Balancing between respiration and fermentation - UvA-DARE
... 5.11 Role of pentose phosphate pathway 5.22 Role of alcohol dehydrogenase isozymes 6.. Transcriptional regulation of respiratory function 6.11 Components of glucose repression pathway 6.1.11 Role of hexokinase in glucose sensing 6.1.22 The Snf1 protein kinase 6.1.33 The Mig1 repressor 6.1.44 The tra ...
... 5.11 Role of pentose phosphate pathway 5.22 Role of alcohol dehydrogenase isozymes 6.. Transcriptional regulation of respiratory function 6.11 Components of glucose repression pathway 6.1.11 Role of hexokinase in glucose sensing 6.1.22 The Snf1 protein kinase 6.1.33 The Mig1 repressor 6.1.44 The tra ...
Mechanisms of animal diapause: recent
... through the dauer stage (97). Both of these dauer-suppressible phenotypes suggest that as the animal transits through dauer, the various pathways that are active during this state affect gene activity in an unprecedented manner; by altering the global genomic readout of the animal. In specific conte ...
... through the dauer stage (97). Both of these dauer-suppressible phenotypes suggest that as the animal transits through dauer, the various pathways that are active during this state affect gene activity in an unprecedented manner; by altering the global genomic readout of the animal. In specific conte ...
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... Critical for maintenanceof membranestructure Modulate behavior of growth factor receptors and extracellular matrix proteins Serve as binding sites for m.o., microbial toxins, and viruses Function as “second messengers”for growth factors, cytokines, differentiation factors, 1 a,25dihyroxycholecalcife ...
... Critical for maintenanceof membranestructure Modulate behavior of growth factor receptors and extracellular matrix proteins Serve as binding sites for m.o., microbial toxins, and viruses Function as “second messengers”for growth factors, cytokines, differentiation factors, 1 a,25dihyroxycholecalcife ...
Role of the cytoskeleton in communication between L
... the pore of the channel which regulates ion conductance, voltage sensing and contains binding sites for channelmodifying second messengers, toxins and drugs.4,13,14 The α2δ subunit of the L-type Ca2+ channel is an accessory subunit which consists of 2 proteins, α2 and δ which are encoded by the same ...
... the pore of the channel which regulates ion conductance, voltage sensing and contains binding sites for channelmodifying second messengers, toxins and drugs.4,13,14 The α2δ subunit of the L-type Ca2+ channel is an accessory subunit which consists of 2 proteins, α2 and δ which are encoded by the same ...
BIOGENESIS OF MITOCHONDRIAL ATPase Studies on
... binding of F 1 to mitochondrial membrane and thus is one of the components which are essential for cold-stable and oligomycin-sensitive ATPase. The activity of OSCP increases during glucose derepression two to three fold as shown by reconstitution experiments with OSCP-enriched fractions [11]. The e ...
... binding of F 1 to mitochondrial membrane and thus is one of the components which are essential for cold-stable and oligomycin-sensitive ATPase. The activity of OSCP increases during glucose derepression two to three fold as shown by reconstitution experiments with OSCP-enriched fractions [11]. The e ...
Engineering Cytosolic Acetyl-CoA Metabolism in
... In connection with biobased chemical production, it is necessary to engineer the metabolism of cell factories such that the raw material, typically sugars, can be efficiently converted to the product of interest. Although IMI076 could grow on glucose, it was still inefficient at conversion of pyruva ...
... In connection with biobased chemical production, it is necessary to engineer the metabolism of cell factories such that the raw material, typically sugars, can be efficiently converted to the product of interest. Although IMI076 could grow on glucose, it was still inefficient at conversion of pyruva ...
Genome-wide Investigation of Cellular Functions for tRNA Nucleus
... In eukaryotic cells tRNAs are transcribed in the nucleus and exported to the cytoplasm for their essential role in protein synthesis. This export event was thought to be unidirectional. Surprisingly, several lines of evidence showed that mature cytoplasmic tRNAs shuttle between nucleus and cytoplasm ...
... In eukaryotic cells tRNAs are transcribed in the nucleus and exported to the cytoplasm for their essential role in protein synthesis. This export event was thought to be unidirectional. Surprisingly, several lines of evidence showed that mature cytoplasmic tRNAs shuttle between nucleus and cytoplasm ...
