September 2006 - Highmark Blue Shield
... the only product available within this therapeutic category. Aliskeren is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Most exposure to date is with diuretics and an angiotensin receptor blocker (ARB), valsartan. Use with max ...
... the only product available within this therapeutic category. Aliskeren is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. Most exposure to date is with diuretics and an angiotensin receptor blocker (ARB), valsartan. Use with max ...
UKMi FAQ 18 - NHS Evidence Search
... Medicines Q&As patient factors such as age and race compared with other antihypertensive agents such as ACE inhibitors.(6) Current advice from NICE recommends calcium channel blockers as potential first line agents in older patients (over 55 years) or black patients of any age and as potential seco ...
... Medicines Q&As patient factors such as age and race compared with other antihypertensive agents such as ACE inhibitors.(6) Current advice from NICE recommends calcium channel blockers as potential first line agents in older patients (over 55 years) or black patients of any age and as potential seco ...
Aldehyde Oxidase Activity in Donor
... Unfortunately, all these aforementioned examples of early clinical failures can be attributed to a lack of complete understanding of metabolic clearance mechanisms because in vitro metabolism studies were only conducted in microsomal liver fractions. In the drug discovery setting, use of human hepat ...
... Unfortunately, all these aforementioned examples of early clinical failures can be attributed to a lack of complete understanding of metabolic clearance mechanisms because in vitro metabolism studies were only conducted in microsomal liver fractions. In the drug discovery setting, use of human hepat ...
Committee on Drugs 1998;101;1079 Pediatrics
... signs in cocaine-exposed infants have used scoring systems designed to assess opiate withdrawal. Some of the signs of opiate abstinence are commonly scored (Tables 3 and 4), but these signs are toxic effects of cocaine rather than evidence of withdrawal. Cocaine or its metabolites have been found in ...
... signs in cocaine-exposed infants have used scoring systems designed to assess opiate withdrawal. Some of the signs of opiate abstinence are commonly scored (Tables 3 and 4), but these signs are toxic effects of cocaine rather than evidence of withdrawal. Cocaine or its metabolites have been found in ...
Ergogenic Aids
... treatment. Side effects of some ergogenic aids can affect heart rate, blood pressure, or other physiologic measures. Individuals using injectable drugs are at risk for disease transmission from shared needle~.~.9 Adolescents and their parents often look to physical therapists providing sports physic ...
... treatment. Side effects of some ergogenic aids can affect heart rate, blood pressure, or other physiologic measures. Individuals using injectable drugs are at risk for disease transmission from shared needle~.~.9 Adolescents and their parents often look to physical therapists providing sports physic ...
A clickable analogue of ketamine retains NMDA receptor activity
... activity following ketamine (50 mg/kg), norketamine, A-NK, and A-NK-amide (100 mg/kg each) did not differ among drugs or against vehicle control (Fig. 2a; n = 5 for each group), suggesting no anesthetic effects of any of the drugs. Doses were chosen based on relatively potencies from previous work1 ...
... activity following ketamine (50 mg/kg), norketamine, A-NK, and A-NK-amide (100 mg/kg each) did not differ among drugs or against vehicle control (Fig. 2a; n = 5 for each group), suggesting no anesthetic effects of any of the drugs. Doses were chosen based on relatively potencies from previous work1 ...
IPA Users Guide - Thomson Reuters
... Abstract ..............................................................................................................................................................26 Index Terms and Thesaurus Terms .................................................................................................. ...
... Abstract ..............................................................................................................................................................26 Index Terms and Thesaurus Terms .................................................................................................. ...
Analysis of 3, 4-Methylenedioxymethamphetamine (MDMA) and its
... metabolites found were MDA, HMA, 3,4-dihydroxymethamphetamine (HHMA),3-hydroxy-4-methoxymethamphetamine, and 3,4-methylenedioxyphenylacetone (38). In a single patient, controlled study, unchanged MDMAwas the major urinary excretion product, and MDAwas the only metabolite identified after the ingesti ...
... metabolites found were MDA, HMA, 3,4-dihydroxymethamphetamine (HHMA),3-hydroxy-4-methoxymethamphetamine, and 3,4-methylenedioxyphenylacetone (38). In a single patient, controlled study, unchanged MDMAwas the major urinary excretion product, and MDAwas the only metabolite identified after the ingesti ...
Bulletin #106
... the issue of wet nebulization in “Breathing Easier: Opportunities to improve the quality of asthma care in Saskatchewan.” The Health Quality Council stated, “the Canadian Asthma Consensus Guidelines discourage the use of wet nebulized drugs because more effective and less expensive drugpowdered form ...
