Autophagy Delivers Viral Antigens for MHC Class II Presentation
... To address the general relevance and the efficacy of this novel MHC class II pathway, we quantified autophagy in MHC class II-positive human cells and demonstrated constitutive autophagosome formation in epithelial, B and dendritic cells. The autophagosome marker Atg8/LC3 strongly overlapped with m ...
... To address the general relevance and the efficacy of this novel MHC class II pathway, we quantified autophagy in MHC class II-positive human cells and demonstrated constitutive autophagosome formation in epithelial, B and dendritic cells. The autophagosome marker Atg8/LC3 strongly overlapped with m ...
The Immune Response to Helicobacter pylori
... vaccinated with a control protein (FlaA) or negative control. Antibody titers remained high even 8 months after the last immunization. Antibodies were able to bind native flagellin from H. pylori lysate. Vaccination with chimeric flagellin provided mice with significant protection against H. pylori. ...
... vaccinated with a control protein (FlaA) or negative control. Antibody titers remained high even 8 months after the last immunization. Antibodies were able to bind native flagellin from H. pylori lysate. Vaccination with chimeric flagellin provided mice with significant protection against H. pylori. ...
EBV immune evasion genes modulating CD8
... carry out this PhD and for your never ending help every step of the way. The hours of meetings we had discussing the many issues which came up during my PhD have been more helpful than I can describe. I would also like to express my thanks to you for your guidance in writing this thesis. Andrew, you ...
... carry out this PhD and for your never ending help every step of the way. The hours of meetings we had discussing the many issues which came up during my PhD have been more helpful than I can describe. I would also like to express my thanks to you for your guidance in writing this thesis. Andrew, you ...
T-Cell Subset Analysis of Lewis Lung Carcinoma
... We have analyzed the phenotypes of the T-cell subsets generated in response to Lewis lung carcinoma clones in C57BL/6J recipients. The metastatic derivative, which expresses low levels of H - 2 K b gene, predominantly elicited CD8, V~8, and VB9 § T-cells. The nonmetastatic clone expressing high leve ...
... We have analyzed the phenotypes of the T-cell subsets generated in response to Lewis lung carcinoma clones in C57BL/6J recipients. The metastatic derivative, which expresses low levels of H - 2 K b gene, predominantly elicited CD8, V~8, and VB9 § T-cells. The nonmetastatic clone expressing high leve ...
High Level Expression of HLA-A*0203
... mixing the biotinylated monomer with streptavidin-PE at a ratio of 4:1. Flow cytometry showed that this tetramer could specifically react with antigen-specific CD8+ T cells, indicating that it was biologically functional. These results provide a foundation for further characterization of antigen-spe ...
... mixing the biotinylated monomer with streptavidin-PE at a ratio of 4:1. Flow cytometry showed that this tetramer could specifically react with antigen-specific CD8+ T cells, indicating that it was biologically functional. These results provide a foundation for further characterization of antigen-spe ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,... University, Stockholm, Sweden
... kept in check so that they are not able to cause disease. The exact biology of granuloma formation is still not completely understood, however, it is believed that mycobacteria in such a condition can be actively dividing or be silent even within a same individual (16, 17). Under appropriate activat ...
... kept in check so that they are not able to cause disease. The exact biology of granuloma formation is still not completely understood, however, it is believed that mycobacteria in such a condition can be actively dividing or be silent even within a same individual (16, 17). Under appropriate activat ...
The role of different monocyte subsets and macrophages in asthma
... monocytes were shown to infiltrate lung tissues and give rise to monocyte-derived pulmonary dendritic cells and macrophages [27]. Notably, capability of monocytes to transmigrate through endothelium remains predominantly a feature of CD16-positive monocytes and seems to be related to increased expre ...
... monocytes were shown to infiltrate lung tissues and give rise to monocyte-derived pulmonary dendritic cells and macrophages [27]. Notably, capability of monocytes to transmigrate through endothelium remains predominantly a feature of CD16-positive monocytes and seems to be related to increased expre ...
