| Specific antigen(s) in sarcoidosis: a link to autoimmunity?
... was weakened when bacterial DNA was identified in sarcoidosis lesions [8, 9]. The results presented by these authors suggest that microorganisms such as propionibacteria and mycobacteria are either the cause or at least an important cofactor in the pathogenesis of sarcoidosis. In this issue of the E ...
... was weakened when bacterial DNA was identified in sarcoidosis lesions [8, 9]. The results presented by these authors suggest that microorganisms such as propionibacteria and mycobacteria are either the cause or at least an important cofactor in the pathogenesis of sarcoidosis. In this issue of the E ...
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the
... Jan Strindhall, Mårten Skog, Jan Ernerudh, M Bengner, S Lofgren, A Matussek, B O. Nilsson and A Wikby, The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study, 2013, Age (Omaha), (35), 3, 985-991. http://dx.doi.org/10.1007/s11357-012-9400-3 ...
... Jan Strindhall, Mårten Skog, Jan Ernerudh, M Bengner, S Lofgren, A Matussek, B O. Nilsson and A Wikby, The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study, 2013, Age (Omaha), (35), 3, 985-991. http://dx.doi.org/10.1007/s11357-012-9400-3 ...
Candida albicans Daniel Gozalbo , Victoria Maneu , María Luisa Gil
... data suggested that neonatal macrophages have a normal capacity to ingest and kill Candida but cannot be fully activated by IFNγ, a finding that could not be attributed to lower expression or binding of IFN-γ receptor to its ligand on neonatal cells. Remarkably, a significantly decreased Stat-1 pho ...
... data suggested that neonatal macrophages have a normal capacity to ingest and kill Candida but cannot be fully activated by IFNγ, a finding that could not be attributed to lower expression or binding of IFN-γ receptor to its ligand on neonatal cells. Remarkably, a significantly decreased Stat-1 pho ...
Brain-resident memory T cells represent an autonomous cytotoxic
... et al., 2014; Fig. 1 H) and extravascular CD8+ T cells identified by immunostaining on brain sections expressed CD69 (95 ± 3%; n = 3 mice). Furthermore, most brain CD69+ TM cells were refractory to depletion by peripherally administered depleting anti-CD8 antibody (Fig. 1 I). Altogether, this demons ...
... et al., 2014; Fig. 1 H) and extravascular CD8+ T cells identified by immunostaining on brain sections expressed CD69 (95 ± 3%; n = 3 mice). Furthermore, most brain CD69+ TM cells were refractory to depletion by peripherally administered depleting anti-CD8 antibody (Fig. 1 I). Altogether, this demons ...
Brain-resident memory T cells represent an autonomous
... et al., 2014; Fig. 1 H) and extravascular CD8+ T cells identified by immunostaining on brain sections expressed CD69 (95 ± 3%; n = 3 mice). Furthermore, most brain CD69+ TM cells were refractory to depletion by peripherally administered depleting anti-CD8 antibody (Fig. 1 I). Altogether, this demons ...
... et al., 2014; Fig. 1 H) and extravascular CD8+ T cells identified by immunostaining on brain sections expressed CD69 (95 ± 3%; n = 3 mice). Furthermore, most brain CD69+ TM cells were refractory to depletion by peripherally administered depleting anti-CD8 antibody (Fig. 1 I). Altogether, this demons ...
Cytokines
... produced by the cells of innate and adaptive immunity in response to microbes and other antigens as a result of cellular activation. Cytokines initiate their actions by binding to specific membrane receptors on target cells. The cellular responses to most cytokines consist of gene activation, res ...
... produced by the cells of innate and adaptive immunity in response to microbes and other antigens as a result of cellular activation. Cytokines initiate their actions by binding to specific membrane receptors on target cells. The cellular responses to most cytokines consist of gene activation, res ...
General Summary - edoc
... Many eukaryotic cells release vesicles spontaneously or under appropriate stimulation. Exosomes are preformed membrane vesicles, which are stored in cellular compartments named multivesicular bodies, and secreted when the multivesicular bodies fuse with the cellmembrane [1]. Many haematopoietic cell ...
... Many eukaryotic cells release vesicles spontaneously or under appropriate stimulation. Exosomes are preformed membrane vesicles, which are stored in cellular compartments named multivesicular bodies, and secreted when the multivesicular bodies fuse with the cellmembrane [1]. Many haematopoietic cell ...
Innate Immune Responses in HIV-Infection
... C8 and polymeric C9 molecules (Fig. 2). The formation of the MAC disrupts the microbial membrane, resulting in lysis of infected cells or pathogens (Stoiber et al., 2007; Speth et al., 2008). Figure 2 summarizes the activation events of the complement cascade using the example of a viral particle. A ...
... C8 and polymeric C9 molecules (Fig. 2). The formation of the MAC disrupts the microbial membrane, resulting in lysis of infected cells or pathogens (Stoiber et al., 2007; Speth et al., 2008). Figure 2 summarizes the activation events of the complement cascade using the example of a viral particle. A ...
Gene Expression Measurement of Immuno
... A homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells ...
