IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... dose dependent increase in mean relative liver/kidney weight and liver/kidney injury at the doses studied. Numerous studies have demonstrated that bromocriptine causes significant reductions in body weight in both animal (11-12) and human studies (13). In our study we did not observe any significant ...
... dose dependent increase in mean relative liver/kidney weight and liver/kidney injury at the doses studied. Numerous studies have demonstrated that bromocriptine causes significant reductions in body weight in both animal (11-12) and human studies (13). In our study we did not observe any significant ...
... quality control of this medicine to be able to ensure their effectiveness and safety. Several existing analytical techniques, which offer flexible and broad-based methods of analysis and in some cases detection, have been discussed in this manuscript, focusing on bioanalytical and pharmaceutical qua ...
REVIEW Arrhythmic risk biomarkers for the assessment of
... Wasserstrom 1988). However, it also blocks the calcium current and a variety of potassium conductances. Its class III effects on IKr have been suggested as the reason for its pro-arrhythmic potential (Yang & Roden 1996). Quinidine was found to increase ERP in a rate-independent manner in humans (Ros ...
... Wasserstrom 1988). However, it also blocks the calcium current and a variety of potassium conductances. Its class III effects on IKr have been suggested as the reason for its pro-arrhythmic potential (Yang & Roden 1996). Quinidine was found to increase ERP in a rate-independent manner in humans (Ros ...
preparation of diazepam rectal gel using cellulose polymers
... Diazepam is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative muscle relaxant properties and it is the most widely used drug for treatment of insomnia, convulsions, and status epilepticus. Considering the advantages of rectal administration of diazepam, the objective of our stud ...
... Diazepam is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative muscle relaxant properties and it is the most widely used drug for treatment of insomnia, convulsions, and status epilepticus. Considering the advantages of rectal administration of diazepam, the objective of our stud ...
Neurobiological substrates for the dark side of compulsivity in
... 1.1. Motivation, withdrawal, and opponent process Motivation is a state that can be defined as a ‘‘tendency of the whole animal to produce organized activity’’ (Hebb, 1972), and such motivational states are not constant but rather vary over time. Early work by Wikler stressed the role of changes in d ...
... 1.1. Motivation, withdrawal, and opponent process Motivation is a state that can be defined as a ‘‘tendency of the whole animal to produce organized activity’’ (Hebb, 1972), and such motivational states are not constant but rather vary over time. Early work by Wikler stressed the role of changes in d ...
Per protocol analysis of therapeutic efficacy of chloroquine for the
... The differences in these responses was however not clinically significant (p=0.101). There was marginal male preponderance in showing response to chloroquine adequately (56.8% vs 43.2%) and also early treatment failure being more in males than females (75% vs 25%). Late clinical failure was seen onl ...
... The differences in these responses was however not clinically significant (p=0.101). There was marginal male preponderance in showing response to chloroquine adequately (56.8% vs 43.2%) and also early treatment failure being more in males than females (75% vs 25%). Late clinical failure was seen onl ...
Reprint
... exposed individual became infectious after the latent period. An infectious patient can shed the virus without showing clinical symptoms. This is referred to as asymptomatic infection with a mean infectious duration of 4.1 days (12-15). The probability of developing symptomatic infection was assumed ...
... exposed individual became infectious after the latent period. An infectious patient can shed the virus without showing clinical symptoms. This is referred to as asymptomatic infection with a mean infectious duration of 4.1 days (12-15). The probability of developing symptomatic infection was assumed ...
Selective Serotonin Reuptake Inhibitor Toxicity And Serotonin
... 7. Identify a drug that has been used to treat serotonin syndrome 8. Identify the SSRIS that has produced the most toxic effects. Introduction Depression is very common; an estimated 18 million Americans are diagnosed with a major depressive disorder each year and of these, 12 million to 18 million ...
... 7. Identify a drug that has been used to treat serotonin syndrome 8. Identify the SSRIS that has produced the most toxic effects. Introduction Depression is very common; an estimated 18 million Americans are diagnosed with a major depressive disorder each year and of these, 12 million to 18 million ...
Alternative antimicrobial drug(s) for treating penicillin
... A. contraindicated in a patient with asthma because it may cause bronchoconstriction B. recovery from anesthesia associated with emergence phenomenon of hallucinations and vivid dreams C. produces dissociative anesthetic state, whereby patient appears awake but is unconscious D. produces analgesia ...
