Generic substitution in the treatment of epilepsy
... were previously well-controlled while on a brand AED, who experienced a breakthrough seizure or an increase in seizure frequency when switched to the corresponding generic AED on the same dosing regimen. The physicians treating these patients believed that the change to the generic was the reason fo ...
... were previously well-controlled while on a brand AED, who experienced a breakthrough seizure or an increase in seizure frequency when switched to the corresponding generic AED on the same dosing regimen. The physicians treating these patients believed that the change to the generic was the reason fo ...
Forensic Toxicology PPT
... generally means a socially unacceptable drug). – Narcotics are analgesic - relieve pain by depressing nervous system (opium, morphine, heroin, codeine, opiates - oxycontin, methadone). – Cocaine (stimulant), Marijuana (hallucinogen), etc are Not classified as narcotics even though they are frequentl ...
... generally means a socially unacceptable drug). – Narcotics are analgesic - relieve pain by depressing nervous system (opium, morphine, heroin, codeine, opiates - oxycontin, methadone). – Cocaine (stimulant), Marijuana (hallucinogen), etc are Not classified as narcotics even though they are frequentl ...
Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase
... samples were prepared as described previously, and the levels of 6a-hydroxypaclitaxel and p-39-hydroxypaclitaxel were quantified. For the time-dependent inhibition component of this assay, kinase inhibitors at a concentration of 10 mM were first incubated with HLMs in the presence of NADPH. After a ...
... samples were prepared as described previously, and the levels of 6a-hydroxypaclitaxel and p-39-hydroxypaclitaxel were quantified. For the time-dependent inhibition component of this assay, kinase inhibitors at a concentration of 10 mM were first incubated with HLMs in the presence of NADPH. After a ...
ACRIDINE: A VERSATILE HETEROCYCLIC NUCLEUS
... of 1-nitro-9-hydroxyethylaminoacridine (XXII) derivatives. The introduction of methyl group at C4 resulted in compounds which showed higher therapeutic efficacy and being developed as anticancer agent for solid tumors (44). ...
... of 1-nitro-9-hydroxyethylaminoacridine (XXII) derivatives. The introduction of methyl group at C4 resulted in compounds which showed higher therapeutic efficacy and being developed as anticancer agent for solid tumors (44). ...
Primaquine-Induced Hemolytic Anemia: Formation and Hemotoxicity
... system (163 M -NADP⫹, 1.7 mM glucose 6-phosphate, and 0.375 U of glucose-6-phosphate dehydrogenase). The incubation was conducted in a shaking water bath at 37°C. Aliquots (100 l) were removed at 1, 3, 5, 10, 20, and 30 min, added to 100 l of cold methanol, and centrifuged at 13,500g for 1 min. ...
... system (163 M -NADP⫹, 1.7 mM glucose 6-phosphate, and 0.375 U of glucose-6-phosphate dehydrogenase). The incubation was conducted in a shaking water bath at 37°C. Aliquots (100 l) were removed at 1, 3, 5, 10, 20, and 30 min, added to 100 l of cold methanol, and centrifuged at 13,500g for 1 min. ...
Methylphenidate vs. amphetamine: Comparative
... Methylphenidate (MPH, e.g., Ritalin®) and amphetamine (AMP), especially its dextroisomer dextroamphetamine (e.g., Dexedrine®, Dextrostat®) and, more recently, a mixture of amphetamine salts marketed as Adderall®, have been respectively the most commonly used and second most commonly used drugs for t ...
... Methylphenidate (MPH, e.g., Ritalin®) and amphetamine (AMP), especially its dextroisomer dextroamphetamine (e.g., Dexedrine®, Dextrostat®) and, more recently, a mixture of amphetamine salts marketed as Adderall®, have been respectively the most commonly used and second most commonly used drugs for t ...
Reflections on Ayahuasca from a Therapeutic Perspective
... In 1990, however, McKenna himself recognizes the hallucinogenic function of Banisteriopsis alone: “numerous tribes of the same region prepare an hallucinogenic drink based of Banisteriopsis caapi or other members of the malpighiaceae. This drink, which contains higher levels of β-carboline alkaloids ...
