Afro-Caribbean Heart Failure in the UK
... Most large heart failure studies in the United Kingdom population fail to include specific data on Afro-Caribbean patients because ethnic minority groups form a relatively small proportion nationwide.1 However, more than one million people of Afro-Caribbean ethnicity live in the Greater London area ...
... Most large heart failure studies in the United Kingdom population fail to include specific data on Afro-Caribbean patients because ethnic minority groups form a relatively small proportion nationwide.1 However, more than one million people of Afro-Caribbean ethnicity live in the Greater London area ...
Loss of Epidermal Growth Factor Receptor in Vascular
... Abstract—The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, contributes to parainflammatory dysregulation, possibly causing cardiovascular dysfunction and remodeling. The physiological role of cardiovascular EGFR is not completely understood. To investigate the physiological im ...
... Abstract—The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, contributes to parainflammatory dysregulation, possibly causing cardiovascular dysfunction and remodeling. The physiological role of cardiovascular EGFR is not completely understood. To investigate the physiological im ...
Copyright Information of the Article Published Online
... in patients with CHF[9,10]. Progression of CHF is associated with persistent loss of cardiomyocytes, which can be clinically detected as a continuous increase in serum H-FABP levels[11]. Electrocardiography (ECG) is routinely performed and is useful for evaluating the etiology of heart failure. Seve ...
... in patients with CHF[9,10]. Progression of CHF is associated with persistent loss of cardiomyocytes, which can be clinically detected as a continuous increase in serum H-FABP levels[11]. Electrocardiography (ECG) is routinely performed and is useful for evaluating the etiology of heart failure. Seve ...
Minimally invasive and transcatheter techniques in high
... versus CABG procedures performed in different countries further attest to the lack of clear evidence. In the USA, approximately 20% of all CABG procedures are performed off-pump [12] and in Europe this number varies between 10 and 30%. In single centers it varies between 0 and 95% [13] . This contro ...
... versus CABG procedures performed in different countries further attest to the lack of clear evidence. In the USA, approximately 20% of all CABG procedures are performed off-pump [12] and in Europe this number varies between 10 and 30%. In single centers it varies between 0 and 95% [13] . This contro ...
Parameter - St George`s, University of London
... Correction of indices and cut-off values Cardiac functional and geometric status is affected by body size. 31 In order to account for the changing body size in pregnancy and among individuals, conventional echocardiographic indices were normalized for the body surface area using the DuBois and DuBo ...
... Correction of indices and cut-off values Cardiac functional and geometric status is affected by body size. 31 In order to account for the changing body size in pregnancy and among individuals, conventional echocardiographic indices were normalized for the body surface area using the DuBois and DuBo ...
Transcatheter Mitral Valve Replacement for Severe Mitral
... severe MR.12 However, around 49 per cent of patients with severe, symptomatic MR are not referred for surgery because they are too ill or weak to withstand the stress of the procedure. Patient characteristics associated with the decision not to operate include older age, congestive heart failure and ...
... severe MR.12 However, around 49 per cent of patients with severe, symptomatic MR are not referred for surgery because they are too ill or weak to withstand the stress of the procedure. Patient characteristics associated with the decision not to operate include older age, congestive heart failure and ...
The Effect of Right Ventricular Filling on the Pressure
... Small incisions were made in the pericardium over the right and left atrium. Both ventricles were vented and the atria opened. Coronary venous return then drained freely into a funnel and was returned to the femoral vein of the support dog. After the chordae tendinae had been cut, a thinwalled ballo ...
... Small incisions were made in the pericardium over the right and left atrium. Both ventricles were vented and the atria opened. Coronary venous return then drained freely into a funnel and was returned to the femoral vein of the support dog. After the chordae tendinae had been cut, a thinwalled ballo ...
EKG Basics - Cobb Learning
... EKG Basics • In the mid 1880’s, while using sensor electrodes placed on a man’s skin, Ludwig and Waller discovered that the heart’s rhythmic electrical activity could be monitored from a person’s skin. • However, their apparatus was not sensitive enough for clinical use. ...
... EKG Basics • In the mid 1880’s, while using sensor electrodes placed on a man’s skin, Ludwig and Waller discovered that the heart’s rhythmic electrical activity could be monitored from a person’s skin. • However, their apparatus was not sensitive enough for clinical use. ...
Mitral valve anatomy for Transcatheter techniques
... the closure while the longest distance occurred at Point 5 (7.78 ± 2.61 mm), as demonstrated in Figure basal zone that is found only in the mural leaflet is mal area that has insertions of basal cords to its v surface. Being distant from the ventricular wall, leaflet does not have attachments to bas ...
... the closure while the longest distance occurred at Point 5 (7.78 ± 2.61 mm), as demonstrated in Figure basal zone that is found only in the mural leaflet is mal area that has insertions of basal cords to its v surface. Being distant from the ventricular wall, leaflet does not have attachments to bas ...
