FUNCTIONS AND APPLICATIONS OF EXOSOMES
... intestinal epithelial cells and tumor cell lines have been described. In vivo, exosomes are found to be present in many biological fluids like: synovial fluid, breast milk, blood, urine and saliva, amniotic liquid and malignant effusions of ascites. In blood serum, exosomes are almost present in a q ...
... intestinal epithelial cells and tumor cell lines have been described. In vivo, exosomes are found to be present in many biological fluids like: synovial fluid, breast milk, blood, urine and saliva, amniotic liquid and malignant effusions of ascites. In blood serum, exosomes are almost present in a q ...
3 - bioRxiv
... coming from their neighbours or from their own autocrine signals [14, 15]. Since the adaptation to the environment occurs at the population level, autocrine and paracrine feedback may play a different role in a cell population responding to opposing signals, notably as a function of cell density. De ...
... coming from their neighbours or from their own autocrine signals [14, 15]. Since the adaptation to the environment occurs at the population level, autocrine and paracrine feedback may play a different role in a cell population responding to opposing signals, notably as a function of cell density. De ...
IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice
... results in rapid activation of T cells and production of inflammatory cytokines, such as Interleukin-2 (IL-2), Interferon-c and Tumor Necrosis Factor-a which mediate TSS. Although IL2 was originally identified as the T cell growth factor and was proposed to contribute to T cell differentiation, its ...
... results in rapid activation of T cells and production of inflammatory cytokines, such as Interleukin-2 (IL-2), Interferon-c and Tumor Necrosis Factor-a which mediate TSS. Although IL2 was originally identified as the T cell growth factor and was proposed to contribute to T cell differentiation, its ...
Proceedings Template - WORD
... B. The Intermediate Phase. While the early phase of the immune response largely governs the ultimate decision, the intermediate and final phases solidify this decision and stabilize it such that, beyond a critical point, reversibility of the immune decision is no longer possible. This aspect of the ...
... B. The Intermediate Phase. While the early phase of the immune response largely governs the ultimate decision, the intermediate and final phases solidify this decision and stabilize it such that, beyond a critical point, reversibility of the immune decision is no longer possible. This aspect of the ...
nuclear hormone receptors enable macrophages and dendritic cells
... activities. The mechanisms of differentiation and subtype specification of immune cells such as macrophages and dendritic cells are critical to understand the regulatory principles and logic of the immune system. In addition to cytokines and pathogens, it is increasingly appreciated that lipid signa ...
... activities. The mechanisms of differentiation and subtype specification of immune cells such as macrophages and dendritic cells are critical to understand the regulatory principles and logic of the immune system. In addition to cytokines and pathogens, it is increasingly appreciated that lipid signa ...
Chapter 15 The Lymphatic System and Immunity
... – Most numerous of immune system cells – Development of B cells—primitive stem cells migrate from bone marrow and go through two stages of development ...
... – Most numerous of immune system cells – Development of B cells—primitive stem cells migrate from bone marrow and go through two stages of development ...
Regulatory T Cells: Mechanisms of Differentiation and Function
... Access provided by Roswell Park Cancer Institute on 06/06/16. For personal use only. ...
... Access provided by Roswell Park Cancer Institute on 06/06/16. For personal use only. ...
Regulation of macrophage development and function in peripheral
... crucial for maintaining a balanced response to homeostatic or tissue-damaging signals and, when this delicate balance is disturbed, inflammatory disease can occur. Recent studies have revealed the ontogeny and functional diversity of tissue-resident macrophages. These studies have established that t ...
... crucial for maintaining a balanced response to homeostatic or tissue-damaging signals and, when this delicate balance is disturbed, inflammatory disease can occur. Recent studies have revealed the ontogeny and functional diversity of tissue-resident macrophages. These studies have established that t ...
Cytokine responses in human Lyme borreliosis
... The Borrelia-specific IFN-γ and IL-4 secretion was detected in blood and cerebrospinal fluid from patients with chronic and subacute neuroborreliosis during the course of the disease. Blood samples were also obtained from patients with erythema migrans (EM) and acrodermatitis chronicum atrophicans. ...
