SAD Kinases Sculpt Axonal Arbors of Sensory Neurons through
... signals transiently activate SADs by inducing dephosphorylation of C-terminal domains, thereby allowing activating phosphorylation of the kinase domain. We propose that SAD kinases integrate long- and short-duration signals from extrinsic cues to sculpt axon arbors within the CNS. ...
... signals transiently activate SADs by inducing dephosphorylation of C-terminal domains, thereby allowing activating phosphorylation of the kinase domain. We propose that SAD kinases integrate long- and short-duration signals from extrinsic cues to sculpt axon arbors within the CNS. ...
Projection patterns from the amygdaloid nuclear complex to
... injected into the lateral wing subdivision (Fig. 1C, R106; Fig. 1D, R127) at intermediate levels of the DR. Individual cases representing midline (Fig. 2A, R119) or lateral wing (Fig. 2B, R127) injections are depicted to show the distribution of retrogradely labeled cells along the rostrocaudal exte ...
... injected into the lateral wing subdivision (Fig. 1C, R106; Fig. 1D, R127) at intermediate levels of the DR. Individual cases representing midline (Fig. 2A, R119) or lateral wing (Fig. 2B, R127) injections are depicted to show the distribution of retrogradely labeled cells along the rostrocaudal exte ...
Martin, Neuroscientist 2005
... Box 1: Organization of the Mature Corticospinal System The corticospinal system connects the frontal and anterior parietal lobes with the spinal gray matter. Early in development, corticospinal neurons are distributed throughout much of the frontal and parietal lobes, and parts of the occipital and ...
... Box 1: Organization of the Mature Corticospinal System The corticospinal system connects the frontal and anterior parietal lobes with the spinal gray matter. Early in development, corticospinal neurons are distributed throughout much of the frontal and parietal lobes, and parts of the occipital and ...
... cellular protein, was subjected to an intracerebral inoculation with a BSE isolate. Neuropathological features where assessed and compared to NTs/NTRs immunolabelling. Furthermore, in this experiment, a wild type mouse line (Balb-C) was included as a control for a thorough -normal- mouse brain mappi ...
Different neurotrophins are expressed and act in a developmental
... trigeminal neurons are clearly observed after 48 hours incubation when virtually all neurons have died in control cultures. Furthermore, since the serum-free medium used in these experiments is not conducive for the growth of fibroblasts, the cultures remain virtually free of non-neuronal cells. Thu ...
... trigeminal neurons are clearly observed after 48 hours incubation when virtually all neurons have died in control cultures. Furthermore, since the serum-free medium used in these experiments is not conducive for the growth of fibroblasts, the cultures remain virtually free of non-neuronal cells. Thu ...
A transcription factor network controls cell migration
... (Turner and Cepko, 1987). While numerous genes that govern this process have been uncovered, precise mechanisms that produce different neuron types remain elusive (for review see Cepko, 2014). ...
... (Turner and Cepko, 1987). While numerous genes that govern this process have been uncovered, precise mechanisms that produce different neuron types remain elusive (for review see Cepko, 2014). ...
Formation of a full complement of cranial proprioceptors requires
... Inactivation of neurotrophin-3 (NT3) completely blocks the development of limb proprioceptive neurons and their end organs, the muscle spindles. We examined whether cranial proprioceptive neurons of the trigeminal mesencephalic nucleus (TMN) require NT3, brain-derived neurotrophic factor (BDNF) or n ...
... Inactivation of neurotrophin-3 (NT3) completely blocks the development of limb proprioceptive neurons and their end organs, the muscle spindles. We examined whether cranial proprioceptive neurons of the trigeminal mesencephalic nucleus (TMN) require NT3, brain-derived neurotrophic factor (BDNF) or n ...
The amygdala: securing pleasure and avoiding pain
... the amygdala, nor the impact that processing in this structure has on the motivational limbic corticostriatal circuitry of which it is an important structure. Here we discuss the interactions between different amygdala nuclei with cortical and striatal regions involved in motivation; interconnection ...
... the amygdala, nor the impact that processing in this structure has on the motivational limbic corticostriatal circuitry of which it is an important structure. Here we discuss the interactions between different amygdala nuclei with cortical and striatal regions involved in motivation; interconnection ...
Relating normalization to neuronal populations across cortical areas
... areas (Heeger, 1992; Carandini et al., 1997; Carandini and Heeger, 2012; Busse et al., 2009; Chance et al., 2002; Rubin et al., 2013; Rust et al., 2006; Sit et al., 2009), but current models of normalization are not mechanistic and focus on trial-averaged responses. To gain insight into the mechanis ...
... areas (Heeger, 1992; Carandini et al., 1997; Carandini and Heeger, 2012; Busse et al., 2009; Chance et al., 2002; Rubin et al., 2013; Rust et al., 2006; Sit et al., 2009), but current models of normalization are not mechanistic and focus on trial-averaged responses. To gain insight into the mechanis ...
