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File - Wk 1-2
File - Wk 1-2

... Depolarisation opens then closes the Na⁺ channels. Both need to be open for Na⁺ to enter but closing either closes the channel. Each active potassium channel has a single voltage gate which is closed at rest and opens slowly during depolarisation. 2. Depolarising phase: ↑ in Na⁺ permeability and rev ...
Unit 4 Test Study sheet
Unit 4 Test Study sheet

... regions. Explain how the following terms relate to the sensory signals and afferent division of the nervous system- adequate stimulus, threshold, receptive field, and perceptual threshold, modality, localization, intensity, and duration, second sensory neurons, and somatosensory cortex 5. Explain ho ...
Central Nervous System
Central Nervous System

... 6) Postsynaptic receptors include all the following types, except :a- G-protein coupled receptors b- ligand-gated cation channels c- G-protein regulated K + channels d- voltage-gated Cl- channels 7) When opened, the ligand-gated cation channels do not allow diffusion of Clbecause :a- the size of Cl- ...
Synaptic Transmisson
Synaptic Transmisson

... where neurotransmitter builds up in the synapse by one of two methods: a) ...
AIP
AIP

... area showed that the anterograde and retrograde labelings in the agranular frontal cortex was almost completely confined to F5 and, therefore, the anatomical linkage between these two areas is highly selective and reciprocal. In addition, the differential distribution of the labeling observed in the ...
د. غسان The Autonomic Nervous System (ANS): The ANS coordinates
د. غسان The Autonomic Nervous System (ANS): The ANS coordinates

... – Cell body lies outside the CNS in an autonomic ganglion – Axon is unmyelinated type C fiber that terminates in a visceral effector. ...
Role of the thalamic nucleus reuniens in mediating interactions
Role of the thalamic nucleus reuniens in mediating interactions

... working memory performance. Davoodi et al. (2009) were one of the first groups to specifically target the RE, examining the effects of RE inactivation on Morris water maze (MWM) performance. They reported both reference memory (RM) and working memory (working memory) impairments on MWM task performa ...
Eye Movement Control by the Cerebral Cortex Charles Pierrot
Eye Movement Control by the Cerebral Cortex Charles Pierrot

... motor sequence. ...
Unit-III-The-Nervous-and-Endocrine-Systems
Unit-III-The-Nervous-and-Endocrine-Systems

... The movement for reflexes occurs before the brain has a chance to process the incoming sensory information. Reflexes enable us to respond to stimuli before they have a chance to do us harm. It’s almost as if the spinal cord is a brain itself – having the ability to process danger before the brain ha ...
Expression of NADPH-d in the vagal nuclei of the
Expression of NADPH-d in the vagal nuclei of the

... and interstitial NTS subnuclei and the compact formation of NA are active during deglutitive activity, whereas commissural and dorsomedial NTS subnuclei and the caudal DMV are active during LES relaxation (4). The commissural and dorsomedial NTS subnuclei and caudal DMV are active in controlling the ...
Lab 9
Lab 9

... areas of the two hemispheres – Association fibers – connect different parts of the same hemisphere – Projection fibers – enter the hemispheres from lower brain or cord centers ...
Role of the thalamic nucleus reuniens in mediating interactions
Role of the thalamic nucleus reuniens in mediating interactions

... working memory performance. Davoodi et al. (2009) were one of the first groups to specifically target the RE, examining the effects of RE inactivation on Morris water maze (MWM) performance. They reported both reference memory (RM) and working memory (working memory) impairments on MWM task performa ...
Impact of thousand-and-one amino acid 2 kinase
Impact of thousand-and-one amino acid 2 kinase

... the mechanisms underlying sophisticated cognitive functions in normal and disease conditions. Evidence suggests that neurodevelopmental disorders with delayed onset, such as autism spectrum disorders (ASDs) might be a consequence of aberrant dendritic arborization. This review is dedicated toward th ...
identification of cell types in brain slices of the inferior colliculus
identification of cell types in brain slices of the inferior colliculus

... This is the ®rst extensive analysis of electrophysiological properties of the central nucleus of the inferior colliculus in vitro. We suggest that there may be at least three functional classes of neurons and have implications for signal processing in the inferior colliculus. q 2000 IBRO. Published ...
Glutamatergic activation of anterior cingulate cortex produces
Glutamatergic activation of anterior cingulate cortex produces

... rons during conditioning, in the absence of a peripheral noxious of a significant spino-thalamo-cingulate nociceptive projection pathstimulus, should produce an aversive teaching signal. Finally, if the way10–15 is also consistent with a major role for the r-ACC in afferent aversive learning is asso ...
Lissencephaly - Cambridge University Press
Lissencephaly - Cambridge University Press

... lissencephaly. The other affected infants are said to have been "just the same". neuronal migration, with production of a four-layered cortex similar to that of a 50-100 mm. foetus (Hanaway et a l . , 1968). It has been suggested that factors intrinsic or extrinsic to the neurons could cause such a ...
A Dendritic Disinhibitory Circuit Mechanism for Pathway
A Dendritic Disinhibitory Circuit Mechanism for Pathway

... the level of dendrites it is sufficiently sparse to support branch-specific disinhibition, and there- ...
Movement
Movement

... (12) In the living animal, an external stretching force, such as gravity or an antagonistic muscle, pulls the muscle back to its original length. ...
The Frontal Lobes: Movement and Morality Part I
The Frontal Lobes: Movement and Morality Part I

... MARCH 1997 ...
Sympathetic nervous system
Sympathetic nervous system

... Outline one assumption of the biological approach. (2 marks) Rita and Holly are identical twins who were separated at birth. When they finally met each other at the age of 35, they were surprised at how different their personalities were. Rita is much more social and out-going than Holly. Use your k ...
Document
Document

... 1. Because the fMRI voxel is sensitive to activity from many neurons, simply showing that an area is active both during action and perception does not guarantee that the same neurons are responding to both action and perception (e.g., Dinstein et al, 2007). ...
Optimal decision making theories - Bristol CS
Optimal decision making theories - Bristol CS

... Another property of basal ganglia organization relevant to the model is that within each nucleus different neurons are selective for different body parts (Georgopoulos, DeLong, & Crutcher, 1983; Gerardin et al., 2003). On the basis of this observation it has been proposed that basal ganglia are orga ...
Bridging Cytoarchitectonics and Connectomics in Human Cerebral
Bridging Cytoarchitectonics and Connectomics in Human Cerebral

... Figure 2. A, Correlation matrix between all 18 microscale cytoarchitectonic metrics (6 layers ⫻ 3 metrics) and the two examined macroscale connectome values (degree and strength). B, Positive association between layer 3 neuron size (y-axis) and macroscale connectivity strength of cortical regions (i ...
Parallel Transformation of Tactile Signals in Central Circuits of
Parallel Transformation of Tactile Signals in Central Circuits of

... characteristic and reliable positions of their cell bodies, as well as their intrinsic properties: recorded neurons in each class had a characteristic input resistance, resting membrane potential, and spike waveform. We were able to reliably record from midline local and projection neurons by target ...
vikram_slides1
vikram_slides1

... later at f2  Monkey discriminates the difference f1 > f2 ?  Receives reward ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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