Non-Cell-Autonomous Effect of Human SOD1G37R
... Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons. ALS can be induced by inherited mutations in the gene encoding the ubiquitously expressed enzyme superoxide dismutase 1 (SOD1) (Boill ...
... Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative adult disease characterized by fatal paralysis in both the brain and spinal cord motor neurons. ALS can be induced by inherited mutations in the gene encoding the ubiquitously expressed enzyme superoxide dismutase 1 (SOD1) (Boill ...
Lissencephaly - Cambridge University Press
... could not be differentiated from the as yet unmyelinated centrum semiovale and it was impossible to discern the internal architecture of the central nuclei. The ventricles were slightly enlarged. Horizontal sections of the brainstem and cerebellum showed poor myelination. Microscopic examination sho ...
... could not be differentiated from the as yet unmyelinated centrum semiovale and it was impossible to discern the internal architecture of the central nuclei. The ventricles were slightly enlarged. Horizontal sections of the brainstem and cerebellum showed poor myelination. Microscopic examination sho ...
PARK9-Associated ATP13A2 Localizes to Intracellular
... rodent ATP13A2 but not with a non-silencing control shRNA (Fig. 4A). We also demonstrate the using an ATP13A2-specific shRNA construct (Fig. 4B). To explore the consequences of shRNAmediated silencing of endogenous ATP13A2 expression in neurons, we employed rat primary midbrain cultures which typica ...
... rodent ATP13A2 but not with a non-silencing control shRNA (Fig. 4A). We also demonstrate the using an ATP13A2-specific shRNA construct (Fig. 4B). To explore the consequences of shRNAmediated silencing of endogenous ATP13A2 expression in neurons, we employed rat primary midbrain cultures which typica ...
Massive Loss of Mid- and Hindbrain Neurons during Embryonic
... animals, was intriguing because axons from this nucleus comprise the V cranial nerve, which controls the muscles required for mastication and suckling. Because this nucleus is required at birth, these cells undergo synaptogenesis and terminal differentiation during embryonic life. To determine wheth ...
... animals, was intriguing because axons from this nucleus comprise the V cranial nerve, which controls the muscles required for mastication and suckling. Because this nucleus is required at birth, these cells undergo synaptogenesis and terminal differentiation during embryonic life. To determine wheth ...
Emx1/2 and neocorticogenesis - Development
... Japan). Subsequently, distribution of BrdU-positive cells was determined at E18.5 or E19.5. In order to investigate cell proliferation, BrdU was delivered to pregnant mice 2 hours before sacrifice. Brains were fixed with Carnoy’s fixative and embedded in paraplast. Sections were subsequently prepare ...
... Japan). Subsequently, distribution of BrdU-positive cells was determined at E18.5 or E19.5. In order to investigate cell proliferation, BrdU was delivered to pregnant mice 2 hours before sacrifice. Brains were fixed with Carnoy’s fixative and embedded in paraplast. Sections were subsequently prepare ...
THE MIRROR SYSTEM HYPOTHESIS: FROM A MACAQUE
... S2: A mirror system for grasping, shared with the common ancestor of human and monkey. S3: A system for simple imitation of grasping shared with the common ancestor of human and chimpanzee. The next 3 stages distinguish the hominid line from that of the great apes: S4: A complex imitation system for ...
... S2: A mirror system for grasping, shared with the common ancestor of human and monkey. S3: A system for simple imitation of grasping shared with the common ancestor of human and chimpanzee. The next 3 stages distinguish the hominid line from that of the great apes: S4: A complex imitation system for ...
Protocol S1.
... almost superposes the entire green curve (global clock) in the Fig. S2B. These results suggest that the molecular clock dating by these two models are consistent. Euclidean distance computation The Euclidean distance was used to define the difference between a pair of profile/distribution (Malins et ...
... almost superposes the entire green curve (global clock) in the Fig. S2B. These results suggest that the molecular clock dating by these two models are consistent. Euclidean distance computation The Euclidean distance was used to define the difference between a pair of profile/distribution (Malins et ...
