Cell-cycle control and cortical development - Stem
... between modes are not completely understood46. Mechanisms determining neuron number. The computations carried out by the cerebral cortex require specific patterns of connections between precise numbers of diverse types of neurons51. One possibility is that there is a tight spatio-temporal control of ...
... between modes are not completely understood46. Mechanisms determining neuron number. The computations carried out by the cerebral cortex require specific patterns of connections between precise numbers of diverse types of neurons51. One possibility is that there is a tight spatio-temporal control of ...
Kenedy,Dehay Cell-cycle control and cortical development
... between modes are not completely understood46. Mechanisms determining neuron number. The computations carried out by the cerebral cortex require specific patterns of connections between precise numbers of diverse types of neurons51. One possibility is that there is a tight spatio-temporal control of ...
... between modes are not completely understood46. Mechanisms determining neuron number. The computations carried out by the cerebral cortex require specific patterns of connections between precise numbers of diverse types of neurons51. One possibility is that there is a tight spatio-temporal control of ...
Sense Organs
... graded voltage change across the plasma membrane of the receptor cell. The receptor potential may cause a receptor cell (which is not always a neuron) to release a neurotransmitter that stimulates an adjacent neuron. If the receptor itself is a neuron and the voltage reaches threshold, the neuron fi ...
... graded voltage change across the plasma membrane of the receptor cell. The receptor potential may cause a receptor cell (which is not always a neuron) to release a neurotransmitter that stimulates an adjacent neuron. If the receptor itself is a neuron and the voltage reaches threshold, the neuron fi ...
firing pattern modulation by oscillatory input in
... (1BF100; WPI) on a Sutter Instruments P-80 micropipette puller and beveled on a Sutter Instruments beveler to a ¢nal resistance of 80^120 M6. Electrodes were ¢lled with 2 M potassium acetate with 1.5^2% (w/v) biocytin for subsequent histological identi¢cation of recorded cells. Recordings were made ...
... (1BF100; WPI) on a Sutter Instruments P-80 micropipette puller and beveled on a Sutter Instruments beveler to a ¢nal resistance of 80^120 M6. Electrodes were ¢lled with 2 M potassium acetate with 1.5^2% (w/v) biocytin for subsequent histological identi¢cation of recorded cells. Recordings were made ...
Linking Genetically Defined Neurons to Behavior through a Broadly
... GFPtox action, therefore, should restrict to just those cells having expressed both Cre and Flpe recombinase. Requiring two recombination events allows for defining the targeted cell subtype with great specificity (cartooned in Figures S1A and S1B), that is, by pairwise combinations of expressed gen ...
... GFPtox action, therefore, should restrict to just those cells having expressed both Cre and Flpe recombinase. Requiring two recombination events allows for defining the targeted cell subtype with great specificity (cartooned in Figures S1A and S1B), that is, by pairwise combinations of expressed gen ...
Homeostatic plasticity mechanisms in mouse V1
... merely cause the simple network to switch states, back and forth, with a period that reflected the time course of the homeostatic mechanism. The existence of persistent states would require a cell-by-cell mechanism of homeostasis that has a very slow time course. The neural flip-flop is only the mos ...
... merely cause the simple network to switch states, back and forth, with a period that reflected the time course of the homeostatic mechanism. The existence of persistent states would require a cell-by-cell mechanism of homeostasis that has a very slow time course. The neural flip-flop is only the mos ...
A Learning Rule for the Emergence of Stable Dynamics and Timing
... FIG. 3. Recurrency and fixed synaptic ratios contribute to the lack of convergence. A: average number of spikes per cell (not Ai) over 2,000 training trials, in networks in which each neurons received 1 (black), 2 (red), or 4 (blue) from other excitatory neurons. With nEx 3 Ex ⫽ 1, synaptic scaling ...
... FIG. 3. Recurrency and fixed synaptic ratios contribute to the lack of convergence. A: average number of spikes per cell (not Ai) over 2,000 training trials, in networks in which each neurons received 1 (black), 2 (red), or 4 (blue) from other excitatory neurons. With nEx 3 Ex ⫽ 1, synaptic scaling ...
Synaptic and peptidergic connectome of a neurosecretory
... Neurosecretory centres in animal brains use peptidergic signalling to influence physiology and behaviour. Understanding neurosecretory centre function requires mapping cell types, synapses, and peptidergic networks. Here we use electron microscopy and gene expression mapping to analyse the synaptic ...
... Neurosecretory centres in animal brains use peptidergic signalling to influence physiology and behaviour. Understanding neurosecretory centre function requires mapping cell types, synapses, and peptidergic networks. Here we use electron microscopy and gene expression mapping to analyse the synaptic ...
