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http://www.utdallas.edu/~tres/papers/Disterhoftetal1994.pdf
http://www.utdallas.edu/~tres/papers/Disterhoftetal1994.pdf

... 1. There are at least three major transmembrane sources of calcium influx: (1) voltage-gated calcium channels, of which there are at least four classes; (2) the NMDA receptor channel complex; and (3) activation of the Na+/Ca*+exchanger. Additional sources of free intracellular calcium come from rele ...
TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3
TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3

... glass coverslips with parafilm bridges. Additional slides were incubated with sense a1 and b3 [ 35S]oligoprobes. Coverslips were removed in 2 × SSC. Sections were washed to a final stringency of 0.5 × SSC at 52–60⬚C according to the calculated oligoprobe Tm. Sections were dehydrated for 5 min in 70% ...
The Calcium Rationale in Aging and Alzheimer`s Disease
The Calcium Rationale in Aging and Alzheimer`s Disease

... 1. There are at least three major transmembrane sources of calcium influx: (1) voltage-gated calcium channels, of which there are at least four classes; (2) the NMDA receptor channel complex; and (3) activation of the Na+/Ca*+exchanger. Additional sources of free intracellular calcium come from rele ...
PDF reprint - UC Davis Mathematics
PDF reprint - UC Davis Mathematics

... Recently investigations have revealed that many local interneuronal networks throughout the brain display electrical coupling through gap junctions (see Galarreta and Hestrin, 2001a). There are different subpopulations of interneurons, and it has been found that the electrical coupling is predominan ...
Alzheimer-like neurodegeneration in aged antinerve growth factor
Alzheimer-like neurodegeneration in aged antinerve growth factor

... forebrain cholinergic neurons (BFCNs) (2, 3) and in regions of the central nervous system innervated by the magnocellular BFCNs (4). NGF promotes the differentiation of BFCNs (5), ameliorates lesion-induced abnormalities in these cells (6), and reverses atrophy of BFCNs (7) and spatial memory impair ...
Cognon Neural Model Software Verification and
Cognon Neural Model Software Verification and

... Little is known yet about how the brain can recognize arbitrary sensory patterns within milliseconds using neural spikes to communicate information between neurons. In a typical brain there are several layers of neurons, with each neuron axon connecting to ∼ 104 synapses of neurons in an adjacent la ...
Pleiotrophin is a Neurotrophic Factor for Spinal Motor Neurons
Pleiotrophin is a Neurotrophic Factor for Spinal Motor Neurons

... Regeneration in the peripheral nervous system is poor after chronic denervation. Denervated Schwann cells act as a ‘‘transient target’’ by secreting growth factors to promote regeneration of axons but lose this ability with chronic denervation. We discovered that the mRNA for pleiotrophin (PTN) was ...
Enhanced Perceptual Functioning in Autism
Enhanced Perceptual Functioning in Autism

... Third, we had been influenced by Minshew’s (Minshew & Goldstein, 1993; Minshew, Goldstein, & Siegel, 1995, 1997) proposition that complexity may represent a way to account both for the level of impaired operations, and for their cross-modal aspect. ...
Cauda Equina Syndrome and Nitric Oxide Synthase
Cauda Equina Syndrome and Nitric Oxide Synthase

... changes in neurotransmitters. In addition, correlative behavioral, neurological, neurophysiological and morphological analyses have been performed. However, recent efforts to assess and describe pathophysiological mechanisms have indicated that mechanical stimulation of the affected lumbosacral nerv ...
Lillienfeld: Chapter 3 lecture PowerPoint
Lillienfeld: Chapter 3 lecture PowerPoint

... Lilienfeld | Lynn | Namy | Woolf ...
18-1 PITUITARY GLAND AND HYPOTHALAMUS 1. The pituitary
18-1 PITUITARY GLAND AND HYPOTHALAMUS 1. The pituitary

... cells to release hormone H2 (yellow squares). All of the hormones released from the anterior pituitary are controlled (at least in part) by hypothalamic hormones. C. Hormone H1 is called a releasing hormone because it can cause the release of another hormone from the anterior pituitary. Some of the ...
Tang et al - Pro Aid Autisme
Tang et al - Pro Aid Autisme

... the protein levels of postsynaptic marker PSD95 and the presynaptic protein synapsin I (Figure 2A). No effects of PMI, cause of death, brain pH, or length of storage on protein levels were detected (Table S2). We observed a decrease in p-mTOR level with age in controls and higher p-mTOR level in ASD ...
Section and Senior Editor - HAL
Section and Senior Editor - HAL