... In 1990, however, McKenna himself recognizes the hallucinogenic function of Banisteriopsis alone: “numerous tribes of the same region prepare an hallucinogenic drink based of Banisteriopsis caapi or other members of the malpighiaceae. This drink, which contains higher levels of β-carboline alkaloids ...
Pharmacogenetic Testing Prior to Initiation of Warfarin
... due to a number of different genetic factors. Genetic variants may influence drug response by altering (1) drug metabolizing enzymes, (2) drug target(s) or receptor(s), and/or (3) drug transport protein(s) or a combination thereof.1 Pharmacogenetics is the investigation of the genetic basis of drug ...
... due to a number of different genetic factors. Genetic variants may influence drug response by altering (1) drug metabolizing enzymes, (2) drug target(s) or receptor(s), and/or (3) drug transport protein(s) or a combination thereof.1 Pharmacogenetics is the investigation of the genetic basis of drug ...
1 Anish et al Journal of Drug Delivery & Therapeutics; 2012, 2(1)
... crosslinked structure allows immobilization of active agents, biomolecules effectively, and allows for its release in well-defined specific manner. Thus the hydrogels biocompatibility and crosslinked structure are responsible for its varied applications. 1. Mechanical properties: For non biodegradab ...
... crosslinked structure allows immobilization of active agents, biomolecules effectively, and allows for its release in well-defined specific manner. Thus the hydrogels biocompatibility and crosslinked structure are responsible for its varied applications. 1. Mechanical properties: For non biodegradab ...
PowerPoint Chapter 16
... Elsevier items and derived items © 2010, 2006, 2003, 2000 by Mosby, an imprint of Elsevier Inc. ...
... Elsevier items and derived items © 2010, 2006, 2003, 2000 by Mosby, an imprint of Elsevier Inc. ...
use of chick embryo in screening for teratogenicity
... duration and size of studies and number of animals used where there is an indication that a low hazard potential exists (5). ...
... duration and size of studies and number of animals used where there is an indication that a low hazard potential exists (5). ...
SHPA Medicines Information Procedure Manual
... referred to as drug information centres. The value and need for MI services Research about the value of MI services is limited. One study in a US hospital indicated a positive benefit in terms of costs based on a cost avoidance model.9 Positive effects on patient care (mainly in terms of medication ...
... referred to as drug information centres. The value and need for MI services Research about the value of MI services is limited. One study in a US hospital indicated a positive benefit in terms of costs based on a cost avoidance model.9 Positive effects on patient care (mainly in terms of medication ...
Pethidine FAQs
... There is a theoretical risk of drugs which induce cytochrome P450 enzymes eg phenytoin increasing hepatic metabolism of pethidine, and thus increasing production of norpethidine. Data are derived from one pharmacokinetic study in which 4 normal subjects received pethidine (50mg IV and 100mg orally) ...
... There is a theoretical risk of drugs which induce cytochrome P450 enzymes eg phenytoin increasing hepatic metabolism of pethidine, and thus increasing production of norpethidine. Data are derived from one pharmacokinetic study in which 4 normal subjects received pethidine (50mg IV and 100mg orally) ...
Pulmonary Drug Absorption
... correlate to the drug lipophilicity, the molecular polar surface area, and the apparent permeability of Caco-2 cell monolayers. In contrast to the intestinal mucosa and the blood-brain barrier, the pulmonary epithelium was highly permeable to drugs with a high molecular polar surface area. According ...
... correlate to the drug lipophilicity, the molecular polar surface area, and the apparent permeability of Caco-2 cell monolayers. In contrast to the intestinal mucosa and the blood-brain barrier, the pulmonary epithelium was highly permeable to drugs with a high molecular polar surface area. According ...
Full Text - AIMS Press
... delivery in bone disease therapy. For bone regeneration in osteoporosis patients, the development of ...
... delivery in bone disease therapy. For bone regeneration in osteoporosis patients, the development of ...
Comparison of Hypertonic Saline to Epinephrine in
... children are too breathless to feed and some require oxygen supplementation to maintain blood oxygen levels. These children may require hospitalization. Treatment is mostly supportive using fluids and oxygen therapy. Nebulised bronchodilators like Salbutamol, Ipravent and Epinephrine have been used ...
... children are too breathless to feed and some require oxygen supplementation to maintain blood oxygen levels. These children may require hospitalization. Treatment is mostly supportive using fluids and oxygen therapy. Nebulised bronchodilators like Salbutamol, Ipravent and Epinephrine have been used ...
