Papazian Lab Homepage Electrical excitability in the brain
... Lin, M.A., Abramson, J., and Papazian, D.M. (2009) Transfer of ion binding site from ether-à-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. Submitted for publication. Figueroa, K.P.*, Minassian, N.A.*, Stevanin G., Waters, M., Garibyan, V., Bürk, K., Brice, A., Dürr, A., ...
... Lin, M.A., Abramson, J., and Papazian, D.M. (2009) Transfer of ion binding site from ether-à-go-go to Shaker: Mg2+ binds to resting state to modulate channel opening. Submitted for publication. Figueroa, K.P.*, Minassian, N.A.*, Stevanin G., Waters, M., Garibyan, V., Bürk, K., Brice, A., Dürr, A., ...
neuronal types and their specification dynamics in
... ”fight-or-flight” response, which prepares the body to either face the stressor or flee from it. Once the stressor is removed, the parasympathetic nervous system restores the homeostasis by bringing the body to a ”rest-and-digest” state. It is believed that autonomic neurons respond in an “all-or-no ...
... ”fight-or-flight” response, which prepares the body to either face the stressor or flee from it. Once the stressor is removed, the parasympathetic nervous system restores the homeostasis by bringing the body to a ”rest-and-digest” state. It is believed that autonomic neurons respond in an “all-or-no ...
Differential effects of nicotine on the activity of substantia nigra and
... firing rate and coefficient of variation (CV = standard deviation of firing frequency/mean firing frequency ´ 100) were calculated from 200-500 successive APs using LabView (National Instr.). A digital frequency meter was used for calculation of the number of spikes within consecutive time intervals ...
... firing rate and coefficient of variation (CV = standard deviation of firing frequency/mean firing frequency ´ 100) were calculated from 200-500 successive APs using LabView (National Instr.). A digital frequency meter was used for calculation of the number of spikes within consecutive time intervals ...
View PDF - Laboratory of Brain, Hearing and Behavior
... performing an odor discrimination task: [19!]). The relationship between task difficulty and performance impairment following SC inactivation was observed in these tasks as well (but see [20]). In addition, focal electrical microstimulation applied to the SC results in a systematic improvement in th ...
... performing an odor discrimination task: [19!]). The relationship between task difficulty and performance impairment following SC inactivation was observed in these tasks as well (but see [20]). In addition, focal electrical microstimulation applied to the SC results in a systematic improvement in th ...
The Molecular Biology of Memory Storage: A Dialog
... Thus, the unique functions of the hippocampus had to arise not so much from the intrinsic properties of pyramidal neurons but from the pattern of functional interconnections of these cells, and how those interconnections are affected by learning. To tackle that problem we needed to know how sensory ...
... Thus, the unique functions of the hippocampus had to arise not so much from the intrinsic properties of pyramidal neurons but from the pattern of functional interconnections of these cells, and how those interconnections are affected by learning. To tackle that problem we needed to know how sensory ...
A Neurodynamical cortical model of visual attention and
... of features or inputs that occur in a given spatial arrangement to be learned by neurons, ensuring that higher-order spatial properties of the input stimuli are represented in the network (Elliffe et al., 2002). This is implemented via convergent connections to each part of a layer from a small regio ...
... of features or inputs that occur in a given spatial arrangement to be learned by neurons, ensuring that higher-order spatial properties of the input stimuli are represented in the network (Elliffe et al., 2002). This is implemented via convergent connections to each part of a layer from a small regio ...
Early Neuronal Loss and Axonal/Presynaptic Damage is Associated
... leads to dementia in Alzheimer’s disease (AD) is consequence of a severe loss of synapses and neurons that selectively affects particular cell subpopulations in brain areas critical for learning and memory [1–6]. Although transgenic mice, based on the overexpression of proteins harboring one or seve ...
... leads to dementia in Alzheimer’s disease (AD) is consequence of a severe loss of synapses and neurons that selectively affects particular cell subpopulations in brain areas critical for learning and memory [1–6]. Although transgenic mice, based on the overexpression of proteins harboring one or seve ...
Uncovering the Forgotten Effect of Superior Cervical Ganglia on
... cause Horner’s syndrome. The role of sympathetic systems regulating pupil diameter should be also investigated if any light reflex anomalies are observed during SAH. In the current study it was noticed that superior cevical ganglia neuron density has an interesting role on the regulation of pupil di ...
... cause Horner’s syndrome. The role of sympathetic systems regulating pupil diameter should be also investigated if any light reflex anomalies are observed during SAH. In the current study it was noticed that superior cevical ganglia neuron density has an interesting role on the regulation of pupil di ...