... The Borrelia-specific IFN-γ and IL-4 secretion was detected in blood and cerebrospinal fluid from patients with chronic and subacute neuroborreliosis during the course of the disease. Blood samples were also obtained from patients with erythema migrans (EM) and acrodermatitis chronicum atrophicans. ...
Leukotriene C4 induces migration of human
... quantitative RT PCR, in comparison with that of untreated, immature DCs (DC Imm). DCs expressed all leukotriene receptors analyzed. BLT1 mRNA was expressed at similar levels by immature, CC and pIC-matured DCs, whereas modest down-regulation (2- to 3-fold) was observed in CD40L and LPS-matured DCs. ...
... quantitative RT PCR, in comparison with that of untreated, immature DCs (DC Imm). DCs expressed all leukotriene receptors analyzed. BLT1 mRNA was expressed at similar levels by immature, CC and pIC-matured DCs, whereas modest down-regulation (2- to 3-fold) was observed in CD40L and LPS-matured DCs. ...
• - Utrecht University Repository
... The human immune system is the product of aeons of evolution, which have brought forth a system that is both delicate in its regulatory mechanisms and powerful in its actions. In order to remain functional and effective, the immune system must be kept in balance. An immune response that is too harsh ...
... The human immune system is the product of aeons of evolution, which have brought forth a system that is both delicate in its regulatory mechanisms and powerful in its actions. In order to remain functional and effective, the immune system must be kept in balance. An immune response that is too harsh ...
EFFECTS OF INCREASED INFLAMMATION ON ANTIVIRAL CD8 T CELL
... 4.4 Increased pro-inflammatory cytokine levels in the serum of TG mice 2 days post infection with a low and a high viral dose ........................................................................................................................ 43 4.5 T cells from naïve TG mice exhibit a similar p ...
... 4.4 Increased pro-inflammatory cytokine levels in the serum of TG mice 2 days post infection with a low and a high viral dose ........................................................................................................................ 43 4.5 T cells from naïve TG mice exhibit a similar p ...
Here - European Macrophage and Dendritic Cell Society
... We are happy to welcome you to the capital of Europe for the 25th Annual Meeting of the European Macrophage and Dendritic Cell Society. We are looking forward to an exciting meeting focused around the theme of Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity. Th ...
... We are happy to welcome you to the capital of Europe for the 25th Annual Meeting of the European Macrophage and Dendritic Cell Society. We are looking forward to an exciting meeting focused around the theme of Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity. Th ...
Mapping the inhibitory determinants within the cytoplasmic tail of CD6
... antigen presenting cells. Integrating this response there are other signals provided by accessory and co-stimulatory molecules targeting at the immunological synapse (IS). The engagement between APCs and T cells triggers several intracellular signaling pathways, which induce early and late responses ...
... antigen presenting cells. Integrating this response there are other signals provided by accessory and co-stimulatory molecules targeting at the immunological synapse (IS). The engagement between APCs and T cells triggers several intracellular signaling pathways, which induce early and late responses ...
Essentials of Human Anatomy and Physiology, 11e
... 25) T cells or B cells that are capable of responding to a specific antigen by binding to it with antigen-specific receptors that appear on the lymphocyte's surface are considered ________. A) clones B) complement C) self-tolerant D) immunocompetent Answer: D Page Ref: 412 Bloom's: 1) Knowledge 26) ...
... 25) T cells or B cells that are capable of responding to a specific antigen by binding to it with antigen-specific receptors that appear on the lymphocyte's surface are considered ________. A) clones B) complement C) self-tolerant D) immunocompetent Answer: D Page Ref: 412 Bloom's: 1) Knowledge 26) ...
Mast cell-orchestrated immunity to pathogens
... and tissue-resident immune cells, including dendritic cells (DCs) (FIG. 1e). Despite having a common lineage, granulated morphology and functions, mast cells are highly heterogeneous and phenotypically malleable cells5,6, the intricacies of which have only begun to be defined, with little known abou ...
... and tissue-resident immune cells, including dendritic cells (DCs) (FIG. 1e). Despite having a common lineage, granulated morphology and functions, mast cells are highly heterogeneous and phenotypically malleable cells5,6, the intricacies of which have only begun to be defined, with little known abou ...
