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Synaptic Transmission Lecture
Synaptic Transmission Lecture

... • Why don’t our brains just use electrical transmission? ...
KKDP4: The role of neurotransmitters in the transmission of neural
KKDP4: The role of neurotransmitters in the transmission of neural

... KKDP4: The role of neurotransmitters in the transmission of neural information between neurons (lock-and-key process) to produce excitatory effects (as with glutamate) or inhibitory effects (as with gamma amino butyric acid [GABA]) ...
The Nervous System
The Nervous System

... – causes partial depolarization bringing neuron closer to firing – one EPSP is probably too weak to trigger an action potential – EPSPs can be added together (summation) – results in firing of neuron ...
KS4_nervous_models_Pupil_Sheets
KS4_nervous_models_Pupil_Sheets

Key Stage 4 – Nervous models Pupil worksheet
Key Stage 4 – Nervous models Pupil worksheet

DevelopmentII
DevelopmentII

... • Neuron-neuron and neuron-muscle synapses develop by similar mechanisms • NMJs are larger, more accessible and simpler than central synapses therefore the molecular mechanisms of synapse formation are best understood for the NMJ ...
Synapse Formation in the Peripheral and Central Nervous System
Synapse Formation in the Peripheral and Central Nervous System

... • Neuron-neuron and neuron-muscle synapses develop by similar mechanisms • NMJs are larger, more accessible and simpler than central synapses therefore the molecular mechanisms of synapse formation are best understood for the NMJ ...
Chapter 4
Chapter 4

... Neural impulse -The propagation of an action potential along an axon. The axon depolarizes in a sequential fashion from the axon hillock to the presynaptic terminal. The neural impulse occurs only one way because of the absolute refractory period. Speed of transmission varies due to thickness of the ...
Message Transmission
Message Transmission

... So, what happens at the end of the axon? • You run into a synapse. – This is the junction between any two communicating neurons – It really is a gap (the synaptic cleft), the cells don't actually touch each other. • The sender neuron is the presynaptic neuron • The receiving one is the postsynaptic ...
Slideshow
Slideshow

... Curare - poison made from frog skin and causes paralysis by blocking Ach receptors at the neuromuscular junction. ...
Neurons
Neurons

...  However, if the neuron gets stimulated, channels in the cell membrane will open allowing positively charged sodium ions to rush in  At that moment, the charge becomes less negative/even positive, creating an action potential  ACTION POTENTIAL- a very brief shift in a neuron’s electrical charge t ...
Synapses and Neurotransmitters Notes
Synapses and Neurotransmitters Notes

... A neuromuscular junction (NMJ) is a contact between a neuron and a muscle: it is like a synapse in that the action potential stops and the signal is carried by a chemical neurotransmitter released by the neuron. Neurotransmitters Are Made and Stored in the Pre-synaptic Terminal The end of the neuron ...
CNS II
CNS II

... • Synaptic cleft • Transmitter vesicles: contain transmitter substance that is released into the synaptic cleft to excite or inhibit the postsynaptic neuron • Excites with excitatory receptors at the membrane or inhibits with inhibitory receptors – Action potentials cause transmitter release from th ...
“The Physiology of Excitable Cells”
“The Physiology of Excitable Cells”

... magnitude of passive changes in membrane potential. Related to [ion channel]. ...
1 Introduction to Neurobiology Rudolf Cardinal NST 1B
1 Introduction to Neurobiology Rudolf Cardinal NST 1B

... are chemical. The presynaptic terminal contains synaptic vesicles — packets containing a chemical neurotransmitter. The type of neurotransmitter varies depending on the neuron (it is true enough for our purposes today to say that one neuron produces only one transmitter). When an AP arrives at a pre ...
2014 chemical signal..
2014 chemical signal..

... -A substance released by one neuron and acting rapidly, briefly and at short range on the membrane of adjacent (postsynaptic) neuron, causing excitation or inhibition. ...
Neural-Ville
Neural-Ville

... 3. It may bind to the first cell's autoreceptors, which tell that cell not to release any more of the neurotransmitter molecules, then leave the autoreceptor and continue trying to bind again somewhere until its activity is ended by step 4, 5 or 6. ...
Sample Prelab Assignment - Neurobiology Laboratory
Sample Prelab Assignment - Neurobiology Laboratory

... of an electrical signal in the presynaptic neuron to a chemical signal and then back to an electrical signal  in the postsynaptic neuron.  Depolarization of the presynaptic neuron causes an influx of calcium at the  nerve terminal, therefore allowing the release of synaptic vesicles. The transmitter ...
Non- directed synapses
Non- directed synapses

... in the speed of conduction, without a large increase in metabolic cost. • 3. Another way of increasing the speed of conduction is by increasing the temperature. ...
The Importance of the Nervous System
The Importance of the Nervous System

... • ensures action potential travels in one direction only ...
HONORS BIOLOGY Chapter 28 Nervous Systems
HONORS BIOLOGY Chapter 28 Nervous Systems

... Are self-propagated in a one-way chain reaction along a neuron ...
9-18-04 Nervous System Peripheral No1
9-18-04 Nervous System Peripheral No1

... – All ganglionic transmission is cholinergic (acetylcholine) • Drugs that block ganglionic transmission block either parasympathetic or sympathetic depending on which is active • This is a paradox many have a problem grasping ...
Nervous system lecture 1
Nervous system lecture 1

... Summation – combination of these graded, local potentials at the axon hillock can bring about an action potential or inhibit the generation of the action potential. – Spatial: stimulation by many neurons at one time. – Temporal: increased numbers of impulses per minute. ...
presentation
presentation

... n Constant PSP = 180mv n Gaussian PSP generates spikes with more timing reliable n Ion-channel variability is included (Gaussian) ...
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Chemical synapse



Chemical synapses are specialized junctions through which neurons signal to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body.At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron. The neurotransmitters are kept within small sacs called vesicles, and are released into the synaptic cleft by exocytosis. These molecules then bind to receptors on the postsynaptic cell's side of the synaptic cleft. Finally, the neurotransmitters must be cleared from the synapse through one of several potential mechanisms including enzymatic degradation or re-uptake by specific transporters either on the presynaptic cell or possibly by neuroglia to terminate the action of the transmitter.The adult human brain is estimated to contain from 1014 to 5 × 1014 (100–500 trillion) synapses. Every cubic millimeter of cerebral cortex contains roughly a billion (short scale, i.e. 109) of them.The word ""synapse"" comes from ""synaptein"", which Sir Charles Scott Sherrington and colleagues coined from the Greek ""syn-"" (""together"") and ""haptein"" (""to clasp""). Chemical synapses are not the only type of biological synapse: electrical and immunological synapses also exist. Without a qualifier, however, ""synapse"" commonly means chemical synapse.
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