The ontogeny of the common carp (Cyprinus carpio L.) immune system
... The fish immune system is surprisingly similar to the mammalian immune system, consisting of both an innate and an acquired component15. Although T cells are generated in the thymus16, fish do not possess bone marrow. Instead, hematopoiesis in adult fish takes place in the kidney and spleen. The mai ...
... The fish immune system is surprisingly similar to the mammalian immune system, consisting of both an innate and an acquired component15. Although T cells are generated in the thymus16, fish do not possess bone marrow. Instead, hematopoiesis in adult fish takes place in the kidney and spleen. The mai ...
Lymphoid follicles in (very) severe COPD: beneficial or harmful? REVIEW
... of B-cell follicles. As seen in other tissues, these follicles are the result of lymphoid neogenesis. The finding of oligoclonality in B-cell follicles in COPD suggests that they play a role in local antigen specific immune responses. To date, it is not known which antigens may be involved; microbia ...
... of B-cell follicles. As seen in other tissues, these follicles are the result of lymphoid neogenesis. The finding of oligoclonality in B-cell follicles in COPD suggests that they play a role in local antigen specific immune responses. To date, it is not known which antigens may be involved; microbia ...
Chapter 13
... symmetrical network theory, that provided an explanation for suppression in terms of I-J expressing specific T cell factors. With time many immunologists found it convenient to sweep the I-J phenomenon, together with suppression and network theory, under the rug, rather than puzzle over something th ...
... symmetrical network theory, that provided an explanation for suppression in terms of I-J expressing specific T cell factors. With time many immunologists found it convenient to sweep the I-J phenomenon, together with suppression and network theory, under the rug, rather than puzzle over something th ...
Aspergillus fumigatus conidia induce interferon-b signalling in respiratory epithelial cells C. Beisswenger*
... the pro-inflammatory responses of alveolar macrophages to swollen and germinating A. fumigatus conidia. Whether respiratory epithelial cells play an active role in the defence against invading fungal pathogens is not well understood. However, in recent years, it has become evident that the epithelia ...
... the pro-inflammatory responses of alveolar macrophages to swollen and germinating A. fumigatus conidia. Whether respiratory epithelial cells play an active role in the defence against invading fungal pathogens is not well understood. However, in recent years, it has become evident that the epithelia ...
THE FORGOTTEN THYMUS
... action of the thymus hormone thymosin. This step may be carried out within the thymus gland or elsewhere in the body by the action of the circulating thymosin. These activated T cells may circulate in the blood and lymph or they may come to rest in the inner cortex of the lymph nodes where they appe ...
... action of the thymus hormone thymosin. This step may be carried out within the thymus gland or elsewhere in the body by the action of the circulating thymosin. These activated T cells may circulate in the blood and lymph or they may come to rest in the inner cortex of the lymph nodes where they appe ...
Liver immunology and its role in inflammation and
... Myeloid-derived suppressor cells (MDSC) are also present in the healthy liver22 and are expanded during chronic liver disease.23 MDSCs are defined by their ability to suppress T-cell activation through the production of the immunosuppressive molecules IL-10, transforming growth factor (TGF)β and argi ...
... Myeloid-derived suppressor cells (MDSC) are also present in the healthy liver22 and are expanded during chronic liver disease.23 MDSCs are defined by their ability to suppress T-cell activation through the production of the immunosuppressive molecules IL-10, transforming growth factor (TGF)β and argi ...
Fatty acids and lymphocyte functions
... also have a role in identifying and eliminating cancer cells. There are however some detrimental effects of the immune system and lymphocytes are central to these effects. First, in the course of its activity to recognise and eliminate foreign antigens, the immune system is responsible for the rejec ...
... also have a role in identifying and eliminating cancer cells. There are however some detrimental effects of the immune system and lymphocytes are central to these effects. First, in the course of its activity to recognise and eliminate foreign antigens, the immune system is responsible for the rejec ...
A study of the contribution of mast cells to vaccination
... cell activation and the build-up of an immune response. One can say that adjuvants are used to mediate the same consequences as natural infection. Dendritic cells (DCs) are believed to play a central role in the presentation of antigens to naïve T cells. This is termed priming of a T cell response a ...
... cell activation and the build-up of an immune response. One can say that adjuvants are used to mediate the same consequences as natural infection. Dendritic cells (DCs) are believed to play a central role in the presentation of antigens to naïve T cells. This is termed priming of a T cell response a ...
Brucella melitensis with Immune Response upon Secondary
... to select candidate vaccines. These markers cannot be deduced from studies of the primary immune response against Brucella, because, as shown in other infectious models (23–29), primary and secondary immune responses frequently implicate different classes of effectors. Live vaccines are widely accep ...
... to select candidate vaccines. These markers cannot be deduced from studies of the primary immune response against Brucella, because, as shown in other infectious models (23–29), primary and secondary immune responses frequently implicate different classes of effectors. Live vaccines are widely accep ...
Lymphatic System 1
... a. Reticular cells are an example of an antibodysecreting leukocyte. b. Diffuse lymphatic tissue is prominent within mucous membranes. c. Lymphoid follicles are usually surrounded by a connective tissue capsule. d. Several regions of the body lack lymph nodes, including the axillary, cervical, a ...
