Structure and Function of the Plasma Membrane A biochemical
... membranes, and possible mechanisms of transmembrane transport and membrane biosynthesis. It is concluded that the classical models, although not disproven, are not well supported by, and are difficult to reconcile with, the data now available. On the other hand, although a model based on lipoprotein ...
... membranes, and possible mechanisms of transmembrane transport and membrane biosynthesis. It is concluded that the classical models, although not disproven, are not well supported by, and are difficult to reconcile with, the data now available. On the other hand, although a model based on lipoprotein ...
A protein domain interaction interface database: InterPare | BMC
... homepage http://www.interfacer.org provides files that are required to view molecules with InterFacer. Atom coordinate files of three different regions are available to download. In addition, 1) the size of the interface and surface area, and 2) amino acid compositions on the surface, interior, and ...
... homepage http://www.interfacer.org provides files that are required to view molecules with InterFacer. Atom coordinate files of three different regions are available to download. In addition, 1) the size of the interface and surface area, and 2) amino acid compositions on the surface, interior, and ...
- Wiley Online Library
... All these particular properties displayed by enzymes are a consequence of their complex 3-D structure. In the native state, the polypeptide chain adopts such a conformation that the hydrophobic residues locate themselves in the protein core, minimizing contact with the polar solvent, while hydrophil ...
... All these particular properties displayed by enzymes are a consequence of their complex 3-D structure. In the native state, the polypeptide chain adopts such a conformation that the hydrophobic residues locate themselves in the protein core, minimizing contact with the polar solvent, while hydrophil ...
Based Method for Identification of Horizontal Gene Transfer in Bacteria
... These are molecules that, when joined together, make up the structural units of RNA and DNA. A nucleotide is composed of a nucleobase (nitrogenous base), a five-carbon sugar (either ribose or 2'-deoxyribose), and one to three phosphate groups. The International Union of Pure and Applied Chemistry (I ...
... These are molecules that, when joined together, make up the structural units of RNA and DNA. A nucleotide is composed of a nucleobase (nitrogenous base), a five-carbon sugar (either ribose or 2'-deoxyribose), and one to three phosphate groups. The International Union of Pure and Applied Chemistry (I ...
The RNA-binding protein repertoire of embryonic
... fluorescence-labeled RNA in vitro16,17. To complement this method, RNA-coated beads were incubated with whole-cell lysate, and the bound proteins were analyzed by LC-MS/MS16. Although these two approaches yielded candidates for novel RBPs, it is difficult to judge whether or not the interactions are ...
... fluorescence-labeled RNA in vitro16,17. To complement this method, RNA-coated beads were incubated with whole-cell lysate, and the bound proteins were analyzed by LC-MS/MS16. Although these two approaches yielded candidates for novel RBPs, it is difficult to judge whether or not the interactions are ...
Sorting of proteins to vacuoles in plant cells
... family of proteins that function as aquaporins, channels to transport water [14], and the sequences of TIPs are homologous with but differ from the sequences of other members of the family that are found in plasma membranes [119]. It has been proposed that TIPs are present in tonoplast because aquap ...
... family of proteins that function as aquaporins, channels to transport water [14], and the sequences of TIPs are homologous with but differ from the sequences of other members of the family that are found in plasma membranes [119]. It has been proposed that TIPs are present in tonoplast because aquap ...
X-ray structures of the N and C-terminal domains of a
... respectively called NTD and CTD. The NTD structure of IBV (Gray strain), determined to 1.3 Å resolution, is similar to the previously published Beaudette strain (12) but makes strikingly different quaternary associations. We describe the first crystal structure of the CTD dimerization domain of the ...
... respectively called NTD and CTD. The NTD structure of IBV (Gray strain), determined to 1.3 Å resolution, is similar to the previously published Beaudette strain (12) but makes strikingly different quaternary associations. We describe the first crystal structure of the CTD dimerization domain of the ...
Does Plant Cell Death Induced by Ptr ToxA Require Toxin Entry?
... Active ToxA is internalized ToxA internalization is required for disease Amino acids required for cell entry: ...