Dr. Coyle`s NIH Biosketch
... 1970-73 Research Associate, Laboratory of Clinical Science, National Institute of Mental Health (Dr. Julius Axelrod), Bethesda, Maryland 1973-76 Resident in Psychiatry, Johns Hopkins Hospital 1974-76 Assistant Professor of Pharmacology, The Johns Hopkins School of Medicine 1978-80 Associate Professo ...
... 1970-73 Research Associate, Laboratory of Clinical Science, National Institute of Mental Health (Dr. Julius Axelrod), Bethesda, Maryland 1973-76 Resident in Psychiatry, Johns Hopkins Hospital 1974-76 Assistant Professor of Pharmacology, The Johns Hopkins School of Medicine 1978-80 Associate Professo ...
the mirror system hypothesis: from a macaque
... S2: A mirror system for grasping, shared with the common ancestor of human and monkey. S3: A system for simple imitation of grasping shared with the common ancestor of human and chimpanzee. The next 3 stages distinguish the hominid line from that of the great apes: S4: A complex imitation system for ...
... S2: A mirror system for grasping, shared with the common ancestor of human and monkey. S3: A system for simple imitation of grasping shared with the common ancestor of human and chimpanzee. The next 3 stages distinguish the hominid line from that of the great apes: S4: A complex imitation system for ...
THz in Biology and Medicine:
... membrane, point to strong specific absorption in the millimeter wave band [18-21]. The authors’ intent in this paper is to describe several experiments, performed in vitro and ex vivo, which address the impact of millimeter waves on individual cells at the microscopic level. In the course of these i ...
... membrane, point to strong specific absorption in the millimeter wave band [18-21]. The authors’ intent in this paper is to describe several experiments, performed in vitro and ex vivo, which address the impact of millimeter waves on individual cells at the microscopic level. In the course of these i ...
Comparative molecular neuroanatomy of mammalian neocortex
... that can adapt to a range of information processing (Douglas and Martin 2004; Bannister 2005). The current evidence indicates that different types of extrinsic and intrinsic neurons constitute each lamina (Lund et al. 1994; Molyneaux et al. 2007; Thomson and Lamy 2007; Leone et al. 2008). The homolo ...
... that can adapt to a range of information processing (Douglas and Martin 2004; Bannister 2005). The current evidence indicates that different types of extrinsic and intrinsic neurons constitute each lamina (Lund et al. 1994; Molyneaux et al. 2007; Thomson and Lamy 2007; Leone et al. 2008). The homolo ...
Physiological Psychology
... emergency. The sympathetic nervous system prepares the body for fighting or fleeing by shutting down low-priority systems and putting blood and oxygen into the most necessary parts of the body. Salivation and digestion are put on standby. If you’re facing a hungry lion on the Serengeti Plain, you do ...
... emergency. The sympathetic nervous system prepares the body for fighting or fleeing by shutting down low-priority systems and putting blood and oxygen into the most necessary parts of the body. Salivation and digestion are put on standby. If you’re facing a hungry lion on the Serengeti Plain, you do ...
Dissipation of dark energy by cortex in knowledge retrieval
... phase of random activity to a structured liquid-like phase. The phase transition is by spontaneous breaking of the symmetry of the random phase (Freeman and Vitiello, 2006). The fragment of knowledge from broken symmetry is expressed in two interactive fields of neural activity, which spread over the ...
... phase of random activity to a structured liquid-like phase. The phase transition is by spontaneous breaking of the symmetry of the random phase (Freeman and Vitiello, 2006). The fragment of knowledge from broken symmetry is expressed in two interactive fields of neural activity, which spread over the ...
Synaptic Neurotransmission and the Anatomically Addressed
... entire book and the road map for a journey through one of the most exciting topics in science today: the neuroscience of how drugs and disorders act on the central nervous system. What is neurotransmission? It can be described in many ways: anatomically, chemically, electrically. This chapter (Chapt ...