Mechanisms of response homeostasis during retinocollicular map
... This report was presented at The Journal of Physiology Symposium on Retinal ganglion cells in model organisms: development, function and disease, which took place in Fort Lauderdale, FL, USA, 26 April 2008. It was commissioned by the Editorial Board and reflects the views of the ...
... This report was presented at The Journal of Physiology Symposium on Retinal ganglion cells in model organisms: development, function and disease, which took place in Fort Lauderdale, FL, USA, 26 April 2008. It was commissioned by the Editorial Board and reflects the views of the ...
All-Optical Interrogation of Neural Circuits
... cells, and thus achieve fully “all-optical” interrogation of neural activity. Implementations of simultaneous optical readout and manipulation have faced three main challenges: reliable delivery and expression of the sensors and actuators in the same neurons, elimination of cross talk between the im ...
... cells, and thus achieve fully “all-optical” interrogation of neural activity. Implementations of simultaneous optical readout and manipulation have faced three main challenges: reliable delivery and expression of the sensors and actuators in the same neurons, elimination of cross talk between the im ...
Chapter 28: Nervous
... Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
... Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
THE ELECTRODE-TISSUE INTERFACE DURING RECORDING
... Figure 1.3. Components of an implanted DBS system....................................................... 7 Figure 2.1. Histological examples of the ETI for microelectrodes and macroelectrodes. 19 Figure 2.2. Components of the ETI. ..................................................................... ...
... Figure 1.3. Components of an implanted DBS system....................................................... 7 Figure 2.1. Histological examples of the ETI for microelectrodes and macroelectrodes. 19 Figure 2.2. Components of the ETI. ..................................................................... ...
Dynamical systems view
... • Dynamical systems approach gives insight into movement without making assumptions about single-neuron tuning. • “Preparation” funnels neural trajectories to achieve fast movement without minimal variation. • Preparatory state predicts both RT and trial-to-trial variability. • Rotational PMd firing ...
... • Dynamical systems approach gives insight into movement without making assumptions about single-neuron tuning. • “Preparation” funnels neural trajectories to achieve fast movement without minimal variation. • Preparatory state predicts both RT and trial-to-trial variability. • Rotational PMd firing ...
genetic techniques for cell lineage tracking
... plasmid contains the reporter transgene of interest and a helper plasmid expresses the transposase. The donor plasmid includes terminal repeats that flank the transgene, which allows for random genomic integration by the transposase. The transgene is then propagated to all progeny within the lineage ...
... plasmid contains the reporter transgene of interest and a helper plasmid expresses the transposase. The donor plasmid includes terminal repeats that flank the transgene, which allows for random genomic integration by the transposase. The transgene is then propagated to all progeny within the lineage ...
Irregular persistent activity induced by synaptic excitatory feedback
... can be reproduced in a network in which persistent activity is induced by excitatory feedback, provided that (i) the post-spike reset is close enough to threshold , (ii) synaptic efficacies are a non-linear function of the pre-synaptic firing rate. Non-linearity between presynaptic rate and effective ...
... can be reproduced in a network in which persistent activity is induced by excitatory feedback, provided that (i) the post-spike reset is close enough to threshold , (ii) synaptic efficacies are a non-linear function of the pre-synaptic firing rate. Non-linearity between presynaptic rate and effective ...
The role of Pitx3 in survival of midbrain dopaminergic neurons
... motor control, reward, emotional and motivated behavior, and is of clinical importance because of its implication in neurological and psychiatric disorders. The A9 cell group located in the substantia nigra pars compacta (SNc) has preferred projections to the dorsal striatum forming the nigrostriata ...
... motor control, reward, emotional and motivated behavior, and is of clinical importance because of its implication in neurological and psychiatric disorders. The A9 cell group located in the substantia nigra pars compacta (SNc) has preferred projections to the dorsal striatum forming the nigrostriata ...
BIOGRAPHICAL SKETCH
... alcohol. My portion of the project involves the investigation of the interaction of ATP and ethanol in mice, either wild-type mice, or KO mice, with and without dysfunction of the P2X4 receptor by knockout or after shRNA treatment. I have been studying the physiology of neurons of the VTA in brain s ...
... alcohol. My portion of the project involves the investigation of the interaction of ATP and ethanol in mice, either wild-type mice, or KO mice, with and without dysfunction of the P2X4 receptor by knockout or after shRNA treatment. I have been studying the physiology of neurons of the VTA in brain s ...
portada-contrapo 59(4) (Page 5)
... with previous studies reporting functional changes in lysosomal and mitochondrial hepatic membranes from rodents treated with microcystins (11, 18). The determination of lipid peroxidation levels in intestinal mucosa showed that the peroxidative status was significantly increased in MCLR-treated rat ...