The Biochemical and Biophysical Mechanisms of Macrophage
... The ability of macrophages to migrate is critical for a proper immune response. During an innate immune response, macrophages migrate to sites of infection or inflammation where they clear pathogens through phagocytosis and activate an adaptive immune response by releasing cytokines and acting as an ...
... The ability of macrophages to migrate is critical for a proper immune response. During an innate immune response, macrophages migrate to sites of infection or inflammation where they clear pathogens through phagocytosis and activate an adaptive immune response by releasing cytokines and acting as an ...
The autoimmunity of primary biliary cirrhosis and the clonal
... normally there is tolerance to these, even if there are responses to bacterial homologs, which are phylogenetically distant from human proteins. During spontaneous or induced apoptosis, numerous— perhaps all—cell types express mitochondrial antigens on the intact plasma membrane and within apoptotic ...
... normally there is tolerance to these, even if there are responses to bacterial homologs, which are phylogenetically distant from human proteins. During spontaneous or induced apoptosis, numerous— perhaps all—cell types express mitochondrial antigens on the intact plasma membrane and within apoptotic ...
Effects of Quercetin Supplementation on Innate Immune Function
... inhibited the phosphorylation and degradation of IκBα, thereby stabilizing the NF-κB/IκB complex and suppressing the activation of NF-κB. Similar experiments were performed by Nair et al. (9) and Min et al. (35). Nair et al. (9) studied TNF-α production and regulation in peripheral blood mononuclea ...
... inhibited the phosphorylation and degradation of IκBα, thereby stabilizing the NF-κB/IκB complex and suppressing the activation of NF-κB. Similar experiments were performed by Nair et al. (9) and Min et al. (35). Nair et al. (9) studied TNF-α production and regulation in peripheral blood mononuclea ...
ImmunoPursuit - Manchester Immunology Group
... Q. Which type of cells are used to produce monoclonal antibodies? A15 ...
... Q. Which type of cells are used to produce monoclonal antibodies? A15 ...
Chapter 1 - Baboola Sumo
... harmless derivatives of human pathogens. Some such pathogens remain outside of living cells for most of their lives, while others reside within host cells. Thus, both extracellular and intracellular xenobiorgs could be created. Chapter 3 focusses on extracellular xenobiorgs. It discusses tasks other ...
... harmless derivatives of human pathogens. Some such pathogens remain outside of living cells for most of their lives, while others reside within host cells. Thus, both extracellular and intracellular xenobiorgs could be created. Chapter 3 focusses on extracellular xenobiorgs. It discusses tasks other ...
Endometrial dendritic cell populations during the normal menstrual
... density (Fig. 2). The density of CD1aþ DCs did not vary between the fundus and the isthmus during the proliferative, secretory and menstrual phases. There were also no significant differences in the density of CD83þ DCs between the fundus and isthmus of the uterus across all phases of the menstrual ...
... density (Fig. 2). The density of CD1aþ DCs did not vary between the fundus and the isthmus during the proliferative, secretory and menstrual phases. There were also no significant differences in the density of CD83þ DCs between the fundus and isthmus of the uterus across all phases of the menstrual ...
... spleen rates have also been seen in the Fulani compared to the non-Fulani. IL-4 and IL-10 are two cytokines with crucial roles in the regulation of both inflammatory- and antibody responses. IL-4 -590 C/T and IL-10 -1087 A/G single nucleotide polymorphisms (SNP) have been shown to result in variable ...
Really Essential Medical Immunology Arthur Rabson
... Mucus secreted by the membranes lining the inner surfaces of the body acts as a protective barrier to block the adherence of bacteria to epithelial cells. Microbial and other foreign particles trapped within the adhesive mucus are removed by mechanical stratagems such as ciliary movement, coughing a ...
... Mucus secreted by the membranes lining the inner surfaces of the body acts as a protective barrier to block the adherence of bacteria to epithelial cells. Microbial and other foreign particles trapped within the adhesive mucus are removed by mechanical stratagems such as ciliary movement, coughing a ...
