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Metabolic changes in Diabetes mellitus (DM)
Metabolic changes in Diabetes mellitus (DM)

Insulin Signaling
Insulin Signaling

... ----Adenine-----Adenosine--------------Adenosine monophosphate(AMP) ----Adenosine diphosphate(ADP)-----------Adenosine triphosphate(ATP)--------------- ...
Analysis of Cell Ageing
Analysis of Cell Ageing

... level of each subunit indicates the organ affected - H after a myocardial infarction and M in hepatitis. Though not used to diagnose heart attacks, its level indicates the amount of tissue infarcted [prognostic value]. This experiment will use PAGE[Polyacrylamide Gel Electrophoresis] to separate t ...
Metabolism of Neoplastic Tissue XII. Effects of Glucose
Metabolism of Neoplastic Tissue XII. Effects of Glucose

... mately 60 per cent of the added glucose was con experiment are given in Table 2. The total oxygen verted to CO2. The oxidation at 0.0025 Mparalleled uptakes and total CO2 yields were approximately the oxygen uptake throughout, being linear until equal for the three lower concentrations. However, the ...
Pyruvate Dehydrogenase Phosphatase Deficiency
Pyruvate Dehydrogenase Phosphatase Deficiency

Metabolism 2
Metabolism 2

... O2 debt (L) = O2 consumption in the entire period 3 (L) – O2 consumption in entire period 1 (L) total O2 consumption for physical activity (L) = = O2 consumption in period 2 (L) + oxygen debt (L) O2 consumption for 1 minute of physical activity (L) = = O2 consumption in period 2 (L) + oxygen debt (L ...
Metabolic transformation in cancer
Metabolic transformation in cancer

Hans A. Krebs - Nobel Lecture
Hans A. Krebs - Nobel Lecture

... of the intermediary reactions by which sugar is anaerobically fermented to lactic acid or to ethanol and carbon dioxide. The success was mainly due to the joint efforts of the schools of Meyerhof, Embden, Parnas, von Euler, Warburg and the Coris, who built on the pioneer work of Harden and of Neuber ...
Lecture 36
Lecture 36

... production and storage. In fact, a much larger percentage of the total energy reserves in animals is lipids in the form of fat deposits. Palmitate (16:0) is a C16 saturated fatty acid that can be carried through the body as a protein-fatty acid complex: ...
Endocrinology – growth hormone (GH)
Endocrinology – growth hormone (GH)

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Microbial Desulfurization
Microbial Desulfurization

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Impact of type 2 diabetes and a - American Journal of Physiology
Impact of type 2 diabetes and a - American Journal of Physiology

... zyme that catalyzes the reversible O-GlcNAcylation of specific serine/threonine residues of numerous cytosolic and nuclear proteins (4). Posttranslational O-GlcNAcylation likely interferes with serine/threonine phosphorylation of these same proteins, thereby altering their function. Because protein ...
metabolomic and computational systems analysis
metabolomic and computational systems analysis

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1.Oxidative phosphorylation
1.Oxidative phosphorylation

... ATP readily forms a complex with magnesium ion, and it is this complex that is required in all reactions in which ATP participates, including its synthesis. A magnesium deficiency impairs virtually all of metabolism, because ATP can neither be made nor utilized in adequate amounts ...
Lipid Breakdown - Rose
Lipid Breakdown - Rose

Quick Quiz1
Quick Quiz1

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Neonatal Hypoglycemia
Neonatal Hypoglycemia

... Newborns have high brain-to-body weight ratio -> higher glucose demand Impaired establishment of normal glucose homeostasis during transition from intrauterine to extrauterine life -> hypoglycemia Normal glucose homeostasis requires supply to meet demands Supply is dependent on adequate stores of gl ...
Name: Block: Date: Biology 12 - Biologically Important Molecules
Name: Block: Date: Biology 12 - Biologically Important Molecules

... the smallest unit of matter that cannot normally be broken into smaller particles the process of breaking down large fat droplets into smaller fat droplets the loose association of amino acids in a polypeptide chain with each other, usually through H-bonds. e.g. alpha helix, beta pleated sheet the l ...
Pharmacokinetic processes: metabolism
Pharmacokinetic processes: metabolism

Interval Training Interval Training Understand Energy Systems to
Interval Training Interval Training Understand Energy Systems to

... All LA removed in 60 min ...
Metabolic production and renal disposal of hydrogen ions
Metabolic production and renal disposal of hydrogen ions

... glucose or carbon dioxide, in proportions which vary from In contrast to the above, the metabolism of anions to neutral species to species. The two possible pathways are in fact end-products will remove hydrogen ions. Again, following equivalent in their net effects on acid-base balance. We begin by ...
Pancreas
Pancreas

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question Examination questions: Digestion and intermediary
question Examination questions: Digestion and intermediary

... (alternative names, active forms, examples of their use in metabolic reactions) (alternative names, active forms, examples of their use in metabolic reactions) (alternative names, active forms, examples of their use in metabolic reactions) (alternative names, active forms, examples of their use in m ...
Fermentation of sugars and fermentative enzymes
Fermentation of sugars and fermentative enzymes

... Poisons have also been used in other ways in work on enzymes. As I stated, fermentation from sugar to alcohol and carbon dioxide passes through a considerable number of intermediate stages, amongst which each has its own enzyme. These partial reactions are so interwoven that it is difficult to separ ...
Human Physiology - Coastline Community College
Human Physiology - Coastline Community College

... In absence of O2, NADH gives its Hs to pyruvate creating Lactic acid (Anaerobic Respiration) In ...
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Glycolysis



Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy compounds ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide).Glycolysis is a determined sequence of ten enzyme-catalyzed reactions. The intermediates provide entry points to glycolysis. For example, most monosaccharides, such as fructose and galactose, can be converted to one of these intermediates. The intermediates may also be directly useful. For example, the intermediate dihydroxyacetone phosphate (DHAP) is a source of the glycerol that combines with fatty acids to form fat.Glycolysis is an oxygen independent metabolic pathway, meaning that it does not use molecular oxygen (i.e. atmospheric oxygen) for any of its reactions. However the products of glycolysis (pyruvate and NADH + H+) are sometimes disposed of using atmospheric oxygen. When molecular oxygen is used in the disposal of the products of glycolysis the process is usually referred to as aerobic, whereas if the disposal uses no oxygen the process is said to be anaerobic. Thus, glycolysis occurs, with variations, in nearly all organisms, both aerobic and anaerobic. The wide occurrence of glycolysis indicates that it is one of the most ancient metabolic pathways. Indeed, the reactions that constitute glycolysis and its parallel pathway, the pentose phosphate pathway, occur metal-catalyzed under the oxygen-free conditions of the Archean oceans, also in the absence of enzymes. Glycolysis could thus have originated from chemical constraints of the prebiotic world.Glycolysis occurs in most organisms in the cytosol of the cell. The most common type of glycolysis is the Embden–Meyerhof–Parnas (EMP pathway), which was discovered by Gustav Embden, Otto Meyerhof, and Jakub Karol Parnas. Glycolysis also refers to other pathways, such as the Entner–Doudoroff pathway and various heterofermentative and homofermentative pathways. However, the discussion here will be limited to the Embden–Meyerhof–Parnas pathway.The entire glycolysis pathway can be separated into two phases: The Preparatory Phase – in which ATP is consumed and is hence also known as the investment phase The Pay Off Phase – in which ATP is produced.↑ ↑ 2.0 2.1 ↑ ↑ ↑ ↑ ↑ ↑
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