Characterization of thymic hyperplasia associated with autoimmune
... is observed in the MG thymus. In addition, Poly(I:C) injections in wildtype mice, but not in IFN-I receptor KO 0"1$2&%,$1"."13445&"-1!$3%$&'(50"1&$+,!$%%")-&).&/-AChR and, in parallel, CXCL13 and CCL21 expression. In periphery, Poly(I:C) even induced an anti-AChR autoimmune response characterized by ...
... is observed in the MG thymus. In addition, Poly(I:C) injections in wildtype mice, but not in IFN-I receptor KO 0"1$2&%,$1"."13445&"-1!$3%$&'(50"1&$+,!$%%")-&).&/-AChR and, in parallel, CXCL13 and CCL21 expression. In periphery, Poly(I:C) even induced an anti-AChR autoimmune response characterized by ...
Origin of Anti-tumor Immunity Failure in Mammals
... variability as a result of the Recombination Activating Genes (RAG) activity (Abbas et al., 2003). MHC class I and class II genes, RAG genes as well as TCR and Ig have only been identified in jawed vertebrates. No molecular evidence has been found that the adoptive immune system traces its origin st ...
... variability as a result of the Recombination Activating Genes (RAG) activity (Abbas et al., 2003). MHC class I and class II genes, RAG genes as well as TCR and Ig have only been identified in jawed vertebrates. No molecular evidence has been found that the adoptive immune system traces its origin st ...
HIV-1 Envelope gp41 Is a Potent Inhibitor of Chemoattractant
... receptor superfamily have been identified as essential cofactors for HIV-1 entry (5), and HIV-1 cell-type tropism seems to be dictated by chemokine receptor usage. After the binding of the envelope gp120 to CD4, the chemokine receptors, CXCR4 for T lymphotropic and CCR5 for monotropic HIV-1, may eit ...
... receptor superfamily have been identified as essential cofactors for HIV-1 entry (5), and HIV-1 cell-type tropism seems to be dictated by chemokine receptor usage. After the binding of the envelope gp120 to CD4, the chemokine receptors, CXCR4 for T lymphotropic and CCR5 for monotropic HIV-1, may eit ...
Assessment of allergen specific response in humans Luis Diego Archila Diaz
... WARNING. On having consulted this thesis you’re accepting the following use conditions: Spreading this thesis by the TDX (www.tdx.cat) service and by the UB Digital Repository (diposit.ub.edu) has been authorized by the titular of the intellectual property rights only for private uses placed in inve ...
... WARNING. On having consulted this thesis you’re accepting the following use conditions: Spreading this thesis by the TDX (www.tdx.cat) service and by the UB Digital Repository (diposit.ub.edu) has been authorized by the titular of the intellectual property rights only for private uses placed in inve ...
Immune profile from high-risk to onset of Type 1 diabetes No. 1275
... present with an intense up-regulation of regulatory (FOXP3, TGF-β and CTLA-4) and proinflammatory (e.g. tumour necrosis factor-α) markers and a suppression of Th1 (e.g. interferon-γ) and Th2-associated immunity (e.g. interleukin-13). This up-regulation of regulatory markers, however, seems to occur ...
... present with an intense up-regulation of regulatory (FOXP3, TGF-β and CTLA-4) and proinflammatory (e.g. tumour necrosis factor-α) markers and a suppression of Th1 (e.g. interferon-γ) and Th2-associated immunity (e.g. interleukin-13). This up-regulation of regulatory markers, however, seems to occur ...
Drosophila as a model to study the role of blood cells in
... © 2013 Wang, Kounatidis and Ligoxygakis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original ...
... © 2013 Wang, Kounatidis and Ligoxygakis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original ...
Leishmania species: models of intracellular parasitism
... cells of the macrophage-dendritic cell lineage. Indeed, the ability to survive and multiply within macrophages is a feature of a surprising number of infectious agents of major importance to public health, including Mycobacterium tuberculosis, Mycobacterium leprae, Listeria monocytogenes, Salmonella ...
... cells of the macrophage-dendritic cell lineage. Indeed, the ability to survive and multiply within macrophages is a feature of a surprising number of infectious agents of major importance to public health, including Mycobacterium tuberculosis, Mycobacterium leprae, Listeria monocytogenes, Salmonella ...
Mechanisms involved in regulation of MHC class I molecules in
... cancer cells but also play an important role in reproduction process and development of embryo during the preimplantation period. In the present study, we use murine embryonic stem cells (ESCs) as model to dissect the molecular mechanism involved in the regulation of MHC class I molecules during dif ...
... cancer cells but also play an important role in reproduction process and development of embryo during the preimplantation period. In the present study, we use murine embryonic stem cells (ESCs) as model to dissect the molecular mechanism involved in the regulation of MHC class I molecules during dif ...
Neutrophil function in the healing wound: adding insult to injury?
... very well In contrast to adult skin, in which injured skin is repaired resulting in a fibrous scar, fetal dermal healing is characterized by scarless regeneration (14-16). During this remarkable process of regeneration, the normal dermal architecture is completely restored not unlike the ability of ...
... very well In contrast to adult skin, in which injured skin is repaired resulting in a fibrous scar, fetal dermal healing is characterized by scarless regeneration (14-16). During this remarkable process of regeneration, the normal dermal architecture is completely restored not unlike the ability of ...
Current Topics in Microbiology and Immunology
... probably important for many aspects of normal and malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The first main section includes three chapters, where the first review by Bonecchi et al. d ...
... probably important for many aspects of normal and malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The first main section includes three chapters, where the first review by Bonecchi et al. d ...