Print
... hippocampus (188), as well as throughout the brain, where activation of CB1 by endocannabinoids can efficiently veto neurotransmitter release in many distinct types of synapses (see sect. IV). The conditions of synthesis, release, distance of diffusion, duration of effect, and site of action were al ...
... hippocampus (188), as well as throughout the brain, where activation of CB1 by endocannabinoids can efficiently veto neurotransmitter release in many distinct types of synapses (see sect. IV). The conditions of synthesis, release, distance of diffusion, duration of effect, and site of action were al ...
NIH Public Access
... As will become apparent in this review, much of the investigation into the role of mitochondrial Ca2+ transport in CNS diseases has focused around the induction of the permeability transition. There has been some controversy over the nature or even existence of the permeability transition in isolate ...
... As will become apparent in this review, much of the investigation into the role of mitochondrial Ca2+ transport in CNS diseases has focused around the induction of the permeability transition. There has been some controversy over the nature or even existence of the permeability transition in isolate ...
all-or-nothing principle
... • Brain damage, plasticity, and repair • Genetics and behavior © 2013 by McGraw-Hill Education. This is proprietary material solely for authorized instructor use. Not authorized for sale or distribution in any manner. This document may not be copied, scanned, duplicated, forwarded, distributed, or p ...
... • Brain damage, plasticity, and repair • Genetics and behavior © 2013 by McGraw-Hill Education. This is proprietary material solely for authorized instructor use. Not authorized for sale or distribution in any manner. This document may not be copied, scanned, duplicated, forwarded, distributed, or p ...
The Role of Neurotrophins in Neurotransmitter Release
... potentiation in response to BDNF, whereas synapses with high Pr show little potentiation in response to BDNF (Lessmann and Heumann 1998; Berninger and others 1999). This differential synaptic enhancement by BDNF could be affected by distinct differences in presynaptic calcium channel modulation and/ ...
... potentiation in response to BDNF, whereas synapses with high Pr show little potentiation in response to BDNF (Lessmann and Heumann 1998; Berninger and others 1999). This differential synaptic enhancement by BDNF could be affected by distinct differences in presynaptic calcium channel modulation and/ ...
Distinct Neuropathologic Phenotypes After Disrupting the
... (J.D.C.), European Commission 6th Framework Research Grant LSHMCT-2003-503051 (J.D.C.), and a UK Medical Research Council Studentship (S.N.R.P. and J.D.C.), the Deutsche Forschungsgemeinschaft to TJJ (Je164/7 and SFB 740), and Academy of Finland 1122404 (J.T.). The following nonprofit agencies also c ...
... (J.D.C.), European Commission 6th Framework Research Grant LSHMCT-2003-503051 (J.D.C.), and a UK Medical Research Council Studentship (S.N.R.P. and J.D.C.), the Deutsche Forschungsgemeinschaft to TJJ (Je164/7 and SFB 740), and Academy of Finland 1122404 (J.T.). The following nonprofit agencies also c ...
Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice
... recruited onto a V2 VPM neuron [infraorbital nerve cut (IONC) model; Takeuchi et al., 2012]. Together with evidence accumulated in in vivo studies, we hypothesized that newly recruited lemniscal fibers originate from different sources, other than the whisker sensory principle trigeminal nucleus (PrV ...
... recruited onto a V2 VPM neuron [infraorbital nerve cut (IONC) model; Takeuchi et al., 2012]. Together with evidence accumulated in in vivo studies, we hypothesized that newly recruited lemniscal fibers originate from different sources, other than the whisker sensory principle trigeminal nucleus (PrV ...
Explaining The Efficiency Of Marte Meo From A Neurobiological
... to them that she needs one more moment for herself in order to really arrive at home (MME: Naming). She has a cup of tea and relaxes. Then, she sits down on the floor in a relaxed attitude and mood where her daughter is playing. Pia looks up from her play, looks at her mother for a short time with a ...
... to them that she needs one more moment for herself in order to really arrive at home (MME: Naming). She has a cup of tea and relaxes. Then, she sits down on the floor in a relaxed attitude and mood where her daughter is playing. Pia looks up from her play, looks at her mother for a short time with a ...
Development of the rat thalamus: VI. The posterior lobule of the
... day E l 4 into two components, the intermediate lobule and that described in detail in the first paper of this series (Altthe posterior lobule (Figs. 4,5in Altman and Bayer, '88a). In man and Bayer, '88a). We made particular use of three colthe subsequent papers we sought to provide evidence that le ...
... day E l 4 into two components, the intermediate lobule and that described in detail in the first paper of this series (Altthe posterior lobule (Figs. 4,5in Altman and Bayer, '88a). In man and Bayer, '88a). We made particular use of three colthe subsequent papers we sought to provide evidence that le ...
Glia Engulf Degenerating Axons during Developmental Axon Pruning
... different developmental time points: larval MB (B), 8 hr (C), 10 hr (D), and 12 hr (E) APF. (B1–E1) Confocal Z projections of MB ␥ neurons expressing UAS-mCD8::GFP driven by 201Y-GAL4, with labeling of dendrites in the calyx (c); axon bundle or peduncle (p); and axon lobes, medial (m) and dorsal (d) ...
