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Relation of the HAS-BLED Bleeding Risk Score to Major Bleeding
Relation of the HAS-BLED Bleeding Risk Score to Major Bleeding

... bleeding risk more difficult. The aim of our study was to evaluate the clinical usefulness of the HAS-BLED score in a large cohort of stable patients with AF on long-term anticoagulation for assessing major bleeding episodes as well as other adverse events, including all-cause mortality and cardiova ...
PDF - European Echocardiography Course
PDF - European Echocardiography Course

... Coronary artery anatomy: Leiden convention !   Facing sinuses supporting the coronary arteries !   Common terminology: aortic sinuses located to the right (sinus 1) and left hand (sinus 2) of the observer ...
AHA/ASA Guideline - Professional Heart Daily
AHA/ASA Guideline - Professional Heart Daily

... • Conventional clinical definitions focal neurological symptoms or signs lasting less than 24 hours has been defined as a TIA • One-third of those are found to have an infarct on brain imaging ...
Cardiorespiratory response to aerobic exercise programs with
Cardiorespiratory response to aerobic exercise programs with

... Context: participation in regular intensive exercise is associated with a modest increase in left ventricular wall thickness and cavity size. The magnitude of improvement depends on frequency, intensity, type, and duration of exercise program. Aims: to determine the effect of sports training on LV m ...
Contemporary Reviews in Cardiovascular Medicine Athlete`s Heart
Contemporary Reviews in Cardiovascular Medicine Athlete`s Heart

... physiology are available20 –22; thus, only key aspects relevant to cardiac remodeling are reviewed here. There is a direct relationship between exercise intensity (external work) and the body’s demand for oxygen. This oxygen demand is met by increasing pulmonary oxygen uptake (VO2). The cardiovascul ...
SCHILLER`s medilog® Holter system
SCHILLER`s medilog® Holter system

... SCHILLER’s medilog® Holter system provides a comprehensive analysis of the human being as a whole. Atrial fibrillation detection, sleep apnoea screening and the determination of the quality of life are just some of the exceptional features of medilog®. Designed with feedback from hundreds of cardiol ...
Quantification and Visualization of Cardiovascular Function using
Quantification and Visualization of Cardiovascular Function using

... I wish to start this thesis referring to a photo of the white-board in our conference room (Figure 1.1). The illustration in the photo, which is taken after one of several long and intensive discussions about cardiovascular mechanics, looks chaotic and very complex. I believe I can with certainty cl ...
My title - rmib.somib.org.mx
My title - rmib.somib.org.mx

... dysfunction [9]. In most of instances, morbidity and mortality is associated with reduction in HRV. However, decreased HRV is also associated with aging [10]. HRV has been recognized as a signal with complex behavior, and it has been studied with different methods to evaluate nonlinear characteristi ...
Left ventricular endocardial longitudinal and transverse - AJP
Left ventricular endocardial longitudinal and transverse - AJP

... assumed that the mitral valve must already be closed at the onset of IVC. Also, finding that the first heart sound occurred during the rapid ventricular pressure development (or IVC), and not at end diastole as expected, they concluded that this sound was generated by the vibration of the already cl ...
Cardioverter-defibrillators (Implantable And External)
Cardioverter-defibrillators (Implantable And External)

... endocardium. The leads sense and transmit information on cardiac rhythm to the generator, which analyzes the rhythm information and produces an electrical shock when a malignant arrhythmia is recognized. A totally subcutaneous ICD (S-ICD®) has also been developed. This device does not employ transve ...
Why, where, and when do cardiac myocytes express - AJP
Why, where, and when do cardiac myocytes express - AJP

... observe in atrial cells. This is also true for neonatal myocytes (12) and Purkinje cells (19), which similarly have substantial InsP3R expression. In fact, it is an interesting correlation that cardiac cells without t-tubules (i.e., not ventricular myocytes) appear to express the most InsP3Rs. Given ...
How to Manage the Renal Patient with Coronary Heart
How to Manage the Renal Patient with Coronary Heart

... reported preliminary findings on the apparent under-utilization of thrombolytic therapy in dialysis patients. Using claims data from USRDS, we identified 33,277 dialysis patients hospitalized for AMI in 1991–97 who did not receive coronary reperfusion therapy and suffered a 2-yr mortality rate of 78 ...
The Relation of Cardiac Effort to Myocardial Oxygen Consumption
The Relation of Cardiac Effort to Myocardial Oxygen Consumption

