HCN channels are a novel therapeutic target for cognitive
... phenotype is further surprising, given that it is not recapitulated in other mouse models in which Ras-ERK signaling is upregulated, such as mouse models for Noonan syndrome and Costello syndrome.7 This suggests that NF1 might also have a Rasindependent function in neurons. Ras-independent targets h ...
... phenotype is further surprising, given that it is not recapitulated in other mouse models in which Ras-ERK signaling is upregulated, such as mouse models for Noonan syndrome and Costello syndrome.7 This suggests that NF1 might also have a Rasindependent function in neurons. Ras-independent targets h ...
Topographic Organization of Corticospinal Projections from the
... At least every fourth cortical section through the frontal lobe was plotted to determine the distribution of corticospinal neurons. In all animals, some glial labeling was seen surrounding intensely labeled FB neurons (Fig. lc). However, we had no difficulty distinguishing this labeling from that of ...
... At least every fourth cortical section through the frontal lobe was plotted to determine the distribution of corticospinal neurons. In all animals, some glial labeling was seen surrounding intensely labeled FB neurons (Fig. lc). However, we had no difficulty distinguishing this labeling from that of ...
PDF - Oxford Academic - Oxford University Press
... form are often spatially localized to the sites of their contacts with the postsynaptic dendrite. This is most clearly evident in a series of elegant experiments in which afferents to the ventral dendrites of neurons in the nucleus laminaris of the chick brainstem were cut. This elimination of excit ...
... form are often spatially localized to the sites of their contacts with the postsynaptic dendrite. This is most clearly evident in a series of elegant experiments in which afferents to the ventral dendrites of neurons in the nucleus laminaris of the chick brainstem were cut. This elimination of excit ...
the resonate-and-fire neuron: time dependent and frequency
... to learn to perform certain desired tasks. The thesis represents a culmination of our endeavors over the past two years to understand nervous system function, and to reflect on the principles that govern engineered as well as living systems. I am grateful to Bucknell University and the Department of ...
... to learn to perform certain desired tasks. The thesis represents a culmination of our endeavors over the past two years to understand nervous system function, and to reflect on the principles that govern engineered as well as living systems. I am grateful to Bucknell University and the Department of ...
Spatially and Functionally Distinct Roles of the PI3
... levels. Representative results from three independent experiments are shown. DA, distal axons; CB, cell bodies. ...
... levels. Representative results from three independent experiments are shown. DA, distal axons; CB, cell bodies. ...
Axonal wiring of guanylate cyclase-D
... neurons is dependent on neuropilin 2 and semaphorin 3F Andreas Walz, Paul Feinstein, Mona Khan and Peter Mombaerts* The olfactory system of the mouse includes several subsystems that project axons from the olfactory epithelium to the olfactory bulb. Among these is a subset of neurons that do not exp ...
... neurons is dependent on neuropilin 2 and semaphorin 3F Andreas Walz, Paul Feinstein, Mona Khan and Peter Mombaerts* The olfactory system of the mouse includes several subsystems that project axons from the olfactory epithelium to the olfactory bulb. Among these is a subset of neurons that do not exp ...
Receptive Fields and Binaural Interactions for Virtual
... al. 1983; see Irvine 1992 for review). However, free-field studies alone cannot determine which acoustic cues are responsible for this directional sensitivity because they do not allow independent control over each cue. Such control can be achieved in dichotic studies that deliver stimuli through cl ...
... al. 1983; see Irvine 1992 for review). However, free-field studies alone cannot determine which acoustic cues are responsible for this directional sensitivity because they do not allow independent control over each cue. Such control can be achieved in dichotic studies that deliver stimuli through cl ...
Reuss 9..48
... GABA is a major transmitter of the SCN. Furthermore, there is multiple evidence that amino acid transmitters are of major importance for SCN function. GABA, thought to be the principal neurotransmitter in the SCN [Moore and Speh, 1993], is found in most if not all neurons, and the mRNA for its synth ...