... Active ToxA is internalized ToxA internalization is required for disease Amino acids required for cell entry: ...
vesicle
... do not touch each other; they have contact points called synapses. A neuron transports its information by way of a nerve impulse. When a nerve impulse arrives at the synapse, it releases neurotransmitters, which influence another cell, either in an inhibitory way or in an excitatory way. The next ne ...
... do not touch each other; they have contact points called synapses. A neuron transports its information by way of a nerve impulse. When a nerve impulse arrives at the synapse, it releases neurotransmitters, which influence another cell, either in an inhibitory way or in an excitatory way. The next ne ...
... of new drugs and therapeutics (Boguslavsky, 2002 and Marsh, 2002). Affinity binding techniques based on protein fusions have seen rapid acceptance in process laboratories because of their simplicity and the relative ease with which they can be built into expression vectors. Immobilized metal ion aff ...
Description of the KDD-Cup 2004 Protein Data
... Description of the KDD-Cup 2004 Protein Data Author: Ron Elber, Department of Computer Science, Cornell University The data are generated by the program LOOPP (Learning Observing and Outputting Protein Patterns) that is a product of the group of Ron Elber, Computer Science, Cornell University. The L ...
... Description of the KDD-Cup 2004 Protein Data Author: Ron Elber, Department of Computer Science, Cornell University The data are generated by the program LOOPP (Learning Observing and Outputting Protein Patterns) that is a product of the group of Ron Elber, Computer Science, Cornell University. The L ...
Amino acid pool
... disintegration to release amino acids which likewise enter the circulation. There is also a continuous synthesis of amino acids (except the "essential" amino acids). Amino acids from all these sources get mixed up to constitute what is known as "general amino acid pool" of the body."Amino acid pool" ...
... disintegration to release amino acids which likewise enter the circulation. There is also a continuous synthesis of amino acids (except the "essential" amino acids). Amino acids from all these sources get mixed up to constitute what is known as "general amino acid pool" of the body."Amino acid pool" ...
Slide 1
... Part 2: What is biological stuff made from? 4. inorganic crystals and salts Calcium-based crystals are essential for making hard bits. ...
... Part 2: What is biological stuff made from? 4. inorganic crystals and salts Calcium-based crystals are essential for making hard bits. ...
Insights into the mechanistic details of protein synthesis
... Decades ago, Schimmel discovered a single basepair within the tRNA associated with the amino acid alanine (tRNAAla) that serves as an 'identity set' critical for recognition and processing by its associated aminoacyl-tRNA synthetase enzyme. Strangely, this base-pair resides far from the active site ...
... Decades ago, Schimmel discovered a single basepair within the tRNA associated with the amino acid alanine (tRNAAla) that serves as an 'identity set' critical for recognition and processing by its associated aminoacyl-tRNA synthetase enzyme. Strangely, this base-pair resides far from the active site ...
NurseMate® ASAP Colostrum Supplement for Kids
... Guaranteed Analysis, Each 30 mL syringe contains: Crude Protein (Min) 3%, Crude Fat (Min.) .1%, and Crude Fiber (Max.) .1% This product was made in a feed manufacturing facility that does not handle or store products containing animal proteins prohibited in ruminant feed. Store in a cool, dry enviro ...
... Guaranteed Analysis, Each 30 mL syringe contains: Crude Protein (Min) 3%, Crude Fat (Min.) .1%, and Crude Fiber (Max.) .1% This product was made in a feed manufacturing facility that does not handle or store products containing animal proteins prohibited in ruminant feed. Store in a cool, dry enviro ...
here - Dr. Alan Dombkowski
... The output text box displays one line per potential disulfide. Each line shows a pair of residues that have the appropriate geometry to form a disulfide bond if the residues were mutated to cysteines. The analysis is based on the assumption that the mutations would not significantly perturb the prot ...
... The output text box displays one line per potential disulfide. Each line shows a pair of residues that have the appropriate geometry to form a disulfide bond if the residues were mutated to cysteines. The analysis is based on the assumption that the mutations would not significantly perturb the prot ...
