 1 episode. If a subsequent episode started within 5 min after the previous episode ended, it was not considered as a ne ...
Vasopressors and Inotropes in Shock
... therapeutic efficacy of norepinephrine. Martin et al. conducted a study identifying factors associated with outcomes in septic shock (29). From a cohort of septic shock patients it was found that the use of norepinephrine to provide hemodynamic support was strongly related to a favorable outcome and ...
... therapeutic efficacy of norepinephrine. Martin et al. conducted a study identifying factors associated with outcomes in septic shock (29). From a cohort of septic shock patients it was found that the use of norepinephrine to provide hemodynamic support was strongly related to a favorable outcome and ...
introduction - Surgical Critical Care. Net
... therapeutic efficacy of norepinephrine. Martin et al. conducted a study identifying factors associated with outcomes in septic shock (29). From a cohort of septic shock patients it was found that the use of norepinephrine to provide hemodynamic support was strongly related to a favorable outcome and ...
... therapeutic efficacy of norepinephrine. Martin et al. conducted a study identifying factors associated with outcomes in septic shock (29). From a cohort of septic shock patients it was found that the use of norepinephrine to provide hemodynamic support was strongly related to a favorable outcome and ...
Triphasic mitral inflow velocity with mid
... myocardial velocities. Previous studies suggested that early diastolic mitral annular velocity (E#) recorded by TDI is a simple and reliable noninvasive index of left ventricular (LV) relaxation3e6 with a significant inverse correlation between E# and t.4,5 It is also useful in estimating LV filling ...
... myocardial velocities. Previous studies suggested that early diastolic mitral annular velocity (E#) recorded by TDI is a simple and reliable noninvasive index of left ventricular (LV) relaxation3e6 with a significant inverse correlation between E# and t.4,5 It is also useful in estimating LV filling ...
Widening Indications of Pacemakers - The Association of Physicians
... AV nodal conduction abnormalities may or may not cause symptoms, but it is the most common indication for pacemaker implantation, more so, because even an ECG can be diagnostic, it is probably the easiest abnormality to be diagnosed and its treatment also is codified. There is geographical variation ...
... AV nodal conduction abnormalities may or may not cause symptoms, but it is the most common indication for pacemaker implantation, more so, because even an ECG can be diagnostic, it is probably the easiest abnormality to be diagnosed and its treatment also is codified. There is geographical variation ...
Common Congenital Heart Disorders in Adults
... proper selection, performance, and interpretation of modalities required for anatomic imaging and hemodynamic assessment.5 In general, patients with simple CHD require a modest level of clinical care aimed at prevention of complications (eg, endocarditis). Those with medium or high-risk CHD may requ ...
... proper selection, performance, and interpretation of modalities required for anatomic imaging and hemodynamic assessment.5 In general, patients with simple CHD require a modest level of clinical care aimed at prevention of complications (eg, endocarditis). Those with medium or high-risk CHD may requ ...
Benefits of Beating Heart Surgery
... Coronary heart disease continues to be a significant health issue in the United States. Today, many patients who present for Coronary Artery Bypass Graft (CABG) surgery are considered higher risk than those seen even just a decade ago, as they are older and have more advanced disease. As a result, s ...
... Coronary heart disease continues to be a significant health issue in the United States. Today, many patients who present for Coronary Artery Bypass Graft (CABG) surgery are considered higher risk than those seen even just a decade ago, as they are older and have more advanced disease. As a result, s ...
Cardiac contractility modulation
.jpg?width=300)
Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.