Exporter la page en pdf
... The SANT domain is a nucleosome recognition module found in transcriptional regulatory proteins, including chromatin-modifying enzymes. It shows high functional degeneracy between species, varying in sequence and copy number. Here, we investigate functions in vivo associated with two SANT motifs, SA ...
... The SANT domain is a nucleosome recognition module found in transcriptional regulatory proteins, including chromatin-modifying enzymes. It shows high functional degeneracy between species, varying in sequence and copy number. Here, we investigate functions in vivo associated with two SANT motifs, SA ...
Gene regulation - Department of Plant Sciences
... Extreme trans-acting effectors of transcription: TAL effectors • From plant pathogenic bacteria Xanthomonas • Secreted by bacteria when they infect • Transcriptional activator-like (TAL) effectors bind with plant promoters to express genes beneficial for the bacteria ...
... Extreme trans-acting effectors of transcription: TAL effectors • From plant pathogenic bacteria Xanthomonas • Secreted by bacteria when they infect • Transcriptional activator-like (TAL) effectors bind with plant promoters to express genes beneficial for the bacteria ...
Chromatin modifying activity of leukaemia associated fusion proteins
... contribute to maintain chromatin in the condensed state (6). ...
... contribute to maintain chromatin in the condensed state (6). ...
Gene Section MYST4 (MYST histone acetyltransferase (monocytic leukemia) 4)
... Schematic representation of MYST4 protein. H15 domain: domain in histone families 1 and 5; PHD zinc fingers: plant homeodomain (PHD) with a C4HC3-type motif, this domain is widely distributed in eukaryotes and it has been found in many chromatin regulatory factors; MOZ-SAS family region: this region ...
... Schematic representation of MYST4 protein. H15 domain: domain in histone families 1 and 5; PHD zinc fingers: plant homeodomain (PHD) with a C4HC3-type motif, this domain is widely distributed in eukaryotes and it has been found in many chromatin regulatory factors; MOZ-SAS family region: this region ...
Looking Beyond Our DNA - Federation of American Societies for
... of the cells in the body have the same DNA sequence, but differences in the “punctuation” in certain genes determine when and how they are turned on (gene activation). It is these differences in the activation of genes that result in a broad array of cell types with various functions (i.e., muscle, ...
... of the cells in the body have the same DNA sequence, but differences in the “punctuation” in certain genes determine when and how they are turned on (gene activation). It is these differences in the activation of genes that result in a broad array of cell types with various functions (i.e., muscle, ...
Molecular Cell Biology Prof. D. Karunagaran Department of
... Nearly half of these bonds form between the amino acid backbone of the histones and the phosphodiester backbone of the DNA. ...
... Nearly half of these bonds form between the amino acid backbone of the histones and the phosphodiester backbone of the DNA. ...
DNA Control Mechanisms
... Gene control during transcription (A through F are associated with transcription.) A. Is the DNA in a state of Heterochromatin vs. Euchromatin? B. DNA Methylation of the DNA 1. This refers to putting a heavy “coat” of methyl (CH3 ) groups of the DNA, thus preventing transcription from occurring. The ...
... Gene control during transcription (A through F are associated with transcription.) A. Is the DNA in a state of Heterochromatin vs. Euchromatin? B. DNA Methylation of the DNA 1. This refers to putting a heavy “coat” of methyl (CH3 ) groups of the DNA, thus preventing transcription from occurring. The ...
THE STRUCTURE OF CHROMATIN
... useful term, as long as we do not consider it to be just some amorphous substance. Chromatin is very structured. We cannot understand how the nucleus “works” unless we understand this structure. (When genes are active in a chromosome then of course transcription is occurring. Then the chromosome, an ...
... useful term, as long as we do not consider it to be just some amorphous substance. Chromatin is very structured. We cannot understand how the nucleus “works” unless we understand this structure. (When genes are active in a chromosome then of course transcription is occurring. Then the chromosome, an ...
Chapter 18 - Regulation of Gene Expression - Bio-Guru
... • Certain molecules such as maternal mRNAs, transcription factors and other proteins are localized in specific cytoplasmic regions of the unfertilized egg or zygote • These molecules affect cell fate decisions by segregating into different embryonic cells and controlling distinct gene activities in ...
... • Certain molecules such as maternal mRNAs, transcription factors and other proteins are localized in specific cytoplasmic regions of the unfertilized egg or zygote • These molecules affect cell fate decisions by segregating into different embryonic cells and controlling distinct gene activities in ...
Transcription start sites
... • genome can be generalised into seven different states • the function of some of these states is known – e.g. promoter Chromatin states: • the function of others is not known, but • The genome can be divided may explain the high level of into seven different types transcription and open chromatin • ...
... • genome can be generalised into seven different states • the function of some of these states is known – e.g. promoter Chromatin states: • the function of others is not known, but • The genome can be divided may explain the high level of into seven different types transcription and open chromatin • ...