... A. contraindicated in a patient with asthma because it may cause bronchoconstriction B. recovery from anesthesia associated with emergence phenomenon of hallucinations and vivid dreams C. produces dissociative anesthetic state, whereby patient appears awake but is unconscious D. produces analgesia ...
- Fred Help Centre
... duplicate side of original prescriptions. You will enjoy the benefits of greater efficiencies through high speed receipt of accurate prescription information and improve patient safety through the reduction of transcription errors. If you are not seeing eRx barcodes on doctors’ prescriptions from yo ...
... duplicate side of original prescriptions. You will enjoy the benefits of greater efficiencies through high speed receipt of accurate prescription information and improve patient safety through the reduction of transcription errors. If you are not seeing eRx barcodes on doctors’ prescriptions from yo ...
Blood biochemical changes in mice after administration of a mixture
... carrier gas. These volatile anesthetics allow rapid anesthesia induction and washout, which facilitates regulation of the concentration of the anesthetic in each individual animal. Monitoring of the vital signs of the animal, as indicative of the depth of anesthesia, allows regulation of the concent ...
... carrier gas. These volatile anesthetics allow rapid anesthesia induction and washout, which facilitates regulation of the concentration of the anesthetic in each individual animal. Monitoring of the vital signs of the animal, as indicative of the depth of anesthesia, allows regulation of the concent ...
“DEVLOPMENT AND VALIDATION OF SPECTROSCOPIC AND
... The neurocircuitry of anxiety has been postulated to arise from the amygdala, the brain area that registers the emotional significance of environmental stimuli and stores emotional memories. The efferent pathways from the central nucleus of the amygdala travel to a multiplicity of critical brain str ...
... The neurocircuitry of anxiety has been postulated to arise from the amygdala, the brain area that registers the emotional significance of environmental stimuli and stores emotional memories. The efferent pathways from the central nucleus of the amygdala travel to a multiplicity of critical brain str ...
metabolism, disposition, excretion, and pharmacokinetics of
... [14C]Levormeloxifene was prepared by dissolution in 0.1 M H2SO4, [10% (v/v)] Tween 80, and injection grade water, and the pH of the solution was adjusted to 4 with sodium hydroxide. For excretion balance studies, three male and three female Sprague-Dawley rats received single oral doses of [14C]levo ...
... [14C]Levormeloxifene was prepared by dissolution in 0.1 M H2SO4, [10% (v/v)] Tween 80, and injection grade water, and the pH of the solution was adjusted to 4 with sodium hydroxide. For excretion balance studies, three male and three female Sprague-Dawley rats received single oral doses of [14C]levo ...
NIDA for Teens Ecstasy Quiz
... C. MDMA is known as a “club drug” because teens and young adults have taken the drug at a nightclub or all-night party. ...
... C. MDMA is known as a “club drug” because teens and young adults have taken the drug at a nightclub or all-night party. ...
anesthetizing the public conscience: lethal injection
... proven unfounded. Dr. Gray was concerned that people would balk at treating humans, even if they are death row inmates, “the same way we’re treating animals.”28 Not so. For thirty years now, states have been treating them worse, and killing them using methods that have long since been abandoned by t ...
... proven unfounded. Dr. Gray was concerned that people would balk at treating humans, even if they are death row inmates, “the same way we’re treating animals.”28 Not so. For thirty years now, states have been treating them worse, and killing them using methods that have long since been abandoned by t ...
evaluation of antidepressant like activity of curcumin and its
... diameter: 15 cm; containing 15 cm hight of water maintained at 25 ± 1OC). Mice placed in the cylinder for the first time were initially highly active, vigorously swimming in circles, trying to climb the wall or diving to the bottom. After 2ñ3 min, activity began to subside and was interspersed with ...
... diameter: 15 cm; containing 15 cm hight of water maintained at 25 ± 1OC). Mice placed in the cylinder for the first time were initially highly active, vigorously swimming in circles, trying to climb the wall or diving to the bottom. After 2ñ3 min, activity began to subside and was interspersed with ...
P otective effects of inhaled ipratropium ... on bronchoconstriction induced by adenosine
... were 0.45 (0.34--0.58) and 0.07 (0.03-0.14) mg, respectively. The challenge procedure with AMP was found to be repeatable, there being a coefficient of repeatability of 1.5 doubling doses. The inhalation test was repeatable to within a single doubling dilution in 10 of the 12 subjects receiving AMP. ...