... GABA is a major transmitter of the SCN. Furthermore, there is multiple evidence that amino acid transmitters are of major importance for SCN function. GABA, thought to be the principal neurotransmitter in the SCN [Moore and Speh, 1993], is found in most if not all neurons, and the mRNA for its synth ...
A Dendritic Disinhibitory Circuit Mechanism for Pathway
... the level of dendrites it is sufficiently sparse to support branch-specific disinhibition, and there- ...
... the level of dendrites it is sufficiently sparse to support branch-specific disinhibition, and there- ...
- Wiley Online Library
... Glowinski and George K. Aghajanian. He is currently Professor of Pharmacology at the University of Virginia. His laboratory studies the neural networks that regulate breathing and blood pressure. ...
... Glowinski and George K. Aghajanian. He is currently Professor of Pharmacology at the University of Virginia. His laboratory studies the neural networks that regulate breathing and blood pressure. ...
Caudal Topographic Nucleus Isthmi and the Rostra1
... neurons labeled in Imr, nucleus lentiformis mesencephali, or profundus mesencephali rostralis (PMr). The axons of neurons in those nuclei were reconstructed from serial sections and found to branch widely, sparsely innervating large areas of the tectum. Fourth, the dense thickets are not terminals o ...
... neurons labeled in Imr, nucleus lentiformis mesencephali, or profundus mesencephali rostralis (PMr). The axons of neurons in those nuclei were reconstructed from serial sections and found to branch widely, sparsely innervating large areas of the tectum. Fourth, the dense thickets are not terminals o ...
Bridging Areas of Injury in the Spinal Cord
... transected adult rat spinal cord stumps (Xu, Chen, and others 1997) (Fig. 2); fibers grow into both ends of the graft, as in the peripheral nerve work cited above. Much of the SC bridge work tested a cable of SCs in Matrigel (a commercial preparation of basal lamina components) inside a PAN/PVC poly ...
... transected adult rat spinal cord stumps (Xu, Chen, and others 1997) (Fig. 2); fibers grow into both ends of the graft, as in the peripheral nerve work cited above. Much of the SC bridge work tested a cable of SCs in Matrigel (a commercial preparation of basal lamina components) inside a PAN/PVC poly ...
Organelle motility and metabolism in axons vs dendrites of cultured
... types. First, in addition to the difference in net transport direction, the large phase-dense organelles exhibited more persistent changes in direction in proximal dendrites where microtubule polarity is mixed than in axons where micro tubule polarity is uniform. Second, while the net direction of ...
... types. First, in addition to the difference in net transport direction, the large phase-dense organelles exhibited more persistent changes in direction in proximal dendrites where microtubule polarity is mixed than in axons where micro tubule polarity is uniform. Second, while the net direction of ...
The physiological role of orexin/hypocretin neurons in the regulation
... as endogenous ligands for two orphan G-protein-coupled receptors in the lateral hypothalamic area. They were initially recognized as regulators of feeding behavior, but they are mainly regarded as key modulators of the sleep/wakefulness cycle. Orexins activate orexin neurons, monoaminergic and choli ...
... as endogenous ligands for two orphan G-protein-coupled receptors in the lateral hypothalamic area. They were initially recognized as regulators of feeding behavior, but they are mainly regarded as key modulators of the sleep/wakefulness cycle. Orexins activate orexin neurons, monoaminergic and choli ...
Learning-related postburst afterhyperpolarization reduction in CA1
... Transgenic mice with a constitutively active form of CREB have recently been shown to have CA1 pyramidal neurons with significantly reduced AHPs (28). Interestingly, EBC is also significantly impaired by disruption of the cAMP/PKA pathway in the cerebellum (29), a structure known to be critically in ...
... Transgenic mice with a constitutively active form of CREB have recently been shown to have CA1 pyramidal neurons with significantly reduced AHPs (28). Interestingly, EBC is also significantly impaired by disruption of the cAMP/PKA pathway in the cerebellum (29), a structure known to be critically in ...
