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Biosynthesis of Pyrimidines
Biosynthesis of Pyrimidines

... • Pyrimidines like Purines does not require any special dietary requirements. • Because body can form Pyrimidines from components of normal diet. • Pyrimidines are not synthesized as nucleotide. • Synthesized by two methods as in purines. • 1)De-novo synthesis • 2)Salavage mechanism ...
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... bond. What is the next step in the process? Show structures and indicate where any cofactor(s) participate(s). Ans: The reaction is that catalyzed by -hydroxyacyl-CoA dehydrogenase, for which NAD+ is cofactor. See Fig. 17-8a, p. 653. 19. Oxidation of fatty acids For each two-carbon increase in the ...
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Objectives 30 - u.arizona.edu
Objectives 30 - u.arizona.edu

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... Phosphagen Energy System: Creatine Kinase Reaction The creatine kinase (CK) reaction is of vital importance to skeletal muscle contraction. This reaction provides the most immediate means to replenish ATP in the cytosol. Traditionally, the reaction has been interpreted to be applicable mainly to the ...
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Glycolysis



Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy compounds ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide).Glycolysis is a determined sequence of ten enzyme-catalyzed reactions. The intermediates provide entry points to glycolysis. For example, most monosaccharides, such as fructose and galactose, can be converted to one of these intermediates. The intermediates may also be directly useful. For example, the intermediate dihydroxyacetone phosphate (DHAP) is a source of the glycerol that combines with fatty acids to form fat.Glycolysis is an oxygen independent metabolic pathway, meaning that it does not use molecular oxygen (i.e. atmospheric oxygen) for any of its reactions. However the products of glycolysis (pyruvate and NADH + H+) are sometimes disposed of using atmospheric oxygen. When molecular oxygen is used in the disposal of the products of glycolysis the process is usually referred to as aerobic, whereas if the disposal uses no oxygen the process is said to be anaerobic. Thus, glycolysis occurs, with variations, in nearly all organisms, both aerobic and anaerobic. The wide occurrence of glycolysis indicates that it is one of the most ancient metabolic pathways. Indeed, the reactions that constitute glycolysis and its parallel pathway, the pentose phosphate pathway, occur metal-catalyzed under the oxygen-free conditions of the Archean oceans, also in the absence of enzymes. Glycolysis could thus have originated from chemical constraints of the prebiotic world.Glycolysis occurs in most organisms in the cytosol of the cell. The most common type of glycolysis is the Embden–Meyerhof–Parnas (EMP pathway), which was discovered by Gustav Embden, Otto Meyerhof, and Jakub Karol Parnas. Glycolysis also refers to other pathways, such as the Entner–Doudoroff pathway and various heterofermentative and homofermentative pathways. However, the discussion here will be limited to the Embden–Meyerhof–Parnas pathway.The entire glycolysis pathway can be separated into two phases: The Preparatory Phase – in which ATP is consumed and is hence also known as the investment phase The Pay Off Phase – in which ATP is produced.↑ ↑ 2.0 2.1 ↑ ↑ ↑ ↑ ↑ ↑
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