Septins promote dendrite and axon development by negatively
... projections and dendritogenesis in perinatal mice, when the microtubules are severely hyperacetylated. The resulting hyperstabilization and growth retardation of microtubules are demonstrated in vitro. The phenotypic similarity between SEPT7 depletion and the pharmacological inhibition of a-tubulin ...
... projections and dendritogenesis in perinatal mice, when the microtubules are severely hyperacetylated. The resulting hyperstabilization and growth retardation of microtubules are demonstrated in vitro. The phenotypic similarity between SEPT7 depletion and the pharmacological inhibition of a-tubulin ...
Spike train propagation in the axon of a visual interneuron,... Locusta migratoria
... transmissions of information in the form of action potentials (APs). The high level of heterogeneity and complexity at all levels of organization within a neuron and the functional requirement of highly permeable cell membranes leave neurons exposed to damage when energy levels are insufficient for ...
... transmissions of information in the form of action potentials (APs). The high level of heterogeneity and complexity at all levels of organization within a neuron and the functional requirement of highly permeable cell membranes leave neurons exposed to damage when energy levels are insufficient for ...
The subtle body: an interoceptive map of central nervous system
... white, masculine waking drops, thought to support the waking state, higher intelligence, conscience, and self-regulation. The second hub, referred to as the thousandfold great bliss hub (māhāsukha-cakra; yoga system: sahasra), is located at the crown, where it is entwined by each of the two polar ...
... white, masculine waking drops, thought to support the waking state, higher intelligence, conscience, and self-regulation. The second hub, referred to as the thousandfold great bliss hub (māhāsukha-cakra; yoga system: sahasra), is located at the crown, where it is entwined by each of the two polar ...
Article Full Text PDF
... Fig. 1B). The M-cells are bilateral, located in the medulla under the cerebellum (C) and behind the optic tectum (OT) near the point of entry of the VIIIth nerve. They have two principal dendrites, one lateral and one ventral. As in other teleosts (Zottoli, 1978) their axon crosses the midline, turn ...
... Fig. 1B). The M-cells are bilateral, located in the medulla under the cerebellum (C) and behind the optic tectum (OT) near the point of entry of the VIIIth nerve. They have two principal dendrites, one lateral and one ventral. As in other teleosts (Zottoli, 1978) their axon crosses the midline, turn ...
The neuroepithelial basement membrane serves as a boundary and
... Figure 1 FBMNs undergo a change in velocity upon contact with the Laminin-containing ventral basement membrane. (A) A maximum intensity projection of a confocal Z-stack of a tg(hoxb1aBAC:mRFP1); tg(isl1:GFP) double transgenic embryo at 48 hpf reveals that most Isl1:GFP positive neurons in both r6 an ...
... Figure 1 FBMNs undergo a change in velocity upon contact with the Laminin-containing ventral basement membrane. (A) A maximum intensity projection of a confocal Z-stack of a tg(hoxb1aBAC:mRFP1); tg(isl1:GFP) double transgenic embryo at 48 hpf reveals that most Isl1:GFP positive neurons in both r6 an ...
Prefrontal Neurons Coding Suppression of Specific Saccades
... lobe (e.g., Hasegawa et al., 1998, 2000a, 2004) in monkeys have dealt with the generation of movement rather than its suppression. The saccadic system provides an excellent model for the suppression of unwanted behavior. Monkeys as well as humans can voluntarily move their eyes not only to look at s ...
... lobe (e.g., Hasegawa et al., 1998, 2000a, 2004) in monkeys have dealt with the generation of movement rather than its suppression. The saccadic system provides an excellent model for the suppression of unwanted behavior. Monkeys as well as humans can voluntarily move their eyes not only to look at s ...
relation between cell size and response characteristics of
... stimulation. Of the 136 vestibulospinal neurons, 80 (58.8%) displayed a reliable periodic modulation of their firing rate during sinusoidal tilt at 0.026 Hz, 10” peak amplitude (see Fig. 3, 0). Among the remaining 56 units (41.2%), 48 did not satisfy the criteria for responsiveness (see Fig. 3, x). ...
... stimulation. Of the 136 vestibulospinal neurons, 80 (58.8%) displayed a reliable periodic modulation of their firing rate during sinusoidal tilt at 0.026 Hz, 10” peak amplitude (see Fig. 3, 0). Among the remaining 56 units (41.2%), 48 did not satisfy the criteria for responsiveness (see Fig. 3, x). ...