... were 0.45 (0.34--0.58) and 0.07 (0.03-0.14) mg, respectively. The challenge procedure with AMP was found to be repeatable, there being a coefficient of repeatability of 1.5 doubling doses. The inhalation test was repeatable to within a single doubling dilution in 10 of the 12 subjects receiving AMP. ...
New Approaches to Chronic Anticoagulation
... • Rivaroxaban was well tolerated, with similar incidence of AEs as enoxaparin • Rivaroxaban did not affect ECG parameters • Rivaroxaban did not have any substance-specific effects on laboratory parameters (except for clotting tests) • LFT increases with BAY 597939 did not exceed the level observed w ...
... • Rivaroxaban was well tolerated, with similar incidence of AEs as enoxaparin • Rivaroxaban did not affect ECG parameters • Rivaroxaban did not have any substance-specific effects on laboratory parameters (except for clotting tests) • LFT increases with BAY 597939 did not exceed the level observed w ...
Pharmacokinetic Interaction Between Prasugrel and Ritonavir
... the bioactivation of oxo-prasugrel to prasugrel AM is performed by CYP3A4 and 2–26% is performed by CYP2B6 [2]. In the present study, ritonavir was used to investigate the effect of the inhibition of CYP3A and possibly other CYPs on the prasugrel AM pharmacokinetics. In the present study, ritonavir ...
... the bioactivation of oxo-prasugrel to prasugrel AM is performed by CYP3A4 and 2–26% is performed by CYP2B6 [2]. In the present study, ritonavir was used to investigate the effect of the inhibition of CYP3A and possibly other CYPs on the prasugrel AM pharmacokinetics. In the present study, ritonavir ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Drugs increase the volume or decrease the viscosity of respiratory secretions, facilitate their removal by ciliary action and coughing. 1.1Mucolytic expectorants: Drugs alter chemical characteristics of sputum to decrease its viscosity and to facilitate its removal by ciliary action or coughing. eg. ...
... Drugs increase the volume or decrease the viscosity of respiratory secretions, facilitate their removal by ciliary action and coughing. 1.1Mucolytic expectorants: Drugs alter chemical characteristics of sputum to decrease its viscosity and to facilitate its removal by ciliary action or coughing. eg. ...
Lilly A. Johnson 4041 Lauri Jo Drive
... CFR 330.10) were unlawful to the extent that they authorized the marketing of Category III drugs after a final monograph had been established. Accordin$y, this provision is now deleted from the regulations. The regulations now provide that any testing necessary to resolve the safety or effectiveness ...
... CFR 330.10) were unlawful to the extent that they authorized the marketing of Category III drugs after a final monograph had been established. Accordin$y, this provision is now deleted from the regulations. The regulations now provide that any testing necessary to resolve the safety or effectiveness ...
This PDF is a selection from an out-of-print volume from... of Economic Research
... cocaine in order to obtain the alternative. A plausible hypothesis is that simply enriching an environment in which cocaine is available by introducing nondrug substitutes without any explicit contingencies between their availability and drug use may more effectively interfere with the initiation of ...
... cocaine in order to obtain the alternative. A plausible hypothesis is that simply enriching an environment in which cocaine is available by introducing nondrug substitutes without any explicit contingencies between their availability and drug use may more effectively interfere with the initiation of ...
Mucosal Protective Agents Prevent Exacerbation of NSAID
... according to the method described in our previous article (Takeuchi et al., 2002). In brief, rats were anesthetized with urethane (1.25 g/kg i.p.) and a midline incision was performed to expose the small intestine. A thin, water-filled balloon, made from silicone rubber and attached to a polyethylen ...
... according to the method described in our previous article (Takeuchi et al., 2002). In brief, rats were anesthetized with urethane (1.25 g/kg i.p.) and a midline incision was performed to expose the small intestine. A thin, water-filled balloon, made from silicone rubber and attached to a polyethylen ...
Psychomotor Stimulants (part 1)
... – separate cocaine base from the salt form – cocaine base vaporizes at 90°C – average temperature for tobacco burning (400-600°C) only 6% of the drug survives pyrolysis – users smoking from a glass pipe will consume less than 50% of the drug ...
... – separate cocaine base from the salt form – cocaine base vaporizes at 90°C – average temperature for tobacco burning (400-600°C) only 6% of the drug survives pyrolysis – users smoking from a glass pipe will consume less than 50% of the drug ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.