Brca1 is required for embryonic development of the mouse cerebral
... manipulation of this process can greatly alter cortical size (Haydar et al., 1999; Rakic, 2005). Loss of progenitor apoptosis by knockout of caspase 3 (Kuida et al., 1996) or caspase 9 (Kuida et al., 1998) leads to massive overgrowth and folding of the neocortex. Constitutive activation of the Notch ...
... manipulation of this process can greatly alter cortical size (Haydar et al., 1999; Rakic, 2005). Loss of progenitor apoptosis by knockout of caspase 3 (Kuida et al., 1996) or caspase 9 (Kuida et al., 1998) leads to massive overgrowth and folding of the neocortex. Constitutive activation of the Notch ...
Arc mRNA induction in striatal efferent neurons associated with response learning
... randomly selected arms. After the initial trial, the rat was moved back into the same arm. The rat continued to run trials from this stem arm until it turned in the direction (right or left) opposite to its initial choice. This was done to prevent the reinforcement of only the initial turn choice. O ...
... randomly selected arms. After the initial trial, the rat was moved back into the same arm. The rat continued to run trials from this stem arm until it turned in the direction (right or left) opposite to its initial choice. This was done to prevent the reinforcement of only the initial turn choice. O ...
Program
and
Abstracts
from
the
Fifth
Annual
Canadian
Neuroscience
Meeting
May
29
–
June
1
2011
Quebec
City
Convention
Center
... have cloned the homologs of FoxP2, Otx1 and FoxO3 in the weakly electric fish Apteronotus leptorhynchus. We also used in situ hybridization to examine the distribution of the mRNA of these genes in the apteronotid telencephalon. Results: There were, in the case of all three genes, good similariti ...
... have cloned the homologs of FoxP2, Otx1 and FoxO3 in the weakly electric fish Apteronotus leptorhynchus. We also used in situ hybridization to examine the distribution of the mRNA of these genes in the apteronotid telencephalon. Results: There were, in the case of all three genes, good similariti ...
Ionotropic Glutamate Receptors in Aplysia californica and Molecular
... nucleic acid isolation from few cells, allowing for targeted studies on subsets of neurons. Glutamate (L-Glu) is the principal fast excitatory neurotransmitter in the central nervous system (CNS) of nearly all animals. In the Aplysia CNS, there is abundant evidence that these sensory neurons use L-G ...
... nucleic acid isolation from few cells, allowing for targeted studies on subsets of neurons. Glutamate (L-Glu) is the principal fast excitatory neurotransmitter in the central nervous system (CNS) of nearly all animals. In the Aplysia CNS, there is abundant evidence that these sensory neurons use L-G ...
Dendritic Computation - UCSD Cognitive Science
... cally, the response to the simultaneous activation is smaller than the sum of the individual responses (Rall et al. 1967). In this context, dendrites might be beneficial because they enable the spatial separation of inputs to minimize their interaction. In some cases, however, this possible sublinea ...
... cally, the response to the simultaneous activation is smaller than the sum of the individual responses (Rall et al. 1967). In this context, dendrites might be beneficial because they enable the spatial separation of inputs to minimize their interaction. In some cases, however, this possible sublinea ...
INVESTIGATING THE SOPHISTICATION OF LONG-LATENCY UPPER LIMB
... 2), it compensates for the size-recruitment principle of the motoneuron pool (Chapter 3) and it accounts for the mechanical properties of the upper-limb (Chapter 5). Further investigation revealed that the long-latency response can be decomposed into two functionally-independent processes (Chapter 4 ...
... 2), it compensates for the size-recruitment principle of the motoneuron pool (Chapter 3) and it accounts for the mechanical properties of the upper-limb (Chapter 5). Further investigation revealed that the long-latency response can be decomposed into two functionally-independent processes (Chapter 4 ...
hippocampo–cerebellar theta band phase synchrony in rabbits
... band oscillation, has been shown to modulate and predict cerebellar learning of which rabbit eyeblink conditioning is perhaps the most well-known example. The contribution of hippocampal neural activity to cerebellar learning is only possible if there is a functional connection between the two struc ...
... band oscillation, has been shown to modulate and predict cerebellar learning of which rabbit eyeblink conditioning is perhaps the most well-known example. The contribution of hippocampal neural activity to cerebellar learning is only possible if there is a functional connection between the two struc ...
