PURINE & PYRIMIDINE METABOLISM
... Purine and pyrimidine biosynthesis are coordinately regulated through PRPP. In purine synthesis is regulated through the first and second enzymes. In pyrimidine synthesis, carbamoyl phosphate synthase II is inhibited by UTP and purine nucleotides, but activated by PRPP. Aspartate transcarbamoy ...
... Purine and pyrimidine biosynthesis are coordinately regulated through PRPP. In purine synthesis is regulated through the first and second enzymes. In pyrimidine synthesis, carbamoyl phosphate synthase II is inhibited by UTP and purine nucleotides, but activated by PRPP. Aspartate transcarbamoy ...
Allosteric Inhibition of Aminoglycoside Phosphotransferase by a
... designed AR proteins. The AR protein binds the C-terminal lobe of APH and thereby stabilizes three ␣ helices, which are necessary for substrate binding, in a significantly displaced conformation. BIAcore analysis and kinetic enzyme inhibition experiments are consistent with the proposed allosteric i ...
... designed AR proteins. The AR protein binds the C-terminal lobe of APH and thereby stabilizes three ␣ helices, which are necessary for substrate binding, in a significantly displaced conformation. BIAcore analysis and kinetic enzyme inhibition experiments are consistent with the proposed allosteric i ...
A Novel Role for Vitamin K1 in a Tyrosine Phosphorylation
... facilitate the binding of vitamin K-dependent proteins to membrane phospholipids in the presence of calcium (4, 5). The vitamin K1 level in the mammalian fetus is tightly regulated by a maternal/fetal placental gradient (6); the median vitamin K1 concentration in human cord plasma is 16 pg/ml as com ...
... facilitate the binding of vitamin K-dependent proteins to membrane phospholipids in the presence of calcium (4, 5). The vitamin K1 level in the mammalian fetus is tightly regulated by a maternal/fetal placental gradient (6); the median vitamin K1 concentration in human cord plasma is 16 pg/ml as com ...
Metabolic regulation of Escherichia coli cultivated under anaerobic
... where the expected result is rarely obtained for strain improvement. The main reason is due to limited knowledge on the metabolic changes caused by gene level and enzyme level regulation. Here, an attempt is made to clarify the regulation mechanisms for the several specific gene knockout mutants und ...
... where the expected result is rarely obtained for strain improvement. The main reason is due to limited knowledge on the metabolic changes caused by gene level and enzyme level regulation. Here, an attempt is made to clarify the regulation mechanisms for the several specific gene knockout mutants und ...
Plant Mitochondrial Electron Transfer and Molecular
... Douce and Neuburger, 1989; Siedow, 1995). In addition to complex I, most plant mitochondria contain two other NAD(P)H dehydrogenases: one facing the n-side of the inner mitochondrial membrane, and the other facing the p-side of the membrane(M0ller and Lin, 1986; Douce and Neuburger, 1989). The addit ...
... Douce and Neuburger, 1989; Siedow, 1995). In addition to complex I, most plant mitochondria contain two other NAD(P)H dehydrogenases: one facing the n-side of the inner mitochondrial membrane, and the other facing the p-side of the membrane(M0ller and Lin, 1986; Douce and Neuburger, 1989). The addit ...
Plant Mitochondrial Electron Transfer and Molecular
... Douce and Neuburger, 1989; Siedow, 1995). In addition to complex I, most plant mitochondria contain two other NAD(P)H dehydrogenases: one facing the n-side of the inner mitochondrial membrane, and the other facing the p-side of the membrane(M0ller and Lin, 1986; Douce and Neuburger, 1989). The addit ...
... Douce and Neuburger, 1989; Siedow, 1995). In addition to complex I, most plant mitochondria contain two other NAD(P)H dehydrogenases: one facing the n-side of the inner mitochondrial membrane, and the other facing the p-side of the membrane(M0ller and Lin, 1986; Douce and Neuburger, 1989). The addit ...
Bioinformatics approaches for functional
... is not well documented compared with their structural aspects. In this comprehensive review, we elaborately focus on three aspects of membrane protein functions: (i) databases for different types of membrane proteins based on their functions including transporters, receptors and ion channels, annota ...
... is not well documented compared with their structural aspects. In this comprehensive review, we elaborately focus on three aspects of membrane protein functions: (i) databases for different types of membrane proteins based on their functions including transporters, receptors and ion channels, annota ...