... Indeed, since von Economo (1926) initially identified a lethargy in patients suffering from inflammatory lesions within the posterior hypothalamus, somnolence, hypersomnia, narcolepsy or coma has been repeatedly reported following lesions/inactivation of this region in several mammalian species (rev ...
C fibres (dull pain)
C fibres (dull pain)

... The conclusion was drawn that the pain experienced by these men was blocked by emotional factors. The physical injuries that these men had received was an escape from the life-threatening environment of battle to the safety of a hospital, or even release form the war. This relationship suggests th ...
2nd year - FORTH-ICS - Foundation for Research and Technology
2nd year - FORTH-ICS - Foundation for Research and Technology

... in visual and somatosensory guidance of reaching and grasping movements and (ii) to unravel its connections. The relevant results are presented in detail under deliverable “D2.2” below. Moreover, the UNIBO group in collaboration with FORTH/ICS has extracted working principles that could improve the ...
Voltage-Gated Na+ Channels in the CNS
Voltage-Gated Na+ Channels in the CNS

... in voltage-gated Na+ channel activity can play a role in reorganization, recovery, or possibly excitotoxic damage following injury. Prolonged hypoxemia in fetal llama brain caused a significant decrease in the expression of Nav1.1 and less so for Nav1.2 channels detected with Anti-Nav1.1 and Nav1.2 ...
Nap, a Novel Member of the Pentraxin Family, Promotes Neurite
Nap, a Novel Member of the Pentraxin Family, Promotes Neurite

... rats received high-frequency (HF) stimulation in one hemisphere and low-frequency (LF) stimulation in the other hemisphere. Electrical stimuli consisted of 200 msec diphasic, constantcurrent pulses given at a stimulus intensity of 500 FA. The LF test stimulation was delivered at 0.1 Hz, and the HF s ...
General and cell type specific mechanisms target
General and cell type specific mechanisms target

... renal epithelial cell or a worm sensory neuron. How TRPP1, TRPP2 and other ciliary proteins localize and gain access to the cilium, a spatially restricted organelle, is not well understood. After proper entrance to the cilium, regulation of PKD-2 ciliary abundance may be an equally important step fo ...
mecp2 and the epigenetic regulation of excitatory synaptic
mecp2 and the epigenetic regulation of excitatory synaptic

... conditional knockout approach, we found that these effects were not due to the loss of MeCP2 during neurodevelopment and that they were primarily due to a deficiency in presynaptic vesicle release. We further extended these findings by looking at two mechanisms for controlling the repression of gene ...
A divergent canonical WNT-signaling pathway
A divergent canonical WNT-signaling pathway

... against nocodazole (Fig. 2, G–I). More importantly, cells expressing both NTCF-4 and DVL-1 contain a large number of stable microtubules after nocodazole, similar to cells expressing DVL-1 only (Fig. 2, J–L). Quantification indicates that NTCF-4 does not block DVL-1 function on microtubules (Fig. ...
α7 nicotinic acetylcholine receptor
α7 nicotinic acetylcholine receptor

... non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underlying the anti-inflammatory potential of cholinergic agonists in immune cells, including astrocytes, and inhibition o ...
The architectural balance of the Ventral Nerve Cord depends
The architectural balance of the Ventral Nerve Cord depends

... as solutions that minimize wiring cost, following the wiring optimization principle postulated by Ramón y Cajal (Cajal, 1899). Wiring cost arises from metabolic requirements, signal delay and attenuation, and possible guidance defects (Tessier-Lavigne & Goodman, 1996). Whatever the origin of the wir ...
Applying Transcranial Alternating Current Stimulation to the Study of Spike Timing Dependent Plasticity in Neural Networks
Applying Transcranial Alternating Current Stimulation to the Study of Spike Timing Dependent Plasticity in Neural Networks

... physiologically accurate than the similar, but more complex, Hodgkin Huxley model, the FN model’s simplicity to implement and accurate mimicking of general neural spiking behavior make it an ideal first choice for the purposes of generating a neural micro-network. The specific FN model used here was ...
The basal forebrain cholinergic projection system in mice. In
The basal forebrain cholinergic projection system in mice. In

... present in the rat cortex. Various cholinergic cell groups in the brain can be identified with numbers and letters Ch based upon their projection target. In the basal forebrain of mammals cholinergic neurons are located in the medial septum (Ch1), the vertical (Ch2) and horizontal (Ch3) limbs of the ...
The Basal Forebrain Cholinergic Projection
The Basal Forebrain Cholinergic Projection

... present in the rat cortex. Various cholinergic cell groups in the brain can be identified with numbers and letters Ch based upon their projection target. In the basal forebrain of mammals cholinergic neurons are located in the medial septum (Ch1), the vertical (Ch2) and horizontal (Ch3) limbs of the ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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