... course of oxygen consumption.10 The delayed or recovery heat in skeletal muscle is considered to be the sum of the heat of 2 processes, exothermic oxidative catabolism and endothermic resynthesis, a reversal of the reactions which are the source of the initial heart and work of the contraction. It i ...
Acute Kidney Injury Definition and In‐Hospital Mortality in Patients
Acute Kidney Injury Definition and In‐Hospital Mortality in Patients

Verapamil-induced polymorphous ventricular tachycardia
Verapamil-induced polymorphous ventricular tachycardia

... triggered forms of automaticity and caused the particular arrhythmia. Myocardial ischemia due to profound hypotension may cause the arrhythmia; however, the absence of chest pain or ischemic changes on the electrocardiogram makes this possibility unlikely. In conclusion, we report a case of polymorp ...
Factors Influencing Prolonged ICU Stay After Open Heart Surgery
Factors Influencing Prolonged ICU Stay After Open Heart Surgery

... hospital mortality, poor long-term prognosis, increased morbidity (2), increased hospital stay, and consequently, increased cost and expenses (3). Knowing these correlations can be effective in reducing the length of ICU stay (4). Some measures such as early tracheal extubation can reduce the length ...
normal ECG manual - Cardiac and Stroke Networks in Lancashire
normal ECG manual - Cardiac and Stroke Networks in Lancashire

... From the Unipolar limb leads, a system was devised by EINTHOVEN which allows the heart to be seen from 3 other leads known as the Bipolar Limb Leads of Einthoven’s Triangle. ...
Isolated neonatal rat papillary muscles: a new model to translate
Isolated neonatal rat papillary muscles: a new model to translate

... Use Committee in accordance with the recommendations of the Guide for the Care and Use of Laboratory Animals (Eighth edition) revised by the National Research Council in 2011 (published by the National Academies Press), National Institutes of Health and American Association for the Accreditation of ...
heart regeneration after miocardial infarction using
heart regeneration after miocardial infarction using

... success of cell therapy. A careful analysis of the available data shows that negative  results may be fundamentally due to the poor permanence of the injected cells inside  the tissue [21,22], since SCs therapeutic efficacy depend on their ability to survive in  the hostile milieu of the damaged hea ...
Factors Influencing Prolonged ICU Stay After
Factors Influencing Prolonged ICU Stay After

... hospital mortality, poor long-term prognosis, increased morbidity (2), increased hospital stay, and consequently, increased cost and expenses (3). Knowing these correlations can be effective in reducing the length of ICU stay (4). Some measures such as early tracheal extubation can reduce the length ...
Disordered Myocardial Ca2+ Homeostasis Results
Disordered Myocardial Ca2+ Homeostasis Results

... channel function (e.g. drugs, oxidative stress). Despite progressive current therapies both VF and AF remains a major health problem. Further understanding of the mechanisms and factors responsible for the onset and maintenance of these arrhythmias is essential. We have previously shown (Tribulova e ...
Heart Failure with Preserved Ejection Fraction
Heart Failure with Preserved Ejection Fraction

... searched using the ICD-9-CM code 428. Among this, 170 with HFPEF were selected for study. To adjust for the impact of baseline differences between the 2 cohorts on clinical outcomes, we calculated a propensity score. To establish a risk score, HFPEF patients were randomly divided into derivation gro ...
ESC Guidelines for the Diagnosis and Treatment of Chronic Heart
ESC Guidelines for the Diagnosis and Treatment of Chronic Heart

... Documents have been issued in recent years by the European Society of Cardiology (ESC) and by different organizations and other related societies. This profusion can put at stake the authority and validity of guidelines, which can only be guaranteed if they have been developed by an unquestionable d ...
Safe Right Bundle Branch Block Pattern During Permanent Right
Safe Right Bundle Branch Block Pattern During Permanent Right

... pacing (7). In our patient, the frontal axis was around -900 and precordial transition by V3. Applying the criteria of Coman and Klein, we considered that such a borderline frontal axis calculation, and the fact that the R wave could not be eliminated by moving leads V1 and V2 as described, did not, ...
Fig. 1
Fig. 1

... rate or transient AV block which usually resolve quickly when current delivery is terminated. Transient AV block may occur due to mechanical or RF injury in the junctional area[10–12]. Application of RF current along the tricuspid or mitral annulus, at sites distant from both the sinus node and the ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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