Shen-Diabetes 2014 - Stanford Medicine
... immune cells with anti-inflammatory phenotypes (alternatively activated M2 macrophages, Th2, regulatory T cells [Treg]) are resident in the adipose tissue of lean mice and individuals, whereas proinflammatory cells (classically activated M1 macrophages, Th1) become enriched and expanded in the adipose ...
... immune cells with anti-inflammatory phenotypes (alternatively activated M2 macrophages, Th2, regulatory T cells [Treg]) are resident in the adipose tissue of lean mice and individuals, whereas proinflammatory cells (classically activated M1 macrophages, Th1) become enriched and expanded in the adipose ...
Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans
... also evident in the peripheral blood (Fig. 2C–E). Thus, enhanced egress from LNs does not account for the decreased frequency of CTLA-4 KO 5C.C7 T cells in the presence of WT 5C.C7 T cells. Longitudinal analysis of T cell responses in blood shows that the presence of CTLA-4 on WT T cells decreases t ...
... also evident in the peripheral blood (Fig. 2C–E). Thus, enhanced egress from LNs does not account for the decreased frequency of CTLA-4 KO 5C.C7 T cells in the presence of WT 5C.C7 T cells. Longitudinal analysis of T cell responses in blood shows that the presence of CTLA-4 on WT T cells decreases t ...
Control of Human Viral Infections by Natural Killer Cells
... NK cells not only contain viral replication by killing infected cells during the earliest stages of infection, prior to the development of adaptive immunity, but also play a critical immunoregulatory role during the development of adaptive immunity (2, 3). Although NK cells are considered part of th ...
... NK cells not only contain viral replication by killing infected cells during the earliest stages of infection, prior to the development of adaptive immunity, but also play a critical immunoregulatory role during the development of adaptive immunity (2, 3). Although NK cells are considered part of th ...
Delayed acquisition of Plasmodium falciparum antigen
... Liverpool School of Tropical Medicine, Liverpool, UK Full list of author information is available at the end of the article ...
... Liverpool School of Tropical Medicine, Liverpool, UK Full list of author information is available at the end of the article ...
Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T
... such as VEGF-C, produced at the site of inflammation or neoplastic growth. VEGF-C acts locally on nearby LVs, but may also be transported via the lymph to the draining LNs (5). Depending on the type of the inflammatory insult, the outcome of this expansion (and the concomitant increase in fluid drai ...
... such as VEGF-C, produced at the site of inflammation or neoplastic growth. VEGF-C acts locally on nearby LVs, but may also be transported via the lymph to the draining LNs (5). Depending on the type of the inflammatory insult, the outcome of this expansion (and the concomitant increase in fluid drai ...
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... performed by Dr Lawrence Schwartz in Virginia, or the 24-hour N-methyl histamine test (not the regular urine histamine test). It would seem reasonable that if chronic GI dysmotility was accompanied by extra-intestinal symptoms that at least a tryptase test would be valuable in evaluating the root of ...
... performed by Dr Lawrence Schwartz in Virginia, or the 24-hour N-methyl histamine test (not the regular urine histamine test). It would seem reasonable that if chronic GI dysmotility was accompanied by extra-intestinal symptoms that at least a tryptase test would be valuable in evaluating the root of ...
Th2-type immune response induced by a phage clone displaying a
... We have recently isolated a phage clone, F2, which displays the CTLA4-binding domain mimic from a phage display library. To investigate the in vivo effects of an F2 motif on the regulation of immune responses, we immunized Balb/c mice intraperitoneally with varying doses of an F2 phage in a phosphat ...
... We have recently isolated a phage clone, F2, which displays the CTLA4-binding domain mimic from a phage display library. To investigate the in vivo effects of an F2 motif on the regulation of immune responses, we immunized Balb/c mice intraperitoneally with varying doses of an F2 phage in a phosphat ...
acALY-18 stimulates release of
... therapeutics, regardless of the disease target. Recent therapeutic advances suggest that innate immunomodulation holds the potential for improved survival after a bioterror attack with an infectious agent. Thus products targeting various processes in the innate immune response are in the initial sta ...
... therapeutics, regardless of the disease target. Recent therapeutic advances suggest that innate immunomodulation holds the potential for improved survival after a bioterror attack with an infectious agent. Thus products targeting various processes in the innate immune response are in the initial sta ...
TISSUE STRUCTURE - Trinity College Dublin
... This course manual is designed to allow you to get the most out of this course, and includes learning outcomes for each lecture. You are encouraged to read the Lessons Synopses before the corresponding lecture to leave you free focus on the key concepts. The material is ...
... This course manual is designed to allow you to get the most out of this course, and includes learning outcomes for each lecture. You are encouraged to read the Lessons Synopses before the corresponding lecture to leave you free focus on the key concepts. The material is ...
Granulocyte-macrophage colony-stimulating factor (GM-CSF)
... The amount of GM-CSF protein in the local microenvironment was determined before the in vivo vaccination studies. To titrate the dose of GM-CSF protein, murine skin was evaluated 24 hours after either a single cutaneous treatment over a B16 tumor site or an injection of B16 transfected ex vivo with ...
