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AORTIC VALVE STENOSIS: FROM FORMULA TO GUIDELINE
AORTIC VALVE STENOSIS: FROM FORMULA TO GUIDELINE

... Aortic valve stenosis is one of the most common valvular diseases and is the third most common cardiovascular disease in developed countries with an exponential age-dependent increase in prevalence. Severe AS occurs in about 2.8% of patients ≥75 years of age and can arise because of degenerative cal ...
The structure and function of cardiac t
The structure and function of cardiac t

... the t-tubule [61]. It has recently been reported to be downregulated proportionally during the progression from hypertrophy to heart failure [62]. This may partly mediate the uncoupling observed between the t-tubule and SR in cardiac muscle [63]. Recent evidence using conditional Proc. R. Soc. B (20 ...
Assessment of Diastolic Hemodynamics by Analyzing Left
Assessment of Diastolic Hemodynamics by Analyzing Left

... ventricle. This pressure gradient generates the driving force to pump the blood deep into the left ventricle, resulting in a propagation of blood flow from the mitral orifice towards the apex. In states of diastolic dysfunction such as myocardial ischemia, impairment of rapid filling leads to a decr ...
Peri-operative Cardiac Arrhythmias
Peri-operative Cardiac Arrhythmias

... Life-threatening cardiovascular events under anaesthesia are uncommon. However, adverse cardiovascular events occurring during and after the emergence of anaesthesia occur more frequently. Although the incidence is higher during cardiac surgery, intra-operative dysrrhythmias affect up to 29% of pati ...
Print - Circulation
Print - Circulation

... our results and those obtained with the pericardial balloon is that the pericardial balloon overestimates pericardial pressure, thus underestimating right ventricular transmural pressure. This might occur for several reasons. Under normal circumstances, with little pericardial fluid the pericardial ...
Tachyarrhythmias
Tachyarrhythmias

... in the setting of heart disease • Monomorphic VT often implies heart disease, but can sometimes be seen in structurally “normal” hearts • Polymorphic VT can result from myoardial ischemia or conditions that prolong ventricular repolarization • Electrolyte derangements, hypoxemia and drug toxicity ca ...
Management of the postoperative Fontan patient
Management of the postoperative Fontan patient

... shunts or PA banding, often requires pulmonary arterioplasty as a component of Fontan surgery. Anomalies of the systemic or pulmonary venous system have been incorporated into the Fontan circulation with minimal additional risk w10x. Significant atrioventricular valve regurgitation is poorly tolerat ...
Aortic Dissection - Society of Cardiovascular Anesthesiologists
Aortic Dissection - Society of Cardiovascular Anesthesiologists

... displacement may only manifest in the presence of myocardial ischemia. In another common scenario, a patient with significant IMR while in decompensated heart failure or during exercise stress testing may only manifest mild mitral regurgitation during intraoperative assessment under general anesthes ...
36th Bethesda Conference - American College of Cardiology
36th Bethesda Conference - American College of Cardiology

... facilitate consideration of significant and timely issues regarding the practice of cardiovascular medicine and matters affecting patient care, research, and training for which absolute or hard data are incomplete. Appropriate organizations other than the American College of Cardiology Foundation (A ...
Abnormal electrocardiographic findings in athletes
Abnormal electrocardiographic findings in athletes

... causes of sudden cardiac death (SCD) in young athletes. Channelopathies represent a heterogeneous group of genetically distinct cardiovascular disorders associated with sudden death and ventricular arrhythmias from disturbed function of the cardiac ion channel.1–3 Ventricular pre-excitation and othe ...
Congenital Aneurysms of the Aortic Sinuses with
Congenital Aneurysms of the Aortic Sinuses with

... it was seen that tricular septal defect, but there right aortic sinus and the right went into complete heartblock treated with Isuprel with good arrest on his 19th post-operative of all defects. ...
Real-Time MR Imaging of Aortic Flow: Influence of Breathing on Left
Real-Time MR Imaging of Aortic Flow: Influence of Breathing on Left

... expiratory intrathoracic pressures can be increased as a result of expiratory obstruction (2). These pressure changes have a distinct influence on cardiac function (3). In combination with other factors, such as hypoxemia and pulmonary hypertension, the heart is subject to chronic hemodynamic and me ...
(1-7)对腹主动脉缩窄大鼠心肌肥厚和纤维化的影响
(1-7)对腹主动脉缩窄大鼠心肌肥厚和纤维化的影响

