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Human Nervous System
Human Nervous System

... • The cranial nerves are arranged in 12 pairs, so the two nerves on a pair are identical in function and structure. • These nerves serve both sensory and motor functions. ...
Sir Charles Scott Sherrington English Neurophysiologist 1857
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... respond. He found that when the spinal cord is severed or a nerve detached from muscle, the reflex fails to respond. In this way, Sherrington determined that simple reflexes are governed by the spinal cord. In addition to explaining spinal reflex activity, Sherrington uncovered the concept of propri ...
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Unit One: Introduction to Physiology: The Cell and General Physiology
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... • Excitatory and Inhibitory Actions of Sympathetic and Parasympathetic Stimulation a. Sympathetic stimulation causes excitatory effects in some organs but inhibitory effects in others b. Parasympathetic likewise is excitatory or inhibitory depending on the organ affected c. See Table 60.2 in the tex ...
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... moved to the correct position by using this response. After checking that the stimulating electrode had been placed on the motor cortex by recording the V-iu of the somatosensory evoked potentials, the electrode was connected to a transmitter which was implanted in the subcutaneous area of the anter ...
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... Normally with the head at rest, in the neutral position the resting discharges in the two vestibular nerve are equal. Vestibulomotor (vestibuloocular and vestibulospinal) reflexes are elicited when inputs from the two vestibular organs or their central projection are made equal, that is, they are un ...
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The Graded Motor Imagery Handbook, 2012
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... Another very interesting bistability is seen in theoretical and experimental work on the R15 neuron of Aplysia (16–19). R15 is a prototypic bursting neuron, an extensive biophysical literature on its membrane currents and their modulation has been gathered (19), and a detailed model of this neuron a ...
Chapter 8: The Nervous System
Chapter 8: The Nervous System

... 48. Describe the nerve impulse as it travels along a nerve fiber and across a synapse. Ans: A nerve impulse is a wave of depolarization and repolarization, during which sodium ions first move into a neuron and then potassium ions move out of a neuron. This is called an action potential. When the act ...
Chapter 8: The Nervous System
Chapter 8: The Nervous System

... 48. Describe the nerve impulse as it travels along a nerve fiber and across a synapse. Ans: A nerve impulse is a wave of depolarization and repolarization, during which sodium ions first move into a neuron and then potassium ions move out of a neuron. This is called an action potential. When the act ...
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Rheobase



Rheobase is a measure of membrane excitability. In neuroscience, rheobase is the minimal current amplitude of infinite duration (in a practical sense, about 300 milliseconds) that results in the depolarization threshold of the cell membranes being reached, such as an action potential or the contraction of a muscle. In Greek, the root ""rhe"" translates to current or flow, and ""basi"" means bottom or foundation: thus the rheobase is the minimum current that will produce an action potential or muscle contraction.Rheobase can be best understood in the context of the strength-duration relationship (Fig. 1). The ease with which a membrane can be stimulated depends on two variables: the strength of the stimulus, and the duration for which the stimulus is applied. These variables are inversely related: as the strength of the applied current increases, the time required to stimulate the membrane decreases (and vice versa) to maintain a constant effect. Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength.The strength-duration curve was first discovered by G. Weiss in 1901, but it was not until 1909 that Louis Lapicque coined the term ""rheobase"". Many studies are being conducted in relation to rheobase values and the dynamic changes throughout maturation and between different nerve fibers. In the past strength-duration curves and rheobase determinations were used to assess nerve injury; today, they play a role in clinical identification of many neurological pathologies, including as Diabetic neuropathy, CIDP, Machado-Joseph Disease, and ALS.
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