Imprinting capacity of gamete lineages in C. elegans
... digitized images of each animal using a CCD camera system. Based on the experimental measurement of total fluorescence integrated over each sample image, we obtain a total signal. These signals are then corrected, as appropriate, by background subtraction to obtain an essentially quantitative compar ...
... digitized images of each animal using a CCD camera system. Based on the experimental measurement of total fluorescence integrated over each sample image, we obtain a total signal. These signals are then corrected, as appropriate, by background subtraction to obtain an essentially quantitative compar ...
Biomarker for Spinal Muscular Atrophy: Expression
... unaided while exhibiting significant muscle weakness and a walking disability, and have a normal life expectancy. Type 4 is the mildest form of SMA with an onset in the fourth to sixth decade of life and a normal life expectancy. It is generally accepted that rather than a disease with discrete type ...
... unaided while exhibiting significant muscle weakness and a walking disability, and have a normal life expectancy. Type 4 is the mildest form of SMA with an onset in the fourth to sixth decade of life and a normal life expectancy. It is generally accepted that rather than a disease with discrete type ...
Tissue- and Development-specific Expression of Multiple
... Cloning and sequencing of cDNA by RACE from brain, kidney, heart, intestine, and embryo led to the identification of three different nNOS mRNA species that are designated as nNOSa, nNOSb, and nNOSc. nNOSa was overall the most abundant isoform, found especially in the brain, while nNOSb was almost ex ...
... Cloning and sequencing of cDNA by RACE from brain, kidney, heart, intestine, and embryo led to the identification of three different nNOS mRNA species that are designated as nNOSa, nNOSb, and nNOSc. nNOSa was overall the most abundant isoform, found especially in the brain, while nNOSb was almost ex ...
protein 2 gene: study of a cohort of Israeli patients - MRC
... Relative expression levels of MECP2_e1 and MECP2_e2 transcription isoforms were determined using primers designed by Primer Express software, TaqMan probes and PCR kit (all from Applied Biosystems). The MECP2_e1 assay, designed by us, included forward primer from exon 1 (59CGG AGG AGG AGG AGG A) and ...
... Relative expression levels of MECP2_e1 and MECP2_e2 transcription isoforms were determined using primers designed by Primer Express software, TaqMan probes and PCR kit (all from Applied Biosystems). The MECP2_e1 assay, designed by us, included forward primer from exon 1 (59CGG AGG AGG AGG AGG A) and ...
Analysis of acid-induced asr gene promoter of Enterobacteriaceae
... PhoB binding site (pho box). Transcription factor binding sites in bacterial genomes are usually long, consisting of ~30 bases and variable. Often most of their regulatory sequences are carried in two conserved subregions, each about 6 bases in length [16], which contain the predominant contacts wit ...
... PhoB binding site (pho box). Transcription factor binding sites in bacterial genomes are usually long, consisting of ~30 bases and variable. Often most of their regulatory sequences are carried in two conserved subregions, each about 6 bases in length [16], which contain the predominant contacts wit ...
VegT activates Bix4 to specify endodermal
... detected, however, with increased levels of MgCl2 and VegT protein in the binding reaction (not shown). To ask whether VegT activates Bix4 expression through direct interaction with these sites, we made transgenic Xenopus embryos in which the 1.6 kb Bix4 upstream regulatory sequence was used to driv ...
... detected, however, with increased levels of MgCl2 and VegT protein in the binding reaction (not shown). To ask whether VegT activates Bix4 expression through direct interaction with these sites, we made transgenic Xenopus embryos in which the 1.6 kb Bix4 upstream regulatory sequence was used to driv ...
Dynamic Model of Paclitaxel Biosynthesis Suggests That the Key
... Paclitaxel, isolated from the bark of several Taxus species, is diterpene alkaloid with remarkable anticancer propertiese specially effective against breast cancer and non-small cell lung cancer [1].The most promising and environmentally friendly way for the sustainable production of paclitaxel is p ...
... Paclitaxel, isolated from the bark of several Taxus species, is diterpene alkaloid with remarkable anticancer propertiese specially effective against breast cancer and non-small cell lung cancer [1].The most promising and environmentally friendly way for the sustainable production of paclitaxel is p ...
Evidence-based guidelines for treating depressive
... unfortunately are too often lacking in relation to the key questions of interest; there remain extensive gaps in the evidence base. Thus, we have taken the decision to include indirect meta-analytic comparisons (e.g. network meta-analysis methods) where other evidence is lacking, but we acknowledge ...
... unfortunately are too often lacking in relation to the key questions of interest; there remain extensive gaps in the evidence base. Thus, we have taken the decision to include indirect meta-analytic comparisons (e.g. network meta-analysis methods) where other evidence is lacking, but we acknowledge ...
