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How Do Short-Term Changes at Synapses Fine
How Do Short-Term Changes at Synapses Fine

... Remarkably, the synapses formed by a single cell onto different target neurons can show different plasticity. This phenomenon was discovered in cerebral cortex (Reyes et al., 1998) and is called “target cell-specific synaptic plasticity.” This phenomenon indicates that Pr is regulated by communicati ...
Role of Active Movement in Place-Specific Firing of Hippocampal
Role of Active Movement in Place-Specific Firing of Hippocampal

... with the body suspended in a hammock with legs dangling freely. Hippocampal neurons showed spatially selective firing patterns, although they were broadly tuned (Gavrilov et al., 1998). This study did not compare active versus passive navigation, thus it is difficult to determine whether hippocampal n ...
166 - UCSF Physiology - University of California, San Francisco
166 - UCSF Physiology - University of California, San Francisco

... antagonist bicuculline methiodide (10 ␮M). Signals were recorded using an Axopatch 200B, filtered at 5 kHz, and digitized at 10 kHz. ...
Zoology 242 Anatomy of Nervous systems Lecture 8
Zoology 242 Anatomy of Nervous systems Lecture 8

... Autonomic Nervous System • 3 major divisions described by John Langley (18521925). – Enteric – Parasympathetic – Sympathetic ...
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in

... (time point = 0) was set to 100% and relative fluorescence decrease 300 s after fusion was analyzed. The percentage of fusion events was calculated by the fraction of vesicles disappearing during BPB application after release experiment. This fraction of vesicles could be also detected by the change ...
KCNQ/M Channels Control Spike Afterdepolarization and Burst
KCNQ/M Channels Control Spike Afterdepolarization and Burst

... adaptation that is seen in numerous peripheral and central neurons (Brown, 1988). This hypothesis is supported by studies showing that muscarinic agonists markedly reduce spike frequency adaptation (Cole and Nicoll, 1983; Madison and Nicoll, 1984; McCormick et al., 1993). It should be noted, however ...
Relating normalization to neuronal populations across cortical areas
Relating normalization to neuronal populations across cortical areas

... The relationship between spike count correlations and connectivity is complicated by the facts that spike count correlations can reflect either direct or indirect inputs and can be reduced when a pair of neurons have either fewer common inputs or have both inhibitory and excitatory inputs in common ...
Brca1 is required for embryonic development of the mouse cerebral
Brca1 is required for embryonic development of the mouse cerebral

... To examine the effects of conditional Brca1 ablation on the neocortex, we first analyzed the size and gross morphology of the P4.5 brain. Compared with the control, Brca1-ablated brains showed a reduction in size specific to the cerebral cortex (Fig. 1C). The whole-brain weight of Brca1-ablated mice ...
Effects of Repeated Administration of 3,4
Effects of Repeated Administration of 3,4

... 3 s) was immediately delivered to the grid floor of the dark room. After 20 s, the rat was removed from the apparatus and placed temporarily into its home cage. Two minutes later, the animal was retested in the same way as in the previous trials; if the rat did not enter the dark compartment during ...
File
File

... • Midbrain – most superior part of brain stem – Sensory and motor impulses – Vision, hearing, motor, temperature, sleep cycle ...
The Nervous System
The Nervous System

... neurons innervate (send axons to) the involuntary effectors— smooth muscle, cardiac muscle, and glands. The cell bodies of the autonomic neurons that innervate these organs are located outside the CNS in autonomic ganglia (fig. 7.3). There are two subdivisions of autonomic neurons: sympathetic and p ...
Alpha-beta and Gamma Rhythms Subserve Feedback and
Alpha-beta and Gamma Rhythms Subserve Feedback and

... The peak in the GC spectra that we have identified as the alpha-beta peak spans the classical alphaand beta-frequency bands. Alpha- and beta-band rhythms vary in frequency across subjects and can be influenced by stimulus and task conditions (Haegens et al., 2014). We calculated the average inter-ar ...
Beyond dreams: do sleep-related movements
Beyond dreams: do sleep-related movements

... view of limb twitching – only now the eyes are watching dreams rather than limbs acting them out. Indeed, the scanning hypothesis has itself become a part of the folk psychological interpretation of dreaming. Although the scanning hypothesis remains popular, REMs may not provide the insight into dre ...
Molecular and anatomical signatures of sleep deprivation in the
Molecular and anatomical signatures of sleep deprivation in the