- CUNY Academic Works
... conditioned approach behaviors similar to the primary rewards with which they are associated. Involved in this type of learning is the brain’s reward system, the mesocorticolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to forebrain regions such as the ...
... conditioned approach behaviors similar to the primary rewards with which they are associated. Involved in this type of learning is the brain’s reward system, the mesocorticolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to forebrain regions such as the ...
The Role of Mirror Neurons in Movement
... The characteristic feature of mirror neurons is that they modulate their firing rate during both a monkey’s own action and during observation of another individual performing a similar action. Some premotor (F5) mirror neurons have also been shown to be corticospinal neurons, meaning that spinal tar ...
... The characteristic feature of mirror neurons is that they modulate their firing rate during both a monkey’s own action and during observation of another individual performing a similar action. Some premotor (F5) mirror neurons have also been shown to be corticospinal neurons, meaning that spinal tar ...
Neuropathological Characteristics of Brachial Plexus Avulsion Injury
... ChAT-positive motor neurons were counted on both the intact and lesioned side of the C5, C6, and C7 spinal segments. Because ChAT immunoreactivity may be changed as a consequence of injury, serials sections stained with CV were also used to quantify the motor neurons as an independent marker. Only C ...
... ChAT-positive motor neurons were counted on both the intact and lesioned side of the C5, C6, and C7 spinal segments. Because ChAT immunoreactivity may be changed as a consequence of injury, serials sections stained with CV were also used to quantify the motor neurons as an independent marker. Only C ...
Examination of Thyrotropin-Releasing Hormone (TRH)
... 1.1. The metabolism of THs Thyroid hormones - 3,3’,5-triiodothyronin (T3) and thyroxine (T4) - are synthesized in the follicles of thyroid gland by iodination of tyrosine residues of thyroglobulin [12]. Although T4 is the predominant product of the thyroid gland, T3 is the form of thyroid hormones t ...
... 1.1. The metabolism of THs Thyroid hormones - 3,3’,5-triiodothyronin (T3) and thyroxine (T4) - are synthesized in the follicles of thyroid gland by iodination of tyrosine residues of thyroglobulin [12]. Although T4 is the predominant product of the thyroid gland, T3 is the form of thyroid hormones t ...
Structure and Function of the Brain Serotonin System
... nuclei possess individual characteristics, such as the presence of cotransmitters, which may influence their anatomy and physiology. Before proceeding, it is important to obtain some general feeling for the numbers involved when we discuss 5-HT anatomy in the CNS. It may seem somewhat surprising tha ...
... nuclei possess individual characteristics, such as the presence of cotransmitters, which may influence their anatomy and physiology. Before proceeding, it is important to obtain some general feeling for the numbers involved when we discuss 5-HT anatomy in the CNS. It may seem somewhat surprising tha ...
Topographically Specific Hippocampal Projections Target Functionally Distinct Prefrontal Areas in the
... a few labeled neurons found mostly in the subicular fields. Lateral prefrontal cortices received the most robust projections from the presubiculum and the supracallosal area 29a-c. Orbital, and to a lesser extent medial, prefrontal areas received projections from a smaller but significant number of ...
... a few labeled neurons found mostly in the subicular fields. Lateral prefrontal cortices received the most robust projections from the presubiculum and the supracallosal area 29a-c. Orbital, and to a lesser extent medial, prefrontal areas received projections from a smaller but significant number of ...
Activity dynamics and behavioral correlates of CA3 and CA1
... recorded from CA1 or CA3 pyramidal layers. Each shank had eight recording sites (160 lm2 each site, 1–3-Ml impedance), and intershank distance was 200 lm. Recordings sites were staggered to provide a two-dimensional arrangement (20-lm vertical separation). In four rats, eight independently movable w ...
... recorded from CA1 or CA3 pyramidal layers. Each shank had eight recording sites (160 lm2 each site, 1–3-Ml impedance), and intershank distance was 200 lm. Recordings sites were staggered to provide a two-dimensional arrangement (20-lm vertical separation). In four rats, eight independently movable w ...