MODELING THE MIRROR: GRASP LEARNING AND ACTION
... Keysers and Evelyne (Kohler) for not only actively involving me in their recording sessions but also offering their sincere friendship. I am very thankful to Hideo Sakata for giving me the opportunity to visit his lab in Tokyo and interact with many researchers including Murata-san with whom I had v ...
... Keysers and Evelyne (Kohler) for not only actively involving me in their recording sessions but also offering their sincere friendship. I am very thankful to Hideo Sakata for giving me the opportunity to visit his lab in Tokyo and interact with many researchers including Murata-san with whom I had v ...
Anatomy of Neuropsychiatry : The New Anatomy of the
... functional neuroanatomy to health care professionals in physical and occupational therapy, psychology, psychiatry, neurology, and neurosurgery, all fields where perhaps a fairly detailed knowledge of the functional-anatomical organization of the brain would seem to be a fundmental element. Neverthel ...
... functional neuroanatomy to health care professionals in physical and occupational therapy, psychology, psychiatry, neurology, and neurosurgery, all fields where perhaps a fairly detailed knowledge of the functional-anatomical organization of the brain would seem to be a fundmental element. Neverthel ...
The Spinal Cord, Spinal Nerves, and Somatic Reflexes
... tracts is essential in diagnosing and managing spinal cord injuries. Ascending tracts carry sensory information up the cord and descending tracts conduct motor impulses down. All nerve fibers in a given tract have a similar origin, destination, and function. Several of these tracts undergo decussati ...
... tracts is essential in diagnosing and managing spinal cord injuries. Ascending tracts carry sensory information up the cord and descending tracts conduct motor impulses down. All nerve fibers in a given tract have a similar origin, destination, and function. Several of these tracts undergo decussati ...
mGluR-dependent persistent firing in entorhinal cortex layer III neurons SYNAPTIC MECHANISMS Motoharu Yoshida,
... antagonist scopolamine in humans (Schon et al., 2005), and scopolamine has been shown to impair performance of delayed matching tasks (Penetar & McDonough, 1983; Robbins et al., 1997; Koller et al., 2003). On the other hand, recent in vivo findings have shown an involvement of group I metabotropic gl ...
... antagonist scopolamine in humans (Schon et al., 2005), and scopolamine has been shown to impair performance of delayed matching tasks (Penetar & McDonough, 1983; Robbins et al., 1997; Koller et al., 2003). On the other hand, recent in vivo findings have shown an involvement of group I metabotropic gl ...
The Structure of Pairwise Correlation in Mouse Primary Visual
... Throughout sensory systems, neurons are organized by response preference, so that like-responding neurons are close to each other, creating a functional map [e.g., orientation pinwheels in primary visual cortex (V1)]. Despite the ubiquity of maps, their role is unclear. For example, although rodent ...
... Throughout sensory systems, neurons are organized by response preference, so that like-responding neurons are close to each other, creating a functional map [e.g., orientation pinwheels in primary visual cortex (V1)]. Despite the ubiquity of maps, their role is unclear. For example, although rodent ...
Organelle motility and metabolism in axons vs dendrites of cultured
... half of dendritic length, and the most distal 10% of dendritic length. Quantitative analysis was done by drawing a line across the video screen perpendicular to and bisecting the process and counting the number of organelles that crossed the line during a 4× time lapse playback of the video sequence ...
... half of dendritic length, and the most distal 10% of dendritic length. Quantitative analysis was done by drawing a line across the video screen perpendicular to and bisecting the process and counting the number of organelles that crossed the line during a 4× time lapse playback of the video sequence ...
Weak orientation and direction selectivity in lateral geniculate
... the LGN is much weaker than the cortex and both structures exhibit only weak direction selectivity. While orientation selectivity did not vary significantly across the layers of the squirrel LGN, the differences in direction selectivity across the layers were significant. Overall, orientation angle ...
... the LGN is much weaker than the cortex and both structures exhibit only weak direction selectivity. While orientation selectivity did not vary significantly across the layers of the squirrel LGN, the differences in direction selectivity across the layers were significant. Overall, orientation angle ...