... the issue of wet nebulization in “Breathing Easier: Opportunities to improve the quality of asthma care in Saskatchewan.” The Health Quality Council stated, “the Canadian Asthma Consensus Guidelines discourage the use of wet nebulized drugs because more effective and less expensive drugpowdered form ...
full text
... the Ca-ATPase enzymatic cycle during the steady state of the reactions were different under both conditions12. Because Ca-ATPase undergoes conformational changes throughout its cycle, different affinities of any inhibitory drug could be expected for each of the different enzymatic conformations; thu ...
... the Ca-ATPase enzymatic cycle during the steady state of the reactions were different under both conditions12. Because Ca-ATPase undergoes conformational changes throughout its cycle, different affinities of any inhibitory drug could be expected for each of the different enzymatic conformations; thu ...
Controlled release of dexamethasone to the inner ear from
... from disabling hearing loss, meaning a loss of 40 or 30 dB in the better hearing ear in adults and children respectively (1). In the USA 15 % of the population over 18 reported at least minor changes in hearing capacities (classification from “a little bit of trouble hearing” to “deaf”) (2). Hearing ...
... from disabling hearing loss, meaning a loss of 40 or 30 dB in the better hearing ear in adults and children respectively (1). In the USA 15 % of the population over 18 reported at least minor changes in hearing capacities (classification from “a little bit of trouble hearing” to “deaf”) (2). Hearing ...
check these out from a debate on legalizing
... nicotine, usually when they are too young to do so legally... There is no evidence that marijuana serves as a stepping stone on the basis of its particular physiological effect." (March 1999) IOM ...
... nicotine, usually when they are too young to do so legally... There is no evidence that marijuana serves as a stepping stone on the basis of its particular physiological effect." (March 1999) IOM ...
First Do No Harm: Responding to Canada`s Prescription Drug Crisis
... his doctor prescribed him more than 13,000 pills in a period of 14½ months. The day before his death Michael was prescribed a drug he had never taken before — Dilaudid®. The active ingredient in Dilaudid is hydromorphone, one of the most powerful opioids ever synthesized. The next morning Michael ne ...
... his doctor prescribed him more than 13,000 pills in a period of 14½ months. The day before his death Michael was prescribed a drug he had never taken before — Dilaudid®. The active ingredient in Dilaudid is hydromorphone, one of the most powerful opioids ever synthesized. The next morning Michael ne ...
cardiovascular effects of ketamine in the pithed rat, rabbit and cat
... mesylate (Rogitine, CIBA), reserpine, tyramine hydrochloride (Sigma Laboratories). With the exception of halothane and reserpine, all drugs were administered i.v. ...
... mesylate (Rogitine, CIBA), reserpine, tyramine hydrochloride (Sigma Laboratories). With the exception of halothane and reserpine, all drugs were administered i.v. ...
Assessment of the Influence of Histaminergic Actions on Cocaine
... completion of the FR 20 response requirement. Food presentation was followed by a 20-s time-out during which all lights were off, and responses had no scheduled consequences other than the feedback click. Sessions ended after 20 food presentations or 15 min, whichever occurred first. Sessions were c ...
... completion of the FR 20 response requirement. Food presentation was followed by a 20-s time-out during which all lights were off, and responses had no scheduled consequences other than the feedback click. Sessions ended after 20 food presentations or 15 min, whichever occurred first. Sessions were c ...
An Exploratory Human Laboratory Experiment Evaluating Vaporized
... astrocytes) 92. Inflammatory mediators released by activated glial cells include tumor necrosis ...
... astrocytes) 92. Inflammatory mediators released by activated glial cells include tumor necrosis ...
Hands-on session: Cox proportional hazard analysis
... Single-Factor ANOVA Power and Sample size • Increase the sample size. With larger samples the standard error of the estimate of effect size is smaller. The effect is estimated with more precision. Roughly, the precision increases in proportion to the square root of the sample size. • Accept less pr ...
... Single-Factor ANOVA Power and Sample size • Increase the sample size. With larger samples the standard error of the estimate of effect size is smaller. The effect is estimated with more precision. Roughly, the precision increases in proportion to the square root of the sample size. • Accept less pr ...
Cocaine Addiction
... threatening dilemma. Not only is it difficult for the addict, professionals. To make a successful recovery, the addict it is extremely hard on those around them who care about needs new tools in order to deal with situations and © Copyright 2002 - 2012 by HeartsOfHope - All Rights Reserved. them. Fo ...
