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Extended PDF
Extended PDF

... SS, somatosensory cortex; MO, motor cortex; AUD, auditory cortex; VISal, visual cortex; PTLp, posterior parietal association areas; Medial, including anterior cingulate area, dorsal peduncular area, infralimbic area, prelimbic area, and retrosplenial area. Data are presented as mean ± SEM. n.s., not ...
Prefrontal Neurons Coding Suppression of Specific Saccades
Prefrontal Neurons Coding Suppression of Specific Saccades

... lobe (e.g., Hasegawa et al., 1998, 2000a, 2004) in monkeys have dealt with the generation of movement rather than its suppression. The saccadic system provides an excellent model for the suppression of unwanted behavior. Monkeys as well as humans can voluntarily move their eyes not only to look at s ...
Morphology of Feedback Neurons in the Mushroom Body of the
Morphology of Feedback Neurons in the Mushroom Body of the

Document
Document

... Loss of efferent component of reflex arc and tone pathway ...
Synchrony Unbound: Review A Critical Evaluation of
Synchrony Unbound: Review A Critical Evaluation of

... We will discuss below our doubts about the utility of coincidence detection models for cortical neurons, but suppose for a moment that we grant the existence of these detectors. If there were special detectors configured to detect the coincident activity of particular groups of their input neurons, ...
Voluntary Nicotine Consumption Triggers Potentiation of Cortical Excitatory Drives to Midbrain
Voluntary Nicotine Consumption Triggers Potentiation of Cortical Excitatory Drives to Midbrain

... Ventral tegmental area recordings. A glass micropipette (tip diameter ⫽ 2–3 ␮m, 4 – 6 M⍀) filled with a 2% ponMaterials and Methods tamine sky blue solution in 0.5 M sodium acetate was lowered into the Animals. Ninety-three male Sprague Dawley rats (Charles River, 175–200 VTA. DA neurons were identi ...
I study the neural circuits that move bodies
I study the neural circuits that move bodies

... I feel lucky to be part of the first group of thesis students to have come through Erik's lab. I think that electrophysiology is some of the coolest, most hands-on biology around, and it was gratifying to gradually become proficient in these technically and manually complicated procedures. Getting y ...
Use of a Recombinant Pseudorabies Virus to
Use of a Recombinant Pseudorabies Virus to

... Since the early 1990s, studies demonstrating plasticity in the cortical somatotopic representation maps of the primary motor cortex (MI) of adult animals have brought about a dramatic change in the concept of the function and role of motor cortical areas as information-processing structures (Sanes a ...
Title Goes here
Title Goes here

... Combined effects of Glutamate and Zinc on the EPSP Figures courtesy of Li, et al. 2001 ...
Comparative molecular neuroanatomy of mammalian neocortex
Comparative molecular neuroanatomy of mammalian neocortex

... Unlike inhibitory neurons, there had been few good antibodies to classify the excitatory neurons, which resulted in the comment that “chemical diversity of neurons in the neocortex is mainly a feature of the population of nonpyramidal cells.” (DeFelipe 1993). Such situation is rapidly changing with ...
The neural basis for combinatorial coding in a cortical population response
The neural basis for combinatorial coding in a cortical population response

... to say that the view of averaging for noise reduction continues to be more prominent in discussions of sensory coding in the cortex. Here we reexamine the issue of combinatorial coding using neural responses to visual motion recorded in the middle temporal (MT) area of visual cortex (Dubner and Zeki ...
A mathematical model on REM-NREM cycle
A mathematical model on REM-NREM cycle

... other neurons. Synapses are connections between neurons through which ”information” flows from one neuron to another. Hence, neurons process all of the ”information” that flows within, to, or out of the CNS. Processing many kinds of information requires many types of neurons; there may be as many as ...
Copy of the full paper
Copy of the full paper

... signals by precisely computing the neurons’ asynchronous spikes. Neuron models can precisely describe the biophysics of spikes (action potentials) by computing the currents flowing through cell membrane and synaptic nodes. It is possible to reduce the size of these models to facilitate their computa ...
Dorsal Column Nuclei Neurons Recorded in a Brain Stem–Spinal
Dorsal Column Nuclei Neurons Recorded in a Brain Stem–Spinal

Mapping Function Onto Neuronal Morphology
Mapping Function Onto Neuronal Morphology

... of the neurons, the fitness functions, and the genetic algorithm. The sets of equations are only weakly connected. By this we mean that one set of equations provides only parameters, initial or boundary conditions to the other set of equations. There is, however, no continuous coupling with the stat ...
Neural Control of Interappendage Phase During Locomotion
Neural Control of Interappendage Phase During Locomotion

... part of the input to another control center. Alternately, it might involve a common phasic input to each of the control centers. "Sensory" mechanisms can couple the discharge of different control centers in several ways. Firstly, the central axons of sensory neurons from one limb may project to the ...
Evidence for a distributed hierarchy of action
Evidence for a distributed hierarchy of action