Neurofilaments and Orthograde Transport Are Reduced in Ventral
... in the perikarya and proximal axons of spinal cord motoneurons by z180 d of age (data not shown). Immunohistochemical studies performed with NF subunit-specific antibodies (e.g., RMO32 specific for highly phosphorylated NFM, RMO24 specific for highly phosphorylated NFH, and rabbit anti-NFL polyclona ...
... in the perikarya and proximal axons of spinal cord motoneurons by z180 d of age (data not shown). Immunohistochemical studies performed with NF subunit-specific antibodies (e.g., RMO32 specific for highly phosphorylated NFM, RMO24 specific for highly phosphorylated NFH, and rabbit anti-NFL polyclona ...
Extraction of Sensory Parameters from a Neural Map by Primary
... stimulus direction causes a continuous variation in the spatial pattern of activation. (2) The restriction of the synaptic connections of an interneuron to a unique set of afferents results from the unique anatomy of that interneuron: its dendritic arbors are ...
... stimulus direction causes a continuous variation in the spatial pattern of activation. (2) The restriction of the synaptic connections of an interneuron to a unique set of afferents results from the unique anatomy of that interneuron: its dendritic arbors are ...
Visual detection deficits following inactivation of the superior colliculus in the cat
... et al., 1982; Overton & Dean, 1988; Lomber et al., 2001). Unfortunately, the interpretation of these studies is limited because of one or more of the following considerations: (1) Most of these experiments used permanent ablation of the SC rather than reversible inactivation. SC ablation initially p ...
... et al., 1982; Overton & Dean, 1988; Lomber et al., 2001). Unfortunately, the interpretation of these studies is limited because of one or more of the following considerations: (1) Most of these experiments used permanent ablation of the SC rather than reversible inactivation. SC ablation initially p ...
The Dialectics of Hebb and Homeostasis within
... (Abbott and Nelson, 2000). Thus correlated firing of pre and postsynaptic partners will drive potentiation only at synapses between those specific neurons (associative LTP). Input-specific LTD, in which uncorrelated pre and postsynaptic firing drives synaptic weakening, is also often called “Hebbian ...
... (Abbott and Nelson, 2000). Thus correlated firing of pre and postsynaptic partners will drive potentiation only at synapses between those specific neurons (associative LTP). Input-specific LTD, in which uncorrelated pre and postsynaptic firing drives synaptic weakening, is also often called “Hebbian ...
Neural Networks
... sible to readers with little previous knowledge. There are larger and smaller chapters: While the larger chapters should provide profound insight into a paradigm of neural networks (e.g. the classic neural network structure: the perceptron and its learning procedures), the smaller chapters give a s ...
... sible to readers with little previous knowledge. There are larger and smaller chapters: While the larger chapters should provide profound insight into a paradigm of neural networks (e.g. the classic neural network structure: the perceptron and its learning procedures), the smaller chapters give a s ...
Cortical Involvement During Sustained Lower Limb Contractions
... extremity and the influence of cortical inputs are poorly understood. The purpose of this dissertation was to investigate the role the cortex plays in modulating force control during static contractions with the lower limb and to determine the influence of manipulating cortical inputs. Aim 1 determi ...
... extremity and the influence of cortical inputs are poorly understood. The purpose of this dissertation was to investigate the role the cortex plays in modulating force control during static contractions with the lower limb and to determine the influence of manipulating cortical inputs. Aim 1 determi ...
Prefrontal Projections to the Thalamic Reticular Nucleus
... Most labeled boutons from prefrontal axons were small, but a second class of large boutons was also prominent. This is in contrast to the homogeneous small TRN terminations from sensory cortices noted previously and in the present study, which are thought to arise exclusively from layer VI. The two ...
... Most labeled boutons from prefrontal axons were small, but a second class of large boutons was also prominent. This is in contrast to the homogeneous small TRN terminations from sensory cortices noted previously and in the present study, which are thought to arise exclusively from layer VI. The two ...
Dynamical Properties of Neuronal Systems with
... spiking activity of large-scale neuronal networks that exhibit several complex network properties. Our main focus lies on the relevance of two particular attributes for the dynamics, namely structural heterogeneity and degree correlations. Although these are fundamental properties of many brain netw ...
... spiking activity of large-scale neuronal networks that exhibit several complex network properties. Our main focus lies on the relevance of two particular attributes for the dynamics, namely structural heterogeneity and degree correlations. Although these are fundamental properties of many brain netw ...