... entire book and the road map for a journey through one of the most exciting topics in science today: the neuroscience of how drugs and disorders act on the central nervous system. What is neurotransmission? It can be described in many ways: anatomically, chemically, electrically. This chapter (Chapt ...
Thermo Scientific TurboFect Transfection Reagent
... Quantities and volumes should be scaled according to the number of wells to be transfected (Table 1). 1. In each well, seed cells in 200 μL of growth medium 24 hours prior to transfection at a density that will give a confluency of 70-90% the day of transfection. Note: The recommended confluency fo ...
... Quantities and volumes should be scaled according to the number of wells to be transfected (Table 1). 1. In each well, seed cells in 200 μL of growth medium 24 hours prior to transfection at a density that will give a confluency of 70-90% the day of transfection. Note: The recommended confluency fo ...
Corticothalamic feedback and sensory processing
... demonstrated by revisiting the experiments of Suga and co-workers [33–35]. Once a sensory signal is initially transmitted from the MGB to the cortex, further activity in the MGB (and other corticofugal targets [39]) is markedly modified by feedback from the activated regions of cortex. The activati ...
... demonstrated by revisiting the experiments of Suga and co-workers [33–35]. Once a sensory signal is initially transmitted from the MGB to the cortex, further activity in the MGB (and other corticofugal targets [39]) is markedly modified by feedback from the activated regions of cortex. The activati ...
Indeterminism And The Brain - Philsci
... mediator between the mental and physical world, not a control unit of its own.4 It will barely need mentioning that such an account is not widely accepted today, neither in philosophical nor in scientific quarters. Neuroscientists today look at the brain as the control center of human behavior, not ...
... mediator between the mental and physical world, not a control unit of its own.4 It will barely need mentioning that such an account is not widely accepted today, neither in philosophical nor in scientific quarters. Neuroscientists today look at the brain as the control center of human behavior, not ...
Environmental Sensing and the Cellular Response
... About the Symposium Trieste is an ancient city on the Adriatic Sea where Italian, Germanic, and Slavic cultures intersect. Before it became part of a united Italy 50 years ago, the city was at various times under the sway of Rome, Venice, Austria, Austria-Hungary, Italy, and Communist Yugoslavia. ...
... About the Symposium Trieste is an ancient city on the Adriatic Sea where Italian, Germanic, and Slavic cultures intersect. Before it became part of a united Italy 50 years ago, the city was at various times under the sway of Rome, Venice, Austria, Austria-Hungary, Italy, and Communist Yugoslavia. ...
Neuroembryology
... appropriately sized, and appropriately interconnected populations? – What is the relationship between structure & function and how is the match between the two achieved? ...
... appropriately sized, and appropriately interconnected populations? – What is the relationship between structure & function and how is the match between the two achieved? ...
Lema and Nevitt, 2004a
... glass slides, it is unlikely that the same AVT-ir cell was counted in more than one section. 2.4. Statistical analysis We used one-factor ANOVAÕs to test for differences in standard length and body weight among males and females from the Amargosa River and Big Spring populations. To determine whether ...
... glass slides, it is unlikely that the same AVT-ir cell was counted in more than one section. 2.4. Statistical analysis We used one-factor ANOVAÕs to test for differences in standard length and body weight among males and females from the Amargosa River and Big Spring populations. To determine whether ...
Channelrhodopsin
Channelrhodopsins are a subfamily of retinylidene proteins (rhodopsins) that function as light-gated ion channels. They serve as sensory photoreceptors in unicellular green algae, controlling phototaxis: movement in response to light. Expressed in cells of other organisms, they enable light to control electrical excitability, intracellular acidity, calcium influx, and other cellular processes. Channelrhodopsin-1 (ChR1) and Channelrhodopsin-2 (ChR2) from the model organism Chlamydomonas reinhardtii are the first discovered channelrhodopsins. Variants have been cloned from other algal species, and more are expected.