Two nearly identical terpene synthases catalyze the
... the sesquiterpene (E)-nerolidol, derived from FPP (Dudareva et al., 2003, 2005). Emission of these compounds follows diurnal rhythms, and is controlled by a circadian clock. Two specialized monoterpene synthases responsible for synthesizing myrcene and (E)-b-ocimene, respectively, have been isolated ...
... the sesquiterpene (E)-nerolidol, derived from FPP (Dudareva et al., 2003, 2005). Emission of these compounds follows diurnal rhythms, and is controlled by a circadian clock. Two specialized monoterpene synthases responsible for synthesizing myrcene and (E)-b-ocimene, respectively, have been isolated ...
patrick_tb_ch18b
... Type: multiple choice question Title: Chapter 18b Question 10 10) Aromatase is an enzyme complex that is the target for several anticancer drugs. What reaction does it catalyse? Feedback: Aromatase is an enzyme which converts androgens to oestrogens. Androgens are male hormones that are responsible ...
... Type: multiple choice question Title: Chapter 18b Question 10 10) Aromatase is an enzyme complex that is the target for several anticancer drugs. What reaction does it catalyse? Feedback: Aromatase is an enzyme which converts androgens to oestrogens. Androgens are male hormones that are responsible ...
Biochemistry 304 2014 Student Edition Glycolysis Lectures
... •Learn where products of glycolysis can go. •Be aware that other sugars can enter the glycolysis pathway ...
... •Learn where products of glycolysis can go. •Be aware that other sugars can enter the glycolysis pathway ...
From Sequence to Structure
... peptide backbone, to polar organic molecules, and to water. This tendency dominates the interactions in which they participate. Some of them can change their charge state depending on their pH or the microenvironment. Aspartic acid and glutamic acid have pKa values near 5 in aqueous solution, so the ...
... peptide backbone, to polar organic molecules, and to water. This tendency dominates the interactions in which they participate. Some of them can change their charge state depending on their pH or the microenvironment. Aspartic acid and glutamic acid have pKa values near 5 in aqueous solution, so the ...
GLUCOKINASE ACTIVATORS: A GLUCOSE SENSOR ROLE IN PANCREATIC ISLETS AND HEPATOCYTE
... Role of glucokinase in the regulatory glucose sensor system and the hepato-parenchymal high-capacity glucose disposal system, it is perhaps not surprising that mutations of the glucokinase gene have a profound influence on glucose homeostasis in humans an activation or inactivation[25-28] of the enz ...
... Role of glucokinase in the regulatory glucose sensor system and the hepato-parenchymal high-capacity glucose disposal system, it is perhaps not surprising that mutations of the glucokinase gene have a profound influence on glucose homeostasis in humans an activation or inactivation[25-28] of the enz ...
Sugar Metabolism in Yeasts: an Overview of Aerobic and Anaerobic
... mitochondrial NAD+-specific one and two NADP+-dependent ones (one mitochondrial and the other cytosolic). A number of pieces of evidence point to the role of mitochondrial NAD+-specific isocitrate dehydrogenase in the regulation of the rate of mitochondrial assembly besides its specific role in the ...
... mitochondrial NAD+-specific one and two NADP+-dependent ones (one mitochondrial and the other cytosolic). A number of pieces of evidence point to the role of mitochondrial NAD+-specific isocitrate dehydrogenase in the regulation of the rate of mitochondrial assembly besides its specific role in the ...
A Comparative Study - Carlos Ibanez Lab @ KI
... Production and quantitation of recombinant NGF Genomic fragments containing the preproNGF coding sequences from the human (see Materials and Methods), rat (Whittemore et al., 1988), and chicken (Ebendal et al., 1986) NGF genes were subcloned in the expression plasmid vector pXM (Yang et al., 1986) a ...
... Production and quantitation of recombinant NGF Genomic fragments containing the preproNGF coding sequences from the human (see Materials and Methods), rat (Whittemore et al., 1988), and chicken (Ebendal et al., 1986) NGF genes were subcloned in the expression plasmid vector pXM (Yang et al., 1986) a ...
Pseudouridine at position 55 in tRNA controls the contents of other
... hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these mutant proteins. Nucleoside analysis revealed that ...
... hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these mutant proteins. Nucleoside analysis revealed that ...