... reduce the detection of region- or cell type-specific gene expression as well as provide an overarching conclusion about the cortex based upon only the most prevalent changes. Second is the lack of precise validation to examine the cellular specificity of the gene expression changes. Two more recent ...
Contact guidance of CNS neurites on grooved quartz: influence of
Contact guidance of CNS neurites on grooved quartz: influence of

... Fig. 1. (A) Scanning electron micrograph of a quartz microscope slide with grooves 520 nm deep and 2 µm wide. Note that the grooves have approximately right angled sides, sharp corners and are evenly spaced. The lower photo is a magnified view of the boxed region. (B) Angle measurement protocol for ...
Neutrophil Contribution in Facilitating Optic Nerve Regeneration
Neutrophil Contribution in Facilitating Optic Nerve Regeneration

... short period following inflammation? Is it possible that neutrophils and macrophages interact to sustain the prolonged regenerative response induced by inflammation? For example, the numbers of regenerating axons were significantly higher 2 weeks after inflammation-induced regeneration, despite the ...
Dissertation 20161009 Text Citations
Dissertation 20161009 Text Citations

... untrustworthy faces, most current research suggests a quadratic response, with increased activation associated with both highly trustworthy and highly untrustworthy faces. The quadratic response in the amygdala is consistent with two separate, but compatible hypotheses regarding why trustworthiness ...
Spike train propagation in the axon of a visual interneuron,... Locusta migratoria
Spike train propagation in the axon of a visual interneuron,... Locusta migratoria

... signaling is an adaptive response to conserve energy in times of limiting oxygen. Action potentials, such as those seen in axons, are required to send information over long distances. Action potentials are required to threshold out the noise, which would otherwise accumulate in a graded potential ov ...
Comparison of Sympathetic and Parasympathetic Divisions
Comparison of Sympathetic and Parasympathetic Divisions

... The two primary types of visceral receptors, mechanoreceptors and chemoreceptors, are distributed throughout the body. Mechanoreceptors sense pressure, stretch, or tension. Slow-adapting mechanoreceptors sense fullness in the bowel, bladder, and stomach. Fast-adapting mechanoreceptors sense the move ...
Heterogeneous Integration of Adult
Heterogeneous Integration of Adult

... whether these cells exhibit other, potentially compensatory, changes is not known. Further confusing the matter, physiologic studies suggest that newborn cells in the epileptic brain receive less excitatory synaptic input than age-matched cells from control animals (Jakubs et al., 2006). The net eff ...
Brain regions involved in heading estimation and steering control in
Brain regions involved in heading estimation and steering control in

... information from our vestibular, visual, and proprioceptive sensory systems (Ivanenko, Grasso, Israel, & Berthoz, 1997; Warren, Kay, Zosh, Duchon, & Sahuc 2001; Wilkie & Wann, 2005). This allows us to execute the appropriate motor response by providing us with information about our relative body ori ...
Electrophysiological and Pharmacological Evidence for the Role of
Electrophysiological and Pharmacological Evidence for the Role of

... synaptic levels of dopamine will prevail in the NAS in a behavioral context of an animal self-administering cocaine. On anatomical and physiological grounds, the NAS has been hypothesized to exert a “filtering” or “gating” function on its limbic afferents, and to initiate or modulate goal-directed b ...
energy balance
energy balance

... away that we do not want • Some of these deviations may have pathological nature, but some of them are because of our behavior, it is better to leave them to themselves.!!!!!!!!!!!!!!! ...
Articles in PresS. J Neurophysiol (March 20, 2003). 10.1152/jn
Articles in PresS. J Neurophysiol (March 20, 2003). 10.1152/jn

... can either enhance or suppress responses of spiny neurons depending on the prior state of the neuron (Hernandez-Lopez et al. 1997). This state-dependence arises from the coordinated modulation of ion channels regulating these states ( Flores-Hernandez et al. 2000; Hernandez-Lopez et al. 1997; Pachec ...
Aalborg Universitet Brain plasticity Wang, Li
Aalborg Universitet Brain plasticity Wang, Li

... This thesis is to: (1) investigate the characteristics of the brain activity in response to the peripheral electrical stimulation in temporal, spatial, and frequency domain. (2) Present a model that describes short-term cortical reorganization. (3) Investigate the modulatory effects of the pain modu ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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