29 Pathways of Sugar Metabolism: Pentose
... seminal fluid. Spermatozoa use fructose as a major fuel source while in the seminal fluid and then switch to glucose once in the female reproductive tract. Utilization of fructose is thought to prevent acrosomal breakdown of the plasma membrane (and consequent activation) while the spermatozoa are s ...
... seminal fluid. Spermatozoa use fructose as a major fuel source while in the seminal fluid and then switch to glucose once in the female reproductive tract. Utilization of fructose is thought to prevent acrosomal breakdown of the plasma membrane (and consequent activation) while the spermatozoa are s ...
Microbial degradation of chloroaromatics Mars, Astrid E.
... Pseudomonas putida GJ31 is able to simultaneously grow on toluene and chlorobenzene. When cultures of this strain were inhibited with 3-fluorocatechol while growing on toluene or chlorobenzene, 3-methylcatechol or 3-chlorocatechol, respectively, accumulated in the medium. To establish the catabolic ...
... Pseudomonas putida GJ31 is able to simultaneously grow on toluene and chlorobenzene. When cultures of this strain were inhibited with 3-fluorocatechol while growing on toluene or chlorobenzene, 3-methylcatechol or 3-chlorocatechol, respectively, accumulated in the medium. To establish the catabolic ...
Additional file 1
... Hydrolyze phospholipids for the release of secondary messenger that participate in different signal transduction pathway Lipid metabolism ...
... Hydrolyze phospholipids for the release of secondary messenger that participate in different signal transduction pathway Lipid metabolism ...
GmPep914, an Eight-Amino Acid Peptide Isolated
... increase in the extracellular pH of the media (Felix and Boller, 1995). An alkalinization assay was developed in the Ryan laboratory that has been a key to the purification of the defense peptides HypSys and AtPeps, as well as the peptide Rapid Alkalinization Factor (Pearce et al., 2001b), which is ...
... increase in the extracellular pH of the media (Felix and Boller, 1995). An alkalinization assay was developed in the Ryan laboratory that has been a key to the purification of the defense peptides HypSys and AtPeps, as well as the peptide Rapid Alkalinization Factor (Pearce et al., 2001b), which is ...
Cuvier meets Watson and Crick: the utility of molecules as classical
... The examples of tyrosine and lysine demonstrate what may be a common problem in biology-otherwise indistinguishable structures formed by different developmental pathways. What do we call homologous in this situation? While a molecule of tyrosine in a bacterium may not be homologous to a molecule of ...
... The examples of tyrosine and lysine demonstrate what may be a common problem in biology-otherwise indistinguishable structures formed by different developmental pathways. What do we call homologous in this situation? While a molecule of tyrosine in a bacterium may not be homologous to a molecule of ...
BAFF, APRIL and their receptors: Structure, function - Serval
... 60-mer formation in the mouse, although this has not been formally demonstrated. In both species, alternative splice variants, in which exon 3 (exon 4 in the mouse) is skipped, generate an in-frame deletion of the first -sheet of the THD to produce a splice variant called BAFF (Figs. 1A, 2 and 3A) ...
... 60-mer formation in the mouse, although this has not been formally demonstrated. In both species, alternative splice variants, in which exon 3 (exon 4 in the mouse) is skipped, generate an in-frame deletion of the first -sheet of the THD to produce a splice variant called BAFF (Figs. 1A, 2 and 3A) ...
Deriving phylogenetic trees from the similarity analysis of metabolic
... Understanding of evolutionary relationships may be further expanded by comparing higher-level functional components among species, such as metabolic pathways. In such pathways, enzymes, substrates, and reactions are grouped conceptually into networks as part of a dynamic information processing syste ...
... Understanding of evolutionary relationships may be further expanded by comparing higher-level functional components among species, such as metabolic pathways. In such pathways, enzymes, substrates, and reactions are grouped conceptually into networks as part of a dynamic information processing syste ...
PDF
... et al., 2001). Despite receiving two signals that promote opposing fates, the cell is still able to resolve these inputs into a robust cell-fate decision. Commonly, this is resolved into a WntON/Notch-OFF response (Uyttendaele et al., 1998). However, how this occurs mechanistically is poorly underst ...
... et al., 2001). Despite receiving two signals that promote opposing fates, the cell is still able to resolve these inputs into a robust cell-fate decision. Commonly, this is resolved into a WntON/Notch-OFF response (Uyttendaele et al., 1998). However, how this occurs mechanistically is poorly underst ...
PDF
... BMP and Wnt signaling pathways play a crucial role in organogenesis, including tooth development. Despite extensive studies, the exact functions, as well as if and how these two pathways act coordinately in regulating early tooth development, remain elusive. In this study, we dissected regulatory fu ...
