Tumors and Ly6Chigh Monocytes Fatemeh Zare
... me along the way. Firstly I would like to acknowledge my supervisor for all his help and support throughout this time. Prof. Antonio Celada, thank you for encouraging me to work independently as a scientist and for providing me the opportunity to be a part of your group. Prof Roger Gomis, given that ...
... me along the way. Firstly I would like to acknowledge my supervisor for all his help and support throughout this time. Prof. Antonio Celada, thank you for encouraging me to work independently as a scientist and for providing me the opportunity to be a part of your group. Prof Roger Gomis, given that ...
$doc.title
... Worldwide, the heterosexual route is the most common mode of sexual transmission of HIV-‐1 and women are particularly susceptible to this infection. After penetration of the mucosal epithelium HIV-‐1 interacts ...
... Worldwide, the heterosexual route is the most common mode of sexual transmission of HIV-‐1 and women are particularly susceptible to this infection. After penetration of the mucosal epithelium HIV-‐1 interacts ...
Document
... opioid receptors on leukocytes, research focus has shifted to direct effects of opioids on immune cells and will therefore be the topic of discussion of this review. In this section, we summarize seminal studies and current literature investigating how morphine directly inhibits the innate immune sy ...
... opioid receptors on leukocytes, research focus has shifted to direct effects of opioids on immune cells and will therefore be the topic of discussion of this review. In this section, we summarize seminal studies and current literature investigating how morphine directly inhibits the innate immune sy ...
Epitope Masking in a Murine Model Independently from Red Cell
... fetal red cells. Much of our information on how anti-D may prevent immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that ca ...
... fetal red cells. Much of our information on how anti-D may prevent immunization to D+ RBCs has come from seminal studies dating back to the 1960s on human male D2 volunteers immunized with D+ RBCs. In many of these studies and others that have followed, it was noticed that the dose of anti-D that ca ...
Inflammation Macrophage Activation and Acute TLR-2 and IL
... lining of the digestive tracts of many insects (1–9). In these locations, chitin is used by the organism to protect it from the harsh conditions in its environment and host anti-parasite/pathogen immune responses. In these settings, chitin accumulation is regulated by the balance of biosynthesis and ...
... lining of the digestive tracts of many insects (1–9). In these locations, chitin is used by the organism to protect it from the harsh conditions in its environment and host anti-parasite/pathogen immune responses. In these settings, chitin accumulation is regulated by the balance of biosynthesis and ...
Radial secondary growth and formation of successive cambia and
... secondary xylem centripetally and secondary phloem centrifugally, like other dicotyledons that show successive rings, and (2) abnormal cambia with reverse orientation. The former type of successive rings originates from the parenchyma cells located outside the phloem produced by previous cambium. Th ...
... secondary xylem centripetally and secondary phloem centrifugally, like other dicotyledons that show successive rings, and (2) abnormal cambia with reverse orientation. The former type of successive rings originates from the parenchyma cells located outside the phloem produced by previous cambium. Th ...
Deep Insight Section
... soluble HLA class I antigens, through upregulation of FasL following the interactions of sHLA-G with CD8, activated T lymphocytes and NK cells come into apoptosis (Fournel et al., 2000; Contini et al., 2003). Moreover, sHLA-G inhibits the cytotoxic activity of antigen-specific CTL (Contini et al., 2 ...
... soluble HLA class I antigens, through upregulation of FasL following the interactions of sHLA-G with CD8, activated T lymphocytes and NK cells come into apoptosis (Fournel et al., 2000; Contini et al., 2003). Moreover, sHLA-G inhibits the cytotoxic activity of antigen-specific CTL (Contini et al., 2 ...
Essential role of Toll-like receptor 2 in
... receptors and C-type lectin receptors (CLRs), play important roles in host defense (Chamaillard et al. 2003; Takeda et al. 2003; Adachi et al. 2004; Saijo et al. 2007; Yoneyama and Fujita 2007). Especially, the TLRs have been extensively studied and demonstrated to participate in host defense agains ...
... receptors and C-type lectin receptors (CLRs), play important roles in host defense (Chamaillard et al. 2003; Takeda et al. 2003; Adachi et al. 2004; Saijo et al. 2007; Yoneyama and Fujita 2007). Especially, the TLRs have been extensively studied and demonstrated to participate in host defense agains ...
Full text - Universiteit Leiden
... focuses on highly conserved motifs in pathogens. It provides the first line of defense for the host and is characterized by fast (minutes to hours) and blunt (lacking exquisite structural specificity) responses. It is a very conserved system, which is already present in many lower organisms. Importa ...
... focuses on highly conserved motifs in pathogens. It provides the first line of defense for the host and is characterized by fast (minutes to hours) and blunt (lacking exquisite structural specificity) responses. It is a very conserved system, which is already present in many lower organisms. Importa ...
Psoriasis - New England Journal of Medicine
... epithelial and mesenchymal cells. This disease vividly highlights the pathogenic importance of T cells and simultaneously illustrates how advances in our understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation ...
... epithelial and mesenchymal cells. This disease vividly highlights the pathogenic importance of T cells and simultaneously illustrates how advances in our understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation ...
Complement: a key system for immune surveillance and homeostasis
... to other systems (Supplementary Fig. 1). Depending on the trigger, several initiation and regulatory mechanisms act together to produce an anticipated result in immune surveillance (Figs. 1 and 2). The classical pathway is often referred to as antibody-dependent because it is strongly initiated by I ...