Measurement of right ventricular volume in healthy term and preterm
... persistent pulmonary hypertension of the newborn and respiratory distress syndrome.8 Right ventricular pathophysiology is potentially important in these conditions. The ability of the right ventricle to maintain adequate pulmonary blood flow despite increased pulmonary vascular resistance may be cri ...
... persistent pulmonary hypertension of the newborn and respiratory distress syndrome.8 Right ventricular pathophysiology is potentially important in these conditions. The ability of the right ventricle to maintain adequate pulmonary blood flow despite increased pulmonary vascular resistance may be cri ...
Early Regional Myocardial Dysfunction in Young
... and dilated cardiomyopathy. The latter leads to congestive heart failure and is the cause of death in nearly 30% of patients with DMD. The dystrophin-deficient myocardium seems to work normally at younger ages, but progressive damage results in severe cardiac dysfunction later in life. It is possible ...
... and dilated cardiomyopathy. The latter leads to congestive heart failure and is the cause of death in nearly 30% of patients with DMD. The dystrophin-deficient myocardium seems to work normally at younger ages, but progressive damage results in severe cardiac dysfunction later in life. It is possible ...
Cardiac Tissue Structure, Properties, and Performance: A Materials
... yet been identified, sarcomeres isolated from the subendocardium exhibit differences in material properties from those isolated from the sub-epicardium of the ventricular wall.1,8,16 In particular, active and passive tension is greater in sub-endocardial cells,9 which may be due to differences in sarc ...
... yet been identified, sarcomeres isolated from the subendocardium exhibit differences in material properties from those isolated from the sub-epicardium of the ventricular wall.1,8,16 In particular, active and passive tension is greater in sub-endocardial cells,9 which may be due to differences in sarc ...
The Effect of Pressure or Flow Stress on Right Ventricular Protein
... results in increased myocardial protein synthesis in vivo and in vitro, but such rapid alterations are not consistently seen in volume loading. The difference in response is difficult to clarify since it is not possible to effect alterations in left ventricular pressure or perfusion without profound ...
... results in increased myocardial protein synthesis in vivo and in vitro, but such rapid alterations are not consistently seen in volume loading. The difference in response is difficult to clarify since it is not possible to effect alterations in left ventricular pressure or perfusion without profound ...
The uses and limitations of end-systolic indexes of left
... better reflection of the slope of the afterload-volume relationship than is the end-systolic pressure-end systolic volume relationship. The stress-volume relationship has also been used successfully in the assessment of left ventricular contractile function. In our laboratory, for example, noninvasi ...
... better reflection of the slope of the afterload-volume relationship than is the end-systolic pressure-end systolic volume relationship. The stress-volume relationship has also been used successfully in the assessment of left ventricular contractile function. In our laboratory, for example, noninvasi ...
intracardiac shunting revealed by angiocardiography in the lizard
... (SV) and right atrium are distended. Frame B also clearly defines the ostium between the CP and the pulmonary arterial trunk (pa). In frame C, ventricular diastole must have just started since the atrioventricular connection, superimposed on the pulmonary outflow tract, is re-established and the RA ...
... (SV) and right atrium are distended. Frame B also clearly defines the ostium between the CP and the pulmonary arterial trunk (pa). In frame C, ventricular diastole must have just started since the atrioventricular connection, superimposed on the pulmonary outflow tract, is re-established and the RA ...
A novel role for cardiac neural crest in heart development
... to formation of pharyngeal arches 3 and 4, which caused a diminished number of right aortic arch arteries to form. The left aortic arch arteries appeared to compensate for resultant flow changes by increasing in size, and the embryos showed no evidence of decreased contractility (R. Hixon et al., ma ...
... to formation of pharyngeal arches 3 and 4, which caused a diminished number of right aortic arch arteries to form. The left aortic arch arteries appeared to compensate for resultant flow changes by increasing in size, and the embryos showed no evidence of decreased contractility (R. Hixon et al., ma ...
Cardiovascular System
... D] The right and left left ventricle ventricles are formed by ventral growth and excavation of Ventricle the bulbus cordis and ventriDevelopment cle, respectively. An interventricular septum, atrioventricular valves, chordae tendineae, papillary muscles, and irregularities of the internal ventricula ...
... D] The right and left left ventricle ventricles are formed by ventral growth and excavation of Ventricle the bulbus cordis and ventriDevelopment cle, respectively. An interventricular septum, atrioventricular valves, chordae tendineae, papillary muscles, and irregularities of the internal ventricula ...
The role of endomyocardial biopsy in the management of
... bioptome-induced tricuspid valve trauma. Delayed complications include access site bleeding, damage to the tricuspid valve, pericardial tamponade, and deep venous thrombosis. Most complications are known from case reports, and therefore the precise frequency of these events is not known. The data on ...