... The amount of GM-CSF protein in the local microenvironment was determined before the in vivo vaccination studies. To titrate the dose of GM-CSF protein, murine skin was evaluated 24 hours after either a single cutaneous treatment over a B16 tumor site or an injection of B16 transfected ex vivo with ...
- Zaharoff Laboratory
... Animal care and use. All mice were housed in microisolator cages under pathogen-free conditions in accordance with the procedures outlined in The Guide for Care and Use of Laboratory Animals (National Research Council). Female C57BL/6 mice (H-2b) were purchased from Taconic Farms. Mice expressing th ...
... Animal care and use. All mice were housed in microisolator cages under pathogen-free conditions in accordance with the procedures outlined in The Guide for Care and Use of Laboratory Animals (National Research Council). Female C57BL/6 mice (H-2b) were purchased from Taconic Farms. Mice expressing th ...
Slide 1
... the activation of T cells, and is expressed on antigen-reactive memory T cells. As reported by the Miami CFS research group, the percentage and number of CD26+ lymphocytes is elevated in CFS. ...
... the activation of T cells, and is expressed on antigen-reactive memory T cells. As reported by the Miami CFS research group, the percentage and number of CD26+ lymphocytes is elevated in CFS. ...
Ianello A, Thompson TW, Ardolino M, Lowe SW, Raulet DH. 2013. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Experimental Medicine 210(10):2057-69.
... fected cells and secrete various inflammatory cytokines, in cluding IFN- and TNF (Vivier et al., 2011). Like other lymphocytes and immune cells, NK cells are recruited to infected or transformed tissue by the action of chemokine gradients (Grégoire et al., 2007). NK cell killing requires engagemen ...
... fected cells and secrete various inflammatory cytokines, in cluding IFN- and TNF (Vivier et al., 2011). Like other lymphocytes and immune cells, NK cells are recruited to infected or transformed tissue by the action of chemokine gradients (Grégoire et al., 2007). NK cell killing requires engagemen ...
Autoimmunity and Apoptosis – Therapeutic Implications Iran Rashedi , Soumya Panigrahi
... the susceptibility to autoimmune disorders [16]. Ignorance of self-antigens occurs either when these molecules are expressed at too low levels to induce the activation or deletion of T-cells [20, 21] or when they are present in immune privileged sites, physically separated from T-lymphocytes (i.e. l ...
... the susceptibility to autoimmune disorders [16]. Ignorance of self-antigens occurs either when these molecules are expressed at too low levels to induce the activation or deletion of T-cells [20, 21] or when they are present in immune privileged sites, physically separated from T-lymphocytes (i.e. l ...
Specific Control of Immunity by Regulatory CD8 T Cells
... specifically down-regulate that immune response. The mechanism is referred to as feedback inhibition, a mechanism that has long been described in macromolecular synthesis. These Treg include CD8+CD28- Treg (24), CD8+CD75s+ Treg (25), plasmacytoid dendritic cell (DC2)-induced CD8 Treg (26), CD8+CD45R ...
... specifically down-regulate that immune response. The mechanism is referred to as feedback inhibition, a mechanism that has long been described in macromolecular synthesis. These Treg include CD8+CD28- Treg (24), CD8+CD75s+ Treg (25), plasmacytoid dendritic cell (DC2)-induced CD8 Treg (26), CD8+CD45R ...
Paroxysmal Murine Hemoglobinuria (?): A Model for Human PNH
... would prevent CD59 from appearing on the surface of red blood cells (RBCs), which would cause these RBCs to be highly vulnerable to the final stage of the complement activation cascade. Complement activation can be triggered by an antigenantibody reaction or, through the alternative pathway, by the ...
... would prevent CD59 from appearing on the surface of red blood cells (RBCs), which would cause these RBCs to be highly vulnerable to the final stage of the complement activation cascade. Complement activation can be triggered by an antigenantibody reaction or, through the alternative pathway, by the ...
MHC
... * MHC molecules can present both autoantigens and MHC molecules themselves. Such that MHC molecules participate in autoimmunity,in the response to non-self MHC molecules as well as in the differentiation of T cells in the thymus. ...
... * MHC molecules can present both autoantigens and MHC molecules themselves. Such that MHC molecules participate in autoimmunity,in the response to non-self MHC molecules as well as in the differentiation of T cells in the thymus. ...
Immune activation and Immunopathology of the HIV infection
... Can the most potent combinations of ARV and immune interventions - That activates « latently » infected cells - That targets cells actively replicating HIV Exhaust the HIV reservoirs ? ...
... Can the most potent combinations of ARV and immune interventions - That activates « latently » infected cells - That targets cells actively replicating HIV Exhaust the HIV reservoirs ? ...
Immunometabolism governs dendritic cell and macrophage function
... response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by ...
... response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by ...
Immunometabolism governs dendritic cell and macrophage function
... response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by ...
... response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by ...
Are Targeted by NK Cells Hematopoietic Progenitors Express H60
... Students t test to evaluate experimental data for significant differences; p ⬍ 0.05 was considered significant. ...
... Students t test to evaluate experimental data for significant differences; p ⬍ 0.05 was considered significant. ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.