... to other systems (Supplementary Fig. 1). Depending on the trigger, several initiation and regulatory mechanisms act together to produce an anticipated result in immune surveillance (Figs. 1 and 2). The classical pathway is often referred to as antibody-dependent because it is strongly initiated by I ...
Chapter 3. Characterising αCXCR3-9C5
... Thank you to my amazing partner Luke, who has remained my rock over the past two years, through all of my academic and personal struggles. I would not have made it this far without your love, support and patience. I would also like to thank my family for all their support and encouragement without w ...
... Thank you to my amazing partner Luke, who has remained my rock over the past two years, through all of my academic and personal struggles. I would not have made it this far without your love, support and patience. I would also like to thank my family for all their support and encouragement without w ...
Chitin, Chitinases and Chitinase
... exogenous chitin activates macrophages and other innate immune cells and also modulates adaptive type 2 allergic inflammation. These studies further demonstrate that chitin stimulate macrophages by interacting with different cell surface receptors such as macrophage mannose receptor, toll-like recep ...
... exogenous chitin activates macrophages and other innate immune cells and also modulates adaptive type 2 allergic inflammation. These studies further demonstrate that chitin stimulate macrophages by interacting with different cell surface receptors such as macrophage mannose receptor, toll-like recep ...
Bacterial lipopolysaccharide stimulates bovine neutrophil production
... the clinical cases of bovine mastitis that occur annually, 40% are caused by Gramnegative bacteria [16, 46]. A key component of the host immune response to Gramnegative infections is the upregulation of cytokine production [5, 39, 40]. Most studies have focused on the immunomodulation changes affecte ...
... the clinical cases of bovine mastitis that occur annually, 40% are caused by Gramnegative bacteria [16, 46]. A key component of the host immune response to Gramnegative infections is the upregulation of cytokine production [5, 39, 40]. Most studies have focused on the immunomodulation changes affecte ...
Role and prognostic importance of regulatory T cells in lung cancer
... complex interaction between the tumor cells with its environment turns into either eradication or the growth and metastasis of the tumors. In our team we have previously demonstrated the role of TLS (tertiary lymphoid structures) in lung tumors, in the generation of the protective anti-tumor respons ...
... complex interaction between the tumor cells with its environment turns into either eradication or the growth and metastasis of the tumors. In our team we have previously demonstrated the role of TLS (tertiary lymphoid structures) in lung tumors, in the generation of the protective anti-tumor respons ...
prolongation of allograft survival in ccr7
... CCR7⫺/⫺ mice (Fig. 2). In contrast, the number of lymphocytes in the spleen of recipients of syngeneic grafts showed no significant differences in CCR7⫺/⫺ and WT 129Sv mice. As shown previously (3), the number of CD4⫹ and CD8⫹ cells in the spleen of CCR7⫺/⫺ mice was increased two- to threefold: naiv ...
... CCR7⫺/⫺ mice (Fig. 2). In contrast, the number of lymphocytes in the spleen of recipients of syngeneic grafts showed no significant differences in CCR7⫺/⫺ and WT 129Sv mice. As shown previously (3), the number of CD4⫹ and CD8⫹ cells in the spleen of CCR7⫺/⫺ mice was increased two- to threefold: naiv ...
C YTOKINES AND IMMUNE BALANCE IN PREECLAMPSIA
... adaptive immune response takes effect, and during this time the innate immune response has a critical role in controlling infections (Janeway 2005). Activated macrophages and NK cells secrete cytokines and chemokines, which initiate the inflammatory response and aid the destruction of phagocytosed p ...
... adaptive immune response takes effect, and during this time the innate immune response has a critical role in controlling infections (Janeway 2005). Activated macrophages and NK cells secrete cytokines and chemokines, which initiate the inflammatory response and aid the destruction of phagocytosed p ...
Macrophage Cell Surface CD4 Type 1 HIV gp120 Induced Loss of A
... Ag gp120 are skewed away from VH3 bearing IgGs, which are normally protective against pathogens (4). Autoimmune responses are also a feature (5, 6) including those against CD4 molecules (7–9). HIV-1 is able to infect CD4⫹ T cells and CD4⫹ APCs, including macrophages and DC, (10 –12). There is also e ...
... Ag gp120 are skewed away from VH3 bearing IgGs, which are normally protective against pathogens (4). Autoimmune responses are also a feature (5, 6) including those against CD4 molecules (7–9). HIV-1 is able to infect CD4⫹ T cells and CD4⫹ APCs, including macrophages and DC, (10 –12). There is also e ...
Characterization of cell-mediated immune responses elicited
... Results. The authors report that all mice, whether they accept or reject grafts, acquire donorspecific DH within 4 weeks of engraftment. This reactivity is primarily directed at minor H, rather than MHC-encoded, alloantigens. Through time, spontaneous DH reactivity disappears in all mice, and therea ...
... Results. The authors report that all mice, whether they accept or reject grafts, acquire donorspecific DH within 4 weeks of engraftment. This reactivity is primarily directed at minor H, rather than MHC-encoded, alloantigens. Through time, spontaneous DH reactivity disappears in all mice, and therea ...
Molecular Studies of T-Lymphocytes From Bovine Leukemia Virus
... The BLV provirus was found in the DNA of peripheral blood lymphocytes and 3 of A purified T lymphocyte preparations from AL animals using hybridization analysis uith radiolabeled BLV-DNA as a probe. ...
... The BLV provirus was found in the DNA of peripheral blood lymphocytes and 3 of A purified T lymphocyte preparations from AL animals using hybridization analysis uith radiolabeled BLV-DNA as a probe. ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.