... BMP and Wnt signaling pathways play a crucial role in organogenesis, including tooth development. Despite extensive studies, the exact functions, as well as if and how these two pathways act coordinately in regulating early tooth development, remain elusive. In this study, we dissected regulatory fu ...
Quantitative iTRAQ Proteomics Revealed Possible Roles for
... Liu et al., 2009), and the MATE (multidrug and toxic compound extrusion) family of citrate efflux transporters in sorghum, barley, and Arabidopsis (Furukawa et al., 2007; Magalhaes et al., 2007; Liu et al., 2009). As much as 90% of the root Al is localized to negatively charged carboxyl residues in ...
... Liu et al., 2009), and the MATE (multidrug and toxic compound extrusion) family of citrate efflux transporters in sorghum, barley, and Arabidopsis (Furukawa et al., 2007; Magalhaes et al., 2007; Liu et al., 2009). As much as 90% of the root Al is localized to negatively charged carboxyl residues in ...
Chapter 18
... However, LDL-mediated endocytosis is not a factor for the development of atherosclerosis: Two reasons, still atherosclerosis 1. Intracellular regulation: LDLR gene activity is cholesterol-dependent; High intracellular cholesterol →insig/SCAP/SREBP pathway ↓→ LDLR gene regulation ↓→ low LDLR gene exp ...
... However, LDL-mediated endocytosis is not a factor for the development of atherosclerosis: Two reasons, still atherosclerosis 1. Intracellular regulation: LDLR gene activity is cholesterol-dependent; High intracellular cholesterol →insig/SCAP/SREBP pathway ↓→ LDLR gene regulation ↓→ low LDLR gene exp ...
Open the publication - UEF Electronic Publications
... drastically affects bodily functions, such as behavior, metabolism and body temperature16–21. The disruptions of the system have been linked to variety of diseases, including obesity, diabetes, certain cancers and mental problems, such as depression and schizophrenia16,19. Pgc1α, key regulator of ce ...
... drastically affects bodily functions, such as behavior, metabolism and body temperature16–21. The disruptions of the system have been linked to variety of diseases, including obesity, diabetes, certain cancers and mental problems, such as depression and schizophrenia16,19. Pgc1α, key regulator of ce ...
Nucleus-Encoded Genes for Plastid
... cDNA sequences produced from an ongoing Helicosporidium sp. (strain AT2000, originally isolated from the black fly, Simulium jonesii) EST project. Genes were identified for further characterization based on the following three criteria: (i) their association with pathways known to occur in the plast ...
... cDNA sequences produced from an ongoing Helicosporidium sp. (strain AT2000, originally isolated from the black fly, Simulium jonesii) EST project. Genes were identified for further characterization based on the following three criteria: (i) their association with pathways known to occur in the plast ...
metabolic pathways - MPG Systems Biology Forum
... D. Letscher and B.O. Palsson, J. theor. Biol. 203 (2000) 229) - distinction between internal and exchange reactions, all internal reversible reactions are split up into forward and reverse steps ...
... D. Letscher and B.O. Palsson, J. theor. Biol. 203 (2000) 229) - distinction between internal and exchange reactions, all internal reversible reactions are split up into forward and reverse steps ...
Biopathways Representation and Simulation on Hybrid Functional
... most traditional approach is to employ ordinary differential equations (ODEs) such as Michaelis-Menten equations and to represent biochemical reactions as a systems of ODEs. Especially, the metabolic control analysis has been well established for many years on the ODE modeling [12, 13] as well as the ...
... most traditional approach is to employ ordinary differential equations (ODEs) such as Michaelis-Menten equations and to represent biochemical reactions as a systems of ODEs. Especially, the metabolic control analysis has been well established for many years on the ODE modeling [12, 13] as well as the ...
Lateral gene transfer and the evolution of plastid
... least one sequence from streptophytes, red algae, and cyanobacteria for appropriate comparison, it was considered chlorophyte in origin. ML phylogenies of two such examples are presented in Fig. 2. The phylogeny of PsbO (Fig. 2 A) shows the B. natans homolog branching robustly with the chlorophytes ...
... least one sequence from streptophytes, red algae, and cyanobacteria for appropriate comparison, it was considered chlorophyte in origin. ML phylogenies of two such examples are presented in Fig. 2. The phylogeny of PsbO (Fig. 2 A) shows the B. natans homolog branching robustly with the chlorophytes ...