... were cut and stained with hematoxylin-eosin for cell morphometry and with collagen-specific Picrosirius red (Direct Red 80, Aldrich) for detection of fibrosis. The myocyte cross-sectional diameter (CSD, μm) was measured on a longitudinal section across the nucleus of the cells using a micrometer in ...
The Clinical Value of Frequency Analysis ofthe First
The Clinical Value of Frequency Analysis ofthe First

... and 3). The interval from Q to onset of S, was measured in all instances, using the electrocardiogram and standard phonocardiogram. Isovolumic contraction time (ICT) was assumed to be 0.06 sec.4 Both intervals were drawn on each of the filtered heart sound read-outs (fig. 3). The ...
Since the function of the heart is that of a pump it is of interest both to
Since the function of the heart is that of a pump it is of interest both to

... 24 hours after the onset of this attack he did not appear acutely ill; there were no signs of congestive heart failure. The heart was not enlarged. The diagnoses were: A, unknown; B, mitral stenosis; C, paroxysmal auricular fibrillation.4 On December 8, 1933, when auricular fibrillation was present, ...
Atrial transport function in coronary artery disease: Relation
Atrial transport function in coronary artery disease: Relation

... premature beat. Furthermore , patients were excluded if the various phases of filling during diastole could not be delineated (see later). This invariably necessitated eliminating patients who had a heart rate of 90 beats/min or greater during the time of the left ventricular angiogram. The electroc ...
Free EBook - Heart Valve Surgery
Free EBook - Heart Valve Surgery

... heart and they frequently become enlarged in heart valve disease and then they fibrillate -- which means they quiver. They don’t contract the way that they are supposed to. You can form a blood clot. The blood clot can break off and cause a stroke. You hear the Pradaxa commercials on the news at nig ...
State of the Art: Degenerative Mitral Valve Disease
State of the Art: Degenerative Mitral Valve Disease

... widely, with five-year survivals quoted between 30 and 95% [24,25], reflecting the very heterogenous population included in most series. A review of 348 consecutive patients with chronic mitral regurgitation due to flail leaflet seen at the Mayo Clinic between 1980 and 1989 showed that the incidence of ...
Document
Document

... monitoring, disease progression. These can be made using M-mode or 2D and must be interpreted in the light of the size and sex of the patient. Many pragmatic normal ranges are outdated and modern data based on large populations include upper dimensions previously regarded as abnormal. Doppler measur ...
Atrial Septal defect (ASD) Device Closure in Detail
Atrial Septal defect (ASD) Device Closure in Detail

... life. Premature babies often have large PDAs and they often close after medical therapy with oral Ibuprofen or Indomethacin. Rarely some preemies need surgery. The baby’s neonatologist will start these. Regarding ASD, small defects upto 3-5mm, often close spontaneously. However, larger defects like ...
His Bundle Pacing Or Biventricular Pacing For Cardiac
His Bundle Pacing Or Biventricular Pacing For Cardiac

... in a crossover design among patients with indications for CRT defibrillator implants[19]. They enrolled 29 patients and were successful in demonstrating electrical resynchronization in 21 (72%) cases. All patients received both a coronary sinus LV lead and a HBP lead connected to the LV port via a Y ...
Clinical aspects of hypertensive myocardial fibrosis
Clinical aspects of hypertensive myocardial fibrosis

... Rossi [3] reported that when postmortem human hypertensive hearts were segregated according to overall heart weight, CVF increased progressively according to heart weight. In addition, the severity of interstitial fibrosis increased progressively in hearts with moderate and marked hypertrophy and in ...
Cardiac MRI: Part 1, Cardiovascular Shunts
Cardiac MRI: Part 1, Cardiovascular Shunts

... ovalis should be acquired on either side of the interatrial septum before concluding that no septal defect is present [6]. Pulmonary vascular resistance (PVR) is an important parameter that needs to be assessed in patients with unrestricted left-to-right shunts who are at risk of obstructive pulmona ...
Neonatal Electrocardiogram
Neonatal Electrocardiogram

... Should this neonatal screening indeed be introduced as part of National Health Services, then hospital cardiologists — most of whom are unfamiliar with neonatal ECGs — would be asked to read these tracings. The European Society of Cardiology (ESC) has realized the potential implications for European ...
Task Force Report
Task Force Report

... Should this neonatal screening indeed be introduced as part of National Health Services, then hospital cardiologists — most of whom are unfamiliar with neonatal ECGs — would be asked to read these tracings. The European Society of Cardiology (ESC) has realized the potential implications for European ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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