IDENTIFICATION AND CHARACTERIZATION OF SYNAPTONEMAL
... Ad (3). Whether there is a mechanism to test long-range homology as a precondition for reciprocal exchange is still a matter of debate (see for instance discussion in Carpenter, 1987). In various objects, for instance mice (De Boer and De Jong, 1989), reciprocal exchange between a translocated segme ...
... Ad (3). Whether there is a mechanism to test long-range homology as a precondition for reciprocal exchange is still a matter of debate (see for instance discussion in Carpenter, 1987). In various objects, for instance mice (De Boer and De Jong, 1989), reciprocal exchange between a translocated segme ...
DOCTORAL THESIS
... humans started to genetically modify plant species. Initially, humans selected more adequate variants of plants for given traits such as larger seeds for greater caloric intake, lack of bitterness, and increased yields. This process of domestication allowed the crops to adapt and eventually become l ...
... humans started to genetically modify plant species. Initially, humans selected more adequate variants of plants for given traits such as larger seeds for greater caloric intake, lack of bitterness, and increased yields. This process of domestication allowed the crops to adapt and eventually become l ...
Emerging role of Nrf2 - Discovery
... survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti-inflammatory, and detoxification enzymes as well as proteins that assist in the repair or removal of damaged macromolecules. Nrf2 has a crucial role in the ...
... survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti-inflammatory, and detoxification enzymes as well as proteins that assist in the repair or removal of damaged macromolecules. Nrf2 has a crucial role in the ...
bacterial hemoglobin proteins - ETH E-Collection
... substrate oxidation to the reduction of oxygen. ...
... substrate oxidation to the reduction of oxygen. ...
Review: can diet influence the selective advantage of mitochondrial
... metabolic and biochemical changes. Remarkably, rather than being harmful, these changes may increase evolutionary potential and decrease susceptibility for disease. Although the exact response depends, in part, on the specific mitochondrial perturbation, in general, the transcriptional response resu ...
... metabolic and biochemical changes. Remarkably, rather than being harmful, these changes may increase evolutionary potential and decrease susceptibility for disease. Although the exact response depends, in part, on the specific mitochondrial perturbation, in general, the transcriptional response resu ...
Plant Biochemistry
... proteins and the basis of enzyme catalysis. I have dealt with topics of general biochemistry only when it seemed necessary for enhancing understanding of the problem in hand. Thus, this book is, in the end, a compromise between a general textbook and a specialized textbook. This book is a translatio ...
... proteins and the basis of enzyme catalysis. I have dealt with topics of general biochemistry only when it seemed necessary for enhancing understanding of the problem in hand. Thus, this book is, in the end, a compromise between a general textbook and a specialized textbook. This book is a translatio ...
Targeting apicoplasts in malaria parasites
... the pathway, only IspE has been successfully targeted with small molecule inhibitors in Plasmodium [50]. Clearly, there are opportunities to employ other MEP pathway inhibitors against the parasite. The MEP pathway continues to be of interest as an antibiotic, and possibly a herbicide [51], and ther ...
... the pathway, only IspE has been successfully targeted with small molecule inhibitors in Plasmodium [50]. Clearly, there are opportunities to employ other MEP pathway inhibitors against the parasite. The MEP pathway continues to be of interest as an antibiotic, and possibly a herbicide [51], and ther ...
H. Heldt
... proteins and the basis of enzyme catalysis. I have dealt with topics of general biochemistry only when it seemed necessary for enhancing understanding of the problem in hand. Thus, this book is, in the end, a compromise between a general textbook and a specialized textbook. This book is a translatio ...
... proteins and the basis of enzyme catalysis. I have dealt with topics of general biochemistry only when it seemed necessary for enhancing understanding of the problem in hand. Thus, this book is, in the end, a compromise between a general textbook and a specialized textbook. This book is a translatio ...
Multiple Functions of the New Cytokine
... Abstract: Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a shor ...
... Abstract: Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a shor ...
metabolism - Garland Science
... Plants show huge genetic variation in metabolism, the multitude of interrelated biochemical reactions that maintain plant life. Tens of thousands of different organic compounds have been discovered in plants. Some of these are ubiquitous. These include compounds involved in the metabolic pathways th ...
... Plants show huge genetic variation in metabolism, the multitude of interrelated biochemical reactions that maintain plant life. Tens of thousands of different organic compounds have been discovered in plants. Some of these are ubiquitous. These include compounds involved in the metabolic pathways th ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.