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stress hyperglycemia in acute myocardial infarction
stress hyperglycemia in acute myocardial infarction

... is the result of glycoregulation alterations in older subjects. Our data are in agreement with other studies’ results (10,15,16,19-22). Hyperglycemic patients in study of Salmasi et al. (29) were older, but not significantly. A few studies investigated the relation between hyperglycemia and heart ra ...
Publications_files/Burggren et al.ActaPhysiol.2013
Publications_files/Burggren et al.ActaPhysiol.2013

... to the laboratory, where complex multifactorial, environmental stressors are difficult to accurately reproduce, and thus the functional benefits of given traits are difficult to quantify. The recent advent of miniaturized electronics and computer-assisted data acquisition (biologging; telemetry) pro ...
AED Resource Information
AED Resource Information

... situations and able to respond appropriately. • Hypothermia. People with hypothermia have been resuscitated even after prolonged exposure. If there is no normal breathing, begin CPR until an AED becomes available. Dry the patient’s chest and attach the AED. If a shock is indicated, deliver a shock a ...
Nelson – pedi cardiology MURMURS ONLY
Nelson – pedi cardiology MURMURS ONLY

... compression of the neck veins ...
glyceryl trinitrate. A randomised study. inferior infarction with
glyceryl trinitrate. A randomised study. inferior infarction with

... beats/minutes. Patients with cardiogenic shock were excluded because of hypotension. Patients with severe cardiac failure or pronounced hypertension were excluded frequently on the basis of either tachycardia, hypotension, or the need for specific antihypertensive treatment. The diagnosis of acute m ...
Cardiac Patient and Family - Cedars
Cardiac Patient and Family - Cedars

Robert Kloner - Ischemic Conditioning Therapy
Robert Kloner - Ischemic Conditioning Therapy

... patients with acute myocardial infarction: a randomised trial. Lancet. 2010 Feb 27;375(9716):727. ...
Transmitral Flow Changes during DipyridamoleInduced lschemia*
Transmitral Flow Changes during DipyridamoleInduced lschemia*

... maximal ...
Heart size-independent analysis of myocardial
Heart size-independent analysis of myocardial

... relation (E⬘max) is a sensitive measure of LV contractility independent of the loading conditions (23, 24), it is still influenced by heart size. Using a stress-strain analysis to measure in vivo cardiac mechanics has the advantage that the slope of the end-systolic stressstrain relation, systolic m ...
Endocardial endothelium in the avascular frog heart - AJP
Endocardial endothelium in the avascular frog heart - AJP

... which to explore the role of diffusion of NO from the endocardial endothelium (EE) without vascular endothelial or cardiac cell NO production. In Xenopus hearts we examined the regulation of cardiac O2 consumption in vitro at 25°C and 37°C. The NO-mediated control of O2 consumption by bradykinin or ...
ADVANCED CARDIAC LIFE SUPPORT
ADVANCED CARDIAC LIFE SUPPORT

... favorable outcomes compared with shallower compressions Potential injuries may result in compression depth greater than 2.4 inches. It is clinically difficult to judge compression depth without the use of a feedback device. Keep in mind that compressions are often found to be too shallow rather than ...
molecular cloning and reduced expression in experimental heart
molecular cloning and reduced expression in experimental heart

... pro-ANP to ANP. Recently, corin, a membrane-bound type II serin protease, also known as LRP4, has been identified as a pro-ANP-converting enzyme (21, 27). Corin converts proANP(1–126) into ANP(99 –126) by cleaving pro-ANP specifically behind arginine at position 98 in vitro (28) and in a murine card ...
Biventricular pacemaker implantation with the BV Pulsera
Biventricular pacemaker implantation with the BV Pulsera

... the body. In some patients there is a conduction block to the left side of the heart, so that if the impulse comes down the septum it goes preferentially to the right-hand side, so that the right side contracts slightly before the left. Thus, instead of both ventricles being synchronous, there is di ...
7.Adrenergic agonists
7.Adrenergic agonists