... a. Reticular cells are an example of an antibodysecreting leukocyte. b. Diffuse lymphatic tissue is prominent within mucous membranes. c. Lymphoid follicles are usually surrounded by a connective tissue capsule. d. Several regions of the body lack lymph nodes, including the axillary, cervical, a ...
Page 1 of 200 - Gamma Delta Conference 2016
... Cartilaginous fish (sharks, skates, rays) are the oldest extant animals with an immunoglobulin (Ig) superfamily domain-based adaptive immune system that includes B cell receptors (BCR) and T cell receptors (TCR). In addition to traditional alpha beta (αβ) and gamma delta (γδ) TCRs, nurse sharks expr ...
... Cartilaginous fish (sharks, skates, rays) are the oldest extant animals with an immunoglobulin (Ig) superfamily domain-based adaptive immune system that includes B cell receptors (BCR) and T cell receptors (TCR). In addition to traditional alpha beta (αβ) and gamma delta (γδ) TCRs, nurse sharks expr ...
Treg and CTLA-4: Two intertwining pathways to
... sequencing project [52] to determine the causal mutation in the scurfy mouse, an animal presenting with a severe lymphoproliferative syndrome [53]. The Foxp3 gene was pinpointed as the culprit, and it was shown that a frameshift mutation in scurfy mice resulted in a product lacking the carboxy-termi ...
... sequencing project [52] to determine the causal mutation in the scurfy mouse, an animal presenting with a severe lymphoproliferative syndrome [53]. The Foxp3 gene was pinpointed as the culprit, and it was shown that a frameshift mutation in scurfy mice resulted in a product lacking the carboxy-termi ...
PHS 398 (Rev. 9/04), Biographical Sketch Format Page
... Homann, D., T. Dyrberg, J. Petersen, M.B.A. Oldstone, M.G. von Herrath. Insulin in oral immune "tolerance": A one amino acid change in the B-chain makes the difference. J. Immunol. 163:1833-1838 (1999) Oldstone, M.B.A., H. Lewicki, D. Thomas, A. Tishon, D. White, S. Dales, J. Patterson, M. Mancheste ...
... Homann, D., T. Dyrberg, J. Petersen, M.B.A. Oldstone, M.G. von Herrath. Insulin in oral immune "tolerance": A one amino acid change in the B-chain makes the difference. J. Immunol. 163:1833-1838 (1999) Oldstone, M.B.A., H. Lewicki, D. Thomas, A. Tishon, D. White, S. Dales, J. Patterson, M. Mancheste ...
basic immunology
... basophils (1%). These proportions can change dramatically in pathological states, such as during infections. [Actual percentages can differ widely from animal to animal as well.....] ...
... basophils (1%). These proportions can change dramatically in pathological states, such as during infections. [Actual percentages can differ widely from animal to animal as well.....] ...
REIGN IN BLOOD IMMUNE REGULATION IN TYPE 1 DIABETES Mikael Pihl
... antigens. We showed positive clinical effects of GAD65 formulated with aluminium hydroxide (GAD-alum) on preservation of C-peptide secretion in a phase II clinical trial. Unfortunately, a phase III clinical trial in a larger population failed to confirm this finding. Regulatory T cells (Treg) are in ...
... antigens. We showed positive clinical effects of GAD65 formulated with aluminium hydroxide (GAD-alum) on preservation of C-peptide secretion in a phase II clinical trial. Unfortunately, a phase III clinical trial in a larger population failed to confirm this finding. Regulatory T cells (Treg) are in ...
T cells - University of East Anglia
... stem cells from which progenitor cells are derived[8-10] and develop into any of one of four major differentiated epithelial cell types; enterocytes, Paneth cells, goblet cells, enteroendocrine cells[6]. Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) stem cells are intermingled w ...
... stem cells from which progenitor cells are derived[8-10] and develop into any of one of four major differentiated epithelial cell types; enterocytes, Paneth cells, goblet cells, enteroendocrine cells[6]. Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) stem cells are intermingled w ...
Role of PD-1 co-inhibitory pathway in HIV Linköping University Post Print
... cells lose the ability to produce cytokines, lyse infected cells and proliferate in a progressive and hierarchical manner. In a mouse model of acute lymphocytic choriomeningitis virus (LCMV-Armstrong) infection, the virusspecific CD8+ T cells expressed lower levels of PD-1 as compared with the clone ...
... cells lose the ability to produce cytokines, lyse infected cells and proliferate in a progressive and hierarchical manner. In a mouse model of acute lymphocytic choriomeningitis virus (LCMV-Armstrong) infection, the virusspecific CD8+ T cells expressed lower levels of PD-1 as compared with the clone ...
Memory Cells in Old Age T Cells Are Potent + CD25
... T cells have also been shown to occur as large expanded clones that may dominate the repertoire (14). In a recent publication (15), we demonstrated that aging as well as CMV infection lead to a decrease in the size of the naive CD8⫹ T cell pool, but to an increase in the number of IFN-␥-producing CD ...
... T cells have also been shown to occur as large expanded clones that may dominate the repertoire (14). In a recent publication (15), we demonstrated that aging as well as CMV infection lead to a decrease in the size of the naive CD8⫹ T cell pool, but to an increase in the number of IFN-␥-producing CD ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.