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Supplemental Content - Annals of Internal Medicine
Supplemental Content - Annals of Internal Medicine

... into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means o ...
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How does the heart work? What is cardiomyopathy? What causes

... HCM can also occur in otherwise healthy cats and where there is no apparent cause and this is termed idiopathic or primary HCM. As the heart muscle becomes thicker the chambers within the heart get smaller and so can hold a smaller volume of blood. Although the heart contracts quite strongly it can ...
Application of Echocardiography in Clinic Practice
Application of Echocardiography in Clinic Practice

... filled with increased pressure ( elevated LV enddiastolic pressure). In the old days, diagnosis can only be arrived at by invasive cardiac catheterisation8. However, nowadays non-invasive echocardiographic assessment has been considered the choice and tool in diastolic cardiac assessment for clinica ...
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"Birth defect of Heart, its presentation and treatment"

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How does the heart work? What is cardiomyopathy? What causes
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CoffinLowry syndrome and left ventricular noncompaction
CoffinLowry syndrome and left ventricular noncompaction

... et al., 2004]. This disorder may be found in isolation or as a feature of several malformation syndromes [Johnson et al., 2006]. It represents a developmental arrest of normal embryologic compaction of the LV myocardium [Richardson et al., 1996]. Since LVNC’s initial description in the medical liter ...
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Acute cardiac failure

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ventricular septal defect (VSD)
ventricular septal defect (VSD)

... in different areas of the left ventricle. Do the following: 1. Identify and describe the lesions 2. Discuss the pathogenesis of the lesions using basic principles of pathology 3. Again, using basic principles of pathology, explain how each of these lesions could have contributed to the sudden cardia ...
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md-broj 08.qxp - md

... within the arrested left heart: inflow check valve (mitral valve), and outflow check valve (aortic valve). Application of aspiration pressure within the arrested left ventricle opens the inflow mitral valve and closes the outflow aortic valve allowing drainage of the whole left heart and even draina ...
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After training, both the students and residents in the SAM group
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... incident. We checked the sensing and stimulation parameters of the electrodes with the new generator implanted, which were similar to those observed before the procedure. No incidents were documented during post-discharge follow-up. Case 2 was a 74-year-old man with a single-chamber pacemaker (Ident ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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