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MacVector 14.0 Getting Started Guide
MacVector 14.0 Getting Started Guide

... Screening clones from a site-specific mutagenesis experiment to identify successful mutations Screening related clones for single nucleotide polymorphisms ...
Visibility with a Moving Point of View
Visibility with a Moving Point of View

rca icml
rca icml

Consistent risk group-associated differences in human
Consistent risk group-associated differences in human

... more than one of the trees, but none was present in all (except the related viruses mentioned above). Bootstrap values in the analyses based on individual genes were generally low. This instability was reflected in an analysis based on all three genes together, which yielded a tree with three stable ...
Horizontal transfer of non-LTR retrotransposons: artifact or rare event
Horizontal transfer of non-LTR retrotransposons: artifact or rare event

Likelihood Based Clustering (LiBaC) for Codon Models, a method
Likelihood Based Clustering (LiBaC) for Codon Models, a method

... negatively impact estimates of substitution rates (e.g., Yang and Nielsen 2000; Dunn, Bielawski and Yang 2001; Aris-Brosou and Bielawski 2006) and classification of sites according to selection pressure (e.g., Anisimova, Bielawski and Yang 2002; Wong et al. 2004; Kosakovsky Pond and Muse, 2005). Reg ...
Multifractal characterisation of length sequences of coding and
Multifractal characterisation of length sequences of coding and

No Slide Title
No Slide Title

... Why Nasonia’s relationships still need studying • Nasonia is a model system for evolutionary biology studies, yet… • Ancestral states cannot be inferred with only three analyzed species! • No agreement in classification of wasps in its family (Pteromalidae) • Needed: means to reject some pteromalid ...
Geneious Sequence Classifier User Manual
Geneious Sequence Classifier User Manual

... database sequences. There is a trade-off between how fast the search runs versus how sensitive it is to finding distantly related matches. A higher sensitivity will align queries that are more distantly related to the database, so if you suspect your query sequence may be only distantly related to y ...
Sequence comparison of aflR from different Aspergillus species
Sequence comparison of aflR from different Aspergillus species

... 1994; Hesseltine et al., 1970), the SBG strain of A. flavus (Cotty and Cardwell, 1999), or A. flavus Group II (Geiser et al., 2000; Geiser et al., 1998). A. nomius isolates were chosen which show considerable morphological, physiological, and genetic divergence. Ex type cultures of A. nomius (Kurtzman ...
Hybrid Cloud and Cluster Computing
Hybrid Cloud and Cluster Computing

... • MDS and GTM are highly memory and time consuming process for large dataset such as millions of data points • MDS requires O(N2) and GTM does O(KN) (N is the number of data points and K is the number of latent variables) • Training only for sampled data and interpolating for out-ofsample set can im ...
Brand, Veronica - Degenerate Primer Design using Computational Tools
Brand, Veronica - Degenerate Primer Design using Computational Tools

Runge-Kutta Methods
Runge-Kutta Methods

... does not meet the user prescribed tolerance  If this is the case, the step size should be decrased, yn is rejected and it’s to be computed again… ...
Multi-objective optimization methods in drug design
Multi-objective optimization methods in drug design

... proposed. The method optimizes two objectives, namely the correlation of docking scores to biological activity and the averaged root mean squared deviation with respect to a defined co-crystallized inhibitor. The set of equivalent QSAR models produced are subsequently clustered and a representative ...
Models of Selection, Isolation, and Gene Flow in Speciation
Models of Selection, Isolation, and Gene Flow in Speciation

... dN/dS. If the rate of accumulation of synonymous substitution differences among sequences is mainly attributed to the accumulation of new mutations over time, and if those substitutions are largely invisible to selection on protein function, then a higher (or lower) rate of accumulation of nonsynony ...
PartitionFinder manual
PartitionFinder manual

Further Topics in Optimization
Further Topics in Optimization

output - UCSB Computer Science
output - UCSB Computer Science

Nucleotide sequence analysis - Bioinformatics Unit
Nucleotide sequence analysis - Bioinformatics Unit

DOCX
DOCX

...  Additions – O(n)  Multiplications by powers of two (actually left-shifts) – O(n)  Four n/2-bit multiplications – xLyL, xLyR, xRyL, xRyR – with recursive calls. Our method for multiplying n-bit numbers starts by making recursive calls to multiply these four pairs of n/2-bit numbers (four sub-prob ...
Prediction and Validation of Gene-Disease Associations
Prediction and Validation of Gene-Disease Associations

Expressed Sequence Tag (EST)
Expressed Sequence Tag (EST)

... EST clustering consists in incorporating overlapping ESTs which tag the same Transcript of the same gene in a single cluster For clustering, we measure the similarity (distance) between any 2 sequences. The distance is then reduced to a simple binary value: - accept or reject two sequences in the sa ...
What is Sequence Alignment?
What is Sequence Alignment?

Maximum likelihood methods for detecting adaptive evolution after
Maximum likelihood methods for detecting adaptive evolution after

... this reason, adaptive evolution will be very difficult to detect in gene families by using a pairwise approach to estimating d N/d S ratios. We need tools to (1) estimate selective pressures at different time points in the phylogenetic history of a gene, and (2) test the hypothesis that those estima ...
Identification and characterization of putative conserved IAM
Identification and characterization of putative conserved IAM

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Computational phylogenetics

Computational phylogenetics is the application of computational algorithms, methods, and programs to phylogenetic analyses. The goal is to assemble a phylogenetic tree representing a hypothesis about the evolutionary ancestry of a set of genes, species, or other taxa. For example, these techniques have been used to explore the family tree of hominid species and the relationships between specific genes shared by many types of organisms. Traditional phylogenetics relies on morphological data obtained by measuring and quantifying the phenotypic properties of representative organisms, while the more recent field of molecular phylogenetics uses nucleotide sequences encoding genes or amino acid sequences encoding proteins as the basis for classification. Many forms of molecular phylogenetics are closely related to and make extensive use of sequence alignment in constructing and refining phylogenetic trees, which are used to classify the evolutionary relationships between homologous genes represented in the genomes of divergent species. The phylogenetic trees constructed by computational methods are unlikely to perfectly reproduce the evolutionary tree that represents the historical relationships between the species being analyzed. The historical species tree may also differ from the historical tree of an individual homologous gene shared by those species.Producing a phylogenetic tree requires a measure of homology among the characteristics shared by the taxa being compared. In morphological studies, this requires explicit decisions about which physical characteristics to measure and how to use them to encode distinct states corresponding to the input taxa. In molecular studies, a primary problem is in producing a multiple sequence alignment (MSA) between the genes or amino acid sequences of interest. Progressive sequence alignment methods produce a phylogenetic tree by necessity because they incorporate new sequences into the calculated alignment in order of genetic distance.
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