Reconstruction of the nigrostriatal dopamine pathway in the adult
... microscope. The VM was dissected free from each embryo as described previously (Dunnett & Björklund, 1992, 2000), taking care to remove the meninges. Single-cell suspensions were prepared from GFP+ ⁄ ) VM tissue as previously described (Nikkhah et al., 1994b). Briefly, pooled VMs were incubated for ...
... microscope. The VM was dissected free from each embryo as described previously (Dunnett & Björklund, 1992, 2000), taking care to remove the meninges. Single-cell suspensions were prepared from GFP+ ⁄ ) VM tissue as previously described (Nikkhah et al., 1994b). Briefly, pooled VMs were incubated for ...
Context Dependency in the Globus Pallidus Internal Segment
... movement. Representative responses from three well-modulated GPi neurons during the execution of the task are shown in Fig. 1. Neuron B181 (Fig. 1A) paused phasically in association with cued movements to all four targets (all P ⬍ 0.0001, small sample test statistic t for difference between two mean ...
... movement. Representative responses from three well-modulated GPi neurons during the execution of the task are shown in Fig. 1. Neuron B181 (Fig. 1A) paused phasically in association with cued movements to all four targets (all P ⬍ 0.0001, small sample test statistic t for difference between two mean ...
The interplay between neurons and glia in synapse
... amenable to experience-dependent remodeling is complicated by the diversity of neurons and synapse types. The establishment of a functional brain depends not only on neurons, but also non-neuronal glial cells. Glia are in continuous bi-directional communication with neurons to direct the formation a ...
... amenable to experience-dependent remodeling is complicated by the diversity of neurons and synapse types. The establishment of a functional brain depends not only on neurons, but also non-neuronal glial cells. Glia are in continuous bi-directional communication with neurons to direct the formation a ...
Subthalamic Stimulation-Induced Synaptic Responses in Substantia
... extrapolated from a linear regression of PSP amplitude versus membrane potential over a restricted range of the I-V curve, typically between 250 and 2100 mV. The PSP amplitude data were well fit with a linear regression over this range as indicated by the values for the regression coefficients under ...
... extrapolated from a linear regression of PSP amplitude versus membrane potential over a restricted range of the I-V curve, typically between 250 and 2100 mV. The PSP amplitude data were well fit with a linear regression over this range as indicated by the values for the regression coefficients under ...
Co-activation of VTA DA and GABA neurons mediates nicotine
... Even within the ventral tegmental area (VTA), the key brain area responsible for the reinforcing properties of all drugs of abuse, nicotine acts on several different cell types and afferents. Identifying the precise action of nicotine on this microcircuit, in vivo, is important to understand reinfor ...
... Even within the ventral tegmental area (VTA), the key brain area responsible for the reinforcing properties of all drugs of abuse, nicotine acts on several different cell types and afferents. Identifying the precise action of nicotine on this microcircuit, in vivo, is important to understand reinfor ...
The beginning of connectomics: a commentary on White
... as the slime mould Dictyostelium discoidium, had no nervous system at all. A new model animal was needed. In seeking a new experimental animal to tackle problems of the nervous system, Brenner was not alone. Two scientists at Columbia University, Cyrus Levinthal and Eduardo Macagno, were similarly e ...
... as the slime mould Dictyostelium discoidium, had no nervous system at all. A new model animal was needed. In seeking a new experimental animal to tackle problems of the nervous system, Brenner was not alone. Two scientists at Columbia University, Cyrus Levinthal and Eduardo Macagno, were similarly e ...
Rapid Changes in Synaptic Vesicle Cytochemistry
... ABstrAct Sympathetic neurons taken from rat superior cervical ganglia and grown in culture acquire cholinergic function under certain conditions. These cholinergic sympathetic neurons, however, retain a number of adrenergic properties, including the enzymes involved in the synthesis of norepinephrin ...
... ABstrAct Sympathetic neurons taken from rat superior cervical ganglia and grown in culture acquire cholinergic function under certain conditions. These cholinergic sympathetic neurons, however, retain a number of adrenergic properties, including the enzymes involved in the synthesis of norepinephrin ...
Interactions between frontal cortex and basal ganglia in working
... tational model of the contributions of the prefrontal cortex and basal ganglia to working memory. We find that the somewhat Byzantine nature of the anatomical loops connecting the frontal cortex and the basal ganglia make good computational sense in terms of a well-defined characterization of workin ...
... tational model of the contributions of the prefrontal cortex and basal ganglia to working memory. We find that the somewhat Byzantine nature of the anatomical loops connecting the frontal cortex and the basal ganglia make good computational sense in terms of a well-defined characterization of workin ...