BIOL 112 – Principles of Zoology
... Inverse relationship between degree of methylation and degree of expression Not a general mechanism in eukaryotes ...
... Inverse relationship between degree of methylation and degree of expression Not a general mechanism in eukaryotes ...
HGD- Gene Regulation in Eukaryotes.pptx
... i. Binding site for proteins that may effect the translation e.g. Iron responsive elements (also in 3’UTR) – regulate gene expression in response to iron. ii. Kozak sequence – RccAUGG, where R is a purine (A or G) 3 bases upstream of the start codon, follow by another G. ...
... i. Binding site for proteins that may effect the translation e.g. Iron responsive elements (also in 3’UTR) – regulate gene expression in response to iron. ii. Kozak sequence – RccAUGG, where R is a purine (A or G) 3 bases upstream of the start codon, follow by another G. ...
No Slide Title
... Formation of the enhanceosome and activation of RNA polymerase by coactivator are necessary for efficient transcription. Transcription of b-interferon gene is activated during viral infection. ...
... Formation of the enhanceosome and activation of RNA polymerase by coactivator are necessary for efficient transcription. Transcription of b-interferon gene is activated during viral infection. ...
Chromatin Structure 1
... I), at hypersensitive sites. These sites are found typically in the regulatory regions of actively transcribed, but they are absent from the same regions of genes that are transcriptionally silent. ...
... I), at hypersensitive sites. These sites are found typically in the regulatory regions of actively transcribed, but they are absent from the same regions of genes that are transcriptionally silent. ...
ppt
... into plant cells by Xanthomonas bacterial. They enter the nucleus, bind to effectorspecific promoter sequences, and activate the expression of individual plant genes, which can either benefit the bacterium or trigger plant defenses. ...
... into plant cells by Xanthomonas bacterial. They enter the nucleus, bind to effectorspecific promoter sequences, and activate the expression of individual plant genes, which can either benefit the bacterium or trigger plant defenses. ...
The presentation
... Genetic determinants of variation in expression levels may contribute to complex traits - phenotype is not just determined by coding regions Biochemical features associated with cis-regulatory modules are being determined genome-wide for a range of cell types. These can be used to predict CRMs, but ...
... Genetic determinants of variation in expression levels may contribute to complex traits - phenotype is not just determined by coding regions Biochemical features associated with cis-regulatory modules are being determined genome-wide for a range of cell types. These can be used to predict CRMs, but ...
Document
... 1. Cloning by nuclear transfer --> regenerate entire organism from transfer of single nucleus (e.g. Dolly) 2. Induced pluripotent stem cells (iPS) --> expression of 4 genes are sufficient to transform differentiated cells to “stem” cells ...
... 1. Cloning by nuclear transfer --> regenerate entire organism from transfer of single nucleus (e.g. Dolly) 2. Induced pluripotent stem cells (iPS) --> expression of 4 genes are sufficient to transform differentiated cells to “stem” cells ...
Chromatin structure - U of L Class Index
... in all cells at all times (DNA that is permanently silenced). The bulk of the constitutive heterochomatin is found in and around the centromere of each chromosome in mammals. The DNA of constitutive heterochromatin consists primarily of highly repeated sequences and contains relatively few genes. Wh ...
... in all cells at all times (DNA that is permanently silenced). The bulk of the constitutive heterochomatin is found in and around the centromere of each chromosome in mammals. The DNA of constitutive heterochromatin consists primarily of highly repeated sequences and contains relatively few genes. Wh ...
Slide 1
... from two different DNAbinding domains, each based on a homeodomain. each homeodomain has a helix-turn-helix motif with one helix inserted into the major groove of DNA ...
... from two different DNAbinding domains, each based on a homeodomain. each homeodomain has a helix-turn-helix motif with one helix inserted into the major groove of DNA ...
Establishing Structure-Activity Relationship of an Enzyme with
... a guanine deaminase. Additionally, it also exhibits a moonlighting activity towards ammeline deamination, which is an intermediate involved in the melamine pathway. A structural analysis of the member belonging to this superfamily reveals that although the core fold is conserved among all family mem ...
... a guanine deaminase. Additionally, it also exhibits a moonlighting activity towards ammeline deamination, which is an intermediate involved in the melamine pathway. A structural analysis of the member belonging to this superfamily reveals that although the core fold is conserved among all family mem ...
Histone acetyltransferase
Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.In general, histone acetylation is linked to transcriptional activation and associated with euchromatin. When it was first discovered, it was thought that acetylation of lysine neutralizes the positive charge normally present, thus reducing affinity between histone and (negatively charged) DNA, which renders DNA more accessible to transcription factors. Research has emerged, since, to show that lysine acetylation and other posttranslational modifications of histones generate binding sites for specific protein–protein interaction domains, such as the acetyllysine-binding bromodomain. Histone acetyltransferases can also acetylate non-histone proteins, such as nuclear receptors and other transcription factors to facilitate gene expression.