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... • Body is mostly made up of water and organic compounds • Anything made up of carbon is called ORGANIC • Carbon forms 4 covalent bonds (form different arrangements of atoms: straight, branched, rings) ...
Basis of Thermophily
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... must be non-polar (e.g. Ala, Val, Leu, Ile, Phe). Second, the very polar CONH groups (peptide bonds) of the polypeptide backbone of transmembrane segments must participate in hydrogen bonds (H-bonds) in order to lower the cost of transferring them into the hydrocarbon interior. This H-bonding is mos ...
Fundamentals of protein structure
Fundamentals of protein structure

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DIAGNOSTIC RELEVANCE OF PREDICTED ANTIGENIC
DIAGNOSTIC RELEVANCE OF PREDICTED ANTIGENIC

... bioinformatics analysis. Recombinant genes encoded selected amino acids sequences have been constructed from synthetic oligonucleotides by using PCR reaction. Proteins were expressed in E.coli as hybrid protein with Glutathione Stransferase and tested individually by enzyme immunoassay against a pan ...
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Fates of Proteins in Cells
Fates of Proteins in Cells

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Kostelecky et al. 2006, Journal of Bacteriology The
Kostelecky et al. 2006, Journal of Bacteriology The

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From Gene to Protein
From Gene to Protein

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Complete and incomplete Proteins
Complete and incomplete Proteins

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Cell Membrane and Regulation

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... understand that amino acids are linked by peptide bonds to form polypeptides; describe the formation of a peptide bond; understand the meaning of the terms primary, secondary, tertiary and quaternary structure and their importance in the structure of enzymes; understand that condensation and hydroly ...
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... damage. Trying to understanding these repair processes has been the focus of my PhD. Specifically, I have been investigating how two key proteins interact with each other and potentially alter each other’s activity. One protein is responsible for identifying and marking break regions within a cell a ...
Proteins Behaving badly - The University of Oklahoma
Proteins Behaving badly - The University of Oklahoma

... The spontaneous conversion of soluble proteins or protein fragments into insoluble aggregates with fibrillar morphology and a regular cross-b sheet structure is linked to a number of neurodegenerative diseases. These aggregates, called amyloid, are believed to be the root cause of disease pathology. ...
Biology 3 Study Guide – Exam #1
Biology 3 Study Guide – Exam #1

... This is a list of the general topics you should be prepared to answer questions on for each chapter. You are still responsible for all material covered in class and need to know all of the key terms at the end of the Powerpoint slides for each chapter. ...
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... - proteins are polymers connected via peptide bonds - made by chain of smaller units called amino acids - Chains can have any combination of the 20 different ...
Protein Purification and Characterization Techniques
Protein Purification and Characterization Techniques

... www.facebook.com/natarboush ...
Biochemistry - Plano Science Tutor
Biochemistry - Plano Science Tutor

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Proteins - (www.ramsey.k12.nj.us).
Proteins - (www.ramsey.k12.nj.us).

... element carbon (bonded to hydrogen).  Hydrocarbons – contain only C & H (ex. CH4)  Most also include oxygen and some also have nitrogen, phosphorus and sulfur.  Carbon can form thousands of different compounds because it can form 4 strong covalent bonds ...
Protein Synthesis PPT
Protein Synthesis PPT

... Why? DNA has the genetic code for the protein that needs to be made, but proteins are made by the ribosomes—ribosomes are outside the nucleus in the cytoplasm. DNA is too large to leave the nucleus (double stranded), but RNA can leave the nucleus (single stranded). ...
Organic Compounds
Organic Compounds

... • 4 Types of Organic Compounds or macromolecules: carbohydrates, lipids, proteins, and nucleic acids. – Essential to maintaining life processes: cell function, storage, energy, homeostasis and genetic information. ...
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Cyclol



The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such ""closed cyclol"" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.
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