... with previous studies reporting functional changes in lysosomal and mitochondrial hepatic membranes from rodents treated with microcystins (11, 18). The determination of lipid peroxidation levels in intestinal mucosa showed that the peroxidative status was significantly increased in MCLR-treated rat ...
Non-Cell-Autonomous Effect of Human SOD1G37R
... incorporate a-bungarotoxin when cocultured with C2C12 myoblasts, indicating that the cells could form functional neuromuscular junctions (Figures 1I and 1J). Live postmitotic human motor neurons could be visualized after transduction with a lentivirus expressing the green fluorescent protein gene (G ...
... incorporate a-bungarotoxin when cocultured with C2C12 myoblasts, indicating that the cells could form functional neuromuscular junctions (Figures 1I and 1J). Live postmitotic human motor neurons could be visualized after transduction with a lentivirus expressing the green fluorescent protein gene (G ...
Multifunctional Laryngeal Premotor Neurons: Their Activities during
... minimize brain edema and to reduce secretion in the airways, respectively. The trachea was intubated, and cannulas were placed in the femoral artery to monitor blood pressure and in the femoral veins for drug administration. Mean blood pressure was maintained above 90 mmHg when necessary using intra ...
... minimize brain edema and to reduce secretion in the airways, respectively. The trachea was intubated, and cannulas were placed in the femoral artery to monitor blood pressure and in the femoral veins for drug administration. Mean blood pressure was maintained above 90 mmHg when necessary using intra ...
Voltage-Sensitive Dye Imaging: Technique review and Models
... the dura mater of the animal, the dye molecules are applied on the surface of the cortex (Fig. 1A). They bind to the external surface of the membranes of all cells without interrupting their normal function and act as molecular transducers that transform changes in membrane potential into optical si ...
... the dura mater of the animal, the dye molecules are applied on the surface of the cortex (Fig. 1A). They bind to the external surface of the membranes of all cells without interrupting their normal function and act as molecular transducers that transform changes in membrane potential into optical si ...
Centrosome positioning in vertebrate development
... becomes oriented between the nucleus and the leading edge (Gotlieb et al., 1981). This orientation positions both the Golgi complex and the endocytic recycling compartment between the nucleus and the leading edge. However, whether the centrosome is ahead of or behind the nucleus depends on the cell ...
... becomes oriented between the nucleus and the leading edge (Gotlieb et al., 1981). This orientation positions both the Golgi complex and the endocytic recycling compartment between the nucleus and the leading edge. However, whether the centrosome is ahead of or behind the nucleus depends on the cell ...
RESEARCH LETTERS 3 Marwood RP. Disappearance of
... putaminal or caudate nucleus DAT* neurons and either LDOPA dose or duration of L-DOPA treatment. If these neurons do have an important role in the synthesis of dopamine from L-DOPA, maintenance of this abnormal source of striatal dopamine in the face of declining production by the nigrostriatal path ...
... putaminal or caudate nucleus DAT* neurons and either LDOPA dose or duration of L-DOPA treatment. If these neurons do have an important role in the synthesis of dopamine from L-DOPA, maintenance of this abnormal source of striatal dopamine in the face of declining production by the nigrostriatal path ...
Nissl substance and cellular structures involved in the intraneuronal
... cells capture an extracellular material by means of endocytosis. In MRN, however, the vesicular transport between perikarion and the neuronal membrane is restricted by the fibrillar envelope surrounding the cell body. Rather few vesicles are observed within this fibrillar layer. Vesicles approach th ...
... cells capture an extracellular material by means of endocytosis. In MRN, however, the vesicular transport between perikarion and the neuronal membrane is restricted by the fibrillar envelope surrounding the cell body. Rather few vesicles are observed within this fibrillar layer. Vesicles approach th ...
Electrophysiology
Electrophysiology (from Greek ἥλεκτρον, ēlektron, ""amber"" [see the etymology of ""electron""]; φύσις, physis, ""nature, origin""; and -λογία, -logia) is the study of the electrical properties of biological cells and tissues. It involves measurements of voltage change or electric current on a wide variety of scales from single ion channel proteins to whole organs like the heart. In neuroscience, it includes measurements of the electrical activity of neurons, and particularly action potential activity. Recordings of large-scale electric signals from the nervous system such as electroencephalography, may also be referred to as electrophysiological recordings.