Program death-1 signaling and regulatory T cells
... Figure 1. PD-1 expressing CD8ⴙ T cells in the liver of AML-bearing mice displayed impaired function. B6 mice were injected intravenously with 106 C1498FFDsR cells and killed 14, 20, or 25 days after tumor injection. Flow cytometric analysis was performed on liver leukocytes and splenocytes (A-C). (A ...
... Figure 1. PD-1 expressing CD8ⴙ T cells in the liver of AML-bearing mice displayed impaired function. B6 mice were injected intravenously with 106 C1498FFDsR cells and killed 14, 20, or 25 days after tumor injection. Flow cytometric analysis was performed on liver leukocytes and splenocytes (A-C). (A ...
Nuclear factor κB (NF-κB)
... such as TNF-α, IL-6 and IL-12. In the anti-viral signalling pathway, this MyD88/IRAK1/IRAK4/TRAF6 complex activates IRF7 (interferon regulatory factor 7), leading to the production of type I IFNs [10–13]. The production of type I IFNs is particularly important in TLR-elicited antiviral and antitumou ...
... such as TNF-α, IL-6 and IL-12. In the anti-viral signalling pathway, this MyD88/IRAK1/IRAK4/TRAF6 complex activates IRF7 (interferon regulatory factor 7), leading to the production of type I IFNs [10–13]. The production of type I IFNs is particularly important in TLR-elicited antiviral and antitumou ...
The Lymphatic System
... lymphocytes, the secondary lymphoid organs then nurture the young lymphocytes and initiate an adaptive immune response. In cell mediated immunity naive T-lymphocytes from the thymus, encounter an antigen in circulation either from outside or inside the body and become sensitised to it. They then cir ...
... lymphocytes, the secondary lymphoid organs then nurture the young lymphocytes and initiate an adaptive immune response. In cell mediated immunity naive T-lymphocytes from the thymus, encounter an antigen in circulation either from outside or inside the body and become sensitised to it. They then cir ...
Tissue Microenvironments Define and Get Reinforced by
... in Homeostasis or during Inflammation, Repair and Fibrosis ...
... in Homeostasis or during Inflammation, Repair and Fibrosis ...
Delivery strategies to enhance oral vaccination against
... impaired nutrient absorption, there is a significant risk that long term developmental disabilities might occur. Stunted growth (often by up to 8 cm at age 7), lower levels of physical fitness, and impaired cognitive function adversely impacting on academic performance can have serious implications in ...
... impaired nutrient absorption, there is a significant risk that long term developmental disabilities might occur. Stunted growth (often by up to 8 cm at age 7), lower levels of physical fitness, and impaired cognitive function adversely impacting on academic performance can have serious implications in ...
Subcellular Localization of Toll-Like Receptor 3
... Toll-like receptor (TLR)3 recognizes dsRNA and transduces signals to activate NF-B and IFN- promoter. Type I IFNs (IFN␣/) function as key cytokines in anti-viral host defense. Human fibroblasts express TLR3 on the cell surface, and anti-TLR3 mAb inhibits dsRNA-induced IFN- secretion by fibroblas ...
... Toll-like receptor (TLR)3 recognizes dsRNA and transduces signals to activate NF-B and IFN- promoter. Type I IFNs (IFN␣/) function as key cytokines in anti-viral host defense. Human fibroblasts express TLR3 on the cell surface, and anti-TLR3 mAb inhibits dsRNA-induced IFN- secretion by fibroblas ...
Intestinal Dendritic Cells Specialize to Activate Transforming Growth
... and commensal bacteria that inhabit the gut.1 Regulatory processes must therefore prevent detrimental immune responses to these harmless antigens while still being able to mount protective responses against pathogens that enter the digestive tract. A breakdown in this tight regulation can lead to de ...
... and commensal bacteria that inhabit the gut.1 Regulatory processes must therefore prevent detrimental immune responses to these harmless antigens while still being able to mount protective responses against pathogens that enter the digestive tract. A breakdown in this tight regulation can lead to de ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.