Immune System
... causes chicken pox. A B-cell will recognize the virus somewhere in your spleen or lymph nodes and be activated with the help of a helper-T cell (discussed shortly). The B-cell will undergo mitosis forming plasma and memory B-cells, which all make the same antibody (it is mitosis so they are all ALMO ...
... causes chicken pox. A B-cell will recognize the virus somewhere in your spleen or lymph nodes and be activated with the help of a helper-T cell (discussed shortly). The B-cell will undergo mitosis forming plasma and memory B-cells, which all make the same antibody (it is mitosis so they are all ALMO ...
full text pdf
... 1.2.3 Pulmonary route The respiratory tract is well equipped with immunocompetent cells to tackle the pathogens which commonly enter the body through the respiratory tract. Human lungs are endowed with a huge surface area, are extensively vascularised, and contain APCs such as dendritic cells and al ...
... 1.2.3 Pulmonary route The respiratory tract is well equipped with immunocompetent cells to tackle the pathogens which commonly enter the body through the respiratory tract. Human lungs are endowed with a huge surface area, are extensively vascularised, and contain APCs such as dendritic cells and al ...
Cells Intestinal Lamina Propria as Regulatory T Cells in Human
... involved compared with uninvolved areas or control tissue (29), being so far believed that these activated CD4⫹CD25⫹ cells should be pathogenic for the development of IBD. These conflicting findings prompted us to determine whether or not the LP ...
... involved compared with uninvolved areas or control tissue (29), being so far believed that these activated CD4⫹CD25⫹ cells should be pathogenic for the development of IBD. These conflicting findings prompted us to determine whether or not the LP ...
Biomarkers and mechanisms of natural disease resistance in dairy
... immune cells and to induce an adaptive immune reaction. Antimicrobial peptides, such as lactoferrin, are amphipathic molecules of < 100 amino acids long with antimicrobial and immunomodulatory functions [41]. They are produced by immune and epithelial cells and can kill among others by direct intera ...
... immune cells and to induce an adaptive immune reaction. Antimicrobial peptides, such as lactoferrin, are amphipathic molecules of < 100 amino acids long with antimicrobial and immunomodulatory functions [41]. They are produced by immune and epithelial cells and can kill among others by direct intera ...
Molecular basis of the CRAC channel - Cahalan Lab-Home
... maintain the resting membrane potential of about −50 mV [12]. Contact with peptide-MHC on the APC initiates the proximal signaling cascade involving adapter molecules and tyrosine kinases, resulting in phospholipase C activation and the formation of the two messengers, IP3 and DAG. IP3 opens the IP3 ...
... maintain the resting membrane potential of about −50 mV [12]. Contact with peptide-MHC on the APC initiates the proximal signaling cascade involving adapter molecules and tyrosine kinases, resulting in phospholipase C activation and the formation of the two messengers, IP3 and DAG. IP3 opens the IP3 ...
Anti-inflammatory properties of peptides derived Ornithodoros savignyi
... In this study the potential anti-inflammatory and antioxidant properties of synthetic AMPs, Os and Os-C, derived from a defensin (OsDef2) previously identified in the tick, Ornithodoros savignyi, were investigated. Os is derived from the carboxy-terminal of OsDef2, whereas Os-C is an analogue of Os ...
... In this study the potential anti-inflammatory and antioxidant properties of synthetic AMPs, Os and Os-C, derived from a defensin (OsDef2) previously identified in the tick, Ornithodoros savignyi, were investigated. Os is derived from the carboxy-terminal of OsDef2, whereas Os-C is an analogue of Os ...
View/Open - Minerva Access
... Complement is typically regarded as a component of the innate immune system, however, degradation products particularly of the third complement factor, C3, are known to enhance the adaptive immune response to foreign antigens (Toapanta and Ross 2006). Activation of C3 leads to the generation of C3dg ...
... Complement is typically regarded as a component of the innate immune system, however, degradation products particularly of the third complement factor, C3, are known to enhance the adaptive immune response to foreign antigens (Toapanta and Ross 2006). Activation of C3 leads to the generation of C3dg ...
Regulatory T cells in human pregnancy Jenny Mjösberg
... have received vast attention as key players in immune regulation. However, the identification of human Tregs is complicated by their similarity to activated nonsuppressive T cells. The general aim of this thesis was to determine the antigen specificity, frequency, phenotype and function of Tregs in ...
... have received vast attention as key players in immune regulation. However, the identification of human Tregs is complicated by their similarity to activated nonsuppressive T cells. The general aim of this thesis was to determine the antigen specificity, frequency, phenotype and function of Tregs in ...
Hannah Akuffo Publications 1990 to 1999
... 42. Maasho K, Akuffo HO. Cells from healthy non-exposed individuals produce cytokines to selected fractions of Leishmania promastigotes. Scand J Immunol Suppl. 1992;11:179-84. 43. Akuffo HO. Cytokine responses to parasite antigens: in vitro cytokine production to promastigotes of L. aethiopica by ce ...
... 42. Maasho K, Akuffo HO. Cells from healthy non-exposed individuals produce cytokines to selected fractions of Leishmania promastigotes. Scand J Immunol Suppl. 1992;11:179-84. 43. Akuffo HO. Cytokine responses to parasite antigens: in vitro cytokine production to promastigotes of L. aethiopica by ce ...
Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell
... Genetic deletion studies were used to confirm the role of cell cycle proteins. None of the cyclin knockout animals had any serious immune defects except for those lacking cyclin D3, which is required for normal hematopoietic development (25). Mice lacking CDK1 are not able to develop at the embryoni ...
... Genetic deletion studies were used to confirm the role of cell cycle proteins. None of the cyclin knockout animals had any serious immune defects except for those lacking cyclin D3, which is required for normal hematopoietic development (25). Mice lacking CDK1 are not able to develop at the embryoni ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.