... A homophilic binding glycoprotein expressed on the surface of neurons, glia, skeletal muscle and natural killer cells ...
Microglial Phagocytosis of FibrillarЯ
... These data demonstrated that engagement of this ensemble of receptors is required for induction of phagocytosis. The phagocytic response stimulated by this receptor complex is driven principally by a 1 integrin-linked process that is morphologically and mechanistically distinct from the classical t ...
... These data demonstrated that engagement of this ensemble of receptors is required for induction of phagocytosis. The phagocytic response stimulated by this receptor complex is driven principally by a 1 integrin-linked process that is morphologically and mechanistically distinct from the classical t ...
Peptide trafficking and translocation across membranes in
... cell–cell communication, peptide hormones and neuropeptides have evolved as important signaling molecules in metazoa. The processing of these peptides can occur intracellularly or in extracellular milieu by specific enzymes. Antimicrobial peptides synthesized by ribosomes are found in all phyla of l ...
... cell–cell communication, peptide hormones and neuropeptides have evolved as important signaling molecules in metazoa. The processing of these peptides can occur intracellularly or in extracellular milieu by specific enzymes. Antimicrobial peptides synthesized by ribosomes are found in all phyla of l ...
MINI-SERIES ‘‘T-CELL CO-STIMULATORY MOLECULES’’ Edited by M. Belvisi and K.F. Rabe
... of specific epitopes of a given antigen presented in combination with the major histocompatibility complex on antigenpresenting cells (APCs). However, activation of T-cells by this receptor interaction alone fails to induce cytokine production and sustained proliferation, but rather results in T-cel ...
... of specific epitopes of a given antigen presented in combination with the major histocompatibility complex on antigenpresenting cells (APCs). However, activation of T-cells by this receptor interaction alone fails to induce cytokine production and sustained proliferation, but rather results in T-cel ...
Major Histocompatibility Complex (MHC)
... viral antigens etc. • Note that the viruses utilize the host cell machinery to produce viral proteins. Thus, viral proteins are also considered as endogenous antigen. ...
... viral antigens etc. • Note that the viruses utilize the host cell machinery to produce viral proteins. Thus, viral proteins are also considered as endogenous antigen. ...
Neisseria gonorrhoeae Variation of Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses
... mainly LOS with a terminal GalNAc residue and a minor component with a terminal Gal residue [22,23]. Western blotting of the variants showed equal Opa protein-negative phenotypes, excluding GC interactions with CD66 receptors (Figure 1C). Bacteria were FITC-labeled to assess their interaction with h ...
... mainly LOS with a terminal GalNAc residue and a minor component with a terminal Gal residue [22,23]. Western blotting of the variants showed equal Opa protein-negative phenotypes, excluding GC interactions with CD66 receptors (Figure 1C). Bacteria were FITC-labeled to assess their interaction with h ...
Antibody Feedback Regulation
... expressed on macrophages, mast cells, DCs and NK cells (2). FcJRI and FcJRIII are hetro-oligomeric complexes, in which the respective ligandbinding D chains are associated with the common J chain (FcRJ). FcJRIII is also associated with a E-chain. FcRJ is required for the assembly and for the trigger ...
... expressed on macrophages, mast cells, DCs and NK cells (2). FcJRI and FcJRIII are hetro-oligomeric complexes, in which the respective ligandbinding D chains are associated with the common J chain (FcRJ). FcJRIII is also associated with a E-chain. FcRJ is required for the assembly and for the trigger ...
T-cell exhaustion in allograft rejection and tolerance
... rejection or acceptance has previously been demonstrated in a study [43] showing that simultaneous transplantation of two kidneys and two hearts resulted in long-term graft acceptance, whereas single allogeneic heart and kidney graft were rejected acutely. Another study [35 ] extended these observat ...
... rejection or acceptance has previously been demonstrated in a study [43] showing that simultaneous transplantation of two kidneys and two hearts resulted in long-term graft acceptance, whereas single allogeneic heart and kidney graft were rejected acutely. Another study [35 ] extended these observat ...
New advances in the pathogenesis and treatment of ITP 2014 ASH
... Steroid therapy and CD8 Tregs • Results – Steroids injection is effective at rescuing platelet counts in both passive and active ITP mouse model. – CD8+ T cell depletion leads less responsiveness to DEX treatment. – The CD8 Tregs populations ( CD8+CD25+Foxp3+, CD8+CD103+, CD8+CD122+ and CD8+CD28-) ...
... Steroid therapy and CD8 Tregs • Results – Steroids injection is effective at rescuing platelet counts in both passive and active ITP mouse model. – CD8+ T cell depletion leads less responsiveness to DEX treatment. – The CD8 Tregs populations ( CD8+CD25+Foxp3+, CD8+CD103+, CD8+CD122+ and CD8+CD28-) ...
Pulparesponser
... proteins that play a key role in the innate immune system. They are single membrane-spanning non-catalytic receptors that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recogn ...
... proteins that play a key role in the innate immune system. They are single membrane-spanning non-catalytic receptors that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recogn ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.