Epigenetics for behavioral ecologists
... In addition to genome-wide studies of methylation changes, the study of “epialleles”—alternate, stable epigenetic states of the same gene—could provide ecologists with a tool for characterizing epigenetic processes within and across rapidly evolving populations (Kalisz and Purugganan 2004). Epiallel ...
... In addition to genome-wide studies of methylation changes, the study of “epialleles”—alternate, stable epigenetic states of the same gene—could provide ecologists with a tool for characterizing epigenetic processes within and across rapidly evolving populations (Kalisz and Purugganan 2004). Epiallel ...
Depression and Anxiety in end stage renal disease patients
... (ESRD) in dialysis (n=109) from four dialysis units in Norway, were to identify the prevalence of depression, anxiety and somatoform disorders, as well as the relationship between these disorders, biological markers, health-related quality of life (HRQOL) and mortality. We intended to identify scree ...
... (ESRD) in dialysis (n=109) from four dialysis units in Norway, were to identify the prevalence of depression, anxiety and somatoform disorders, as well as the relationship between these disorders, biological markers, health-related quality of life (HRQOL) and mortality. We intended to identify scree ...
A novel C. elegans zinc finger transcription factor, lsy
... morphologically bilaterally symmetric taste-receptor neurons ASEL and ASER develop from a common ground state to express a number of features that are specific for ASEL versus ASER (Fig. 1A). These left/right asymmetric features include the expression of several putative chemoreceptors of the GCY fa ...
... morphologically bilaterally symmetric taste-receptor neurons ASEL and ASER develop from a common ground state to express a number of features that are specific for ASEL versus ASER (Fig. 1A). These left/right asymmetric features include the expression of several putative chemoreceptors of the GCY fa ...
Targeting gene expression to cones with human cone opsin
... neurotrophic or cone survival factors, could provide rescue and sustained cone function. For these therapeutic investigations, dogs represent a valuable model for the development of cone-directed gene therapy, especially since two canine achromatopsic lines exist with either a genomic deletion (that ...
... neurotrophic or cone survival factors, could provide rescue and sustained cone function. For these therapeutic investigations, dogs represent a valuable model for the development of cone-directed gene therapy, especially since two canine achromatopsic lines exist with either a genomic deletion (that ...
KAIE LOKK Comparative genome-wide DNA methylation
... the genome (Busche et al., 2015). The remaining unmethylated CpG dinucleotides are mostly grouped in dense clusters called CpG islands (CGIs), and these are often found near gene promoters and other regulatory regions. Housekeeping genes have CGIs proximal to their promoters, and these CGIs are typi ...
... the genome (Busche et al., 2015). The remaining unmethylated CpG dinucleotides are mostly grouped in dense clusters called CpG islands (CGIs), and these are often found near gene promoters and other regulatory regions. Housekeeping genes have CGIs proximal to their promoters, and these CGIs are typi ...
X-adrenoleukodystrophy
... which is caused by a mutation in the ABCD1 (ALD) gene which usually results in the loss of a functional protein. This results in the build up of very long chain fatty acids (VLCFAs), demyelination in the central and peripheral nervous system and impaired function of the adrenal glands. In this study ...
... which is caused by a mutation in the ABCD1 (ALD) gene which usually results in the loss of a functional protein. This results in the build up of very long chain fatty acids (VLCFAs), demyelination in the central and peripheral nervous system and impaired function of the adrenal glands. In this study ...
B-Bolivia, an Allele of the Maize b1 Gene with Variable Expression
... this difference between the average values was not statistically significant. These results indicate that the on or off pigment expression state of a particular seed is not heritable because both types produce similar numbers of colored kernels in progeny. The loss of pigment that occurs upon male t ...
... this difference between the average values was not statistically significant. These results indicate that the on or off pigment expression state of a particular seed is not heritable because both types produce similar numbers of colored kernels in progeny. The loss of pigment that occurs upon male t ...
True Remission in Depression: The Ultimate Goal
... will rank in second position among all diseases in terms of prevalence by the year 2010, thus contributing heavily to the global burden of disease in humans. Advances in the treatment of depressive disorders will therefore constitute a major challenge for the medical community and for society in the ...
... will rank in second position among all diseases in terms of prevalence by the year 2010, thus contributing heavily to the global burden of disease in humans. Advances in the treatment of depressive disorders will therefore constitute a major challenge for the medical community and for society in the ...
In vitro fertilization (IVF) in mammals: epigenetic and developmental
... He named this process Epigenetics, which is now understood as the conditions that control the expression of genes that are highly influenced by environment. A more precise definition is: “The study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a ...
... He named this process Epigenetics, which is now understood as the conditions that control the expression of genes that are highly influenced by environment. A more precise definition is: “The study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a ...