Initial characterization of ayrRABC
... higher than that observed in the absence of arylomycin (Fig. 1F). These results confirm that AyrR acts as a repressor of ayrRABC and that SPase inhibition induces derepression. Each gene of the ayrRABC operon contributes to tolerating SPase inhibition. ayrA encodes a putative membrane protein, predi ...
... higher than that observed in the absence of arylomycin (Fig. 1F). These results confirm that AyrR acts as a repressor of ayrRABC and that SPase inhibition induces derepression. Each gene of the ayrRABC operon contributes to tolerating SPase inhibition. ayrA encodes a putative membrane protein, predi ...
PDF - International Journal of Biological Sciences
... in B. xylophilus (herein refers to as “BxPrx”) is highly conserved in comparison to 2-cysteine peroxiredoxins (Prx2s) in other nematodes, which have two conserved cysteine amino acids (Cp and Cr), a threonine-cysteine-arginine catalytic triad, and two signature motifs (GGLG and YF) sensitive to hydr ...
... in B. xylophilus (herein refers to as “BxPrx”) is highly conserved in comparison to 2-cysteine peroxiredoxins (Prx2s) in other nematodes, which have two conserved cysteine amino acids (Cp and Cr), a threonine-cysteine-arginine catalytic triad, and two signature motifs (GGLG and YF) sensitive to hydr ...
F1000 - CBGP
... RNA-binding proteins play a central role in post-transcriptional mechanisms that control gene expression. Identification of novel RNA-binding proteins in fungi is essential to unravel post-transcriptional networks and cellular processes that confer identity to the fungal kingdom. Here, we carried ou ...
... RNA-binding proteins play a central role in post-transcriptional mechanisms that control gene expression. Identification of novel RNA-binding proteins in fungi is essential to unravel post-transcriptional networks and cellular processes that confer identity to the fungal kingdom. Here, we carried ou ...
ArnoldSpr09
... VNTR region in carcinoma epithelia is thought to elucidate an immune response that leads to the production of antibodies.2 Furthermore, the extracellular portion of mucin may be cleaved from the epithelium and circulate in the blood. As a result, individuals with cancer can be identified by detectin ...
... VNTR region in carcinoma epithelia is thought to elucidate an immune response that leads to the production of antibodies.2 Furthermore, the extracellular portion of mucin may be cleaved from the epithelium and circulate in the blood. As a result, individuals with cancer can be identified by detectin ...
Motor protein control of ion flux is an early step in embryonic left
... Unanswered questions The idea that vortical cilia motion results in a net asymmetric localization of a morphogen is intellectually satisfying, but it possesses a number of problems. First, there are inconsistencies(2,10 –12) between the predictions of the cilia model in the data on directly measured ...
... Unanswered questions The idea that vortical cilia motion results in a net asymmetric localization of a morphogen is intellectually satisfying, but it possesses a number of problems. First, there are inconsistencies(2,10 –12) between the predictions of the cilia model in the data on directly measured ...
Full-Text PDF
... H. pylori strain 26695 with a molecular weight of 9.1 kDa and a calculated pI of 6.1 [34,35]. The structure of HP1242 is fully helical, and is composed of three α-helices. These correspond to residues 6-14 (αI), 18-38 (αII), and 43-75 (αIII) (Figure 3B). Based on the sequence homology, this protein ...
... H. pylori strain 26695 with a molecular weight of 9.1 kDa and a calculated pI of 6.1 [34,35]. The structure of HP1242 is fully helical, and is composed of three α-helices. These correspond to residues 6-14 (αI), 18-38 (αII), and 43-75 (αIII) (Figure 3B). Based on the sequence homology, this protein ...
Characterizing the O-glycosylation landscape of human plasma
... critical to the maintenance of vascular integrity. Multiple studies indicate that glycans play important roles in the hemostatic system; however, most investigations have focused on N-glycans because of the complexity of O-glycan analysis. Here we performed the first systematic analysis of native-O-g ...
... critical to the maintenance of vascular integrity. Multiple studies indicate that glycans play important roles in the hemostatic system; however, most investigations have focused on N-glycans because of the complexity of O-glycan analysis. Here we performed the first systematic analysis of native-O-g ...
Cyclol
The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such ""closed cyclol"" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.