... threatening dilemma. Not only is it difficult for the addict, professionals. To make a successful recovery, the addict it is extremely hard on those around them who care about needs new tools in order to deal with situations and © Copyright 2002 - 2012 by HeartsOfHope - All Rights Reserved. them. Fo ...
Enhancement of naturally acquired immunity against malaria by
... and Zambia, which previously reported reductions, illustrate the fragility of the current successes. This underlines the need for additional and innovative strategies. Availability of an effective vaccine would greatly contribute to malaria control and elimination. It is well known that clinical imm ...
... and Zambia, which previously reported reductions, illustrate the fragility of the current successes. This underlines the need for additional and innovative strategies. Availability of an effective vaccine would greatly contribute to malaria control and elimination. It is well known that clinical imm ...
Synergistic interaction between metformin and
... and were significantly higher than the actual observed experimental ED50 values (7.57 mg/kg and 8.43 mg/kg, respectively). cOncluSIOn: Pretreatment with glibenclamide, glipizide or metformin blocked DIA in a dose-dependent manner, and combining either sulfonylurea with metformin produced even greate ...
... and were significantly higher than the actual observed experimental ED50 values (7.57 mg/kg and 8.43 mg/kg, respectively). cOncluSIOn: Pretreatment with glibenclamide, glipizide or metformin blocked DIA in a dose-dependent manner, and combining either sulfonylurea with metformin produced even greate ...
Dept. of Quality Assurance
... widely used technique called swab testing. Clean wet, swabs are applied to areas that have been cleaned and an extract of that swab is analyzed to show the effectiveness of that cleaning. Swab testing, however, is expensive and time consuming, but sampling does not represent the entire part of equip ...
... widely used technique called swab testing. Clean wet, swabs are applied to areas that have been cleaned and an extract of that swab is analyzed to show the effectiveness of that cleaning. Swab testing, however, is expensive and time consuming, but sampling does not represent the entire part of equip ...
Drug formulary - Johns Hopkins University
... (Buprenorphine, Fentanyl, Butorphanol, Oxymorphone, etc.) administered at 5:00 PM will not be effective at 8:00 AM the next morning. Thus, administration after typical business hours, use of extended release formulations, and/or trans‐dermal patch can be considered depending on the species. Current ...
... (Buprenorphine, Fentanyl, Butorphanol, Oxymorphone, etc.) administered at 5:00 PM will not be effective at 8:00 AM the next morning. Thus, administration after typical business hours, use of extended release formulations, and/or trans‐dermal patch can be considered depending on the species. Current ...
Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer`s
... Etminan et al. 2003). Nonetheless, given the failure of recent clinical trials, the potential of NSAIDs for the treatment of AD is still a matter of debate (Aisen et al. 2003; Reines et al. 2004). This failure could be due to a number of factors, e.g. the selection of patients which already had mild ...
... Etminan et al. 2003). Nonetheless, given the failure of recent clinical trials, the potential of NSAIDs for the treatment of AD is still a matter of debate (Aisen et al. 2003; Reines et al. 2004). This failure could be due to a number of factors, e.g. the selection of patients which already had mild ...
Positive and negative ion mode ESI-MS and MS/MS for - ORBi
... Introduction Since intact noncovalent complexes have been observed for the first time by electrospray mass spectrometry [1], the interest in the field has constantly been growing, and ESI-MS has now analytical applications for the study of noncovalent complexes, notably for the determination of the ...
... Introduction Since intact noncovalent complexes have been observed for the first time by electrospray mass spectrometry [1], the interest in the field has constantly been growing, and ESI-MS has now analytical applications for the study of noncovalent complexes, notably for the determination of the ...
toxicity - Bighorn Botanicals Inc
... 2) Another confusing issue regarding toxicity of Taxus brevifolia is also a case of ‘guilt-by-association’. Adverse effects of chemotherapeutic drugs produced from Taxus brevifolia (Taxol) and Taxus baccata (Paclitaxel) are different than herbal preparations of Taxus brevifolia. “The ethanol:Cremoph ...
... 2) Another confusing issue regarding toxicity of Taxus brevifolia is also a case of ‘guilt-by-association’. Adverse effects of chemotherapeutic drugs produced from Taxus brevifolia (Taxol) and Taxus baccata (Paclitaxel) are different than herbal preparations of Taxus brevifolia. “The ethanol:Cremoph ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.