...  Cardiac arrest: epinephrine injected directly into the heart  Heart failure: positive inotropic effect (increases the force of contraction)  Shock: characterized by profound hypotension and reduced tissue perfusion. Primary goal of treatment is to maintain blood flow to vital organ. By increasin ...
Assessment of Ventricular Function with Cardiovascular Magnetic
Assessment of Ventricular Function with Cardiovascular Magnetic

... system for each subepicardial and subendocardial node point. Axes are radial (R) using the direction perpendicular to wall; fiber (F), tangent to surface and parallel to local fiber direction at either epicardium or endocardium; and cross-fiber (X), tangent to surface and perpendicular to F. (From Boga ...
The effects of daily exercise on susceptibility to sudden
The effects of daily exercise on susceptibility to sudden

... rate produced by a 30 mm Hg increase in systolic arterial pressure were also calculated. The myocardial infarct size was determined by the nitro blue tetrazolium enzymatic staining technique22 and is reported as percentage of the left ventricle involved. These data were compared as described above. ...
Myosin Types and Fiber Types in Cardiac Muscle I . Ventricular
Myosin Types and Fiber Types in Cardiac Muscle I . Ventricular

... subendocardium (Fig. 11), whereas reactive fibers were especially frequent in subepicardium (Fig . 12) and were generally more numerous in the right than in the left ventricle. However, there was no clear-cut separation between areas showing fiber type predominance, the various fiber types being oft ...
Abnormal Diurnal Variation of Blood Pressure, Cardiac
Abnormal Diurnal Variation of Blood Pressure, Cardiac

... operation.14 The two methods were well correlated (r=.94; n=64), and the SD of the differences between the methods against the mean of the methods was 10.6%. Cardiac output was calculated by the equation CO=SVxHR, where CO is cardiac output, SV is stroke volume, and HR is heart rate. Total periphera ...
Role of neural modulation in the pathophysiology of atrial fibrillation
Role of neural modulation in the pathophysiology of atrial fibrillation

... being treated with standard AADs, catheter or surgical ablation. As mentioned earlier, adding GP ablation to conventional PVI could be an option since, clinically it has shown to increase the success rate from 70 to 91 per cent and 60 to 85 per cent in two different studies25,26. However, it has its ...
Document
Document

... Electively intubated and controlled ventilation ...
2016 ACC/AHA/HFSA Focused Update on New Pharmacological
2016 ACC/AHA/HFSA Focused Update on New Pharmacological

... may lead to angioedema, as well. The use of ACE inhibitors is beneficial for patients with prior or current symptoms of chronic HFrEF to reduce morbidity and mortality (9-14, 25). ACE inhibitors have been shown in large RCTs to reduce morbidity and mortality in patients with HFrEF with mild, moderat ...
Cardiovascular Disease Prevention and Rehabilitation 2012
Cardiovascular Disease Prevention and Rehabilitation 2012

... achieve sustainable health outcomes for patients. These standards and core components support an integrated approach to the prevention and rehabilitation of cardiovascular disease as the foundation of every cardiac rehabilitation programme. The illustrative model of the seven core components represe ...
Diagnosis and Management of Common Types of
Diagnosis and Management of Common Types of

... Figure 4. Algorithm for the short-term management of supraventricular tachycardia. (CHF = congestive heart failure; ECG = electrocardiography; IV = intravenous; NS = normal saline; VT = ventricular tachycardia.) Reprinted with permission from Neumar RW, Otto CW, Link MS, et al. Part 8: adult advance ...
Energy Levels at Systole vs. Diastole in Normal Hamster Hearts vs
Energy Levels at Systole vs. Diastole in Normal Hamster Hearts vs

... dF/dt and mid-diastole. The left ventricle was cannulated through the apex for pressure measurements, and pacing wires were inserted in the base of the right ventricle. Pressure recordings were obtained from the left ventricle and aorta with Statham pressure transducers. Oxygen consumption was measu ...
Relation of the HAS-BLED Bleeding Risk Score to Major Bleeding
Relation of the HAS-BLED Bleeding Risk Score to Major Bleeding

... bleeding risk more difficult. The aim of our study was to evaluate the clinical usefulness of the HAS-BLED score in a large cohort of stable patients with AF on long-term anticoagulation for assessing major bleeding episodes as well as other adverse events, including all-cause mortality and cardiova ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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