Neuropilin 1 is expressed on thymus-derived natural
... the issue of division of labor required very specialized strains of mice. However, these experimental systems cannot be used to identify nT reg and iT reg cells in unmanipulated WT mice. In this study, we show that surface expression of Neuropilin 1 (Nrp1) is preferentially up-regulated by nT reg ce ...
... the issue of division of labor required very specialized strains of mice. However, these experimental systems cannot be used to identify nT reg and iT reg cells in unmanipulated WT mice. In this study, we show that surface expression of Neuropilin 1 (Nrp1) is preferentially up-regulated by nT reg ce ...
Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
... immunoregulatory functions [16]. For instance, IFN-I do not only play a crucial role in the control of the replication of many viruses, but they can also promote NK cell or CD8 T cell antiviral cytotoxic activity, either directly [17-20] or through the licensing of accessory cells such as convention ...
... immunoregulatory functions [16]. For instance, IFN-I do not only play a crucial role in the control of the replication of many viruses, but they can also promote NK cell or CD8 T cell antiviral cytotoxic activity, either directly [17-20] or through the licensing of accessory cells such as convention ...
ABSTRACT Title of Document:
... phenomenon was independent of the phosphorylation activity of the NFAT1 and 2 kinases p38 and JNK, and resultant nuclear exit, as cellular translocation assays using specific kinase and nuclear export inhibitors caused no change in pattern of NFAT1 and NFAT2 nuclear localization. Proliferative and t ...
... phenomenon was independent of the phosphorylation activity of the NFAT1 and 2 kinases p38 and JNK, and resultant nuclear exit, as cellular translocation assays using specific kinase and nuclear export inhibitors caused no change in pattern of NFAT1 and NFAT2 nuclear localization. Proliferative and t ...
Immunological studies on Swine Influenza Virus in Massimiliano Baratelli
... of SwIV in Spain needed to be updated and more genetic data were required to allow the use of reverse vaccinology. The study showed that the epidemiological situation of Spain was similar to other European countries in which circulating strains were closed related and evolving in the same way. Howev ...
... of SwIV in Spain needed to be updated and more genetic data were required to allow the use of reverse vaccinology. The study showed that the epidemiological situation of Spain was similar to other European countries in which circulating strains were closed related and evolving in the same way. Howev ...
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the
... was initially identified using a cluster analysis approach in octogenarian individuals participating in the Swedish OCTO Immune study (Ferguson et al. 1995). Subsequent studies of very old individuals participating in the Swedish OCTO and NONA immune studies indicated that this IRP could be defined ...
... was initially identified using a cluster analysis approach in octogenarian individuals participating in the Swedish OCTO Immune study (Ferguson et al. 1995). Subsequent studies of very old individuals participating in the Swedish OCTO and NONA immune studies indicated that this IRP could be defined ...
study of the human humoral immune response against rotavirus
... induced by the RIX4414 RV vaccine, and be a better correlate of protection than circulating RV-IgA after vaccination. Recently, it was confirmed in an IgA deficient mouse model that this Ig is very important for the intestinal primary immune response against RV, and that it has a fundamental role i ...
... induced by the RIX4414 RV vaccine, and be a better correlate of protection than circulating RV-IgA after vaccination. Recently, it was confirmed in an IgA deficient mouse model that this Ig is very important for the intestinal primary immune response against RV, and that it has a fundamental role i ...
The role of inflammation in cutaneous repair
... neutrophils show their depletion has no effect on fibrosis, the same cannot be said for macrophages. It is clear that macrophage numbers in the wound can dictate the level of scar formation, with reduced numbers being linked to less fibrosis. In foetal wounds, when monocytes have yet to develop, wou ...
... neutrophils show their depletion has no effect on fibrosis, the same cannot be said for macrophages. It is clear that macrophage numbers in the wound can dictate the level of scar formation, with reduced numbers being linked to less fibrosis. In foetal wounds, when monocytes have yet to develop, wou ...
The functional network of ion channels in T lymphocytes
... Printed in Singapore. All rights reserved ...
... Printed in Singapore. All rights reserved ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.