... By using functional brain imaging of action observation and an exciting new methodological approach to experimental design called repetition suppression, we can, for the first time, stratify the understanding of goal-oriented behavior into distinct levels of control at a level of detail previously un ...
MECHANISMS OF CENTRAL TRANSMISSION OF RESPIRATORY
MECHANISMS OF CENTRAL TRANSMISSION OF RESPIRATORY

... to the reactions of typical respiratory neurons in the efferent part of the central rhythmogenic structure. Whereas respiration runs closely parallel with inspiratory neuron activity the behaviour of expiratory neurons cannot be derived from the resulting reflex changes of respiration. So expiratory ...
1 also mediates MMP-2 and MMP-9 activation. In our
1 also mediates MMP-2 and MMP-9 activation. In our

... usually appears sporadic (SALS), but 1%-13% of cases are familial (FALS). Today, more than 20 causative genes are known, and mutations in most are very rare. Based on functions of the genes, oxidative stress, axonal transport, vesicular transport, protein aggregation, and RNA metabolism are relevant ...
Center-Surround Interactions in the Middle Temporal Visual Area of
Center-Surround Interactions in the Middle Temporal Visual Area of

... every 100 ␮m to obtain adequate spatial sampling. In situations where this was not possible, multi-unit activity was recorded. Once the location of the receptive field was found, its borders were mapped with a light bar using the minimal response technique (Barlow et al. 1967). This region will be s ...
Single-trial decoding of intended eye movement goals from lateral
Single-trial decoding of intended eye movement goals from lateral

... the log is base 2. Spike counts were quantized using a maximum of 8 quantiles (Musallam et al. 2004), but often fewer quantiles were needed to represent all unique spike count values, especially when analyzing neurons with low firing rates and short epochs. The quantile indexes were used as r in Eq. ...
Neural circuit rewiring: insights from DD synapse remodeling
Neural circuit rewiring: insights from DD synapse remodeling

... in some cases, even the death of inappropriately connected neurons,32 DD remodeling appears to be unique. However, the discovery of this unique form of neural plasticity is primarily because of our complete understanding of the neural connectivity of C. elegans, made possible by work from John White ...
Cooperation and biased competition model can explain attentional
Cooperation and biased competition model can explain attentional

... of certain stimuli in the environment is enhanced relative to other concurrent stimuli of less importance. A remarkable phenomenon of selective attention, known as inattentional blindness, has been described for human vision (for a review see Simons, 2000). The inattentional blindness refers to the ...
Interactions between Adjacent Ganglia Bring About the Bilaterally
Interactions between Adjacent Ganglia Bring About the Bilaterally

... in other, neighboringganglia.Evidence of suchinteractions was previously obtained by transecting the embryonic nerve cord prior to the appearanceof AS neuron asymmetry. Transections of the posterior nerve cord significantly reducedthe probability of CAS neuron alternation in the vicinity of the lesi ...
Lack of response suppression follows repeated ventral tegmental
Lack of response suppression follows repeated ventral tegmental

... Abstract—Cannabinoid compounds have been reported to excite ventral tegmental neurons through activation of cannabinoid CB1 receptors. More recently, biochemical and whole-cell voltage-clamp studies carried out on CB1-transfected AtT20 cells have shown a rapid desensitization of these receptors foll ...
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Mirror neuron

A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron ""mirrors"" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in primate species. Birds have been shown to have imitative resonance behaviors and neurological evidence suggests the presence of some form of mirroring system. In humans, brain activity consistent with that of mirror neurons has been found in the premotor cortex, the supplementary motor area, the primary somatosensory cortex and the inferior parietal cortex.The function of the mirror system is a subject of much speculation. Many researchers in cognitive neuroscience and cognitive psychology consider that this system provides the physiological mechanism for the perception/action coupling (see the common coding theory). They argue that mirror neurons may be important for understanding the actions of other people, and for learning new skills by imitation. Some researchers also speculate that mirror systems may simulate observed actions, and thus contribute to theory of mind skills, while others relate mirror neurons to language abilities. Neuroscientists such as Marco Iacoboni (UCLA) have argued that mirror neuron systems in the human brain help us understand the actions and intentions of other people. In a study published in March 2005 Iacoboni and his colleagues reported that mirror neurons could discern if another person who was picking up a cup of tea planned to drink from it or clear it from the table. In addition, Iacoboni has argued that mirror neurons are the neural basis of the human capacity for emotions such as empathy.It has also been proposed that problems with the mirror neuron system may underlie cognitive disorders, particularly autism. However the connection between mirror neuron dysfunction and autism is tentative and it remains to be seen how mirror neurons may be related to many of the important characteristics of autism.Despite the excitement generated by these findings, to date, no widely accepted neural or computational models have been put forward to describe how mirror neuron activity supports cognitive functions such as imitation. There are neuroscientists who caution that the claims being made for the role of mirror neurons are not supported by adequate research.
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