... different developmental time points: larval MB (B), 8 hr (C), 10 hr (D), and 12 hr (E) APF. (B1–E1) Confocal Z projections of MB ␥ neurons expressing UAS-mCD8::GFP driven by 201Y-GAL4, with labeling of dendrites in the calyx (c); axon bundle or peduncle (p); and axon lobes, medial (m) and dorsal (d) ...
Dopaminergic control of the globus pallidus and its impact
... dopamine ainsi que ses agoniste/antagoniste), nous avons étudié chez le rat l‟effet modulateur de la dopamine sur l‟activité du GPe ainsi que son impact sur ses deux structures efférentes qui sont le noyau sous-thalamique (NST) et la substance noire reticulée (SNr) en utilisant l‟électrophysiologiqu ...
... dopamine ainsi que ses agoniste/antagoniste), nous avons étudié chez le rat l‟effet modulateur de la dopamine sur l‟activité du GPe ainsi que son impact sur ses deux structures efférentes qui sont le noyau sous-thalamique (NST) et la substance noire reticulée (SNr) en utilisant l‟électrophysiologiqu ...
Cortical and subcortical afferents to the nucleus reticularis tegmenti
... Anatomical findings are presented that identify cortical and subcortical sources of afferents to the nucleus reticularis tegmenti pontis (NRTP) and basal pontine nuclei. Projections from the middle temporal visual area (MT), medial superior temporal visual area (MST), lateral intraparietal area (LIP ...
... Anatomical findings are presented that identify cortical and subcortical sources of afferents to the nucleus reticularis tegmenti pontis (NRTP) and basal pontine nuclei. Projections from the middle temporal visual area (MT), medial superior temporal visual area (MST), lateral intraparietal area (LIP ...
Transitional Probabilities Are Prioritized over Stimulus/Pattern
... age of the remaining 13 participants for behavioral analysis was 26.2 years (SD ⫽ 6.3 years, three males). Participants gave written informed consent after the experimental procedure was explained to them. They received modest payment for their participation. The study was conducted in full accordan ...
... age of the remaining 13 participants for behavioral analysis was 26.2 years (SD ⫽ 6.3 years, three males). Participants gave written informed consent after the experimental procedure was explained to them. They received modest payment for their participation. The study was conducted in full accordan ...
Postnatal Development of the Corticospinal Tract in the Reeler Mouse
... 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI; Molecular Probe, D-282). The numbers of the animals used in the present DiI study were as follows: 2 normal and 4 reeler on P0.5, 3 normal and 5 reeler on P1, 2 normal and 2 reeler on P2, 2 normal and 3 reeler on P3, 3 normal a ...
... 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI; Molecular Probe, D-282). The numbers of the animals used in the present DiI study were as follows: 2 normal and 4 reeler on P0.5, 3 normal and 5 reeler on P1, 2 normal and 2 reeler on P2, 2 normal and 3 reeler on P3, 3 normal a ...
Involvement of GABAergic and cholinergic medial septal neurons in
... neurons. A fixed recording electrode was placed in the dentate midmolecular layer, and stimulating electrodes were placed in the posterior hypothalamus (PH), and medial perforant path (PP). Under urethane anesthesia, HPC was induced by tail pinch, PH stimulation, and systemic physostigmine; none of ...
... neurons. A fixed recording electrode was placed in the dentate midmolecular layer, and stimulating electrodes were placed in the posterior hypothalamus (PH), and medial perforant path (PP). Under urethane anesthesia, HPC was induced by tail pinch, PH stimulation, and systemic physostigmine; none of ...
Paper
... in detail. The appearance of the claustrum in frontal sections is generally consistent with that of other commonly used laboratory primate species, including the macaque (Pearson et al., 1982; Kowianski et al., 1999), vervet monkey (Kowianski et al., 1999), and marmoset (Burman et al., 2011a; Paxino ...
... in detail. The appearance of the claustrum in frontal sections is generally consistent with that of other commonly used laboratory primate species, including the macaque (Pearson et al., 1982; Kowianski et al., 1999), vervet monkey (Kowianski et al., 1999), and marmoset (Burman et al., 2011a; Paxino ...
Galanin-like peptide: a key player in the homeostatic regulation of
... hormone, which is derived from pro-opiomelanocortin in neurons in the ARC,36 with orexin-1 receptor immunoreactivity also being observed in a few GALP-positive neurons.38 We have previously reported that 3–12% of GALP-positive cells contain a-melanocyte-stimulating hormone-like immunoreactivity.36 I ...
... hormone, which is derived from pro-opiomelanocortin in neurons in the ARC,36 with orexin-1 receptor immunoreactivity also being observed in a few GALP-positive neurons.38 We have previously reported that 3–12% of GALP-positive cells contain a-melanocyte-stimulating hormone-like immunoreactivity.36 I ...