... bioptome-induced tricuspid valve trauma. Delayed complications include access site bleeding, damage to the tricuspid valve, pericardial tamponade, and deep venous thrombosis. Most complications are known from case reports, and therefore the precise frequency of these events is not known. The data on ...
Copyright Information of the Article Published Online TITLE 12
... a J-point elevation of at least 1 mm in two contiguous leads with a “notching” type appearance, i.e., a positive Jdeflection inscribed in the S wave, or a “slurring”, i.e., a gradual transition of the QRS to the ST segment in the inferior, lateral or inferolateral leads, as defined by Haissaguerre i ...
... a J-point elevation of at least 1 mm in two contiguous leads with a “notching” type appearance, i.e., a positive Jdeflection inscribed in the S wave, or a “slurring”, i.e., a gradual transition of the QRS to the ST segment in the inferior, lateral or inferolateral leads, as defined by Haissaguerre i ...
CASE REPORT CASE Unusual case of pulmonary valve atresia
... PA-VSD is a cyanotic congenital heart disease characterised by underdevelopment of the right ventricular (RV) outflow tract (i.e. subpulmonary infundibulum) with atresia of the pulmonary valve, a large VSD, and overriding of the aorta. In the past, this anomaly was termed pseudotruncus or truncus ar ...
... PA-VSD is a cyanotic congenital heart disease characterised by underdevelopment of the right ventricular (RV) outflow tract (i.e. subpulmonary infundibulum) with atresia of the pulmonary valve, a large VSD, and overriding of the aorta. In the past, this anomaly was termed pseudotruncus or truncus ar ...
Epiblastic Cited2 deficiency results in cardiac phenotypic
... mice were used to investigate haploinsufficiency. Embryos were examined by magnetic resonance imaging, by sectioning and by quantitative real-time polymerase chain reaction (qRT-PCR). Epiblastspecific deletion of Cited2 using Sox2Cre recapitulated penetrant and phenotypically heterogenous cardiovascul ...
... mice were used to investigate haploinsufficiency. Embryos were examined by magnetic resonance imaging, by sectioning and by quantitative real-time polymerase chain reaction (qRT-PCR). Epiblastspecific deletion of Cited2 using Sox2Cre recapitulated penetrant and phenotypically heterogenous cardiovascul ...
PDF - Circulation: Arrhythmia and Electrophysiology
... arrhythmias is indicated only in patients with a distant infarct and an ICD with recurrent ventricular tachycardia (VT) or VT storms refractory to medications. In this population, catheter ablation has been shown to be effective.4 ICD implantation combined with prophylactic catheter ablation remote ...
... arrhythmias is indicated only in patients with a distant infarct and an ICD with recurrent ventricular tachycardia (VT) or VT storms refractory to medications. In this population, catheter ablation has been shown to be effective.4 ICD implantation combined with prophylactic catheter ablation remote ...
New Treatment Options for Late Na Current, Arrhythmias, and
... wall and Purkinje fiber preparations. Midmyocardial cells are known to have action potentials that prolong disproportionately relative compared to those of epi- or endocardial cell types in response to many QT-prolonging drugs [51, 52]. Moreover, these cells have the largest late INa while IKr is si ...
... wall and Purkinje fiber preparations. Midmyocardial cells are known to have action potentials that prolong disproportionately relative compared to those of epi- or endocardial cell types in response to many QT-prolonging drugs [51, 52]. Moreover, these cells have the largest late INa while IKr is si ...
Transcatheter aortic valve implantation
... in Europe are not referred for surgical AVR8. revascularisation, severe renal insufficiency, and Patients who are not referred for surgery are more life expectancy <12 months due to non-cardiac likely to be older than those who are, and more co-morbid conditions. The trial appears to have likely to ...
... in Europe are not referred for surgical AVR8. revascularisation, severe renal insufficiency, and Patients who are not referred for surgery are more life expectancy <12 months due to non-cardiac likely to be older than those who are, and more co-morbid conditions. The trial appears to have likely to ...
Pacemaker Syndrome During Managed Ventricular
... block. During MVP, the AAI(R) mode operates with a dynamic atrial refractory period (ARP) set either to 75% of the R–R cycle length if heart rate is 75 bpm or faster, or to 600 ms if heart rate is slower than 75 bpm. The purpose of dynamic ARP is to avoid inappropriate switches to DDD(R) mode in the ...
... block. During MVP, the AAI(R) mode operates with a dynamic atrial refractory period (ARP) set either to 75% of the R–R cycle length if heart rate is 75 bpm or faster, or to 600 ms if heart rate is slower than 75 bpm. The purpose of dynamic ARP is to avoid inappropriate switches to DDD(R) mode in the ...
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.