Drug Formulary
... (Buprenorphine, Fentanyl, Butorphanol, Oxymorphone, etc.) administered at 5:00 PM will not be effective at 8:00 AM the next morning. Thus, administration after typical business hours, use of extended release formulations, and/or trans‐dermal patch can be considered depending on the species. Current ...
... (Buprenorphine, Fentanyl, Butorphanol, Oxymorphone, etc.) administered at 5:00 PM will not be effective at 8:00 AM the next morning. Thus, administration after typical business hours, use of extended release formulations, and/or trans‐dermal patch can be considered depending on the species. Current ...
Off-Label: Combating the Dangerous Overprescription
... Adderall is a psychotropic stimulant made from amphetamine and dextroamphetamine.42 Adderall XR is the same medication in an extended-release form.43 Although Adderall is indicated to treat ADHD and narcolepsy,44 Adderall XR is indicated to treat only ADHD.45 The FDA reviewed no other uses when it a ...
... Adderall is a psychotropic stimulant made from amphetamine and dextroamphetamine.42 Adderall XR is the same medication in an extended-release form.43 Although Adderall is indicated to treat ADHD and narcolepsy,44 Adderall XR is indicated to treat only ADHD.45 The FDA reviewed no other uses when it a ...
... time of the day (i.e. 7:30 am). They were allowed a light breakfast while still at home. The two bronchoprovocations were separated by an interval of 2–6 weeks, and the same protocol for allergen dose increments was used at both occasions. For each challenge, the starting allergen dose was selected ...
Cocaine - South Carolina Department of Alcohol and Other Drug
... People use cocaine to change their moods and mental states by altering brain function. The cocaine “high” consists of a state of euphoria with feelings of increased energy, confidence, mental alertness and sexual arousal. The drug stimulates neurotransmitters (the body’s chemical messengers that sen ...
... People use cocaine to change their moods and mental states by altering brain function. The cocaine “high” consists of a state of euphoria with feelings of increased energy, confidence, mental alertness and sexual arousal. The drug stimulates neurotransmitters (the body’s chemical messengers that sen ...
ANAMIRTA COCCULUS LINN Research Article V. SATYA*
... tissue [6]. Wounds heal by primary intention or secondary intention depending upon whether the wound may be closed with sutures or left to repair, whereby damaged tissue is restored by the formation of connective tissue and re-growth of epithelium [7]. Several drugs obtained from plant sources are k ...
... tissue [6]. Wounds heal by primary intention or secondary intention depending upon whether the wound may be closed with sutures or left to repair, whereby damaged tissue is restored by the formation of connective tissue and re-growth of epithelium [7]. Several drugs obtained from plant sources are k ...
Chapter-3 Drug and Excipients profile
... requirements. The capsules should be taken with food once or twice daily. Adults including adolescents and the elderly Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response to Isotretinoin and some of the adverse effects are doserelated and vary between patien ...
... requirements. The capsules should be taken with food once or twice daily. Adults including adolescents and the elderly Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response to Isotretinoin and some of the adverse effects are doserelated and vary between patien ...
A Lay Person`s Guide to Medicines
... PREFACE TO EARLIER VERSION This book aims at providing necessary information about prescription drugs to the population at large. When a doctor prescribes a drug, he/she is expected to tell the patient some important points. These points should include not only the dose but also precautions to be t ...
... PREFACE TO EARLIER VERSION This book aims at providing necessary information about prescription drugs to the population at large. When a doctor prescribes a drug, he/she is expected to tell the patient some important points. These points should include not only the dose but also precautions to be t ...
Abstract
... enzyme PGG/H synthase, also called cyclooxygenase (COX). COX occurs in two isoforms, COX-1 and COX-2, which differ in their tissue distribution and regulation. The isoforms serve different biological functions, in that COX-1 is expressed under basal conditions and is involved in the biosynthesis of PG ...
... enzyme PGG/H synthase, also called cyclooxygenase (COX). COX occurs in two isoforms, COX-1 and COX-2, which differ in their tissue distribution and regulation. The isoforms serve different biological functions, in that COX-1 is expressed under basal conditions and is involved in the biosynthesis of PG ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.