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DNA Bases Beyond Watson and Crick
DNA Bases Beyond Watson and Crick

... the new nucleobases 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5carboxycytosine (caC).1 These nucleobases seem to play an important role in epigenetic reprogramming of stem cells and some of these bases are also detected at relatively high levels in brain tissues. I will present new s ...
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... enhanced therapeutic potency of MSCs. Employing a newly synthesized fluorescent probe (FreSH tracer) which exhibit reversible reaction with various thiol-compounds by forming thioether adduct, Human embryonic stem cells (hES) derived MSC (hES-MSC) were FACS sorted as GSHhigh verus GSHlow fractions. ...
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... mark of histone H3K9 methylation and its ligand HP-1, may need revision. Moreover, the ability of a multicellular organism to survive and differentiate without H3K9 methylation is unlikely to be unique to C. elegans, since the relevant HMTs are quite conserved: MET-2 is the homolog of human SetDB1 o ...
Epigenetics: Biologic Targets, Biomarkers and Role in Disease
Epigenetics: Biologic Targets, Biomarkers and Role in Disease

... between individuals of each species, epigenetic variation accounts for the vast differences in function and appearance of tissues in each multicellular organism. Epigenetic regulation includes chromatin organization and modification of histone tails to provide a “code” for the expression or silencin ...
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B5 Revision questions - Blackpool Aspire Academy

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Introduction to Epigenetics - BITS Embryo

... • Well-established paradigm of how genetic information is transcribed and translated • Human genome project has given plenty of data, which is still being mined for useful information • An estimated 140,000 proteins in the human body • Different cells express a different subset of proteins • Yet alm ...
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Epigenetics in stem-cell differentiation

Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on its position within the body. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence.The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells are controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.This regulation of chromatin through epigenetic modifications is a molecular mechanism that will determine whether the cell will continue to differentiate into the desired fate. A research study performed by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells.
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